US3918452A - Tampons impregnated with contraceptive compositions - Google Patents

Tampons impregnated with contraceptive compositions Download PDF

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Publication number
US3918452A
US3918452A US49383174A US3918452A US 3918452 A US3918452 A US 3918452A US 49383174 A US49383174 A US 49383174A US 3918452 A US3918452 A US 3918452A
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Prior art keywords
tampon
contraceptive
sponge
composition
microcapsules
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Edward Cornfeld
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MEDICAL PHYSICS Corp
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Edward Cornfeld
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/15Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/20Tampons, e.g. catamenial tampons; Accessories therefor
    • A61F13/26Means for inserting tampons, i.e. applicators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms

Abstract

Vaginal sponges and/or tampons impregnated with contraceptive compositions and methods of preventing conception or implantation by insertion in an animal organism of said sponge or tampon prior to exposure to conception.

Description

United States Patent 1191 Cornfeld [451 Nov. 11, 1975 [5 1 TAMPONS IMPREGNATED WITH 3.108.043 10/1963 Somerville 128/270 I CONTRACEPTIVE COMPOSITIONS 3.108043 10/1963 Mi11man 128/270 X 3,424,159 1/1969 Whitehead at 211.... 128/263 1 Inventorl Edward Potomac, 3.490.454 1/1970 G01df2ll'b et a1 128/285 3.521637 7/1970 Waterbury 1 128/270 [73] Asslgnee' ai S'lver Spnng 3.639562 2/1972 Gordon et Z11..... 128/270 x 3,679,102 7/1972 Charle 1 1 128/260 X [22] i Aug 1 974 3,749,094 7/1973 Duncan 128/270 3,756,238 9/1973 Hanke.... 128/270 [21] Appl. No: 493,831 3,850,173 11/1974 Dash 128/261 152 US. Cl. 128/270; 128/260; 128/263 i' Medbery 424/16 Attorney, Agent, or Firm-Sherman & Shalloway [51] Int. Cl. A61F 13/20; A61K 7/00 [58] Field of Search 128/260, 270, 285, 290 R, [57] ABSTRACT 261; 424/16 45 Vaginal sponges and/or tampons impregnated with contraceptive compositions and methods of prevent- [56] References Clted ing conception or implantation by insertion in an ani- UNITED STATES PATENTS mal organism of said sponge or tampon prior to expo- 702,570 6/1902 Lohlein 128/263 sure to conception. 2,943,979 7/1960 Elias 424/16 3.091.241 5/1963 K6116 128/270 3 Clams, 5 Drawlng Figures US. Patent Nov. 11, 1975 FIG.4

FIGJ

FIG.5

TAMPONS IMPREGNATED WITH CONTRACEPTIVE COMPOSITIONS BACKGROUND OF THE INVENTION DESCRIPTION OF THE PRIOR ART It has long been an object of the pharmaceutical industry to discover a safe and'effective method of preventing conception which can be utilized precoitus that is non-interfering and easy to use.

Heretofore, it has been known to impregnate tampons with an abortive facient, such as pi'ostaglandin, in order to terminate a conception in the very early states of the pregnancy.

Additionally, prior art methods are known for preventing conception by utilization of vaginal foams or creams containing cont'faceptive compositions. The prior art means of preventing conception are either inconvenient to use or have physiological or psychological drawbacks once pregnancy has begun.

U.S. Pat. No. 3,105,128 shows a method of microencapsulation.

U.S. Pat. No. 3,691,271 shows a sanitary napkin with microcapsules filled with a bactericidal and fungicidal deodorant.

U.S. Pat. No. 3,814,809 shows the combination of a suppository and tampon with a contraceptive drug for use after exposure.

I SUMMARY OF THE PRESENT INVENTION It is a general feature of the present invention to avoid and overcome the foregoing and other difficulties and objections to prior art contraceptive means by the provision of a more effective and generally acceptable means. More specifically, a feature of the present invention is to provide a vaginal sponge or tampon which is impregnated with a known safe and effective contra ceptive composition.

Further, another feature of the present invention is to provide a vaginal sponge or tampon which is impregnated with a contraceptive drug that is microencapsulated so that there is a sustained release of the contraceptive composition before, during and/or after coitus.

It is still another feature of the present invention to provide a means for insertion of the sponge or tampon into the vagina which can be packaged as a single unit.

A yet further feature of the present invention is to provide a means for housing the impregnated sponge or tampon, inserting the sponge or tampon and, if desired, removing the sponge or tampon from the vagina.

The aforesaid features of the present invention, and other features which will become apparent as the description proceeds, are accomplished by providing a vaginal sponge or tampon that is impregnatedupreferably 'a microencaptlital eenrrlce snve cameos:

' sules which maybe used are those which provide a sustained release and/or those which are pressure rupturable. The contraceptive composition may include any of the known steroidal or non-steroidal compounds.

A method having certain features of this invention includesthe step of inserting and maintaining in the vagina a sponge or tampon impregnated with a contraceptive composition, preferably a composition which is microencapsulated.

DETAILED DESCRIPTION OF THE PRESENT INVENTION For a better understanding of the present invention, reference should be made to the accompanying drawings,. wherein like numerals indicate similar parts throughout the several views and wherein:

FIG. 1 isa perspective view of a tampon and applicator inaccordance with this invention. I

FIG. 2 isa perspective view of a further applicator and tampon of the present invention.

FIG. 3 is a perspective view of a tampon of this invention. p

FIG. 4 is a cross-sectional view of the impregnated tampon of FIG. 3

FIG. 5 is a cross-sectional view of an impregnated sponge having aspring means.

PREFERRED EMBODIMENTS OF THE PRESENT I INVENTION able in the housing 12 so as to eject the tampon 14 from the housing 12. If the tampon 14 is provided with a means for removal, such as a string 19, the housing 12 may be provided with'a slot 18 so as to accommodate the string. V

FIG. 2 illustrates a further embodiment of the invention wherein there is provided an applicator 20 having a housing 28 containing an impregnatedtampon 24 in the front end portion. The applicator 20 is provided with a plunger 26 which ejects the tampon 24 and is capable of providing a vacuum suction so as to withdraw the tampon when desired. x

FIG. 3 shows the tampon prior to compression and insertion into the applicator shown in FIG. 1. The tampon comprises any of the known cellulosic tampons that are well known in the art. The tampon includes those which contain the conventional polyurethane foams, the reaction product of liquid polyols (polyester or polyether) and a disfunctional isocyanate, usually toluene diisocyanate. A catalyst such as tin, an ammine, a flowing agent, generally water, and foaming stabilizers are also employed. The required cylinders for tampon use are cut from the prepared foam. The string 19 is provided for removal of the tampon either preor post-coitus FIG. 4 is a cross-sectional view of the tampon of FIG. 3 showing the microencapsulations 40 The microcapsules used in the present: invention uahrbe madeabf any Beaver-newly mplayea material in :the mieroefic apwanna new; -Represenmive of polymeric mataria-ls to prcs'anee- @He--mi@f6capsules aresuellz polymfli's an polymyimeehol, pdlyerh ylene, polypropylene. polystyrilefpolyatrylamidesg polyethers; pdlyestehs; polyamides, polybutadiene, polyisoprene, epoxy resins, polyurethanes, ethyl cellulose, carboxymethyl cellulose and the like. The nature and the size of the walls will be generally chosen for their compatibility with the contraceptive composition used. Generally, the ratio of the weight of the wall to the total weight of the filled microcapsule ranges from between 3-10:100.

Any conventional technique of microcapsule fabrication can be used, particularly microencapsulation by mechanical means such as centrifugal microencapsulatioh. In this method, droplets of the material to be microencapsulated are formed by the centrifugal force of a turntable which then traverse by means of the velocity with which they thus acquire a thin film of fluid product designed to form the wall of the microcapsule. Conventional wall-hardening treatment can be employed which, in a case where the wall is prepared from a thermoplastic material, can simply be a sudden cooling of the microcapsules formed. Representative suitable microencapsulation operation can be found in the literature, for instance U.S. Pat. No. 3,015,128.

The material encapsulated in the microcapsules can be, for instance, such contraceptive compounds as nonylphenoxypolyethoxyethanol and an estrongenic compound such as 3-methoxy-19-nor-170z-pregna- 1,3,5( l)-trien-20-yn-17-o1; l9-nor-17oz-pregn-4-enyne-l3B, 17 diol and the like.

FIG. is a cross-sectional view of a vaginal sponge 50 which comprises preferably a cellular resilient material 52 having therein a spring 54 for maintaining the sponge in an expanded state. The sponge 52 may comprise any of the known water-resistant cellular matter such as cellulosic sponge, polyurethane, polyesters, and the like which are compatible with the body. The sponge 50 contains throughout the microcapsules 40 containing the contraceptive material. The size and composition of the capsule wall is preferably varied in solubility and rupturability so as to provide a sustained release during usage. Additionally, the microcapsules may contain in addition to the contraceptive compositions any spermicide which is known in the art. The microencapsulation permits the utilization of known compatible compositions simultaneously.

The method in accordance with this invention comprises inserting in the animal organism one vaginal tampon which is impregnated with a contraceptive composition and/or spermicidal composition between one hour and twenty-four hours prior to exposure. As stated above, the contraceptive has a sustained release in the vagina during and after coitus so that any exteriorally inserted fluids, such as semen resulting from coitus, will be exposed to the contraceptive compositions and any accompanying spermicide released by the rupturability and solubility of the micro capsules 40 in the normal muscosa fluid present in the vagina.

Obviously, the dosage form will depend upon the contraceptive composition employed, besides that the microcapsules generally have a size ranging from about 50 1,000 microns in diameter. The thickness of the wall of the microcapsule will vary according to the materials used and to the effect desired,

The microcapsules are introduced either directly into the sponge or tampon at a moment-in which its fluidity porate them before termination of the polymerization of the sponge.

In general, microcapsules are introduced into the sponge or tampon in the course of manufacture in the form of a liquid or suspension; the best possible homogenization is obtained by suitable mixing by agitation, shaking or blowing in of a gas. The density of the liquid or of the suspension is then adjusted to that of the microcapsules by addition of a suitable inert substance. It is also possible to select microcapsules whose density corresponds to that of the liquid or suspension at the time of their introduction into the sponge or tampon. The following non-limiting examples, in which parts and percentages refer to weight, are given by way of illustration and allow a fuller understanding of the present invention.

EXAMPLE 1 Tampon containing a microencapsulated contraceptive composition:

The following contraceptive composition is prepared:

Contraceptive Compound 4.0 Vaseline 6.0 Glycerol 10.0 Anti-ferment 0.1 Water to make-up 100.0

The contraceptive composition is then microencapsulated by the known technique, using polypropylene, the microcapsules having an average diameter of 50-100 microns and preferably 60-80 microns. Microcapsules are dispersed either by a suitable mechanical device or by projection using compressed air or gas.

The contraceptive compound may be any of the known estrogenic agents such as Enovid (Trademark).

EXAMPLE 11 The sponge containing microencapsulated contraceptive composition:

The following solution is prepared:

Glycerin 5.00 Contraceptive Compound 10.00 Oxytoxin 0.50

EXAMPLE 111 The following composition is prepared:

Spermicide 10.00 Gl yrine 10.00 Sodium Lauryl SulfateSolution (30%) 30.00

This composition containing-- the spermicide; is thh microencapsulated utilizing p e lyyiay l 'a uhalfiay any positions, the vaginal sponge or tampon may be surface coated or impregnated with a contraceptive composition dissolved or suspended in a melt of a low-melting, biodegradable wax. The 'wax with the contraceptive compound incorporated is then either powdered or the melt is poured over a cold surface and a waxy material scraped off in the forms of powder or flakes. Among the vehicles for slow release of the contraceptive composition in biological fluids are acetyl palmitate, carbona wax, lauric acid, a mixture of sodium laurate and lauric acid, a mixture of stearic acid and sodium stearate, a mixture of archidonic acid and sodium archidonate and acetyl palmitate.

Obviously, the embodiments shown are exemplary only and a wide variety of embodiments may be devised without departing from the spirit and scope of the invention.

What is claimed is:

l. The method of preventing conception or implantation which comprises inserting into the vagina of a mammal a sponge tampon impregnated with microcapsules having a contraceptive composition prior to exposure to exteriorally inserted fluids and permitting said sponge tampon to remain in the vagina until at least an effective amount of said composition is released and leaving the sponge tampon in the vagina at least during the insertion of said exterior fluids so as to prevent conception or implantation from said fluids.

2. The method of claim 1 wherein said comosition is microencapsulated in a sustained release form and said composition is caused to be released by the biological muscosa fluid.

3. The method of claim 1 wherein said microcapsules include a spermicide and said spermicide is released with said contraceptive composition.

Claims (3)

1. The method of preventing conception or implantation which comprises inserting into the vagina of a mammal a sponge tampon impregnated with microcapsules having a contraceptive composition prior to exposure to exteriorally inserted fluids and permitting said sponge tampon to remain in the vagina until at least an effective amount of said composition is released and leaving the sponge tampon in the vagina at least during the insertion of said exterior fluids so as to prevent conception or implantation from said fluids.
2. The method of claim 1 wherein said comosition is microencapsulated in a sustained release form and said composition is caused to be released by the biological muscosa fluid.
3. The method of claim 1 wherein said microcapsules include a spermicide and said spermicide is released with said contraceptive composition.
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WO1980000008A1 (en) * 1978-06-09 1980-01-10 Donald Enterprises Inc Contraceptive-antivenereal disease tampon
EP0006861A1 (en) * 1977-06-27 1980-01-23 Vorhauer Lab Biologically compatible tampon sponge.
FR2455902A1 (en) * 1979-05-07 1980-12-05 Langlois Pierre Spermicidal contraceptive tampon of cellular synthetic sponge - has semi-open cells contg. spermicide and prolonged release medium
EP0029708A1 (en) * 1979-11-21 1981-06-03 Vorhauer Laboratories, Ltd. Biologically compatible tampon contraceptive
US4271835A (en) * 1978-05-17 1981-06-09 Kcdp Corporation Fluid-expansible contraceptive tampon and applicator
FR2484247A1 (en) * 1980-03-26 1981-12-18 Langlois Pierre Contraceptive tampon of elastic foam with an integral pull cord - for ease of use and removal
US4309997A (en) * 1978-06-09 1982-01-12 Donald Jack W Contraceptive and/or antivenereal disease tampon
US4318405A (en) * 1980-07-24 1982-03-09 Sneider Vincent R Tampon and drug delivery device
EP0051709A1 (en) * 1980-11-07 1982-05-19 Atlantic Pharmaceutical Products Contraceptive tampon, set of a tampon and an applicator and process for preparing the tampon
US4351338A (en) * 1980-05-21 1982-09-28 Pierre Langlois Vaginal tampon
US4393871A (en) * 1977-06-27 1983-07-19 Vli Corporation Vaginal device
FR2560516A1 (en) * 1984-03-01 1985-09-06 Ahi Operations Ltd A device for insertion in a body cavity of an animal, and its applicator
US4553965A (en) * 1978-05-17 1985-11-19 Shepard Conn Fluid-expansible contraceptive tampon and applicator
US4585651A (en) * 1978-10-17 1986-04-29 Stolle Research & Development Corporation Active/passive immunization of the internal female reproductive organs
US4618496A (en) * 1984-07-16 1986-10-21 Johnson & Johnson Antimicrobial peat moss composition
US4645488A (en) * 1982-08-12 1987-02-24 Board Of Trustees Of The University Of Alabama Syringe for extrusion of wetted, particulate material
US4732763A (en) * 1978-10-17 1988-03-22 Stolle Research And Development Corporation Active/passive immunization of the internal female reproductive organs
US4742820A (en) * 1984-09-21 1988-05-10 Hannegret Leuchtenberger Device for introducing a diaphragm
US5141515A (en) * 1990-10-11 1992-08-25 Eberbach Mark A Apparatus and methods for repairing hernias
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US5527534A (en) * 1992-10-21 1996-06-18 Gynetech Laboratories, Ltd. Vaginal sponge delivery system
FR2754450A1 (en) * 1996-10-11 1998-04-17 3X Engineering microcapsule support material
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US6558362B1 (en) * 1999-02-03 2003-05-06 Bernard Chaffringeon Disposable device for transferring an active liquid into a body cavity
US20030153864A1 (en) * 2001-10-16 2003-08-14 Bernard Chaffringeon Disposable device and method for transferring an active liquid into a body cavity
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US6645136B1 (en) 2000-09-28 2003-11-11 Kimberly-Clark Worldwide, Inc. Incontinence insert applicators and methods for their use
US6676594B1 (en) 2002-09-18 2004-01-13 Kimberly-Clark Worldwide, Inc. C-shaped vaginal incontinence insert
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US20040077924A1 (en) * 2002-10-21 2004-04-22 Kimberly-Clark Worldwide, Inc. Ellipitcal applicator system
US20040078013A1 (en) * 2002-10-21 2004-04-22 Kimberly-Clark Worldwide, Inc. Lubricated incontinence device applicator
USD492033S1 (en) 2003-04-04 2004-06-22 Playtex Products, Inc. Tampon applicator assembly
US6758840B2 (en) 2000-04-20 2004-07-06 Metris Therapeutics Limited Drug delivery device
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US6808485B2 (en) 2002-12-23 2004-10-26 Kimberly-Clark Worldwide, Inc. Compressible resilient incontinence insert
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US20070293837A1 (en) * 2006-06-16 2007-12-20 Sokal David C Vaginal drug delivery system and method
US7527614B2 (en) 2005-03-25 2009-05-05 Kimberly-Clark Worldwide, Inc. Protective tube for a medicated tampon
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US7744556B2 (en) 2005-03-25 2010-06-29 Kimberly-Clark Worldwide, Inc. Delivery tube assembly for an applicator
US7846171B2 (en) 2004-05-27 2010-12-07 C.R. Bard, Inc. Method and apparatus for delivering a prosthetic fabric into a patient
US7919453B2 (en) 2005-03-25 2011-04-05 Kimberly-Clark Worldwide, Inc. Dosage cap assembly for an applicator
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Cited By (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4393871A (en) * 1977-06-27 1983-07-19 Vli Corporation Vaginal device
EP0006861A1 (en) * 1977-06-27 1980-01-23 Vorhauer Lab Biologically compatible tampon sponge.
EP0006861A4 (en) * 1977-06-27 1980-09-12 Vorhauer Lab Biologically compatible tampon sponge.
US4271835A (en) * 1978-05-17 1981-06-09 Kcdp Corporation Fluid-expansible contraceptive tampon and applicator
US4553965A (en) * 1978-05-17 1985-11-19 Shepard Conn Fluid-expansible contraceptive tampon and applicator
US4186742A (en) * 1978-06-09 1980-02-05 Donald Enterprises, Inc. Contraceptive-antivenereal disease tampon
US4309997A (en) * 1978-06-09 1982-01-12 Donald Jack W Contraceptive and/or antivenereal disease tampon
WO1980000008A1 (en) * 1978-06-09 1980-01-10 Donald Enterprises Inc Contraceptive-antivenereal disease tampon
US4732763A (en) * 1978-10-17 1988-03-22 Stolle Research And Development Corporation Active/passive immunization of the internal female reproductive organs
US4585651A (en) * 1978-10-17 1986-04-29 Stolle Research & Development Corporation Active/passive immunization of the internal female reproductive organs
FR2455902A1 (en) * 1979-05-07 1980-12-05 Langlois Pierre Spermicidal contraceptive tampon of cellular synthetic sponge - has semi-open cells contg. spermicide and prolonged release medium
EP0029708A1 (en) * 1979-11-21 1981-06-03 Vorhauer Laboratories, Ltd. Biologically compatible tampon contraceptive
FR2484247A1 (en) * 1980-03-26 1981-12-18 Langlois Pierre Contraceptive tampon of elastic foam with an integral pull cord - for ease of use and removal
US4351338A (en) * 1980-05-21 1982-09-28 Pierre Langlois Vaginal tampon
US4318405A (en) * 1980-07-24 1982-03-09 Sneider Vincent R Tampon and drug delivery device
EP0051709A1 (en) * 1980-11-07 1982-05-19 Atlantic Pharmaceutical Products Contraceptive tampon, set of a tampon and an applicator and process for preparing the tampon
US4645488A (en) * 1982-08-12 1987-02-24 Board Of Trustees Of The University Of Alabama Syringe for extrusion of wetted, particulate material
FR2560516A1 (en) * 1984-03-01 1985-09-06 Ahi Operations Ltd A device for insertion in a body cavity of an animal, and its applicator
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