EP1244673A2 - Nouveaux imidazo 1,3,5]triazinones et leur utilisation - Google Patents
Nouveaux imidazo 1,3,5]triazinones et leur utilisationInfo
- Publication number
- EP1244673A2 EP1244673A2 EP00993611A EP00993611A EP1244673A2 EP 1244673 A2 EP1244673 A2 EP 1244673A2 EP 00993611 A EP00993611 A EP 00993611A EP 00993611 A EP00993611 A EP 00993611A EP 1244673 A2 EP1244673 A2 EP 1244673A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- hydrogen
- different
- alkyl
- diseases
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19962928 | 1999-12-24 | ||
DE1999162928 DE19962928A1 (de) | 1999-12-24 | 1999-12-24 | Neue Imidazo[1,3,5]triazinone und ihre Verwendung |
DE10003323A DE10003323A1 (de) | 2000-01-27 | 2000-01-27 | Neue Imidazo[1,3,5[triazinone und ihre Verwendung |
DE10003323 | 2000-01-27 | ||
PCT/EP2000/012597 WO2001047928A2 (fr) | 1999-12-24 | 2000-12-12 | Nouveaux imidazo[1,3,5]triazinones et leur utilisation |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1244673A2 true EP1244673A2 (fr) | 2002-10-02 |
Family
ID=26004043
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP00993611A Withdrawn EP1244673A2 (fr) | 1999-12-24 | 2000-12-12 | Nouveaux imidazo 1,3,5]triazinones et leur utilisation |
Country Status (13)
Country | Link |
---|---|
US (2) | US6803365B2 (fr) |
EP (1) | EP1244673A2 (fr) |
JP (1) | JP2003519150A (fr) |
KR (1) | KR20020062770A (fr) |
CN (1) | CN1434825A (fr) |
AU (1) | AU781028B2 (fr) |
BR (1) | BR0017043A (fr) |
CA (1) | CA2395548A1 (fr) |
IL (1) | IL150022A0 (fr) |
MX (1) | MXPA02006240A (fr) |
PL (1) | PL356848A1 (fr) |
TR (1) | TR200201638T2 (fr) |
WO (1) | WO2001047928A2 (fr) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU230154B1 (hu) * | 1997-11-12 | 2015-09-28 | Bayer Intellectual Property Gmbh | Eljárás 2-es helyzetben fenil-szubszituenst hordozó imidazo-triazinon-származékok előállítására |
CA2395548A1 (fr) * | 1999-12-24 | 2001-07-05 | Bayer Aktiengesellschaft | Nouveaux imidazo[1,3,5]triazinones et leur utilisation |
CA2417631A1 (fr) * | 2000-08-01 | 2003-01-29 | Bayer Aktiengesellschaft | Inhibiteurs selectifs de pde 2 comme medicaments ameliorant la perception |
BR0209541A (pt) * | 2001-05-09 | 2004-04-20 | Bayer Healthcare Ag | Uso das imidazotriazinonas 2-fenil-substituìdas |
GB0126417D0 (en) * | 2001-11-02 | 2002-01-02 | Pfizer Ltd | Crystal structure |
PL205936B1 (pl) | 2002-02-22 | 2010-06-30 | Schering Corp | Farmaceutyczny preparat zawierający termozolomid oraz sposób jego wytwarzania |
DE10224462A1 (de) * | 2002-06-03 | 2003-12-11 | Bayer Ag | Verwendung von cGMP stimulierenden Verbindungen |
DE10229778A1 (de) * | 2002-07-03 | 2004-01-29 | Bayer Ag | Neue Verwendung von Imidazotriazinonen |
DE10232113A1 (de) | 2002-07-16 | 2004-01-29 | Bayer Ag | Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel |
FR2842809A1 (fr) * | 2002-07-26 | 2004-01-30 | Greenpharma Sas | NOUVELLES PYRAZOLO[1,5-a]-1,3,5-TRIAZINES SUBSTITUEES ET LEURS ANALOGUES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION |
UY28213A1 (es) * | 2003-02-28 | 2004-09-30 | Bayer Pharmaceuticals Corp | Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos. |
CN1548438A (zh) * | 2003-05-16 | 2004-11-24 | 烟台开发区北方药物研究所 | 2-取代苯基-6,8-二烃基-3H-咪唑[1,5α][1,3,5]三嗪-4-酮衍生物,其制备方法及其药物用途 |
JP2006219374A (ja) | 2003-06-13 | 2006-08-24 | Daiichi Asubio Pharma Co Ltd | Pde7阻害作用を有するイミダゾトリアジノン誘導体 |
JP2007512242A (ja) * | 2003-10-29 | 2007-05-17 | イーラン ファーマスーティカルズ、インコーポレイテッド | N−置換ベンゼンスルホンアミド |
DE102004023069A1 (de) * | 2004-05-11 | 2005-12-08 | Bayer Healthcare Ag | Neue Darreichungsformen des PDE 5-Inhibitors Vardenafil |
DE102004038328A1 (de) * | 2004-08-06 | 2006-03-16 | Bayer Healthcare Ag | Neue Verwendungen von 2-Phenyl-substituierten Imidazotriazinon-Derivaten |
DE102005001989A1 (de) * | 2005-01-15 | 2006-07-20 | Bayer Healthcare Ag | Intravenöse Formulierungen von PDE-Inhibitoren |
EA018668B1 (ru) * | 2005-02-18 | 2013-09-30 | Сурфейс Логикс Инк. | Фармакокинетически улучшенные соединения |
JP2008530246A (ja) * | 2005-02-18 | 2008-08-07 | サーフェイス ロジックス,インコーポレイティド | 機能性残基又は官能基を含む薬物動態学的に改善された化合物、及び上述の化合物を含む医薬組成物の製造方法 |
DE102005009240A1 (de) * | 2005-03-01 | 2006-09-07 | Bayer Healthcare Ag | Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften |
BRPI0616633A2 (pt) * | 2005-09-29 | 2011-06-28 | Bayer Healthcare Ag | inibidores de pde e combinações dos mesmos para o tratamento de transtornos urológicos |
EP1984321A1 (fr) * | 2006-02-17 | 2008-10-29 | Wyeth | Méthodes de synthèse d'alcools substitués par sulfonamide et intermédiaires correspondants |
KR20080094685A (ko) * | 2006-02-17 | 2008-10-23 | 와이어쓰 | 2-아미노 플루오로- 및 트리플루오로알킬 치환된 알코올의 선택적 n-술폰화 |
JP5539717B2 (ja) * | 2006-07-14 | 2014-07-02 | 塩野義製薬株式会社 | オキシム化合物およびその使用 |
EP2061322B1 (fr) | 2006-08-24 | 2015-07-01 | Surface Logix, Inc. | Composés de pharmacocinétique améliorée |
BRPI0823416A2 (pt) * | 2007-05-08 | 2015-06-16 | Schering Corp | Métodos de tratamento usando formulações intravenosas compreendendo temozolomida. |
JP2010532319A (ja) * | 2007-06-13 | 2010-10-07 | バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト | 聴覚障害の処置用のpde阻害剤 |
CN103374002B (zh) * | 2012-04-19 | 2015-07-15 | 山东轩竹医药科技有限公司 | 磷酸二酯酶-5抑制剂 |
CN113461694A (zh) * | 2021-08-05 | 2021-10-01 | 广东西捷药业有限公司 | 一种伐地那非类似物及其合成方法和应用 |
CN113583003A (zh) * | 2021-08-05 | 2021-11-02 | 广东西捷药业有限公司 | 一种伐地那非类似物及其合成方法和应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9013750D0 (en) | 1990-06-20 | 1990-08-08 | Pfizer Ltd | Therapeutic agents |
GB9126260D0 (en) * | 1991-12-11 | 1992-02-12 | Pfizer Ltd | Therapeutic agents |
GB9218322D0 (en) | 1992-08-28 | 1992-10-14 | Pfizer Ltd | Therapeutic agents |
GB9311920D0 (en) | 1993-06-09 | 1993-07-28 | Pfizer Ltd | Therapeutic agents |
ZA969888B (en) | 1995-11-28 | 1997-05-26 | Schering Corp | 2'-[[4'-halo-[1,1-biphenyl]-4-yl]methyl]-5'-methyl-spiro[cyclopentane-1,7'(8'H)-[3H]imidazo[2,1-b]purin]-4'(5'H)-ones |
EA004315B1 (ru) | 1997-04-25 | 2004-02-26 | Пфайзер Инк. | Новые сульфонилбензойные кислоты и способ получения 4-бензамидопиразоло-5-карбоксамидов с их использованием |
HU230154B1 (hu) | 1997-11-12 | 2015-09-28 | Bayer Intellectual Property Gmbh | Eljárás 2-es helyzetben fenil-szubszituenst hordozó imidazo-triazinon-származékok előállítására |
TW542719B (en) * | 1998-02-23 | 2003-07-21 | Pfizer Res & Dev | Method of treating impotence due to spinal cord injury |
CA2395548A1 (fr) * | 1999-12-24 | 2001-07-05 | Bayer Aktiengesellschaft | Nouveaux imidazo[1,3,5]triazinones et leur utilisation |
-
2000
- 2000-12-12 CA CA002395548A patent/CA2395548A1/fr not_active Abandoned
- 2000-12-12 TR TR2002/01638T patent/TR200201638T2/xx unknown
- 2000-12-12 PL PL00356848A patent/PL356848A1/xx not_active Application Discontinuation
- 2000-12-12 WO PCT/EP2000/012597 patent/WO2001047928A2/fr active IP Right Grant
- 2000-12-12 CN CN00818969A patent/CN1434825A/zh active Pending
- 2000-12-12 BR BR0017043-7A patent/BR0017043A/pt not_active IP Right Cessation
- 2000-12-12 IL IL15002200A patent/IL150022A0/xx unknown
- 2000-12-12 US US10/168,194 patent/US6803365B2/en not_active Expired - Fee Related
- 2000-12-12 KR KR1020027008156A patent/KR20020062770A/ko not_active Application Discontinuation
- 2000-12-12 EP EP00993611A patent/EP1244673A2/fr not_active Withdrawn
- 2000-12-12 AU AU28420/01A patent/AU781028B2/en not_active Ceased
- 2000-12-12 JP JP2001549398A patent/JP2003519150A/ja not_active Withdrawn
- 2000-12-12 MX MXPA02006240A patent/MXPA02006240A/es active IP Right Grant
-
2004
- 2004-07-15 US US10/892,984 patent/US7091203B2/en not_active Expired - Fee Related
Non-Patent Citations (1)
Title |
---|
See references of WO0147928A2 * |
Also Published As
Publication number | Publication date |
---|---|
US20050043303A1 (en) | 2005-02-24 |
US6803365B2 (en) | 2004-10-12 |
TR200201638T2 (tr) | 2002-11-21 |
CN1434825A (zh) | 2003-08-06 |
AU781028B2 (en) | 2005-04-28 |
CA2395548A1 (fr) | 2001-07-05 |
KR20020062770A (ko) | 2002-07-29 |
BR0017043A (pt) | 2003-01-07 |
WO2001047928A3 (fr) | 2002-05-16 |
JP2003519150A (ja) | 2003-06-17 |
MXPA02006240A (es) | 2003-01-28 |
AU2842001A (en) | 2001-07-09 |
US7091203B2 (en) | 2006-08-15 |
WO2001047928A2 (fr) | 2001-07-05 |
PL356848A1 (en) | 2004-07-12 |
US20030195210A1 (en) | 2003-10-16 |
IL150022A0 (en) | 2002-12-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR |
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AX | Request for extension of the european patent |
Free format text: AL;LT;LV;MK;RO;SI |
|
17P | Request for examination filed |
Effective date: 20021118 |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: BAYER HEALTHCARE AG |
|
RTI1 | Title (correction) |
Free format text: NOVEL IMIDAZO 1,3,5 TRIAZINONES AND THE USE THEREOF |
|
17Q | First examination report despatched |
Effective date: 20080402 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20080813 |