EP1087927A1 - Procede de disubstitution asymetrique catalytique d'amides d'acide carboxylique avec deux differents reactifs de grignard - Google Patents

Procede de disubstitution asymetrique catalytique d'amides d'acide carboxylique avec deux differents reactifs de grignard

Info

Publication number
EP1087927A1
EP1087927A1 EP99929279A EP99929279A EP1087927A1 EP 1087927 A1 EP1087927 A1 EP 1087927A1 EP 99929279 A EP99929279 A EP 99929279A EP 99929279 A EP99929279 A EP 99929279A EP 1087927 A1 EP1087927 A1 EP 1087927A1
Authority
EP
European Patent Office
Prior art keywords
carbon atoms
general formula
sep
group
cocatalyst
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99929279A
Other languages
German (de)
English (en)
Inventor
Herwig Buchholz
Urs Welz-Biermann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of EP1087927A1 publication Critical patent/EP1087927A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/023—Preparation; Separation; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/66—Preparation of compounds containing amino groups bound to a carbon skeleton from or via metallo-organic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

L'invention concerne un nouveau procédé de disubstitution asymétrique d'amides d'acide carboxylique sur l'atome de C-carbonyle géminé à l'aide de deux différents réactifs de Grignard, en présence d'un composé alcoolat métallique comme catalyseur et d'un autre composé organométallique comme catalyseur.
EP99929279A 1998-06-18 1999-06-18 Procede de disubstitution asymetrique catalytique d'amides d'acide carboxylique avec deux differents reactifs de grignard Withdrawn EP1087927A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19827163 1998-06-18
DE19827163A DE19827163A1 (de) 1998-06-18 1998-06-18 Verfahren zur katalytischen, unsymmetrischen Disubstitution von Carbonsäureamiden mit 2 unterschiedlichen Grignardreagenzien
PCT/EP1999/004250 WO1999065858A1 (fr) 1998-06-18 1999-06-18 Procede de disubstitution asymetrique catalytique d'amides d'acide carboxylique avec deux differents reactifs de grignard

Publications (1)

Publication Number Publication Date
EP1087927A1 true EP1087927A1 (fr) 2001-04-04

Family

ID=7871277

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99929279A Withdrawn EP1087927A1 (fr) 1998-06-18 1999-06-18 Procede de disubstitution asymetrique catalytique d'amides d'acide carboxylique avec deux differents reactifs de grignard

Country Status (6)

Country Link
US (2) US6512145B1 (fr)
EP (1) EP1087927A1 (fr)
JP (1) JP2002518361A (fr)
KR (1) KR20010052877A (fr)
DE (1) DE19827163A1 (fr)
WO (1) WO1999065858A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050202119A1 (en) * 2004-03-10 2005-09-15 Donald Ullman Apparatus for enhancing a chewing gum experience
AU2005307772B2 (en) * 2004-11-16 2010-06-10 Limerick Biopharma, Inc. Methods and compositions for treating pain
US20070087977A1 (en) * 2004-11-16 2007-04-19 Wendye Robbins Methods and compositions for treating pain

Also Published As

Publication number Publication date
JP2002518361A (ja) 2002-06-25
US20030125549A1 (en) 2003-07-03
DE19827163A1 (de) 1999-12-23
WO1999065858A1 (fr) 1999-12-23
KR20010052877A (ko) 2001-06-25
US6512145B1 (en) 2003-01-28

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