WO2016098965A1 - Composition antiseptique et son utilisation - Google Patents

Composition antiseptique et son utilisation Download PDF

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Publication number
WO2016098965A1
WO2016098965A1 PCT/KR2015/004678 KR2015004678W WO2016098965A1 WO 2016098965 A1 WO2016098965 A1 WO 2016098965A1 KR 2015004678 W KR2015004678 W KR 2015004678W WO 2016098965 A1 WO2016098965 A1 WO 2016098965A1
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Prior art keywords
composition
antiseptic
antiseptic composition
weight
present
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PCT/KR2015/004678
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English (en)
Korean (ko)
Inventor
전용석
조희원
최태근
Original Assignee
코오롱생명과학 주식회사
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Priority to KR1020177014904A priority Critical patent/KR20170087469A/ko
Publication of WO2016098965A1 publication Critical patent/WO2016098965A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/08—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • D—TEXTILES; PAPER
    • D21—PAPER-MAKING; PRODUCTION OF CELLULOSE
    • D21H—PULP COMPOSITIONS; PREPARATION THEREOF NOT COVERED BY SUBCLASSES D21C OR D21D; IMPREGNATING OR COATING OF PAPER; TREATMENT OF FINISHED PAPER NOT COVERED BY CLASS B31 OR SUBCLASS D21G; PAPER NOT OTHERWISE PROVIDED FOR
    • D21H21/00—Non-fibrous material added to the pulp, characterised by its function, form or properties; Paper-impregnating or coating material, characterised by its function, form or properties
    • D21H21/14—Non-fibrous material added to the pulp, characterised by its function, form or properties; Paper-impregnating or coating material, characterised by its function, form or properties characterised by function or properties in or on the paper
    • D21H21/36—Biocidal agents, e.g. fungicidal, bactericidal, insecticidal agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/09—Fish posts

Definitions

  • the present invention relates to antiseptic compositions and uses thereof.
  • microorganisms such as bacteria and fungi are not only numerous but also widely distributed in the natural world such as soil, air, water, and seawater, and can be grown and reproduced at any time when growth conditions are suitable. Diseases, food corruption, housing, clothing, industrial products to the damage caused by microorganisms is a serious situation.
  • CMIT chloromethylisothiazolinone
  • IPBC 3-iodo-2-propynylbutylcarbamate
  • BKC Benzalkonium Chloride
  • PHMG polyhexamethylene guanidine
  • PHMB polyhexamethylene biguanide
  • paraben Paraben and alcohol are used as antibacterial and fungicides.
  • CMIT and PHMB are guadiin-based chemicals that cause acute lung injury syndrome caused by a humidifier cleaner, and 3-iodine-2-propynylbutyl.
  • Carbamate is a socially-issued substance that is regulated for infant products by Japan's Ministry of Health, Labor and Welfare, and therefore, development of an antiseptic substance that can replace them is required.
  • Cetylpyridinium Chloride is a quaternary ammonium cation used in mouthwashes, toothpastes, oral sprays, nasal sprays, etc., which has bactericidal effects against bacteria and microorganisms, and prevents plaque from teeth. It is known to reduce gingivitis (Source: www.wikipedia.com).
  • U.S. Patent No. 6,861,047 discloses toothpastes and mouthwashes containing CPC and sodium dihydroacetate
  • Korean Patent Application No. 10-2001-0045337 discloses seed or cultivars of soybeans such as bean sprouts. Disclosed is a method for preventing rot of two vegetables by dipping, spraying or irrigation of CPC.
  • the present inventors conducted a study in order to overcome the problems of the preservatives currently used, as a result of using a mixture of cetylpyridinium chloride and sodium metabisulfite, excellent antibacterial and antifungal power, while increasing the durability, When the freezing point and the recrystallization temperature is low and used in the product, it was confirmed that the skin has a hypoallergenic effect, which is excellent in stability, and completed the present invention.
  • Patent Document 1 US Patent Registration No. 6,861,047
  • Patent Document 2 Korean Patent Application No. 10-2001-0045337
  • An object of the present invention is not irritating skin, harmless to the human body, having the same or more antiseptic force without including components such as CMIT, PHMB, PHMG, Paraben, which may be harmful to the human body, low freezing point and recrystallization temperature
  • the present invention provides an antiseptic composition having improved product stability and a use thereof.
  • the present invention provides an antiseptic composition
  • an antiseptic composition comprising sodium metabisulfite (SDS) and cetylpyridinium chloride (CPC) in a weight ratio of 1: 0.2 to 5.
  • the antiseptic composition may further include any one selected from the group consisting of sodium sulfite, hexylene glycol, surfactants, and combinations thereof.
  • the preservative composition is SDS and sodium sulfite in the case of sodium sulfite 1: 0.1 to 1.5 by weight, SDS and hexylene glycol in the weight ratio of 1: 0.1 to 1.5 for hexylene glycol, SDS and It may include a surfactant 1: 0.1 to 300.
  • the surfactant may be a ionic surfactant of carboxylate, sulfate ester salt, sulfonate salt or phosphate ester salt; Polyethylene glycol-based or polyhydric alcohol-based non-ionic surfactants; And amino acid-based or betaine-based amphoteric surfactants.
  • the antiseptic composition may be one in which the formulation is selected from an aqueous solution, an emulsion, a dispersion, a suspension and a useful solution.
  • the present invention provides a composition for wet wipes comprising the antiseptic composition.
  • the wet wipes composition may include 0.01 wt% to 10 wt% of the antiseptic composition.
  • composition for wet wipes may further include any one selected from the group consisting of glycerin, citric acid, a pH adjusting agent, and combinations thereof.
  • the present invention provides a cosmetic composition comprising the antiseptic composition.
  • the cosmetic composition may include 0.1 wt% to 10 wt% of the antiseptic composition.
  • the cosmetic composition may further include any one selected from the group consisting of cyclopentasiloxane (cyclopentasiloxane), disodium ethane (EDTA-2NA), glycerin, butylene glycol and combinations thereof.
  • cyclopentasiloxane cyclopentasiloxane
  • EDTA-2NA disodium ethane
  • glycerin glycerin
  • butylene glycol butylene glycol
  • the present invention provides a shampoo composition comprising the antiseptic composition.
  • the shampoo composition may include 0.1 wt% to 10 wt% of the antiseptic composition.
  • the shampoo composition may further comprise any one selected from the group consisting of disodium coco ampodiacetate, cocamidopropyl betaine, disodium laureth sulfosuccinate, decyl glucoside, and combinations thereof.
  • the present invention provides a detergent composition comprising the antiseptic composition.
  • the detergent composition may include 0.1 wt% to 10 wt% of the antiseptic composition.
  • the present invention provides a composition for fabric softener comprising the antiseptic composition.
  • the fabric softener composition may include 0.1 wt% to 10 wt% of the antiseptic composition.
  • the present invention provides an industrial detergent composition comprising the antiseptic composition.
  • the industrial detergent composition may include 0.1 wt% to 10 wt% of the antiseptic composition.
  • the antiseptic composition has excellent antibacterial and antifungal activity and persistence, thus protecting the product and the user against microorganisms from external exposure environment, having low skin irritation, harmless to the human body, and treating the antiseptic composition to the product. Not only does not affect the physical and chemical properties of the product, but also has high physical stability such as low temperature stability, high temperature stability and pH stability of the antiseptic composition, which is useful for wet wipes, human cleaners, household cleaners, diapers, hygiene products, cosmetics and disinfectants. Can be used.
  • the present invention relates to an antiseptic composition
  • an antiseptic composition comprising sodium metabisulfite (SDS) and cetylpyridinium chloride (CPC).
  • the antiseptic composition has a sterile or bactericidal effect on microorganisms, and includes both an antibacterial effect on bacteria and an antifungal effect on fungi.
  • the sodium metabisulfite (SDS) is used as an antioxidant and a reducing agent, and the composition of the present invention was confirmed to have excellent antibacterial and antifungal effects by mixing with CPC.
  • SDS has a disadvantage that there is a sulfuric acid odor at less than pH 5.0, in the antiseptic composition of the present invention confirmed the effect of improving the physical stability and odor.
  • the antiseptic composition may include SDS and CPC in a weight ratio of 1: 0.2 to 5, preferably, in a weight ratio of 1: 0.2 to 0.25 or 1: 4 to 5. When it satisfies the weight ratio, it is preferable for stabilizing physical properties and improving antibacterial and antifungal properties of the antiseptic composition.
  • the antiseptic composition may include 0.001 to 20% by weight of sodium metabisulfite, 0.001 to 20% by weight of cetylpyridinium chloride, and a residual amount of purified water.
  • the cetylpyridinium chloride is less than 0.001% by weight relative to the total weight of the antiseptic composition, the antimicrobial and antifungal activity of the target microorganism is reduced, and the antimicrobial agent does not have an antimicrobial spectrum.
  • the physical properties such as low temperature stability, high temperature stability and pH stability in the manufacturing, and it is not suitable for use because of compatibility with other compounds.
  • the sodium metabisulfite is less than 0.001% by weight relative to the total weight of the antiseptic composition, the antimicrobial and antifungal activity of the target microorganism is reduced, and the antimicrobial spectrum has no antimicrobial spectrum. It is difficult to control physical properties such as low temperature stability, high temperature stability and pH stability at the time of manufacture, and it is not suitable for use because it is incompatible with other compounds.
  • the antiseptic composition may further include any one selected from the group consisting of sodium sulfite, hexylene glycol, surfactants, and combinations thereof.
  • the mixing ratio of the SDS and CPC is improved to further improve the antimicrobial and antifungal power of the preservative composition, the freezing point and recrystallization temperature is lowered, and the pH is stabilized to help stabilize the product Excellent effect.
  • SDS and sodium sulfite may be included in a weight ratio of 1: 0.1 to 1.5, preferably 0.5 to 1.5.
  • the content of sodium sulfite is less than 0.1 weight ratio, it is difficult to control the freezing point and recrystallization temperature of the preservative composition, which is a problem in stabilization of the product, and when it exceeds 1.5 weight ratio, it is difficult to control physical properties such as low temperature stability and high temperature stability of the product and stabilize pH. There is a problem.
  • SDS and hexylene glycol may be included in a weight ratio of 1: 0.1 to 1.5, preferably 0.5 to 1.5.
  • the content of sodium sulfite is less than 0.1 weight ratio, it is difficult to control the freezing point and recrystallization temperature of the preservative composition, which is a problem in stabilization of the product, and when it exceeds 1.5 weight ratio, it is difficult to control physical properties such as low temperature stability and high temperature stability of the product and pH. There is a problem with stabilization.
  • the weight ratio of the SDS and the surfactant may include 1: 0.1 to 300, preferably 1: 0.1 to 10. If the content of the surfactant is outside the above range, it is difficult to control the freezing point and recrystallization temperature of the preservative composition and difficult to stabilize the pH, there is a problem in the stabilization of the product.
  • the surfactant can be anionic, non-ionic or amphoteric.
  • the anionic surfactant may be carboxylate, sulfate ester salt, sulfonate salt or phosphate ester salt, and the like, and may be in the form of sodium salt, calcium salt, ammonium salt, ethanolamine salt, and the like. It may be a polyethylene glycol-based or polyhydric alcohol, etc., the amphoteric surfactant may be an amino acid or betaine (betaine) and the like.
  • the anionic surfactants include fatty acid salts, alkyl dicarboxylates, alcohol sulfate ester salts, higher alkyl sulfonates, higher alkyl disulfonates, sulfated fatty acids and fatty acid sulfonated higher fatty acid salts, and higher alkyl phosphoric acid. Ester salt etc. can be illustrated.
  • amphoteric surfactant examples include betaine amphoteric surfactants, glycine amphoteric surfactants, alanine amphoteric surfactants, and sulfobetaine amphoteric surfactants.
  • non-ionic surfactants examples include glycerin esters of higher fatty acids, glycol esters of higher fatty acids, pentaerythritol esters of higher fatty acids, sucrose esters of higher fatty acids, sorbitan and mannitanic ester higher alcohol condensates of higher fatty acids, Higher fatty acid condensates, higher fatty acid amide condensates, higher alkylamine condensates, higher alkyl mercaptan condensates, alkylphenol condensates, polypropylene oxide condensates, and any one selected from the group consisting of It is not limited to.
  • the antiseptic composition may be one in which the formulation is selected from aqueous solutions, emulsions, dispersions, suspensions and useful solutions.
  • the antiseptic composition may further include additives such as perfumes, vegetable extracts, pH adjusting agents, other additives, purified water, thickeners and antioxidants.
  • additives such as perfumes, vegetable extracts, pH adjusting agents, other additives, purified water, thickeners and antioxidants.
  • the antiseptic composition of the present invention is sodium metabisulfite (SDS) and cetylpyridinium chloride (Cetylpyridinium chloride (CPC)), optionally sodium sulfite (Sodium Sulfite), hexylene glycol (Hexylene Glycol), Any one selected from the group consisting of surfactants, additives, and combinations thereof may be prepared by mixing at room temperature, preferably, it is prepared by mixing at 25 ° C. or higher and 80 ° C. or lower, and sonicated to enhance mixing. Or stirring may be performed. In addition, purified water may be prepared by mixing a predetermined amount with these components and stirring or drying after stirring.
  • the present invention relates to a composition for wet wipes comprising the antiseptic composition.
  • the wet wipes composition may include 0.01 wt% to 10 wt% of the antiseptic composition, preferably 0.1 to 1.5 wt%.
  • the content of the antiseptic composition is less than 0.01% by weight, the antibacterial and antifungal effect and persistence is lowered, and when the content exceeds 10% by weight, there is a problem of severe skin irritation or difficult to control physical properties.
  • composition for wet wipes may further include any one selected from the group consisting of a pH adjusting agent, a moisturizing agent, a flavoring agent, and a combination thereof, and preferably, 0.03 to 0.05% by weight of a pH adjusting agent, 0.2 to 0.7% by weight of a moisturizing agent, and 0.01 to 0.01 perfume 0.2 wt%.
  • the moisturizing agent may be used in the field to which the present invention belongs, and examples thereof include glycerin, butylene glycol, natural extracts, skin components, and the like.
  • the pH adjusting agent may be used that is commonly used in the field of the present invention, and examples thereof include citric acid, sodium citrate, lactic acid, sodium hydroxide, potassium hydroxide, tromethamine, tee.
  • the fragrance may be used commonly used in the field to which the present invention belongs, and includes, for example, plant extracts.
  • the wet tissue composition may have a pH of 4.5 to 6.0, preferably pH of 5.0 to 5.8.
  • the wet wipes composition comprising the antiseptic composition of the present invention does not occur sulfuric acid odor by SDS even in the above pH range, it is excellent in low temperature stability of CPC can be used stably without changing the physical properties when manufacturing wet wipes, low skin irritation Has an excellent effect.
  • the present invention relates to a cosmetic composition comprising the antiseptic composition.
  • the cosmetic composition is 0.1% by weight of the antiseptic composition It may be included in 10% by weight, preferably 0.1% to 1.5% by weight. If the content of the antiseptic composition is less than 0.1% by weight, the antimicrobial and antifungal effect and persistence is lowered, and when the content of the antiseptic composition is greater than 10% by weight, skin irritation is severe or physical properties are difficult to control, thereby deteriorating physical stability of the cosmetic composition.
  • the cosmetic composition may further include any one selected from the group consisting of pH adjusters, moisturizers, perfumes, surfactants, other additives, purified water, and combinations thereof, depending on the formulation or physical properties of the cosmetic composition to be prepared, preferably 0.01% to 10% by weight of pH adjuster, 0.01% to 30% by weight of moisturizer, 0.01% to 3.0% by weight of perfume, 0.01% to 30% by weight of surfactant, and other additives and purified water.
  • pH adjusters preferably 0.01% to 10% by weight of pH adjuster, 0.01% to 30% by weight of moisturizer, 0.01% to 3.0% by weight of perfume, 0.01% to 30% by weight of surfactant, and other additives and purified water.
  • the present invention relates to a shampoo composition comprising the antiseptic composition.
  • the shampoo composition is 0.1 wt% to the preservative composition 10 It may be included in the weight%, preferably 0.1 to 1.5% by weight. If the content of the antiseptic composition is less than 0.1% by weight, the antimicrobial and antifungal effect and persistence is lowered, if the content exceeds 10% by weight of the skin irritation is severe or difficult to control the shampoo properties.
  • the shampoo composition may further include any one selected from the group consisting of pH adjusters, moisturizers, fragrances, surfactants, other additives, purified water and combinations thereof.
  • pH adjusters Preferably, 0.01% to 10.0% by weight of pH adjuster, 0.01% to 30% by weight of moisturizer, 0.01% to 3.0% by weight of perfume, 0.01% to 30% by weight of surfactant, and other additives and purified water may be included.
  • the antibacterial and antifungal effect of the present invention is excellent, but the stability of physical properties is excellent.
  • the present invention relates to a composition for detergent comprising the antiseptic composition.
  • the detergent composition may include 0.1 wt% to 10 wt% of the antiseptic composition, preferably 0.1 wt% to 1.5 wt%.
  • the content of the antiseptic composition is less than 0.1% by weight, the antibacterial and antifungal effects and persistence is lowered, and when the content of the antiseptic composition exceeds 10% by weight, skin irritation is severe or physical property is difficult to control.
  • the detergent composition may further include any one selected from the group consisting of pH adjusters, moisturizers, fragrances, surfactants, antifoaming agents, other additives, purified water, and combinations thereof.
  • pH adjusters Preferably 0.01 wt% to 10.0 wt% of pH adjuster, 0.01 wt% to 30 wt% of moisturizer, 0.01 wt% to 3.0 wt% of perfume, 0.01 wt% to 30 wt% of surfactant, 0.01 wt% to 1 wt% of antifoaming agent, Other additives and purified water.
  • the detergent composition satisfying the above range, while excellent in the antibacterial and antifungal effect of the present invention, there is an effect excellent in the stability of physical properties.
  • the present invention relates to a composition for fabric softener comprising the antiseptic composition.
  • the composition for the fabric softener is 0.1% by weight to the antiseptic composition It may comprise 10% by weight.
  • the content of the antiseptic composition is less than 0.1% by weight, the antimicrobial and antifungal effect and persistence are inferior, and when the content is greater than 10% by weight, skin irritation is severe or it is difficult to control properties of the fabric softener.
  • the fabric softener composition may further include any one selected from the group consisting of pH adjusters, moisturizers, flavoring agents, surfactants, antifoaming agents, other additives, purified water and combinations thereof.
  • pH adjusters Preferably 0.01 wt% to 10.0 wt% of pH adjuster, 0.01 wt% to 30 wt% of moisturizer, 0.01 wt% to 3.0 wt% of perfume, 0.01 wt% to 30 wt% of surfactant, 0.01 wt% to 1 wt% of antifoaming agent, Other additives and purified water.
  • the antibacterial and antifungal effect of the present invention is excellent, but the stability of physical properties is excellent.
  • the present invention relates to an industrial detergent composition comprising the antiseptic composition.
  • the industrial detergent composition is 0.1% by weight of the antiseptic composition It may be included in 10% by weight, preferably from 0.1% to 5% by weight. When the content of the antiseptic composition is less than 0.1% by weight, the antimicrobial and antifungal effect and persistence is lowered, and when the content of the antiseptic composition exceeds 10% by weight, it is difficult to control the physical properties of the industrial cleaning composition.
  • the industrial detergent composition may further include any one selected from the group consisting of the pH adjusting agent, moisturizer, flavoring agent, surfactant, antifoaming agent, other additives, purified water, and combinations thereof.
  • the pH adjusting agent Preferably 0.01 wt% to 10.0 wt% of pH adjuster, 0.01 wt% to 30 wt% of moisturizer, 0.01 wt% to 3.0 wt% of perfume, 0.01 wt% to 30 wt% of surfactant, 0.01 wt% to 1 wt% of antifoaming agent, Other additives and purified water.
  • Industrial cleaning composition satisfying the above range, while excellent in the antibacterial and antifungal effect of the present invention, there is an effect of excellent stability of physical properties.
  • the present invention provides an article comprising the antiseptic composition
  • examples of the article include a diaper, a sanitary ware, a cosmetic, a detergent, an industrial cleaner, a disinfectant, and a hygiene product.
  • the hygiene article may be, for example, oral tissue, mouthwash, shampoo, soap, shower gel, and the like.
  • the article comprises an antiseptic composition of the present invention in an amount of 0.1 wt% to 10 wt% based on the total weight of the article. If the antiseptic composition is less than 0.1% by weight relative to the total weight of the article, the antimicrobial and antifungal effects are insufficient, and when the antiseptic composition is more than 10% by weight, the physical properties of the product and skin irritation may be caused.
  • An article comprising the antiseptic composition of the present invention may be prepared according to a method of manufacturing an article in the field of the present invention, for example, prepared by mixing the antiseptic composition of the present invention as an additional component or preparing an article. In the last step, it can be prepared by the method of treating the preservative composition of the present invention in the article of manufacture.
  • the antiseptic composition may be sprayed onto the article, the antiseptic composition is impregnated with the manufactured article, or at a predetermined stage of the manufactured article manufacturing process. It can process by the method of adding an antiseptic composition and mixing.
  • the article is a cosmetic, it can be prepared by the method of adding the antiseptic composition of the present invention to a certain step of the manufacturing article manufacturing process and mixing using a method such as a stirrer.
  • the antiseptic composition of the present invention may be added to a predetermined step of the manufacturing process of the manufactured article and mixed by using a method such as a stirrer, and may be prepared in a solid or powder state.
  • the preservative composition of the present invention may be added to a predetermined step of the manufacturing process of the manufactured article, and mixed by using a method such as a stirrer, dried, or crushed after drying.
  • the article is a diaper and feminine hygiene products in most cases is made in the form of fibers and can be prepared by the method of adding the impregnated composition of the present invention, impregnated, combined and dried in a certain step of the manufacturing article manufacturing process.
  • Example 7 Example 8
  • Example 9 Example 10 Sodium Metabisulfite 10 10 10 10 10 Cetylpyridinium chloride 40 40 40 40 Sodium sulfite 0 10 0 5 Hexylene glycol 0 0 10 5 Purified water 80 80 80 80 80 80 80
  • Wet tissue compositions were prepared using the antiseptic compositions prepared in Examples 1 to 6 and Comparative Examples 1 and 2 of Table 1.
  • the antiseptic composition shown in Table 1 was added to purified water and stirred, and additionally, flavors, extracts, and moisturizers were added in any order and stirred at room temperature.
  • fragrance 0.01% by weight of citrus flavor, 0.1% by weight of extract of Machi, and 0.5% by weight of glycerin as a moisturizing agent were added. After adding the fragrance, extract and moisturizer, 0.05 wt% of citric acid, sodium citrate and other pH adjusting agents were added as a pH adjusting agent, and the final product was prepared by buffering the pH to 4.8 to 5.8.
  • the wet tissue composition was sprayed onto the fabric using a spray apparatus when the wet tissue fabric passed through the converting machine through the wet tissue manufacturing machine, and the wet tissue fabric was cut to meet the specifications to prepare a wet tissue.
  • No. 9-11 was stirred for 10 minutes at 78 degreeC in 2500 rpm Disper, and No. After stirring 1 ⁇ 8 also at 78 °C, they were mixed with each other for 15 minutes with a Homo mixer at 4000rpm, was stirred at 78 °C. Thereafter, the mixture was slowly cooled, and the emulsion was prepared by uniformly adding the fragrance and the antiseptic composition prepared in Example at a temperature of 40 ° C. or lower.
  • Escherichia coli Esherichia which is a bacterium through Shaking Flask Method coli
  • Staphylococcus aureus Staphylococcus aureus and Pseudomonas aeruginosa
  • 100 mL of nutrient broth Aspergillus niger
  • strains incubated in 100 mL of Potato dextrose Broth were inoculated with platinum.
  • the inoculated medium was incubated at 30 ° C. for 24 hours in a shaking incubator.
  • Example 1 Example 2
  • Example 3 Example 4
  • Example 5 Example 6 Comparative Example 2 Strain (CFU / ml) Day 2 Escherichia coli 2.5 x 10 6 3 2 2 2 2 One 0 0 2 Staphylococcus aureus 1.5 x 10 6 4 2 2 2 2 One 0 0 2 Pseudomonas aeruginosa 3.1 x 10 6 3 2 2 2 2 One 0 0 3
  • Candida albicans 1.4 x 10 5 4 One One One One One One One One 0 0 2
  • One One One One One One 0 3 Day 3 Escherichia coli 2.5 x 10 6 4 2 0 0 0 0 0 0 2 Staphylococcus aureus 1.5 x 10 6 3 One 0 0 0 0 0 One Pseudomonas aeruginosa 3.1 x 10 6 3 One 0 0 0 0 0 0
  • antibacterial and antiseptic properties are superior to those of SDS or CPC alone.
  • antifungal effect in particular, in the case of the antiseptic composition of Examples 1 to 6 it was confirmed that there are excellent antibacterial and antifungal effect of at least 99.9% in all the various strains within 3 days.
  • examples 5 to 6 it was confirmed that the excellent antibacterial and antifungal effect of at least 99.9% in all the various strains on the second day.
  • the antimicrobial and antifungal effects of the cosmetic composition (emulsion) prepared in Preparation Example 2 were confirmed by the following method.
  • a cosmetic composition emulsion (emulsion) with the ASTM D2574 method Escherichia coli
  • 10 4 CFU / ml Staphylococcus aureus 10 4 CFU / ml Pseudomonas aeroginosa
  • the results were observed after incubation at room temperature for 3 days and 7 days, and streaking candida albicans and Aspergillus niger at 10 5 CFU / ml.
  • Example 11 Elapsed date Test strain Inoculation number Control Comparative Example 1 Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Comparative Example 2 Strain (CFU / ml) Day 2 Escherichia coli 2.8 x 10 6 3 One 2 One One One 0 0 2 Staphylococcus aureus 1.6 x 10 6 4 One One One One One One 0 0 2 Pseudomonas aeruginosa 2.1 x 10 6 3 One One One One One One One One 0 0 3 Candida albicans 1.6 x 10 5 4 One One One One One One One One One 0 0 2 Black 1.4 x 10 5 4 2 One One One One One One 0 0 4 Day 3 Escherichia coli 2.8 x 10 6 4 3 0 0 0 0 0 0 2 Staphylococcus aureus 1.6 x 10 6 4 2 0 0 0 0 0 2 Pseudomonas aeruginosa 2.1 x 10
  • Examples 1 to 6 of the antiseptic composition of the invention was excellent in the killing rate of more than 99.9% of all bacteria, fungi in the third day, in the cosmetic composition comprising the antiseptic compositions of Comparative Examples 1 and 2 Insufficient antibacterial activity against bacteria and fungi was confirmed to be not completely killed even on day 7.
  • Comparative Example 1 where the content of cetylpyridinium chloride is relatively high, it was confirmed that the antibacterial and antifungal activity was relatively weaker. Therefore, in the case of the antiseptic composition of the present invention, it was confirmed that the SDS and CPC are not simply mixed, but also have an antibacterial and antifungal effect improvement in the weight ratio. In particular, in Examples 5 to 6 antifungal was killed on the second day.
  • Antimicrobial and antifungal effects of the shampoo prepared in Preparation Example 3 were tested in the following manner.
  • Escherichia coli of 10 4 CFU / ml in a shampoo as a target through ASTM D2574 method coli 10 4 CFU / ml Staphylococcus aureus , 10 4 CFU / ml Pseudomonas aeroginosa , streaking and mixed incubation at room temperature for 1, 3, 7 days
  • the antifungal 10 5 CFU / ml Candida albicans and Black fungus Aspergillus niger were also streaking, and the results were observed after incubation at room temperature for 3 days and 7 days.
  • a control (control) was prepared according to Preparation Example 3 by adding the same amount of purified water instead of the preservative composition of the present invention. The test results are shown in Table 12 below.
  • Example 12 Elapsed date Test strain Inoculation number Control Comparative Example 1 Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Comparative Example 2 Strain (CFU / ml) Day 2 Escherichia coli 2.8 x 10 6 3 One 0 0 0 One One One 2 Staphylococcus aureus 1.8 x 10 6 4 One 0 0 0 One One One One One Pseudomonas aeruginosa 2.9 x 10 6 4 2 0 0 0 One One One One One Candida albicans 1.4 x 10 5 4 3 0 0 One One One One One 3 Black fungus 1.9 x 10 5 4 2 0 0 0 One One One One Day 3 Escherichia coli 2.8 x 10 6 4 3 0 0 0 0 0 0 One Staphylococcus aureus 1.8 x 10 6 4 2 0 0 0 0 0 0 0 One Pseudomonas aeruginosa
  • the antimicrobial and antifungal effect of the laundry detergent prepared in Preparation Example 4 was confirmed by the following method.
  • Escherichia coli of 10 6 CFU / ml in a detergent as a target through ASTM D2574 method coli ), 10 6 CFU / ml Staphylococcus aureus and 10 6 CFU / ml Pseudomonas aeroginosa were mixed and streaking, and the results were observed after incubation at room temperature for 3 days and 7 days.
  • Example 13 Elapsed date Test strain Inoculation number Control Comparative Example 1
  • Example 2 Example 3
  • Example 4 Example 5
  • Example 6 Comparative Example 2 Strain (CFU / ml) Day 2 Escherichia coli 3.3 x 10 6 2 One 0 0 0 0 0 One 2 Staphylococcus aureus 2.8 x 10 6 3 One 0 0 0 0 0 0 One Pseudomonas aeruginosa 2.1 x 10 6 3 2 0 0 0 0 0 0 0 One Candida albicans 2.4 x 10 5 3 3 0 0 One 0 One One One 3 Black fungus 3.2 x 10 5 4 2 0 0 One One One One Day 3 Escherichia coli 3.3 x 10 6 4 One 0 0 0 0 0 0 One Staphylococcus aureus 2.8 x 10 6 4 0 0 0 0 0 0 0 0 One Pse
  • the antimicrobial and antifungal effects of the fabric softener prepared in Preparation Example 5 were tested in the following manner.
  • Escherichia coli of 10 6 CFU / ml in a detergent as a target through ASTM D2574 method coli ), 10 6 CFU / ml Staphylococcus aureus and 10 6 CFU / ml Pseudomonas aeroginosa were mixed and streaking, and the results were observed after incubation at room temperature for 3 days and 7 days.
  • Example 14 Elapsed date Test strain Inoculation number Control Comparative Example 1 Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Comparative Example 2 Strain (CFU / ml) Day 2 Escherichia coli 2.5 x 10 6 2 2 0 0 0 0 0 One 2 Staphylococcus aureus 2.1 x 10 6 2 2 0 0 0 0 0 2 Pseudomonas aeruginosa 4.2 x 10 6 2 2 0 0 0 0 0 0 2 Candida albicans 1.9 x 10 5 2 One 0 0 One One One One 3 Black fungus 3.5 x 10 5 4 2 0 0 One One One One Day 3 Escherichia coli 2.5 x 10 6 2 2 0 0 0 0 0 0 2 Staphylococcus aureus 2.1 x 10 6 One One 0 0 0 0 0 0 One Pseudomonas aeruginosa 4.2
  • the antibacterial and antifungal effects of the industrial degreaser remover prepared in Preparation Example 6 were tested in the following manner.
  • 10 6 CFU / ml Escherichia coli , 10 6 CFU / ml Staphylococcus aureus , 10 6 CFU / ml Pseudomonas aeroginosa were mixed and streaking, respectively, and the results were observed after incubation at room temperature for the initial, 3 and 7 days, and 10 5 CFU / ml of candida albicans and black mold
  • the bacteria Aspergillus niger
  • were also streaking and the results were observed after incubation at room temperature for the initial, 1, 3, and 7 days.
  • a control was used to prepare an industrial degreaser removed according to Preparation Example 6 by adding the same amount of purified water instead of the preservative composition of the present invention, the test results are shown in Table 15.
  • Example 1 Example 2
  • Example 3 Example 4
  • Example 6 Comparative Example 2 Strain (CFU / ml) Day 2 Escherichia coli 3.5 x 10 6 3 3 0 One 0 0 0 0 2 Staphylococcus aureus 2.3x 10 6 3 3 One One One One 0 0 2 Pseudomonas aeruginosa 4.1 x 10 6 3 2 0 One 0 0 0 0 2 Candida albicans 1.9 x 10 5 3 3 One One One One One One 0 0 3 Black fungus 3.8 x 10 5 4 3 One One One One One 0 0 One Day 3 Escherichia coli 3.5 x 10 6 3 2 0 0 0 0 0 2 Staphylococcus aureus 2.3x 10 6 2 One 0 0 0 0 0 0 One Pseudomonas aeruginosa 4.1 x 10 6 3 3 0 One 0 0 0 2
  • the temperature (recrystallization temperature) of the fine crystal cloud of the cloud-shaped cloud phenomenon was measured by dropping the temperature with the cooling water with respect to the 100 ml solution. These results are shown in Table 16 below.
  • Example 7 2.0 10.0
  • Example 15 -22.0 0.1
  • Example 8 -3.0 7.0
  • Example 16 -21.0 0.3
  • Example 9 -11.0 6.0
  • Example 17 -22.0 0.3
  • Example 10 -14.0 4.0
  • Example 18 -23.0 0.1
  • Example 11 -15.0 2.0
  • Example 19 -22.0 0.3
  • Example 12 -16.0 1.5
  • Example 20 -22.0 0.2
  • Example 13 -16.5 1.0
  • Example 21 -21.0 0.5
  • Example 14 -20.0 0.5
  • Example 22 -21.0 0.5
  • the antiseptic composition of the present invention may be a formulation selected from an aqueous solution, an emulsion, a disperse, a suspension and a useful solution, the antiseptic composition is a wet wipes composition, cosmetic composition, shampoo composition, detergent composition, fabric softener composition, industrial It can be used in detergent compositions and the like.

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Abstract

La présente invention concerne une composition antiseptique présentant des activités antibactériennes et antifongiques sans provoquer d'irritation de la peau. Des lingettes humides, des agents de nettoyage pour le corps humain, des agents de nettoyage pour des produits ménagers, des couches, des produits d'hygiène, des produits cosmétiques, des produits d'assainissement, et des produits similaires utilisant la composition antiseptique de la présente invention présentent d'excellentes activités antibactériennes et antifongiques sans provoquer d'irritation de la peau, et la composition antiseptique a une stabilité élevée.
PCT/KR2015/004678 2014-12-15 2015-05-11 Composition antiseptique et son utilisation WO2016098965A1 (fr)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113073015A (zh) * 2021-02-25 2021-07-06 郑州百瑞动物药业有限公司 一种宠物用杀菌除臭洗衣液及其制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994027436A1 (fr) * 1993-05-20 1994-12-08 Decicco Benedict T Conservateurs presentant une efficacite antimicrobienne amelioree
WO2000065911A1 (fr) * 1999-04-30 2000-11-09 Sintal International, Inc. Composition antibacterienne et son emploi pour les soins de la peau et le traitement de tissus
JP2003079530A (ja) * 2001-09-12 2003-03-18 Uni Charm Corp ウエットティッシュ
KR101195724B1 (ko) * 2011-11-29 2012-10-29 보령메디앙스 주식회사 방부조성물 및 이를 포함하는 물품
KR20130082399A (ko) * 2012-01-11 2013-07-19 (주)에스피산업 피부 저자극성 물티슈용 방부제 조성물

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994027436A1 (fr) * 1993-05-20 1994-12-08 Decicco Benedict T Conservateurs presentant une efficacite antimicrobienne amelioree
WO2000065911A1 (fr) * 1999-04-30 2000-11-09 Sintal International, Inc. Composition antibacterienne et son emploi pour les soins de la peau et le traitement de tissus
JP2003079530A (ja) * 2001-09-12 2003-03-18 Uni Charm Corp ウエットティッシュ
KR101195724B1 (ko) * 2011-11-29 2012-10-29 보령메디앙스 주식회사 방부조성물 및 이를 포함하는 물품
KR20130082399A (ko) * 2012-01-11 2013-07-19 (주)에스피산업 피부 저자극성 물티슈용 방부제 조성물

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113073015A (zh) * 2021-02-25 2021-07-06 郑州百瑞动物药业有限公司 一种宠物用杀菌除臭洗衣液及其制备方法

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