EP1274396A2 - Verfahren und vorrichtung für die abgabe eine pharmaceutische oder kosmetische aktive agents - Google Patents
Verfahren und vorrichtung für die abgabe eine pharmaceutische oder kosmetische aktive agentsInfo
- Publication number
- EP1274396A2 EP1274396A2 EP01904036A EP01904036A EP1274396A2 EP 1274396 A2 EP1274396 A2 EP 1274396A2 EP 01904036 A EP01904036 A EP 01904036A EP 01904036 A EP01904036 A EP 01904036A EP 1274396 A2 EP1274396 A2 EP 1274396A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- capsules
- microcapsules
- tearing
- active
- application
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/11—Encapsulated compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q13/00—Formulations or additives for perfume preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
Definitions
- the present invention relates to devices made of a support material for capsules or microcapsules containing one or more active ingredients to be stored in the air before use and relates in particular to a device for applying principles active ingredients formed of a material of this type which can be used in particular for pharmaceutical or cosmetic applications.
- microcapsules So we thought about using microcapsules.
- the microcapsule technique is well known in the biomedical field.
- the microcapsules are spherical particles, made up of a solid envelope containing a liquid, a solid or a pasty substance.
- microcapsule which can have a dimension ranging between 50 ⁇ m and 1.5 mm therefore constitutes a tank itself.
- Microencapsulation the first industrial application of which was in fact the development of carbonless carbon paper, made it possible to solve a large number of problems in pharmacy.
- the microcapsules thanks to their membrane which limits exchanges with the outside, provide protection of the drug against various chemical or physical agents such as humidity, heat or oxidation.
- the microcapsules make it possible to control the speed of release of the active principles which are contained therein and therefore to modulate their bioavailability. This can be achieved by acting on a large number of technological parameters: nature of the material constituting the membrane, proportion of the active principles, size of the particles, thickness of the envelope of the microcapsules.
- the material used is a foam such as polyurethane foam, polyethylene foam or other polymer having a spongy consistency.
- Polyurethane foam for example, is conventionally manufactured by polycondensation by mixing a polyol and isocyanate in the presence of water which causes a gassing of carbon dioxide and therefore the formation of cells which gives a foam appearance. spongy to the resulting polymer.
- the microcapsules are added to the three components mentioned above and the whole is mixed homogeneously. When the polymerization is complete, the product obtained is therefore a spongy material comprising microcapsules disseminated in the mass of the foam which serves as a binder.
- the cells communicate with each other so that the products contained in the microcapsules can flow when the material is used. he must therefore put a sufficient amount of water to cause the formation of open cells (ie communicating with each other).
- the ideal is of course to have a material comprising 100% open cells, but the applications mentioned below are possible if we are dealing with a foam comprising only 60% open cells. Indeed, in addition to the diffusion through the interior of the cells, it turns out that there is also a diffusion of the products by impregnation and by capillarity.
- microcapsule support material described in this document is done by exerting a pressure on the material so as to burst the microcapsules so that the active principle or principles contained therein can be released and easily reach the surface of the material thanks to the presence of open cells.
- microcapsule support material as described in document FR-A-2,754,450 has a major drawback. Indeed, the application surface can be soiled by undesirable bodies such as dirt, dust, or microbes, even if the material is wrapped in a package before use. Therefore, the active ingredients can be polluted when they are released on the surface of the material and their application on the skin of the user can then lead to contamination of the latter with pathological consequences.
- the object of the invention is to provide a device for applying active ingredients contained in capsules or microcapsules disseminated in a spongy material in which perfect sterility of the active ingredients is maintained due to the fact that the application surface only exists when the device is used.
- the object of the invention is therefore a device for applying at least one active principle consisting of a material in which one or more capsules or microcapsules containing the active ingredient (s) are disseminated in a binder of spongy consistency so that the active ingredient (s) are released when pressure is exerted on the material.
- the device consists of a first part and a second part separated by a tear-off portion, the capsule or a majority of capsules or microcapsules being in the first part near the tear-off portion, the first part being detached from the second part by tearing the tearable portion so as to obtain, at the place of the tear, an application surface of the active ingredient (s) located in the first part when pressure is exerted on it.
- FIG. 1 represents a preferred embodiment of the device according to the invention
- FIG. 2 represents a cross section of the device illustrated in FIG. 1, as well as a magnification showing the skin formed after formation of the spongy material, and
- FIG. 3 is an enlarged view of the tearable portion after the device illustrated in Figure 1 has been separated into two parts according to the principles of the invention.
- the device comprises two parts 10 and 12 which can be easily separated thanks to the tearable portion 14.
- This portion is formed by a thinning of the two parts 10 and 12 in the form of truncated cones forming an angle of about 45 ° so that lead to a thinned zone 16 at the intersection of the two truncated cones.
- the thinned zone allows easy separation of the two parts 10 and 12 further facilitated by the tear initiation due to the angular shape of the tearable portion. To carry out this operation, it suffices to hold the part 12 in one hand while grasping the part 10 at the places marked with an arrow and by exerting a torque on the part 10 to cause tearing at the place of the zone 16.
- the device according to the invention consists of a sponge support material such as foam comprising a high percentage of open cells.
- This foam can be of any kind, in particular a foam obtained by polymerization such as a polyurethane foam, or any other polymer having a spongy consistency.
- a biodegradable material will preferably be chosen.
- the microcapsules 18 are concentrated mainly in a volume including the tearable portion near the thinned zone 16.
- the microcapsules 18 are of variable dimensions, for example d 'a diameter ranging between 50 ⁇ m and 1.5 mm. But we can consider putting capsules (rather than microcapsules) with a diameter of several mm without departing from the scope of the invention.
- the portion 14 is presented in the manner illustrated in FIG. 3; the tear having taken place at the thinned zone 16, the upper part 10 comprises an application surface 20 having in the immediate vicinity a maximum of capsules or microcapsules.
- this new surface is absolutely sterile insofar as it has not been in contact with foreign bodies. The user can then release the active ingredient (s) to the surface 20 by applying pressure to part 10, for example between the thumb and forefinger at the locations indicated by arrows in FIG. 1.
- a characteristic of the invention is to concentrate the microcapsules (or capsules) as close as possible to the tearable portion 14.
- a polyurethane foam material this is achieved by injecting the constituent products into a mold. the foam before polymerization, then the capsules or microcapsules and finally again the polymerization products.
- the time of polymerization which lasts a few seconds
- the microcapsules are disseminated in the zone intended to become the tearable portion. So that the microcapsules are evenly distributed in the foam. It is possible to act on the foaming time, but also to constitute a very fluid foam or to subject the mold to vibrations.
- the application devices or applicators according to the invention can have any shape as long as they comprise a tearable portion and a concentration of capsules or microcapsules in the vicinity of this tearable portion.
- the device may consist of two parts intended to serve as applicators of the active ingredients.
- the thinned zone 16 constitutes, after tearing, the application surface for the two applicators obtained after separation.
- the device has two parts identical to part 10 of the device illustrated in FIG. 1, the separation of the two parts then making it possible to obtain two identical applicators.
- the external shape can also be associated with an aesthetic effect or with a gripping ergonomics allowing a gripping of the applicator resulting in an automatic crushing of the microcapsules in the tearable portion.
- the microcapsules can contain a skin cleaning product, a liquid soap, a drug intended for a skin treatment, a perfume, a makeup-removing product or any other toilet product.
- a particular embodiment consists in fixing, by gluing, a plurality of devices such as the device illustrated in FIG. 1 on a vertical support.
- the user can easily detach using a single hand, a sterile applicator ready for use, whenever he needs it until the devices fixed on the support are used up.
- the device according to the invention can be used in all applications where the product to be applied should not be released until it is used by crushing capsules or microcapsules. It should be noted that the number of capsules or microcapsules or their size does not matter, and one could consider having only a small number of capsules in the tearable portion and ultimately, only one large capsule (for example 5mm in diameter) near the application surface which crashes to release the active product when the user exerts pressure.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Birds (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0001621 | 2000-02-04 | ||
FR0001621A FR2804601B1 (fr) | 2000-02-04 | 2000-02-04 | Dispositif d'application de principes actifs utilisables dans le domaine pharmaceutique ou cosmetique |
PCT/FR2001/000319 WO2001056540A2 (fr) | 2000-02-04 | 2001-02-02 | Dispositif d'application de principes actifs utilisable dans le domaine pharmaceutique ou cosmetique |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1274396A2 true EP1274396A2 (de) | 2003-01-15 |
Family
ID=8846822
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP01904036A Withdrawn EP1274396A2 (de) | 2000-02-04 | 2001-02-02 | Verfahren und vorrichtung für die abgabe eine pharmaceutische oder kosmetische aktive agents |
Country Status (6)
Country | Link |
---|---|
US (1) | US7128925B2 (de) |
EP (1) | EP1274396A2 (de) |
JP (1) | JP2003521340A (de) |
AU (1) | AU2001231964A1 (de) |
FR (1) | FR2804601B1 (de) |
WO (1) | WO2001056540A2 (de) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080038301A1 (en) * | 2006-08-08 | 2008-02-14 | The Procter & Gamble Company | Personal care product comprising collapsible water-containing capsules |
US8778387B2 (en) | 2009-09-02 | 2014-07-15 | Hyprotek, Inc. | Antimicrobial medical dressings and protecting wounds and catheter sites |
SG182452A1 (en) | 2010-01-22 | 2012-08-30 | Hyprotek Inc | Antimicrobial agent comprising peroxide, alcohol and chelating agent |
WO2011100780A1 (en) * | 2010-02-19 | 2011-08-25 | Majic Beauty Pty Ltd | Cosmetic applicator |
US20130199946A1 (en) | 2012-02-06 | 2013-08-08 | Hyprotek, Inc. | Portable Medical Device Protectors |
WO2014165334A1 (en) * | 2013-04-03 | 2014-10-09 | United Technologies Corporation | Dynamic method of obtaining a sample of materials |
FR3071584B1 (fr) | 2017-09-24 | 2020-01-10 | 3X Engineering | Dispositif pour faciliter la reparation des pipelines |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2004836A1 (de) * | 1969-02-04 | 1970-09-17 | ||
US3918452A (en) * | 1974-08-01 | 1975-11-11 | Edward Cornfeld | Tampons impregnated with contraceptive compositions |
JPS58158299A (ja) * | 1982-03-16 | 1983-09-20 | ホ−ライ糊工業株式会社 | 倒立式糊容器の糊漏防止装置 |
DE3437833A1 (de) | 1984-10-16 | 1986-04-17 | Eichholz Willi | Eingabegeraet zum konstruieren am bildschirm |
DE3447833A1 (de) * | 1984-12-29 | 1986-07-10 | Allan Gerhard 8047 Karlsfeld Frühauf | Tuch o.dgl. mit einen wirkstoff enthaltenden mikrokapseln |
US4828542A (en) * | 1986-08-29 | 1989-05-09 | Twin Rivers Engineering | Foam substrate and micropackaged active ingredient particle composite dispensing materials |
JPS63178178A (ja) | 1987-01-19 | 1988-07-22 | Toray Ind Inc | 水なし平版用インキ組成物 |
FR2633167B1 (fr) * | 1988-06-27 | 1990-09-21 | Oreal | Ensemble applicateur d'un produit en poudre ou pateux notamment d'un produit cosmetique |
US4904524A (en) * | 1988-10-18 | 1990-02-27 | Scott Paper Company | Wet wipes |
JPH0427726A (ja) * | 1990-05-18 | 1992-01-30 | Nissan Motor Co Ltd | 自動車用ディーゼルエンジンの制御装置 |
JPH0427724A (ja) * | 1990-05-23 | 1992-01-30 | Hitachi Ltd | 回転角度検出装置組立体 |
JPH05222231A (ja) * | 1992-02-07 | 1993-08-31 | Inoac Corp | 芳香ポリウレタンフォームおよびその製造方法 |
FR2754450B1 (fr) * | 1996-10-11 | 1998-12-31 | 3X Engineering | Materiau support de microcapsules |
JPH10314314A (ja) * | 1997-05-14 | 1998-12-02 | Sekisui Chem Co Ltd | 薬液塗布具 |
US6508604B1 (en) * | 1999-03-19 | 2003-01-21 | The Procter & Gamble Company | Article comprising a cell system |
-
2000
- 2000-02-04 FR FR0001621A patent/FR2804601B1/fr not_active Expired - Lifetime
-
2001
- 2001-02-02 AU AU2001231964A patent/AU2001231964A1/en not_active Abandoned
- 2001-02-02 WO PCT/FR2001/000319 patent/WO2001056540A2/fr active Application Filing
- 2001-02-02 EP EP01904036A patent/EP1274396A2/de not_active Withdrawn
- 2001-02-02 JP JP2001556232A patent/JP2003521340A/ja active Pending
- 2001-02-02 US US10/203,033 patent/US7128925B2/en not_active Expired - Fee Related
Non-Patent Citations (1)
Title |
---|
See references of WO0156540A2 * |
Also Published As
Publication number | Publication date |
---|---|
WO2001056540A2 (fr) | 2001-08-09 |
US20040050402A1 (en) | 2004-03-18 |
WO2001056540A3 (fr) | 2002-04-04 |
US7128925B2 (en) | 2006-10-31 |
FR2804601A1 (fr) | 2001-08-10 |
AU2001231964A1 (en) | 2001-08-14 |
JP2003521340A (ja) | 2003-07-15 |
FR2804601B1 (fr) | 2002-04-26 |
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Legal Events
Date | Code | Title | Description |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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AK | Designated contracting states |
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AX | Request for extension of the european patent |
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17P | Request for examination filed |
Effective date: 20021120 |
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R17P | Request for examination filed (corrected) |
Effective date: 20020904 |
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17Q | First examination report despatched |
Effective date: 20060803 |
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RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: SUBMIN LIMITED Owner name: 3X ENGINEERING |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61Q 19/00 20060101ALI20090514BHEP Ipc: A61K 8/11 20060101ALI20090514BHEP Ipc: A61K 9/48 20060101ALI20090514BHEP Ipc: A61J 1/00 20060101AFI20090514BHEP Ipc: A61M 35/00 20060101ALI20090514BHEP |
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Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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18D | Application deemed to be withdrawn |
Effective date: 20091215 |