EP1185377B1 - Dispositif de distribution de produit fluide - Google Patents

Dispositif de distribution de produit fluide Download PDF

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Publication number
EP1185377B1
EP1185377B1 EP00929621A EP00929621A EP1185377B1 EP 1185377 B1 EP1185377 B1 EP 1185377B1 EP 00929621 A EP00929621 A EP 00929621A EP 00929621 A EP00929621 A EP 00929621A EP 1185377 B1 EP1185377 B1 EP 1185377B1
Authority
EP
European Patent Office
Prior art keywords
reservoir
intermediate element
piston
relative
dose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP00929621A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1185377A1 (fr
Inventor
François OECHSEL
Bruno Simon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aptar France SAS
Original Assignee
Valois SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Valois SAS filed Critical Valois SAS
Publication of EP1185377A1 publication Critical patent/EP1185377A1/fr
Application granted granted Critical
Publication of EP1185377B1 publication Critical patent/EP1185377B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/02Membranes or pistons acting on the contents inside the container, e.g. follower pistons
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/02Membranes or pistons acting on the contents inside the container, e.g. follower pistons
    • B05B11/025Membranes or pistons acting on the contents inside the container, e.g. follower pistons with stepwise advancement of the piston, e.g. for spraying a predetermined quantity of content
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/109Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle the dispensing stroke being affected by the stored energy of a spring
    • B05B11/1091Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle the dispensing stroke being affected by the stored energy of a spring being first hold in a loaded state by locking means or the like, then released

Definitions

  • the present invention relates to a device for dispensing a fluid product, and more particularly a fluid dispenser device intended for dispensing a limited number of doses, such as monodoses or bidoses, according to the preamble of claim 1.
  • a fluid dispenser device intended for dispensing a limited number of doses, such as monodoses or bidoses, according to the preamble of claim 1.
  • Such a device is known from document FR 2 714 624.
  • Monodose or bidose type devices are well known in the state of the art. and find part of their application in the field of distributors pharmaceuticals for nasal use, in which a dose of product should be distributed in each of the two nostrils.
  • Document FR-2 761 281 discloses such a bidose device.
  • the user places the dispensing orifice in his nostril and exerts pressure axial on the actuating element of the device.
  • This axial pressure must be high enough to overcome means of energy accumulation in order to guarantee the distribution of the whole of each of the two doses.
  • it is difficult to precisely control the position of the end of the device comprising the dispensing opening in the nostril, and it may happen that the end of the head of the device comes up against the bottom of the nostril, which can be annoying and / or painful for the user.
  • this device requires a predetermined minimum force to be able to be actuated, it may be difficult to use for elderly or poorly mobile people who may have difficulty exerting this force with the device placed in the nostril.
  • the present invention aims to provide a product distribution device fluid, in particular a device of the bidose type, which does not have the drawbacks above.
  • the present invention aims to provide a device for distribution of fluid product such as a bidose which is simple and reliable to use, and in which product distribution is independent of the actuation effort of the user.
  • the present invention also aims to provide such a device for distribution which guarantees the distribution of the entire dose on each actuation while ensuring a perfect seal of the product before and after each distribution.
  • the present invention also aims to provide such a device which facilitates assembly and filling, and which in particular allows the use of a tank pre-filled, so the final assembly of the device is not necessarily perform in a sterile environment.
  • the present invention therefore relates to a product distribution device fluid according to claim 1.
  • said piston cooperates fixedly with said body and said spring cooperates with an intermediate element integral with said tank and movable with said tank relative to said body, said element intermediate being blocked with respect to said body in at least one blocking position and released by said at least one trigger, so that the displacement of the intermediate element, together with the reservoir, relative to said body, under the effect of the spring, moves said piston in said reservoir to distribute a dose of product.
  • said reservoir comprises a hollow tube open on one side only and closed by a piston-cap having a slot adapted to open under the effect of a determined pressure created inside the tank by the displacement of the piston-cap, to dispense the product from the reservoir to the dispensing orifice.
  • said tank after filling and sealing tightly by said plug piston, is fixed, in particular snapped, on said intermediate element.
  • said tank is fixed in said body and said piston which cooperates with a stressed intermediate element by said spring and movable together with said piston relative to said body, said intermediate element being blocked with respect to said body in at least one position of blocking and released by said at least one trigger, so that the displacement of the intermediate element, together with the piston, relative to said body, under the effect of the spring, moves said piston in said reservoir to distribute a dose of product.
  • said tank comprises a hollow tube open on both sides and closed on one side by said piston cooperating with the intermediate element, and on the other side by a plug cooperating fixedly with the body, said fixed plug comprising a slot adapted to open under the effect of a determined pressure created inside the reservoir by displacement of the piston, to distribute the product from the reservoir to the orifice of distribution.
  • said intermediate element comprises at least one element of blocking, such as an elastic tab, cooperating with at least one opening in the body to block said intermediate element relative to said body, said element intermediate being released by said at least one cooperating trigger member with said at least one locking tab through said at least one opening.
  • element of blocking such as an elastic tab
  • said at least one triggering member is produced under the form of a radially movable side push-button adapted to cooperate with said intermediate element.
  • said at least one triggering member is formed on a external element fixed to said body and comprises an inwardly projecting lug adapted to cooperate with said intermediate element through at least one opening corresponding formed in said body when the triggering member is actuated.
  • said reservoir comprises two doses of fluid
  • said member has two distinct locking positions, respectively for each dose
  • said intermediate element has two distinct blocking positions, respectively for each dose
  • said device comprises two organs for separate trigger, respectively for each dose.
  • the two triggering members are axially offset and / or peripherally relative to one another on the body of the device.
  • the reservoir is a syringe comprising on one side a piston cooperating with said intermediate element and on the other side a nozzle forming a shutter at rest and defining a profile of spraying at the dispensing orifice when the device is actuated.
  • said body incorporates said at least one organ for trigger and an internal sleeve is fixed in said body, said sleeve cooperating with said intermediate element and with said arming member to define the respective locking and locking positions, and cooperating with said at least one trigger member for releasing said intermediate element.
  • said arming member is released from its position (s) of locking when the user exerts a predetermined axial force on him.
  • said reservoir is made of glass and said piston of material elastomer.
  • the present invention will be made with reference to three alternative embodiments shown in the drawings and which relate to product distribution devices bidose type fluid, that is to say comprising two doses of product to be dispensed, the product being intended to be distributed in the nose of the user. It is understood that the present invention also applies to single-dose devices, that is to say not with only one dose to dispense. Likewise, the present invention could be applied to multi-doses comprising more than two doses, for example three or four. In addition, the present invention is not limited to dispensers of the nasal type.
  • the device comprises a reservoir 20 preferably formed by a glass tube 21 open on one side and closed at this opening by a piston plug 25.
  • this reservoir 20 can be filled separately with the product to be dispensed and then sealed off by said product cap 25, said pre-filled reservoir 20 which can then be adapted in the distribution of the invention.
  • the installation of the distribution device is therefore not necessarily performed under sterile conditions, which has an advantage important, especially when the manufacturer of the product to be distributed is not the manufacturer of the distribution device.
  • the device comprises a body 10 incorporating a dispensing opening 11.
  • the dispensing orifice 11 is located at the end of a nasal nozzle which incorporates the distribution channel, in which a nozzle can advantageously be arranged internal to promote good spraying and limit dead volume.
  • an intermediate element 60 is provided inside of body 10. movable axially with respect to to said body 10 and comprising at least one locking position relative to said body 10.
  • the intermediate element 60 has two blocking positions, one for each dose, respectively.
  • Figure 1 represents the intermediate element 60 in its first locking position.
  • the intermediate element 60 comprises at least one blocking element 65, such as a flexible elastic tab, which advantageously cooperates with at least one corresponding opening 15, 16 formed in the body 10.
  • the body 10 has a first opening 15 in which comes snap on said flexible elastic tab 65 in its first front locking position distribution of the first dose (fig. 1), and a second opening 16 in which said elastic tab 65 of the intermediate element 60 snaps before dispensing of the second dose (fig. 3).
  • the intermediate element 60 is biased by a spring 30 which cooperates on the one hand with said intermediate element 60 and on the other hand with a member armament 40 also disposed sliding axially in said body 10.
  • Said arming member 40 comprises at least one locking position.
  • the arming member 40 has two locking positions, one for each dose.
  • Figures 1 and 2 show the cocking member in its first position locking and FIG. 3 shows said arming member 40 in its second position lock.
  • the arming member 40 comprises at least one locking element 41, such as a flexible tab or an outwardly projecting lug which cooperates with at least one corresponding opening 17, 18, 19 formed by the body 10 of the device.
  • the arming member 40 and the intermediate element 60 are made in such a way so that they can slide axially with respect to the body in one direction only, know about the figures in the direction directed from the bottom to the top of the device.
  • the lugs or elastic tabs 65, 41 may have an upper surface inclined which allows them to deform and come out of the body openings to be moved axially upward, and a flat horizontal bottom surface which prevents any return of these two elements in the opposite direction.
  • the figures show only specific examples of implementation and other equivalent means could be used to allow movement of the arming member 40 and the intermediate element 60 in one direction as well as to define the positions locking and blocking of these two parts.
  • the device comprises at least one triggering member to allow product distribution.
  • the device comprises two triggering members, one for each dose.
  • These trigger members 50 and 51 are preferably formed on an external element 55 fixed to the outside of the body 10 and are advantageously produced in the form of push-buttons comprising a trigger element 57, such as a lug projecting towards the interior, which cooperates through the openings 15; 16 of body 10 with element intermediate 60, in particular the elastic tab 65 thereof.
  • the two triggering members 50 and 51 are advantageously offset axially relative to each other on the body 10, so there is no risk of confusion for the user, the lower push button 50 being intended to dispense the first dose and the upper push button 51 being intended to dispense the second dose.
  • the two trip devices are also offset peripherally, advantageously at an angle of 90 °.
  • the tank 20 pre-filled can be fixed, in particular snapped into the intermediate element 60, advantageously by means of a latching member 90 fixed to the element intermediate 60 and having a certain elasticity and allowing fixing and good positioning of the pre-filled reservoir in the already assembled dispensing device.
  • the arming member When the user wishes to dispense the first dose of product, he exerts a axial pressure on the arming member and pushing it towards the inside of the body 10.
  • the arming member In starting position (not shown), the arming member is in a position rest in which its protruding lug 41 cooperates with an opening 17 in the body 10.
  • the arming member 40 is made in such a way that from an axial force predetermined exerted on him, he can disengage from its locked position, by the lug 41 can come out of said first opening 17 thus allowing a sliding of the arming member 40 in said body 10 until said lug 41 comes to cooperate with a second opening 18 of the body 10, axially offset towards the high relative to the first opening 17.
  • the user After having armed the device, the user, when he wishes to distribute the first dose of product places the dispensing orifice 11 in its nostril and presses exerting radial pressure on the first trigger member 50. This pressure radial on the first trigger member 50 moves radially inward the lug 57, which therefore pushes out of the opening 15 the elastic tab 65 of the intermediate element 60.
  • the intermediate member 60 is therefore released from its first locking position and the compressed spring 30 then moves the element axially intermediate inside the body 10 to the position shown in Figure 2.
  • the reservoir 20 being secured to the intermediate element 60 and the piston 25 being secured of the body 10, this movement of the intermediate element 60 causes the piston 25 to move the interior of the reservoir 20 for dispensing the first dose of product.
  • the volume of the dispensed dose is therefore defined by the axial stroke of the element intermediate.
  • This axial stroke is delimited by a stop position corresponding to the second locking position of the intermediate element 60, in which the elastic tab 65 cooperates with its second corresponding opening 16 of the body 10.
  • the intermediate element comprises at least two elastic tabs 65 also offset on the periphery of the intermediate element 60 to cooperate with the openings 15; 16 also offset peripherally on the body 10.
  • each trigger member 50 and 51 is composed of a pair of diametrically opposed pushbuttons requiring simultaneous pinching between two fingers of each pair to activate the device.
  • the element intermediate 60 has pairs of diametrically opposed elastic legs 65 correspondingly.
  • the device After dispensing the first dose of product, the device is therefore in a position in which the arming member 40 is in its first position locking and the intermediate element 60 is in its second locking position.
  • the user to prepare the second dose again activates the arming member 40 by exerting axial pressure on it again as before.
  • the arming member from a predetermined axial pressure, slides inside the body 10 until its lug 41 comes to cooperate with a third opening 19 provided in the body 10 to define the second position of locking of the arming member 40.
  • the spring 30 is compressed during this arming operation, since the intermediate element 60 is blocked in its second locking position.
  • the device is then brought to the position shown on the Figure 3, ready to be used to dispense the second dose.
  • the user places the device in its second nostril and actuates the second trigger member 51 which via its lug 57 releases the intermediate element 60 from its second blocking position again allowing movement of the reservoir 20 relative to to the piston 25 to dispense the rest of the product, namely the second dose.
  • the piston 25 which forms a sealed cap at rest is made of such that it has a slot adapted to open by pressing predetermined created inside the tank to allow the distribution of the product.
  • FIGS. 4 to 7 there is shown a second embodiment of the invention.
  • the general operation of the device is similar to that of the first embodiment, the difference being that the intermediate element 60 cooperates with the piston 25 while the reservoir 20 is fixed relative to the body 10.
  • the reservoir is made in the form of a tube in glass 21 open on both sides and closed on the one hand by the piston 25 which cooperates with the intermediate element 60 and on the other hand by a tight plug 26 adapted to open when a predetermined pressure is created inside the tank 20 by the displacement of the piston 25.
  • said plug 26 is made so similar to the piston 25 of the first embodiment, that is to say with a slot.
  • Figures 4 to 7 show the different phases of distribution.
  • Figure 4 shows the armed position before the distribution of the first dose in which the arming member is in its first locked position and the intermediate element is in its first position blocking.
  • Figure 5 shows the position after the distribution of the first dose, in which the arming member 40 is always in the first locking position while the intermediate element 60 is in its second locking position.
  • Figure 6 shows the device before dispensing its second dose, the arming member being now in its second locking position and the intermediate element in its second locking position.
  • Figure 7 shows the device after the distribution of the second dose of product, the piston 25 having completely emptied the tank and abutting against the upper plug 26.
  • the reservoir 20 is a syringe, advantageously of the standard type closed on one side by a piston 25, also advantageously of the standard type and comprising on the opposite side at the level of the orifice distribution 11 a nozzle 70 advantageously forming a shutter in the position of rest and allowing to define a spray profile during the distribution of product.
  • This variant allows the use of a well-known and easy-to-fill tank, which can be pre-filled at the manufacturer of the product to be distributed and sealed on both sides, on the one hand by the piston 25 and on the other hand by the end piece 70, to finally be fixed to inside the body 10 during assembly of the dispensing device.
  • the fixing can be performed by any means.
  • the element intermediate 60 cooperates again with the piston 25 and moves the latter inside the tank 20.
  • the arming and triggering phases for dispensing the doses are similar to the two previous embodiments.
  • Figure 8 shows a alternative embodiment of the distribution device in that the organs of trigger 50 and 51, (the second trigger member 51 not being shown), are made directly on the body 10.
  • an internal sleeve 80 is advantageously fixed inside the body 10, said sleeve 80 comprising the openings 15 to 19 which make it possible to define the locking positions of the member arming 40 and the locking positions of the intermediate element 60.
  • this alternative embodiment is entirely applicable to the first two modes of embodiment described with reference to FIGS. 1 to 7.
  • a syringe of the type standard is advantageous in that it allows the manufacturer of the product to be distributed very simply fill the tank without the need for tools different specific to fill a different specific tank.
  • the syringe being prefilled and sealed, the assembly of the dispensing device can also be performed under non-sterile conditions.
  • the present invention is neither limited to bidose-type devices, nor to nasal-type devices. We could for example consider such a device to distribute one, three or four doses, for example in the user's eyes, ears or mouth.

Landscapes

  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
EP00929621A 1999-05-21 2000-05-17 Dispositif de distribution de produit fluide Expired - Lifetime EP1185377B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9906495 1999-05-21
FR9906495A FR2793707B1 (fr) 1999-05-21 1999-05-21 Dispositif de distribution de produit fluide ameliore
PCT/FR2000/001320 WO2000071262A1 (fr) 1999-05-21 2000-05-17 Dispositif de distribution de produit fluide

Publications (2)

Publication Number Publication Date
EP1185377A1 EP1185377A1 (fr) 2002-03-13
EP1185377B1 true EP1185377B1 (fr) 2003-07-30

Family

ID=9545882

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00929621A Expired - Lifetime EP1185377B1 (fr) 1999-05-21 2000-05-17 Dispositif de distribution de produit fluide

Country Status (7)

Country Link
US (1) US6401987B1 (zh)
EP (1) EP1185377B1 (zh)
JP (1) JP4255622B2 (zh)
CN (1) CN1144622C (zh)
DE (1) DE60004219T2 (zh)
FR (1) FR2793707B1 (zh)
WO (1) WO2000071262A1 (zh)

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EP2077132A1 (en) 2008-01-02 2009-07-08 Boehringer Ingelheim Pharma GmbH & Co. KG Dispensing device, storage device and method for dispensing a formulation
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US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
EA026241B1 (ru) 2009-11-25 2017-03-31 Бёрингер Ингельхайм Интернациональ Гмбх Распылитель
JP5874724B2 (ja) 2010-06-24 2016-03-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ネブライザ
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DE102012106438A1 (de) * 2011-11-04 2013-05-08 Karl-Heinz Fuchs Einwegdosierer
WO2013152894A1 (de) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Zerstäuber mit kodiermitteln
GB2516434B (en) 2013-07-19 2015-11-25 Consort Medical Plc Fluid delivery device
US9744313B2 (en) 2013-08-09 2017-08-29 Boehringer Ingelheim International Gmbh Nebulizer
EP2835146B1 (en) 2013-08-09 2020-09-30 Boehringer Ingelheim International GmbH Nebulizer
DK3139979T3 (da) 2014-05-07 2023-10-09 Boehringer Ingelheim Int Enhed, forstøver og fremgangsmåde
NZ724449A (en) 2014-05-07 2022-01-28 Boehringer Ingelheim Int Nebulizer and container
EP3139984B1 (en) 2014-05-07 2021-04-28 Boehringer Ingelheim International GmbH Nebulizer
GB201413181D0 (en) 2014-07-25 2014-09-10 Dunne Consultancy Services Ltd Inhaler cartridge system
FR3052691B1 (fr) * 2016-06-20 2021-01-22 Aptar France Sas Dispositif de distribution de produit fluide.
FR3075650B1 (fr) * 2017-12-22 2020-01-03 Aptar France Sas Dispositif de distribution de produit fluide.
FR3101619B1 (fr) 2019-10-07 2021-12-17 Aptar France Sas Procédé de remplissage d’un dispositif de distribution de produit fluide
FR3108536B1 (fr) * 2020-03-30 2022-06-17 Aptar France Sas Dispositif de distribution de produit fluide, en particulier pour un nombre limité de doses
EP4149598B1 (en) 2020-05-14 2024-10-02 Eli Lilly and Company Nasal delivery device
WO2023111635A1 (en) * 2021-12-14 2023-06-22 A. Nattermann & Cie Gmbh Fluid dispensing device and mechanical energy storage
CN118647424A (zh) * 2021-12-14 2024-09-13 纳特曼有限公司 流体分配装置

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Also Published As

Publication number Publication date
DE60004219T2 (de) 2004-04-22
JP2003500295A (ja) 2003-01-07
JP4255622B2 (ja) 2009-04-15
FR2793707A1 (fr) 2000-11-24
CN1144622C (zh) 2004-04-07
CN1355731A (zh) 2002-06-26
US6401987B1 (en) 2002-06-11
FR2793707B1 (fr) 2002-02-15
DE60004219D1 (de) 2003-09-04
EP1185377A1 (fr) 2002-03-13
WO2000071262A1 (fr) 2000-11-30

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