EP1179980A4 - Composition antibacterienne et son emploi pour les soins de la peau et le traitement de tissus - Google Patents

Composition antibacterienne et son emploi pour les soins de la peau et le traitement de tissus

Info

Publication number
EP1179980A4
EP1179980A4 EP00926454A EP00926454A EP1179980A4 EP 1179980 A4 EP1179980 A4 EP 1179980A4 EP 00926454 A EP00926454 A EP 00926454A EP 00926454 A EP00926454 A EP 00926454A EP 1179980 A4 EP1179980 A4 EP 1179980A4
Authority
EP
European Patent Office
Prior art keywords
weight
water
based composition
composition
fabric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00926454A
Other languages
German (de)
English (en)
Other versions
EP1179980A1 (fr
Inventor
Jacob Danieli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sintal International Inc
Original Assignee
Sintal International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sintal International Inc filed Critical Sintal International Inc
Publication of EP1179980A1 publication Critical patent/EP1179980A1/fr
Publication of EP1179980A4 publication Critical patent/EP1179980A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/05—Mixers using radiation, e.g. magnetic fields or microwaves to mix the material
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/02—Amines; Quaternary ammonium compounds
    • A01N33/12—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/84—Accessories, not otherwise provided for, for absorbent pads
    • A61F13/8405—Additives, e.g. for odour, disinfectant or pH control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208—Tissues; Wipes; Patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A61K8/416—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B01F23/411—Emulsifying using electrical or magnetic fields, heat or vibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
    • B01F27/90—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with paddles or arms 
    • A—HUMAN NECESSITIES
    • A41—WEARING APPAREL
    • A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
    • A41D19/00—Gloves
    • A41D19/0055—Plastic or rubber gloves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
    • A61L2300/208—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/21—Mixing of ingredients for cosmetic or perfume compositions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B01F27/07—Stirrers characterised by their mounting on the shaft
    • B01F27/072—Stirrers characterised by their mounting on the shaft characterised by the disposition of the stirrers with respect to the rotating axis
    • B01F27/0725—Stirrers characterised by their mounting on the shaft characterised by the disposition of the stirrers with respect to the rotating axis on the free end of the rotating axis

Definitions

  • This invention relates to a water-based composition having at least one of anti- bacterial or anti-fungal properties and use thereof for skin care and for fabric treatment.
  • the composition is not only effective as an anti-bacterial and/or anti-fungal material when included in a skin care gel or lotion for topical use, such as in a sun screen composition, or in conjunction with sanitary elastic gloves as a coating therein, it is gentle to the user's skin and may include constituents which advantageously indicate its presence.
  • the composition is not only effective as an anti-bacterial and/or anti-fungal material when used as a liquid to treat fabric employed for personal hygiene aids including disposable diapers for children and adults, sanitary napkins, and wipes, it is gentle to the skin and may be formulated to provide odor control. Users include humans and animals.
  • a lotion which is a water-based composition useful as an antiseptic barrier for pre- and post-milking, and dry period treatment of the teats of milk cows under the trade name tSHIELDTM (Quest Research, Inc.).
  • This composition is formulated as a soothing dip or lotion for topical application or is impregnated in toweling used as a cleansing wipe.
  • the lotion product shields the skin of the cow against bacterial penetration for up to four days and may be marked with a dye to indicate its presence and hence provide an effectiveness indicator.
  • the composition includes four anti-bacterially-active constituents known to target bacteria commonly found for this application, namely, in % by weight based on the weight of the total composition, 0.30 % of a Quaternium 12 (C.T.F.A. name, i.e., a Cosmetic, Toiletries, and Fragrances Association name), such as BORDAC 2250 a disinfectant manufactured by Lonza, Inc.; 2.80 % of a Cetrimonium chloride (C.T.F.A.
  • a Quaternium 12 C.T.F.A. name, i.e., a Cosmetic, Toiletries, and Fragrances Association name
  • BORDAC 2250 a disinfectant manufactured by Lonza, Inc.
  • Cetrimonium chloride C.T.F.A.
  • composition additionally includes silicone fluids, i.e., 0.90 % of
  • SILICONE 344 and 0.70 % of SILICONE 1401 manufactured by Dow Corning to improve adherence of the lotion to the cow's teats, as well as other ingredients including emulsifiers, colorants, such as about 0.0023 % by weight of FD&C Red, fragrances, and diluents, such as from about 85 to about 90 % deionized water.
  • QUATRO- DERMTM Quest Research, Inc.
  • This composition includes four active constituents, hence the name "quatro", namely, in % by weight based on the weight of the total composition, 0.1 % of a Quaternium 12 (C.T.F.A. name), such as BORDAC 2250 a disinfectant manufactured by Lonza, Inc.; 0.5 % of Didecyl-dimethyl ammonium chloride; 1.0 % of a Cetrimonium Chloride (C.T.F.A.
  • the composition additionally includes various other constituents, such as 1.25 % of METHOCEL 40-101 (manufactured by Dow Chemical Corporation) as a thickening agent to provide a viscosity of about 4000 centipoise to the composition, and 0.5 % GERMABEN II (manufactured by ISP Corporation) as a formaldehyde donor for the composition.
  • METHOCEL 40-101 manufactured by Dow Chemical Corporation
  • GERMABEN II manufactured by ISP Corporation
  • This composition was not as gentle to the user's skin as was desired, suffered from color instability, and, in any event, was not free of formaldehyde due to the presence of GERMABEN II. It is an object of the present invention to provide an anti-bacterial composition, which is gentle, which can be used repetitively, and yet which is anti- bacterially effective for humans and animals.
  • a fabric hygiene article such as a disposable diaper (child and adult), a feminine hygiene pad, and a wipe for men and women but having particular utility for women for use in the groin, rectum, inner ears, eyelids, and for makeup removal which also treats the skin, containing the anti-bacterial and/or antifungal composition of the present invention.
  • composition which is a gel or lotion and which has at least one of antibacterial or anti-fungal properties, comprising from about 85 to about 90 % by weight of pure water, such as deionized water, from about 0.80 to about 1.3 % by weight of Cetrimonium chloride; and from about 0.07 to about 0.08 % by weight of at least one substance selected from the group consisting of Benzalkonium chloride and Grapefruit seed extract; from about 0.15 to about 0.35 % by weight of Didecyl-dimethyl ammonium chloride; and from about 0.08 % to about 1.55 % of Quaternium 22.
  • the gel or lotion composition is a non-toxic, non-flammable, non-drying, non- irritating cleanser. It is advantageously alcohol-free, pH balanced, and does not leave any residue on body parts such as the breasts of nursing mothers or in the mother's milk.
  • compositions according to the invention contain no toxic metals, such as arsenic, and no formaldehyde, yet have a very long shelf life.
  • the compositions are gentle enough for any skin type including, but not limited to, lips, breasts, groin, rectal, and eye areas, and may be used repetitively with no adverse effects.
  • the present invention additionally provides a fabric hygiene article selected from the group consisting of a disposable diaper, a feminine hygiene pad, and a wipe, comprising a fabric assembly; and a water-based composition comprised of from about 85 to about 90 % by weight of water; from about 2.20 to about 3.00 % by weight of Behentrimonium metholsulfate & stearyl alcohol; from about 0.15 to about 0.33 % by weight of Quaternium 12; from about from about 0.80 to about 3.00 % by weight of Cetrimonium chloride; and from about 0.08 % to about 1.55 % of Cetylpyridinium chloride present in an amount which is at least effective to provide anti-bacterial and/or anti-fungal properties to the surface of the fabric assembly which contacts the user.
  • a fabric hygiene article selected from the group consisting of a disposable diaper, a feminine hygiene pad, and a wipe, comprising a fabric assembly
  • a water-based composition comprised of from about 85 to about 90 % by weight of water; from
  • the amount of composition used may range up to an amount which does not substantially prevent moisture uptake by the fabric assembly.
  • the wipe is preferably completely saturated by the water-based composition and is made of a non- woven fabric composed of a material such as a natural material, for example, a cotton pulp, or a synthetic material such as polyester fibers.
  • the present invention further provides a sanitary glove, comprising a glove comprised of an elastic material; and a coating provided on at least a part of the inner surface of the glove and being comprised of a water-based composition having at least one of anti-bacterial or anti-fungal properties and comprising from about 85 to about 90 % by weight of water; from about 2.20 to about 3.00 % by weight of Behentrimonium metholsulfate & stearyl alcohol; from about 0.15 to about 0.33 % by weight of Quaternium 12; from about 0.80 to about 3.00 % by weight of Cetrimonium chloride; and from about 0.08 % to about 1.55 % of Cetylpyridinium chloride.
  • the composition for skin care of the present invention includes four anti- bacterially active constituents, namely, from about 0.80 to about 1.30 %, preferably about 1.20 % , by weight of Cetrimonium chloride and from about 0.07 to about 0.08 %, preferably about 0.08 %, by weight of at least one substance selected from the group consisting of Benzalkonium chloride and Grapefruit seed extract; from about 0.15 to about 0.35 % , preferably about 0.30, by weight of Didecyl-dimethyl ammonium chloride; and from about 0.08 % to about 1.55 %, preferably about 0.1 % , of Quaternium 22 (C.T.F.A. name), such as those manufactured by manufactured by Lonza, Inc.
  • C.T.F.A. name Quaternium 22
  • composition of the present invention may additionally includes thickening agents, such as from about 0.09 to about 1.20 %, preferably about 1.00 %, by weight of NATRNSOOL HHR 250 manufactured by Aqualon Corporation or METHOCEL
  • composition additionally may includes moisturizers, such as from about
  • Lanolin or glycerine may be included, and additional materials such as Vitamin E and citric acid may be added.
  • the composition may additionally include an orgonolepticically effective constituent for odor control, namely, from about 1.00 to about 2.50 % , preferably about 2.50 %, by weight of a sodium salt of an organic sesquicarbonate, such as those manufactured by Dow Chemical.
  • an orgonolepticically effective constituent for odor control namely, from about 1.00 to about 2.50 % , preferably about 2.50 %, by weight of a sodium salt of an organic sesquicarbonate, such as those manufactured by Dow Chemical.
  • the anti-bacterial composition for sanitary elastic glove application of the present invention includes four anti-bacterially active constituents, namely, from about 0.15 to about 0.33 % , preferably about 0.30 % , by weight of Quaternium 12
  • C.T.F.A. name & stearyl alcohol
  • C.T.F.A. name & stearyl alcohol
  • C.T.F.A. name a & stearyl alcohol
  • C.T.F.A. name a & stearyl alcohol
  • C.T.F.A. name a & stearyl alcohol
  • C.T.F.A. name a & stearyl alcohol
  • C.T.F.A. name cetylpyridinium chloride
  • composition of the present invention additionally includes thickening agents, such as from about 0.80 to about 1.20 %, preferably about 0.90 % , by weight of CYCLOMETHICONE manufactured by Dow Chemical, and from about 0.05 to about 0.90 %, preferably about 0.07%, by weight of CYCLOMETHICONE
  • the composition additionally includes moisturizers, such as from about 0.09 to about 0.12 %, preferably about 0.10 %, by weight of aloe vera extract, and Vitamin E and glycerine.
  • the composition may additionally include an orgonolepticically effective constituent for odor control, namely, from about 1.00 to about 2.50 %, preferably about 2.50 %, by weight of a sodium salt of an organic sesquicarbonate.
  • the composition may additionally include an indicator for activity which advises a human user or observer of the presence or absence of the composition either by color, or absence thereof, or by fragrance or absence thereof.
  • an indicator for activity which advises a human user or observer of the presence or absence of the composition either by color, or absence thereof, or by fragrance or absence thereof.
  • a dye may be employed such as, by way of example but not limitation, FD&C Red #28 or Red Fluorescent #40.
  • the dye material moreover, may have any suitable color and may change color depending on the pH of the skin of the recipient.
  • Any suitable water-soluble fragrance may be used, such as those manufactured by ARILYESSENCE. For example, cherry fragrance may be included.
  • Figure 1 illustrates in cross-section a treated fabric assembly, such as commonly employed in a sanitary napkin or disposable diaper, showing that the antibacterial and/or anti-fungal composition of the present invention is impregnated into at least the surface of the fabric assembly which contacts the user's skin;
  • Figure 2 illustrates in cross-section a portion of a sanitary elastic glove provided on its inner surface with a coating composed of the anti-bacterial and/or anti-fungal composition of the present invention
  • Figure 3 schematically illustrates an apparatus for mixing and magnetically treating a composition according to the invention.
  • Figure 1 shows a cross-section of a treated fabric assembly 1 having an inner padding 2 and outer fabric cover layers 3, 4, such as commonly employed in a sanitary napkin or in a disposable diaper, with the anti-bacterial and/or anti-fungal composition of the present invention impregnated into at least a surface area 5 of the outer cover layer 3 which contacts the user's skin.
  • Figure 2 shows in cross-section a portion of an elastic glove 10 including an elastic layer 11 composed of, for example latex or vinyl, and a coating 12 composed of the anti-bacterial and/or anti-fungal composition of the present invention applied as a coating onto inner surface 13 of the latex glove 10.
  • FIG. 3 schematically illustrates an apparatus 20 for mixing and magnetically treating a composition according to the invention.
  • the apparatus includes a mixing vessel 21 including a tank 22, stirring means 23 shown as a shaft 24 provided with stirring blades 25 powered by a motor 26, heating means 27 shown as resistance heater 28 (not to scale), and lids 29 for retaining heat within the vessel 21.
  • a magnetic field generation means shown generally at 30 is positioned in a manner effective to magnetically influence the composition within the tank.
  • the magnetic field generation means 30 includes at least two electrodes 31 (anode 31a and cathode 31b) provided with wound coils of wire 32a, 32b respectively surrounding conductive metal rods 33a, 33b, and at least one D.C.
  • the power source 34 sufficient to provide a current at the at least two electrodes 31a, 31b ranging from about 20 up to but less than about 40 amperes.
  • the at least two electrodes 31 are mounted on a bridge 35 which extends the width of the tank 22 but which is electrically insulated from tank 22 which may be made of stainless steel.
  • the tank 22 is provided with a drain line 40 and valve 41.
  • the apparatus of Figure 3 may be employed to practice a method of manufacturing a composition according to the invention, which method includes, in the order recited, providing the mixing vessel 21 including the tank 22, stirring means 23 positioned within the tank 22, and a magnetic field generation means 30 positioned in a manner effective to magnetically influence the composition within the tank 22.
  • the mixing vessel 21 is filled with about one half of the water and the water is heated to a temperature of about 50°C.
  • the at least four active ingredients of the composition of according to the invention are added to the water in the mixing vessel 21, and are stirred slowly and at low shear to provide a pre-mix.
  • the pre-mix is treated in a magnetic field having a field strength and for a time effective to increase specific gravity of the pre-mix to a specific gravity ranging from 1.015 to 1.018.
  • the remainder of the water is added to provide a treated mixture.
  • the water is advantageously allowed to relax prior to heating.
  • the at least four active ingredients are preferably added to the water in the mixing vessel 21 slowly, sequentially, and with the stirring means 23 operating at low shear.
  • the method may additionally include adding at least one additional constituent to the treated mixture slowly and with mixing at low shear.
  • the at least one additional constituent is advantageously selected from the group consisting of a thickening agent, a moisturizer, a surfactant, an organoleptically effective ingredient for odor control, a dye, and a fragrance, examples of which are discussed in the following.
  • the method advantageously additionally includes mixing the at least two additional constituents together in a separate vessel (not shown) prior to adding same to the treated mixture in vessel 21.
  • the pre-mix is treated in a magnetic field for a time ranging from about 1 to about 60 minutes, preferably, for a time ranging from about 20 to about 40 minutes.
  • the mixing vessel employed was cylindrical as illustrated in Figure 3 and had a diameter of about six and one half feet and a depth of about four feet. Batches of about 250 gallons were made and each batch filled the mixing vessel to a depth of about three feet.
  • Two electrodes for generating a magnetic field were provided, i.e., an anode and a cathode, and were separated from one another by a distance of about six feet.
  • the stirring blades extended about six feet taken as a whole, were positioned beneath the lower ends of the two electrodes, and were powered by a one half horsepower, variable speed motor.
  • the anode and cathode were each constructed of about 25 foot lengths of current-carrying copper wire which had a thickness of about that of telephone wire and which was wound around a three foot length of steel rod having a one and one quater inch diameter.
  • the wire was wound in the middle portion of the respective steel rods. No wire was wound on the ends of the steel rods so that about six inches of rod remained at each respective end thereof.
  • the wire was coiled into a series of turns which were positioned as close together as possible.
  • the magnetic field generation means was advantageously configured to provide a current at the coils of about 30 amps for time period of about 20 minutes, with a D.C. voltage applied of about 24 volts.
  • the parameters which define the electric field including the length of the electrodes, the distance between them, and the D.C. voltage applied to them, may be varied over a wide range.
  • the parameters which define the magnetic field including the number of turns, the cross-sectional area of the coils, and the current at the coils, may be varied over a wide range.
  • the color and the specific gravity of the mixture varied during magnetic treatment and were used to monitor progress. The color of the mixture starts out as water white and turns a light yellow during magnetic treatment indicating that some type of change is occurring, such as perhaps formation of a complex or coordination compound between one or more of the four active ingredients. Current below about 20 amps was found to require too much time for the desired changes in color and specific gravity to occur. Current of 40 amps or more was found to undesirably turn the composition a dark yellow-brown color.
  • the specific gravity of the compositions being magnetically treated gradually increased to a range of from 1.015 to 1.018.
  • the magnetic field generation means produced a large field parallel to the axis of the electrodes (in the z-direction). Between these magnetic field generation electrodes (anode and cathode), the fields from individual coils added together to form a very strong field along the center line between the anode and the cathode. Components of the magnetic field in other directions were cancelled by opposing fields from neighboring coils. Outside of the magnetic field generation means, the magnetic field was very weak due to the cancellation effect. For magnetic field generation electrodes that are long in comparison to their diameter, the field is very close to zero.
  • Example 1 Glove Coating Composition (QUATROGLOVE) And Method
  • a composition suitable for dip coating the interior of an elastic glove was prepared and included the following constituents in amounts by weight as stated.
  • N-alkyl-dimethylbenzyl-ammonium chloride for example, BARQUAT MB-50, by Lonza, Inc. or Pacific Coast Chemicals;
  • Cetramonium Chloride for example, CARSOQUAT CT-429, Cetyl- trimethylammonium chloride, by Lonza, Inc. or Pacific Coast Chemicals;
  • Dimethicone (a silicone fluid)
  • the first mixing vessel which corresponded to the pilot plant apparatus schematically illustrated in Figure 3, was allowed to relax, and was heated to about 50°C.
  • the N-alkyl-dimethylbenzyl- ammonium chloride, Cetramonium Chloride, OCTOXYNOL-9, Quaterniun 22, and Chlorohexadine gluconate were added to the heated water slowly and sequentially, and were stirring slowly and at low shear to provide a first mixture.
  • the first mixture was treated in a magnetic field having a field strength and for a time effective to increase specific gravity of the first mixture to a specific gravity ranging from
  • the color of the first mixture was seen to change from a clear water-white to a light yellow color which the inventor considers may be due to formation of a complex having extended conjugation and hence the color change.
  • treatment in a magnetic field took place at a current at the magnetic coils of about 30 amps with about 24 volts applied. If the current was lowered to about 20 amps, the treatment required an impractical, extended amount of time to achieve the desired specific gravity range. If the current was increased to 40 amps, the mixture turned an aesthetically unpleasant dark yellow-brown color which, as a practical matter, would not be useful for this type of composition and which may be due, at least in part, to undesirable electrolysis of the constituents.
  • the remaining half of the water was filled into a second mixing vessel and heated to a temperature of about 50°C.
  • the Cherry Fragrance, Dimethicone (a silicone fluid), and Incroquat Behenyl (tms) were added to the water in the second mixing vessel and were stirred to obtain a second mixture having a specific gravity of
  • This second mixing vessel was not provided with a magnetic treatment means.
  • the second mixture was then slowly added to the first mixture in the first mixing vessel with stirring at low shear to provide a composition suitable for spray coating the interior of an elastic glove.
  • the pH of the composition ranged between 5.5 to 7.0.
  • the specific gravity of the composition ranged between 0.85 to 0.89 with respect to water.
  • a latex composition was coated onto a mold maintained at about 50 °C to form a green latex glove.
  • the green latex glove while still on the mold was dipped into the composition according to the invention to form a coating thereon, and was dried in a hot air tunnel maintained at a temperature ranging from about 110 to 120°C.
  • the glove was removed from the mold and turned inside out so that the coating of the inventive composition was present on the inside of the glove.
  • a liquid composition having a viscosity of 800 cps was prepared and included the following four active constituents as percent by weight: 0.13% of Quaternium 12 (useful range 0.08 - 0.13%); 2.8% of Cetrimonium chloride (useful range 0.80 - 3.00%); 2.8%o of Behentimonium methosulfate & Stearyl alcohol (useful range 2.20 - 3.00%); and 0.1%) of Cetylpyridinium chloride (useful range 0.08 - 1.55%)). These were mixed in an apparatus and treated with a magnetic field as described in Example 1.
  • composition additionally included the following constituents which were mixed in a second vessel, heated, and subsequently added to the mixed and magnetically treated active ingredients in the apparatus mentioned above:
  • a thickening agent comprised of:
  • cyclomethicone 30.00% of cyclomethicone (useful range 27.20 - 33.80%); and 0.70%) of cyclomethicone dimethiconol (useful range 0.05 - 0.90%); (2) a moisturizer comprised of 0.1% of aloe vera extract (useful range 0.09 - 0.12%); (3) a constituent which serves to remove objectionable odors which is 1.0% of at least one sodium salt of an organic sesquicarbonate (useful range 1.00 - 2.50 %); and
  • an indicator for presence of the composition which is a dye and which is 0.0023% of FC&C red #28 (useful range 0.0021 - 0.0024%); and/or which is a water- soluble fragrance and which is 0.01%> of a cherry fragrance (useful range 0.01 - 0.012%).
  • N liquid composition having a specific gravity of 1.01 was prepared and included water and the following four active constituents as percent by weight:
  • composition additionally included the following constituents which were mixed with water in a second vessel, heated, and subsequently added to the mixed and magnetically treated active ingredients in the apparatus mentioned above:
  • a constituent which serves to remove objectionable odors which is 2.50% of at least one sodium salt of an organic sesquicarbonate (useful range 1.00 - 2.50 %); and (2) at least one water-soluble fragrance and which is 0.01% of a cherry fragrance (useful range 0.01 - 0.012%>).
  • This composition can be prepared as a liquid or as' a gel by varying the amount of constituents, particularly the thickener as one skilled in the art would understand.
  • This composition or any composition according to the invention can be prepared without the magnetic treatment and be useful for the stated purposes. Magnetic treatment of the active ingredients, however, significantly lengthens the period of time the composition provides functional activity, e.g., anti-bacterial or anti-fungal properties, to the applied area of the recipient, human or animal.
  • An additional advantage is that the magnetically treated composition leaves no visible residue on the applied area of the recipient, human or animal.

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Abstract

L'invention porte sur une préparation aqueuse présentant au moins une propriété antibactérienne ou antifongique, et sur son emploi pour les soins de la peau et le traitement de tissus. Ladite préparation est non seulement efficace comme matériau antibactérien ou antifongique lorsqu'intégrée à un gel traitant pour la peau ou à une lotion à usage topique par exemple de protection solaire, ou comme revêtement intérieur de gants élastiques médicaux, mais elle est douce pour la peau et peut en outre comporter des ingrédients rendant sa présence agréable. Ladite préparation est non seulement efficace comme matériau antibactérien ou antifongique sous forme liquide pour traiter des tissus utilisés à des fins d'hygiène personnelle tel que ceux des protections jetables pour enfants et adultes, des serviettes hygiéniques et des tampons de ménage. Elle est douce pour la peau et peut être composée pour agir sur les odeurs. Ses applications concernent l'homme et l'animal.
EP00926454A 1999-04-30 2000-04-28 Composition antibacterienne et son emploi pour les soins de la peau et le traitement de tissus Withdrawn EP1179980A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US302425 1989-01-26
US30242599A 1999-04-30 1999-04-30
PCT/US2000/011425 WO2000065911A1 (fr) 1999-04-30 2000-04-28 Composition antibacterienne et son emploi pour les soins de la peau et le traitement de tissus

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EP1179980A4 true EP1179980A4 (fr) 2006-04-26

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MY119235A (en) 2000-12-21 2005-04-30 Matang Mfg Sdn Bhd Aloe vera impregnated elastomeric article and method of manufacture
JP2002209788A (ja) * 2001-01-16 2002-07-30 Uni Charm Corp ウエットワイパー
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CA2460535A1 (fr) 2001-09-13 2003-03-20 Ansell Healthcare Products, Inc. Revetement a microcapsules pour gants
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JP4395333B2 (ja) * 2003-06-20 2010-01-06 ユニ・チャームペットケア株式会社 ペットのトイレ用吸液シート
US8067350B2 (en) 2005-12-15 2011-11-29 Kimberly-Clark Worldwide, Inc. Color changing cleansing composition
CN101528277A (zh) * 2006-11-17 2009-09-09 Sca卫生用品公司 吸收制品
WO2008060209A1 (fr) * 2006-11-17 2008-05-22 Sca Hygiene Products Ab Article absorbant
CN101181208B (zh) * 2007-11-20 2010-06-09 美晨集团股份有限公司 一种含天然抗菌素的漱口液及其制备方法
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US9149567B2 (en) * 2009-03-11 2015-10-06 Ansell Limited Powder-free antimicrobial coated glove
CN103255679B (zh) * 2013-05-06 2015-11-25 金红叶纸业集团有限公司 抗菌混合液、抗菌纸及抗菌纸生产工艺
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BR112018076823A2 (pt) * 2016-06-24 2019-04-02 Lonza Inc. combinação sinergética de biocidas
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CN1359260A (zh) 2002-07-17
EP1179980A1 (fr) 2002-02-20
WO2000065911A1 (fr) 2000-11-09

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