JP2015522053A - プロピオニバクテリウム・アクネスに対する抗菌薬としてのコセス硫酸亜鉛の使用 - Google Patents
プロピオニバクテリウム・アクネスに対する抗菌薬としてのコセス硫酸亜鉛の使用 Download PDFInfo
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- JP2015522053A JP2015522053A JP2015520943A JP2015520943A JP2015522053A JP 2015522053 A JP2015522053 A JP 2015522053A JP 2015520943 A JP2015520943 A JP 2015520943A JP 2015520943 A JP2015520943 A JP 2015520943A JP 2015522053 A JP2015522053 A JP 2015522053A
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- skin
- propionibacterium acnes
- zinc sulfate
- antibacterial agent
- coses
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- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 title description 21
- 229960001763 zinc sulfate Drugs 0.000 title description 20
- 229910000368 zinc sulfate Inorganic materials 0.000 title description 20
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- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
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- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/02—Local antiseptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
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- A61Q19/00—Preparations for care of the skin
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
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- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
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- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Detergent Compositions (AREA)
Abstract
Description
・セバシン酸の脂肪族物質の良好な脂質除去力
・跳ね返り効果によって皮脂腺を刺激しないような良好な界面活性剤忍容性
・脂腺機能の調節
・関連する細菌増殖の阻害。
・陰イオン性界面活性剤であるラウリルメチルイセチオン酸ナトリウム、
・および/またはギンバイカ抽出物、より具体的には、EP1112079に記載されているようなギンバイカ抽出物、モノカプリル酸ポリグリセリル−3、カプリン酸グリセリル、臭化セトリモニウムの中から選択される別の抗菌薬、
・および/またはWO2011/073370に記載されているようなラウリン酸グリセリル、サバール抽出物、カボチャ種子油、セイヨウイラクサ(urtica dioic)抽出物などの中から選択される抗脂漏薬
とともに含んでなる、組成物、より好ましくは、アクネができやすくかつ/またはアクネ傾向がある肌に向けた洗浄用組成物に関する。
・ギンバイカ抽出物、好適的には、EP1112079に記載されているギンバイカの抽出物、モノカプリル酸ポリグリセリル−3、カプリン酸グリセリル、臭化セトリモニウムなどの抗菌成分
・またはラウリン酸グリセリル、サバール抽出物、カボチャ種子油、セイヨウイラクサ抽出物などの、アクネ病変に対する相互補完的作用成分
と組み合わせて使用される。
・環化ソルビトールとエトキシル化ラウレル鎖を併せ持つポリソルベート20
・エトキシル化硬化ヒマシ油(40EO)
・セテアレス−60ミリスチルグリコール(脂肪鎖が皮膚表面を保護する)。
実施例1:
ラウリルメチルイセチオン酸ナトリウム(Iselux(登録商標)、Innospec社製) 5〜20%
コセス硫酸亜鉛(Zetesol Zn(登録商標)、Zchimmer & Schwarz社製) 5〜20%
ココアンホ酢酸二ナトリウム 3〜10%
ポリソルベート20 0.5〜4%
セテアレス−60ミリスチルグリコール 0.5〜1.5%
エトキシル化硬化ヒマシ油 0.5%〜2%
ラウリン酸グリセリル 0.1〜1%
グルコン酸亜鉛 0.1〜0.5%
クエン酸/EDTA 2Na 適量 pH=5
初期病原菌数に対する病原菌数log10値の経時的減少(log Rパラメーター)を評価する。
・試験を行う製品を、約106CFU/mlに力価調整したP.アクネス懸濁液と1分、5分、10分および15分間接触させる。
・サンプル1mlを培養寒天培地(コロンビア)に含めることにより、各接触時間経過後に生存数を測定する。
・嫌気性条件下、36℃で72時間インキュベーションを行う。
・直接計数することによって残留細菌の生存数を測定する。
ディッシュの計数を行い、この結果をCFU数/mlと比較する。
対数減少=
LOG10(T0時点で存在するCFU数/Tx時点で残留するCFU数)。
本発明による組成物の別の例に対して、上述した同じプロトコールに従って、同じ殺菌活性評価を行った。
・Zetesol Zn(濃度20%、つまり、有効成分であるコセス硫酸亜鉛は5%)
・Iselux(濃度10%、つまり、有効成分であるラウロイルメチルイセチオン酸ナトリウムは8%)
・セテアレス−60ミリスチルグリコール−増粘剤
・ココアンホ酢酸Na−両性界面活性剤
・カプリルグリコール(Capryl Glycol)
・乳酸
・NaOH
・適量の水
上記と同じプロトコールを使用する。
・実施例1による組成物を滅菌蒸留水で20%に希釈する=洗い流す製品の使用希釈度。
・プロピオニバクテリウム・アクネスATCC6919
・プロピオニバクテリウム・アクネス ソバージュ(Sauvage)(R エリスロマイシン耐性株)
・プロピオニバクテリウム・アクネス ソバージュ(Sauvage)(S エリスロマイシン感受性株)。
Claims (3)
- プロピオニバクテリウム・アクネスに対する抗菌薬としてのコセス硫酸亜鉛をラウリルメチルイセチオン酸ナトリウムと組み合わせて含んでなる皮膚用衛生組成物であって、グリチルリチン酸またはグリシルレチン酸の塩または誘導体を含まない、組成物。
- ギンバイカ抽出物、モノカプリル酸ポリグリセリル−3、カプリン酸グリセリル、臭化セトリモニウムの中から選択される抗菌薬をさらに含有することを特徴とする、請求項1に記載の皮膚用衛生組成物。
- ラウリン酸グリセリル、サバール抽出物、カボチャ種子油、セイヨウイラクサ抽出物の中から選択される抗脂漏薬を含有することを特徴とする、請求項1または2のいずれか一項に記載の皮膚用衛生組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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FR1256606A FR2992859B1 (fr) | 2012-07-09 | 2012-07-09 | Utilisation de coceth sulfate de zinc comme agent antibacterien vis a vis de propionibacterium acnes |
FR1256606 | 2012-07-09 | ||
PCT/EP2013/064391 WO2014009315A2 (fr) | 2012-07-09 | 2013-07-08 | Utilisation de coceth sulfate de zinc comme agent antibacterien vis a vis de propionibacterium acnes |
Publications (2)
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JP2015522053A true JP2015522053A (ja) | 2015-08-03 |
JP2015522053A5 JP2015522053A5 (ja) | 2016-09-01 |
Family
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JP2015520943A Pending JP2015522053A (ja) | 2012-07-09 | 2013-07-08 | プロピオニバクテリウム・アクネスに対する抗菌薬としてのコセス硫酸亜鉛の使用 |
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US (1) | US9855205B2 (ja) |
EP (1) | EP2874711B1 (ja) |
JP (1) | JP2015522053A (ja) |
KR (1) | KR102209331B1 (ja) |
CN (1) | CN104602764B (ja) |
AR (1) | AR091705A1 (ja) |
AU (1) | AU2013289294B2 (ja) |
BR (1) | BR112015000186B1 (ja) |
CA (1) | CA2878633C (ja) |
ES (1) | ES2727967T3 (ja) |
FR (1) | FR2992859B1 (ja) |
HK (1) | HK1209675A1 (ja) |
IN (1) | IN2015DN00710A (ja) |
MX (1) | MX366805B (ja) |
PT (1) | PT2874711T (ja) |
RU (1) | RU2638799C2 (ja) |
TW (1) | TWI645849B (ja) |
WO (1) | WO2014009315A2 (ja) |
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GB2526784A (en) * | 2014-05-26 | 2015-12-09 | Skf Ab | Micro electro optical mechanical system |
US10736831B2 (en) | 2015-07-17 | 2020-08-11 | Colgate-Palmolive Company | Oral care compositions |
CN112472617B (zh) * | 2020-12-10 | 2022-07-01 | 南京泛成生物科技有限公司 | 一种脂肪酰烷基磺酸盐的自增稠体系、其制备方法及应用 |
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Also Published As
Publication number | Publication date |
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ES2727967T3 (es) | 2019-10-21 |
BR112015000186B1 (pt) | 2019-09-17 |
CA2878633A1 (fr) | 2014-01-16 |
RU2015104101A (ru) | 2016-08-27 |
WO2014009315A3 (fr) | 2014-10-23 |
US20150196474A1 (en) | 2015-07-16 |
EP2874711B1 (fr) | 2019-03-13 |
MX366805B (es) | 2019-07-24 |
AR091705A1 (es) | 2015-02-25 |
KR20150036378A (ko) | 2015-04-07 |
AU2013289294B2 (en) | 2017-11-30 |
HK1209675A1 (en) | 2016-04-08 |
CN104602764A (zh) | 2015-05-06 |
BR112015000186A2 (pt) | 2017-06-27 |
FR2992859B1 (fr) | 2014-10-03 |
KR102209331B1 (ko) | 2021-01-28 |
WO2014009315A2 (fr) | 2014-01-16 |
AU2013289294A1 (en) | 2015-02-19 |
US9855205B2 (en) | 2018-01-02 |
CN104602764B (zh) | 2017-03-29 |
CA2878633C (fr) | 2020-08-18 |
PT2874711T (pt) | 2019-06-18 |
MX2015000275A (es) | 2015-07-21 |
TWI645849B (zh) | 2019-01-01 |
EP2874711A2 (fr) | 2015-05-27 |
IN2015DN00710A (ja) | 2015-06-26 |
RU2638799C2 (ru) | 2017-12-15 |
FR2992859A1 (fr) | 2014-01-10 |
TW201408289A (zh) | 2014-03-01 |
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