EP1289379A1 - Additif pour substances fourrageres - Google Patents

Additif pour substances fourrageres

Info

Publication number
EP1289379A1
EP1289379A1 EP01933998A EP01933998A EP1289379A1 EP 1289379 A1 EP1289379 A1 EP 1289379A1 EP 01933998 A EP01933998 A EP 01933998A EP 01933998 A EP01933998 A EP 01933998A EP 1289379 A1 EP1289379 A1 EP 1289379A1
Authority
EP
European Patent Office
Prior art keywords
feed
feed additive
weight
additive according
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01933998A
Other languages
German (de)
English (en)
Inventor
Klaus-Peter Priebe
Ralf Goldmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DACO INVESTMENT N.V.
Original Assignee
DACO Investment NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DACO Investment NV filed Critical DACO Investment NV
Publication of EP1289379A1 publication Critical patent/EP1289379A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/168—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A23K20/147—Polymeric derivatives, e.g. peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/153—Nucleic acids; Hydrolysis products or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A23K20/28—Silicates, e.g. perlites, zeolites or bentonites
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
    • A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry

Definitions

  • the invention relates to a feed additive made from plant material and its use for feeding animals such as farm animals and pets.
  • Feed has a lasting impact on the performance and health of farm animals and domestic animals. For example, rapid growth of the animals in good health is just as desirable as an effective conversion of the feed consumed by the animals.
  • Appropriate husbandry, feeding and breeding are the basis for animal health and fertility.
  • Preventive measures to maintain health, which strengthen the body's immune system and contribute to the prevention of illnesses, are either not very effective or are linked to the prophylactic use of conventional medicines and hormones, which are prohibited by legal regulations or for ethical reasons or for reasons of health and health Environmental consciousness is rejected or undesirable by the consumer of farm animals.
  • the present invention has for its object to provide a feed additive and a feed with which the immune system of farm and domestic animals is strengthened, the performance values of farm and domestic animals are improved and which are inexpensive to manufacture.
  • the solution to this problem is a feed additive comprising at least one stress protein, at least one chelate compound, at least one phytomineral and at least one nucleotide.
  • a further solution to this problem is a feed comprising a feed additive which comprises at least one stress protein, at least one chelate compound, at least one phytomineral and at least one nucleotide.
  • the chelate compound can be, for example, an amino acid chelate compound and preferably has a molecular weight of not more than 1,500.
  • the at least one stress protein preferably comprises a stress protein with a molecular weight of 65 kDa (HSP 65) or a stress protein with a molecular weight of 70 kDA (HSP 70).
  • the at least one stress protein is preferably present in an amount of 0.0003 to 2.0% by weight, based on the total weight of the feed additive.
  • the at least one chelate compound in an amount of 0.3 to 80.0% by weight, the at least one phytomineral in an amount of 0.03 to 40.0% by weight and the at least one nucleotide in an amount of 0.3 to 80.0% by weight, based in each case on the total weight of the feed additive and independently of one another.
  • a carrier selected from the group consisting of semolina, green flour and mixtures thereof, is preferably additionally present in the feed additive.
  • Silicic acids and / or silicates are preferably present in the feed additive, and a zeolite and / or a silicon dioxide-containing compound containing the components SiO 2 , Al 2 O 3 , Fe 2 O 3 , CaO, MgO, K 2 O and is particularly preferred Na 2 O, present.
  • the feed additive according to the invention can be used to produce supplemented feed, in order to produce a feed comprising a feed additive according to the invention.
  • the feed preferably contains 0.1 to 8.5% by weight of the feed additive according to the invention.
  • Alfalfa, soybeans, cereals, grass and mixtures thereof can be used as animal feed.
  • the feedstuffs according to the invention are preferably used for feeding animals selected from the group consisting of cattle, pigs, poultry, horses, rabbits, calves, piglets, chicks and pets.
  • FIG. 1 shows a diagram which shows the ammonia concentration when feeding initially without and then with the feed additive according to the invention.
  • FIG. 2 shows antimicrobial effects which are based on the use of the feed additive.
  • Figure 3 shows the average weight gain of piglets depending on the use of the feed.
  • Figure 4 shows the nitrogen and phosphorus excretion in pig feeding depending on the use of the feed.
  • Figure 5 shows the conversion of feed in pig feeding.
  • Figure 6 shows the weight gain of piglets depending on the use of the feed additive.
  • FIG. 7 shows the amount of transaminases in the liver after the injection of galactosamine.
  • Figure 8 shows the liver weight of geese after feeding mycotoxins.
  • FIG. 9 shows the detoxification of mycotoxin in the liver by using the feed additive.
  • FIGS 10 to 13 show the influence of the use of the feed on the immune system.
  • the response of the immune system and its effectiveness can be improved by the feed additives according to the invention.
  • the feed additives according to the invention comprise natural, activated amino acid peptides, so-called NT proteins.
  • Preferred NT proteins are stress proteins.
  • Additives containing NT protein sentences show effects on organs such as the intestine or liver, fat metabolism and the immune system. For example, the intestinal flora can be improved, the growth and differentiation of the intestine can be accelerated, the length of the villi can be increased and the recovery of the intestine after damage can be accelerated. After liver damage, the detoxification of mycotoxins and after stress, NT proteins significantly help recovery, and they increase the weight of the intestinal mucosa and the activity of the brush border enzymes (maltase, sucrose and lactase).
  • NT proteins influence the metabolism of long-chain polyunsaturated fatty acids. They also affect lipoprotein metabolism.
  • the NT proteins can affect humoral immunity and cellular immunity.
  • FIG. 1 illustrates this using the example of the ammonia concentration in ppm, plotted over a period of 26 days.
  • the dotted, vertical line indicates the time at which the feed additive according to the invention was used.
  • Table 1 shows a mineral mixture with reduced values and preferably with a calcium / phosphorus ratio of 1: 1 or 1: 0.8, which comes into play when using NT proteins.
  • Table 1 Feed additive with NT proteins
  • the plant juice was separated in a cross-flow ultrafiltration system (cross-flow ultra filtration) into a polymer-rich alfalfa juice and a polymer-poor alfalfa juice.
  • the polymer-rich alfalfa juice was slowly warmed until a protein conglomerate precipitated.
  • the protein conglomerate was separated from the liquid supernatant.
  • the polymer-poor alfalfa juice was separated into a dilute aqueous phase and a phytomineral-rich phase by means of reverse osmosis.
  • the protein conglomerate and phytominerals, amino acid chelates and a silicate were added to the press cake, giving the following composition of the feed additive: Protein conglomerate 30 g
  • Silicon dioxide 4290 g SiO 2 -Al2 ⁇ 3-Fe2 ⁇ 3-CaO-MgO-K2 ⁇ + Na 2 O).
  • Chicks per hen 116.60 104.50 +12.10 The test group achieved a significantly higher productivity in eggs and chicks by using the feed additive according to the invention.
  • test group achieved a significantly higher productivity in eggs and chicks by using the feed additive according to the invention.
  • the use of the feed additive according to the invention significantly improves the transfer of antibody titers to the chicks.
  • 50,000 breeding chickens (Ross broiler parents) were fed with the control feed in a conventional manner. From week 10 onwards, 25,000 (test group) of the 50,000 breeding chickens were fed the supplemented feed and 25000 (control group) the control feed, the feed consumption rates per bird being dosed differently according to the following table. After 50 weeks, the production performance of the control group was compared with the test group:
  • the production index can be increased significantly by using the feed additive according to the invention. Despite the lower feed dosage, a higher mean final weight of the chickens was achieved in the experimental group with the same fattening period.
  • test group achieved higher productivity with regard to eggs and chicks by using the feed additive according to the invention.
  • the improvement corresponds to 4.6 one day old chicks per hen.
  • the feed additive was added to the conventional feed, in different amounts depending on the animal to be fed according to the following table
  • Control group test group difference in% 100 (test group) of the 200 pigs was added to the feed additive according to the table above and 100 (control group) were also fed conventionally afterwards. After 50 weeks, the production performance and mortality rates of the control group were compared with that of the test group: Control group test group difference in%
  • Piglets from the experimental and control groups were weighed daily and the average weight gain of the piglets was determined. The results are shown in Figure 3 (y-axis weight in kg).
  • the use of a feed additive according to the invention reduced the mortality rate of the piglets and accelerated their weight gain.
  • the weight loss of the mother pigs during the suckling phase was reduced.
  • 197 pigs initially 20 days old, were fed over a period of 80 days. According to the table above, the feed additive was added to the feed of 99 (test group) of the 197 pigs and 98 animals (control group) were fed conventionally (test group). The pigs in the experimental and comparison groups were weighed daily and the daily weight gain was determined. The weight gain and mortality rates of the control group were compared with that of the test group: Control group, experimental group
  • test group achieved a higher mean final weight of the pigs with the same fattening time.
  • mortality rate of the test group was significantly lower.
  • Figures 4 and 5 show further effects that can be observed when using the feed additive according to the invention in pig feeding.
  • FIG. 6 shows the weight gain of piglets in kg when fed with a feed supplemented with the feed additive according to the invention.
  • FIG. 7 shows the level of serum of GOT or GTP in a control group (feeding without feed additive according to the invention with glucose and amino acids (group S: bars on the left)) and a test group (feeding was additionally carried out with feed addition according to the invention (group OG: bars) right)).
  • FIGS. 8 and 9 show effects after feeding with mycotoxin (DON, DAS, F2) for 3 months on geese with and without the feed additive according to the invention.
  • FIG. 8 shows an effect on the detoxification of mycotoxins by the feed additives according to the invention (weight of the liver in g in the control group (bar below) and test group, ie when feeding the feed according to the invention (bar above)).
  • FIG. 9 shows a further effect on the detoxification of mycotoxins by the feed additives according to the invention (% mycotoxin in the control group (bar below) and test group, that is to say when feeding the feed according to the invention (bar above)).
  • FIG. 10 explains the effect on the immune system using the example of the antibody titer of reovirus, plotted over weeks 9 to 57, a feed according to the invention being used from week 23: (diamonds: control group, that is to say fed without feed additives according to the invention; circles: test group , ie from week 23, feed mixed with feed additive according to the invention is used for feeding).
  • FIG. 11 explains the effect on the immune system using the example of the antibody titer of reovirus, plotted over weeks 1 to 64, a feed according to the invention being used for feeding from week 23: (squares: control group, ie fed without feed additives according to the invention; circles: Experimental group, that is to say feed used with feed additive according to the invention used for feeding from week 23)
  • FIG. 12 explains the effect on the immune system using the example of the antibody titer in Newcastle disease (Newcastle disease).
  • the experimental animals were vaccinated against the disease.
  • the logarithmic mean of the antibody titer is plotted in a control group, ie fed without feed additives according to the invention (band in the foreground: light gray), in a first test group, feed mixed with feed additive according to the invention being used for the test animals before and after vaccination ( Band in the middle of the picture: dark gray), and in a second test group, the feed being used for the test animals only after the vaccination with feed additive according to the invention (band in the background: black)
  • Figure 13 explains the effect on the immune system using the example of protection in percent in Newcastle disease (Newcastle disease).
  • the test animals (chickens) were vaccinated against the virulent strains of NDV. Protection is applied in percent for a control group, i.e. fed without feed additives according to the invention (bar in the foreground: light gray), in a first test group, feed mixed with feed additive according to the invention being used for the test animals before and after vaccination (bar in the center of the picture: dark gray), and in a second Experimental group, the feed used for the experimental animals only after the vaccination with feed additive according to the invention for feeding (bars in the background: black)
  • the following table shows examples of further effects that can be achieved by using a feed according to the invention when feeding chickens and chicks.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Fodder In General (AREA)
  • Feed For Specific Animals (AREA)

Abstract

L'invention concerne un additif pour substances fourragères contenant des matières végétales et son utilisation pour l'alimentation d'animaux tels que des bovins et des animaux domestiques.
EP01933998A 2000-05-19 2001-05-21 Additif pour substances fourrageres Withdrawn EP1289379A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10024746A DE10024746A1 (de) 2000-05-19 2000-05-19 Futtermittelzusatz
DE10024746 2000-05-19
PCT/EP2001/005830 WO2001089316A1 (fr) 2000-05-19 2001-05-21 Additif pour substances fourrageres

Publications (1)

Publication Number Publication Date
EP1289379A1 true EP1289379A1 (fr) 2003-03-12

Family

ID=7642753

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01933998A Withdrawn EP1289379A1 (fr) 2000-05-19 2001-05-21 Additif pour substances fourrageres

Country Status (4)

Country Link
EP (1) EP1289379A1 (fr)
AU (1) AU2001260323A1 (fr)
DE (1) DE10024746A1 (fr)
WO (1) WO2001089316A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1455593T3 (da) * 2001-10-06 2013-08-26 Merial Ltd Fremgangsmåder og sammensætninger til fremme af vækst og medfødt immunitet hos unge dyr
ES2391558T3 (es) 2003-06-23 2012-11-27 Nestec S.A. Suplemento de aminoácidos para un ecosistema microbiótico sano
ES2283912T3 (es) * 2004-08-17 2007-11-01 Lesaffre Et Compagnie Aditivo alimentario.
GB0718991D0 (en) * 2007-09-28 2007-11-07 Univ Ghent Methods and compositions to treat aquatic organisms
CN107156518A (zh) * 2017-06-06 2017-09-15 辽东学院 一种提高肉鸡生产性能中草药添加剂
CN115462473B (zh) * 2022-09-26 2024-04-19 禾丰食品股份有限公司 一种改善产蛋后期蛋壳品质的日粮及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GEP20002333B (en) * 1999-05-19 2000-09-10 Method for Inducing Synthesis of Heat Stress Proteins in Herbal Plants

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
None *
See also references of WO0189316A1 *

Also Published As

Publication number Publication date
DE10024746A1 (de) 2001-11-22
AU2001260323A1 (en) 2001-12-03
WO2001089316A1 (fr) 2001-11-29

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