EP1192009A4 - Verfahren zur erzeugung eines aerosols - Google Patents

Verfahren zur erzeugung eines aerosols

Info

Publication number
EP1192009A4
EP1192009A4 EP00938249A EP00938249A EP1192009A4 EP 1192009 A4 EP1192009 A4 EP 1192009A4 EP 00938249 A EP00938249 A EP 00938249A EP 00938249 A EP00938249 A EP 00938249A EP 1192009 A4 EP1192009 A4 EP 1192009A4
Authority
EP
European Patent Office
Prior art keywords
aerosol
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP00938249A
Other languages
English (en)
French (fr)
Other versions
EP1192009A1 (de
EP1192009B1 (de
Inventor
Joan Rosell
Alfonso Ganan-Calvo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidad de Sevilla
Aradigm Corp
Original Assignee
Universidad de Sevilla
Aradigm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidad de Sevilla, Aradigm Corp filed Critical Universidad de Sevilla
Publication of EP1192009A1 publication Critical patent/EP1192009A1/de
Publication of EP1192009A4 publication Critical patent/EP1192009A4/de
Application granted granted Critical
Publication of EP1192009B1 publication Critical patent/EP1192009B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/02—Spray pistols; Apparatus for discharge
    • B05B7/04—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge
    • B05B7/0416—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid
    • B05B7/0441—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid with one inner conduit of liquid surrounded by an external conduit of gas upstream the mixing chamber
    • B05B7/0475—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid with one inner conduit of liquid surrounded by an external conduit of gas upstream the mixing chamber with means for deflecting the peripheral gas flow towards the central liquid flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/02—Spray pistols; Apparatus for discharge
    • B05B7/04—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge
    • B05B7/0416—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid
    • B05B7/0483—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid with gas and liquid jets intersecting in the mixing chamber
EP00938249.0A 1999-06-11 2000-06-09 Verfahren zur erzeugung eines aerosols Expired - Lifetime EP1192009B1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13869899P 1999-06-11 1999-06-11
US138698P 1999-06-11
PCT/US2000/015931 WO2000076673A1 (en) 1999-06-11 2000-06-09 Method for producing an aerosol

Publications (3)

Publication Number Publication Date
EP1192009A1 EP1192009A1 (de) 2002-04-03
EP1192009A4 true EP1192009A4 (de) 2006-10-18
EP1192009B1 EP1192009B1 (de) 2013-05-01

Family

ID=22483216

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00938249.0A Expired - Lifetime EP1192009B1 (de) 1999-06-11 2000-06-09 Verfahren zur erzeugung eines aerosols

Country Status (6)

Country Link
EP (1) EP1192009B1 (de)
JP (1) JP2003501257A (de)
AU (1) AU767486B2 (de)
CA (1) CA2374232C (de)
ES (1) ES2424713T4 (de)
WO (1) WO2000076673A1 (de)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060169800A1 (en) * 1999-06-11 2006-08-03 Aradigm Corporation Aerosol created by directed flow of fluids and devices and methods for producing same
US7766013B2 (en) 2001-06-05 2010-08-03 Alexza Pharmaceuticals, Inc. Aerosol generating method and device
EP1392262A1 (de) 2001-05-24 2004-03-03 Alexza Molecular Delivery Corporation Verabreichung von arzneimittel-estern durch inhalation
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US7078016B2 (en) 2001-11-21 2006-07-18 Alexza Pharmaceuticals, Inc. Delivery of caffeine through an inhalation route
WO2002094242A1 (en) 2001-05-24 2002-11-28 Alexza Molecular Delivery Corporation Delivery of rizatriptan or zolmitriptan through an inhalation route
US6737043B2 (en) 2001-05-24 2004-05-18 Alexza Molecula Delivery Corporation Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route
US6805853B2 (en) 2001-11-09 2004-10-19 Alexza Molecular Delivery Corporation Delivery of diazepam through an inhalation route
JP4834861B2 (ja) * 2001-09-25 2011-12-14 株式会社イノアックコーポレーション 流体混合機構
EP1446104B2 (de) 2001-11-01 2011-08-03 Novartis AG Sprühtrocknungsverfahren
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
JP2006507921A (ja) 2002-06-28 2006-03-09 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 流体分散のための方法および装置
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
EP1610888A2 (de) * 2003-04-10 2006-01-04 President And Fellows Of Harvard College Erzeugung und steuerung von fluidarten
ATE510174T1 (de) 2003-05-21 2011-06-15 Alexza Pharmaceuticals Inc Schlag gezündete unabhängige heizeinheit
US20040235308A1 (en) 2003-05-22 2004-11-25 Dainippon Screen Mfg. Co., Ltd. Substrate treatment method and sustrate treatment apparatus
EP2662135A3 (de) 2003-08-27 2013-12-25 President and Fellows of Harvard College Verfahren zur Mischung von Tröpfchen in einem Mikrokanal
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US9477233B2 (en) 2004-07-02 2016-10-25 The University Of Chicago Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets
ES2264608B2 (es) * 2004-09-30 2007-08-16 Universidad De Sevilla Dispositivo y procedimiento para la atomizacion neumatica de liquidos mediante flujo implosivo de gas.
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
US8201351B2 (en) 2005-01-17 2012-06-19 Alfonso Miguel Ganan Calvo Procedure and device for the micro-mixing of fluids through reflux cell
ES2265270B1 (es) * 2005-04-18 2008-01-01 Universidad De Sevilla Procedimiento y dispositivo para micro-mezclado de fluidos mediante celula de reflujo.
AU2006220816A1 (en) 2005-03-04 2006-09-14 President And Fellows Of Harvard College Method and apparatus for forming multiple emulsions
US20100137163A1 (en) 2006-01-11 2010-06-03 Link Darren R Microfluidic Devices and Methods of Use in The Formation and Control of Nanoreactors
US9074242B2 (en) 2010-02-12 2015-07-07 Raindance Technologies, Inc. Digital analyte analysis
EP2481815B1 (de) 2006-05-11 2016-01-27 Raindance Technologies, Inc. Mikrofluidische Vorrichtungen
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
WO2008021123A1 (en) 2006-08-07 2008-02-21 President And Fellows Of Harvard College Fluorocarbon emulsion stabilizing surfactants
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
ES2594867T3 (es) 2007-03-09 2016-12-23 Alexza Pharmaceuticals, Inc. Unidad de calentamiento para usar en un dispositivo de administración de fármaco
US7776927B2 (en) 2007-03-28 2010-08-17 President And Fellows Of Harvard College Emulsions and techniques for formation
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
US9091434B2 (en) 2008-04-18 2015-07-28 The Board Of Trustees Of The University Of Alabama Meso-scaled combustion system
EP2315629B1 (de) 2008-07-18 2021-12-15 Bio-Rad Laboratories, Inc. Tröpfchenbibliotheken
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
US20100176063A1 (en) * 2009-01-12 2010-07-15 Yuri Kokotov Method for coalescence induced liquid-liquid separations and apparatus thereof
EP3415235A1 (de) 2009-03-23 2018-12-19 Raindance Technologies Inc. Manipulation von mikrofluidiktröpfchen
CN102574078B (zh) 2009-09-02 2016-05-18 哈佛学院院长等 使用喷射和其它技术产生的多重乳液
WO2011042564A1 (en) 2009-10-09 2011-04-14 Universite De Strasbourg Labelled silica-based nanomaterial with enhanced properties and uses thereof
US10837883B2 (en) 2009-12-23 2020-11-17 Bio-Rad Laboratories, Inc. Microfluidic systems and methods for reducing the exchange of molecules between droplets
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
EP2576078B1 (de) 2010-05-28 2018-04-25 Arizona Board of Regents acting for and on behalf of Arizona State University Vorrichtung und verfahren für gasdynamische virtuelle düse
US20120048963A1 (en) 2010-08-26 2012-03-01 Alexza Pharmaceuticals, Inc. Heat Units Using a Solid Fuel Capable of Undergoing an Exothermic Metal Oxidation-Reduction Reaction Propagated without an Igniter
EP3447155A1 (de) 2010-09-30 2019-02-27 Raindance Technologies, Inc. Sandwichassays in tröpfchen
EP3412778A1 (de) 2011-02-11 2018-12-12 Raindance Technologies, Inc. Verfahren zur bildung gemischter tröpfchen
US9150852B2 (en) 2011-02-18 2015-10-06 Raindance Technologies, Inc. Compositions and methods for molecular labeling
EP2714254B1 (de) 2011-05-23 2017-09-06 President and Fellows of Harvard College Kontrolle von emulsionen, einschliesslich mehrerer emulsionen
US9556470B2 (en) 2011-06-02 2017-01-31 Raindance Technologies, Inc. Enzyme quantification
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
WO2013006661A2 (en) 2011-07-06 2013-01-10 President And Fellows Of Harvard College Multiple emulsions and techniques for the formation of multiple emulsions
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
EP2777818A1 (de) 2013-03-15 2014-09-17 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Verfahren und Vorrichtung zur Herstellung eines intermittierenden Flüssigkeitsstrahls
EP2991768B1 (de) 2013-04-30 2018-11-21 Arizona Board of Regents on behalf of Arizona State University Vorrichtung und verfahren für kubische lipidphaseninjektion für membranproteinuntersuchungen
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
WO2015103367A1 (en) 2013-12-31 2015-07-09 Raindance Technologies, Inc. System and method for detection of rna species
EP4272744A3 (de) 2015-03-11 2024-01-24 Alexza Pharmaceuticals, Inc. Verwendung von antistatischen materialien im atemweg für thermisches aerosolkondensationsverfahren
EP3341132B1 (de) 2015-08-28 2021-10-06 Regents of the University of Minnesota Düsen und verfahren zum mischen von fluidströmen
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
ES2663217B1 (es) * 2016-10-10 2019-02-07 Ingeniatrics Tecnologias S L Aparato y método para mezclar al menos dos líquidos
WO2019241488A1 (en) 2018-06-14 2019-12-19 Regents Of The University Of Minnesota Counterflow mixer and atomizer
US10369579B1 (en) 2018-09-04 2019-08-06 Zyxogen, Llc Multi-orifice nozzle for droplet atomization
CN115228642A (zh) * 2022-08-02 2022-10-25 北京航空航天大学 小流量分散流雾化喷嘴及低流速雾化器

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0899017A1 (de) * 1996-05-13 1999-03-03 Universidad De Sevilla, Vicerrectorado De Investigacion Verfahren zur zerstäubung von flüssigkeiten

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05138080A (ja) * 1991-11-25 1993-06-01 Matsushita Electric Ind Co Ltd 霧化装置
US5868322A (en) * 1996-01-31 1999-02-09 Hewlett-Packard Company Apparatus for forming liquid droplets having a mechanically fixed inner microtube
US5884846A (en) * 1996-09-19 1999-03-23 Tan; Hsiaoming Sherman Pneumatic concentric nebulizer with adjustable and capillaries
AU745904B2 (en) 1997-12-17 2002-04-11 Universidad De Sevilla Device and method for creating spherical particles of uniform size

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0899017A1 (de) * 1996-05-13 1999-03-03 Universidad De Sevilla, Vicerrectorado De Investigacion Verfahren zur zerstäubung von flüssigkeiten

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO0076673A1 *

Also Published As

Publication number Publication date
AU5331800A (en) 2001-01-02
CA2374232C (en) 2013-08-20
EP1192009A1 (de) 2002-04-03
AU767486B2 (en) 2003-11-13
ES2424713T3 (es) 2013-10-07
CA2374232A1 (en) 2000-12-21
ES2424713T4 (es) 2014-01-23
EP1192009B1 (de) 2013-05-01
WO2000076673A1 (en) 2000-12-21
JP2003501257A (ja) 2003-01-14

Similar Documents

Publication Publication Date Title
EP1192009A4 (de) Verfahren zur erzeugung eines aerosols
IL144454A0 (en) Method for producing l-phenylephrine hydrochloride
AU2002213972A1 (en) Method for producing polyisobutenylphenoles
PL361146A1 (en) Method for producing isocyanato-organosilanes
HUP0102967A3 (en) Method for producing organosilylalkyl-polysulphanes
HK1044780A1 (en) Method for producing cyclo-)asp-dphe-nmeval-arg-gly).
IL144651A0 (en) Method for producing l-sorbose
AU4663601A (en) Method for preparing 9-deoxo-8a-aza-(8a-alkyl)-8a-homoerythromycin derivativesfrom 9-deoxo-9(z)-hydroxyiminoerythromycin
AU2002212224A1 (en) Method for producing delta1-pyrrolines
AU1283001A (en) Method for producing alkylhalogenosilanes
SG97871A1 (en) Method for shaping strip-like-films
HUP0201977A2 (en) Method for producing 4-cyano-2-aminomethylthiazol
AU7265900A (en) Method for producing otoplastics
AU1141501A (en) Method for producing hydroxymethylpyridines
IL147769A0 (en) Method for producing 2-aminomethyl-4-cyano-thiazol
AU2001262147A1 (en) Method for producing 4-bromo- and 4-chloro-2-nitro-1-trifluoromethoxybenzene
GB2361475B (en) Method for producing 3-isochromanone
HUP0200455A3 (en) Method for producing 4-amino-5-chloro-1-phenyl pyridazinone-(6)
AU2001272448A1 (en) Method for producing dna-arrays
AU5680800A (en) Method for producing 4-chloro-6-hydroxypyrimidine
HUP0301741A3 (en) Method for producing 4-bromine-aniline derivatives
AU2002221828A1 (en) Method for producing nitro-dihydroisoxazoles
IL130733A0 (en) Method for making trans-2-dibromoindan-1-OL
AU7647600A (en) Method for producing aldehydes
AU3154801A (en) Method for producing optionally substituted 3-halopyridines

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20020109

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: ARADIGM CORPORATION

Owner name: UNIVERSIDAD DE SEVILLA

A4 Supplementary search report drawn up and despatched

Effective date: 20060918

17Q First examination report despatched

Effective date: 20080229

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

RIC1 Information provided on ipc code assigned before grant

Ipc: B05B 7/04 20060101AFI20090929BHEP

18D Application deemed to be withdrawn

Effective date: 20100330

18RA Request filed for re-establishment of rights before grant

Effective date: 20101220

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

D18D Application deemed to be withdrawn (deleted)
AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 609553

Country of ref document: AT

Kind code of ref document: T

Effective date: 20130515

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 60047984

Country of ref document: DE

Effective date: 20130627

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 609553

Country of ref document: AT

Kind code of ref document: T

Effective date: 20130501

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2424713

Country of ref document: ES

Kind code of ref document: T3

Effective date: 20131007

REG Reference to a national code

Ref country code: NL

Ref legal event code: VDEP

Effective date: 20130501

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130501

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130902

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130501

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130501

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130802

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130501

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130501

Ref country code: BE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130501

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130501

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

26N No opposition filed

Effective date: 20140204

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20130630

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20130609

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20130630

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 60047984

Country of ref document: DE

Effective date: 20140204

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130501

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20130609

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 17

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 18

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 19

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20180727

Year of fee payment: 19

Ref country code: IT

Payment date: 20180719

Year of fee payment: 19

Ref country code: GB

Payment date: 20180627

Year of fee payment: 19

Ref country code: FR

Payment date: 20180726

Year of fee payment: 19

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: ES

Payment date: 20181214

Year of fee payment: 19

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 60047984

Country of ref document: DE

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20190609

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190609

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200101

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190609

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190630

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20201027

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190610