EP1062206A2 - Aminoanthracyclinonderivate und ihre verwendung zur behandlung von amyloidosis - Google Patents
Aminoanthracyclinonderivate und ihre verwendung zur behandlung von amyloidosisInfo
- Publication number
- EP1062206A2 EP1062206A2 EP99910304A EP99910304A EP1062206A2 EP 1062206 A2 EP1062206 A2 EP 1062206A2 EP 99910304 A EP99910304 A EP 99910304A EP 99910304 A EP99910304 A EP 99910304A EP 1062206 A2 EP1062206 A2 EP 1062206A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- formula
- compound
- hydroxy
- hydrogen
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
Definitions
- the present invention relates to anthracyclinone derivatives, to their use for the treatment of amyloidoses, to the methods for their preparation and to the pharmaceutical compositions containing them.
- the present invention provides anthracyclinone derivatives of formula 1
- x represents : hydrogen, hydroxy, a group of formula OR 7 wherein R 7 is alkyl, C 2 -C 6 alkenyl ;
- R 2 represents: hydrogen, hydroxy , diethylamino, piperidino, tetrahydropyridino or morpholino; either R 3 , taken alone, represents hydrogen or hydroxy; and R 4 and R 5 , taken alone, independently represent hydrogen, hydroxy or, taken together with the carbon atom, represent a carbonyl group; or R 3 and R 4 , taken together, represent a group of formula
- R 8 and R 9 represent alkyl, and R 5 represents hydrogen; R 6 represents: hydrogen or a phenyl group, optionally substituted by methyl, methoxy or halogen, and the pharmaceutically acceptable salt thereof .
- Preferred compounds of formula 1 are those wherein: R- L represents : hydrogen, hydroxy or methoxy; R 2 represents : hydrogen, hydroxy or morpholino
- R 3 represents hydroxy
- R 4 taken alone, represents hydroxy
- R 5 taken alone, represents hydrogen or R 4 and R 5 taken together with the carbon atom represent a carbonyl group ;
- R 6 represents hydrogen, and the pharmaceutically acceptable salt thereof.
- C-Cg "alkyl" as used herein includes both straight and branched chain alkyl groups or moieties such as methyl, ethyl, propyl, isopropyl, butyl, isobutyl, t-butyl, pentyl, hexyl and, in case of pentyl and hexyl, a branched chain isomer thereof.
- C 2 -C 6 "alkenyl” as used herein includes both straight and branched chain radicals of up to 6 carbons such as, for example, vinyl, allyl, butenyl, pentenyl and hexenyl .
- halogen as used herein means fluorine, chlorine, bromine or iodine.
- This invention also includes all the possible isomers of compounds of formula 1 and mixtures thereof, for example diastereoisomeric mixtures and racemic mixtures.
- the stereocenter at position 9, and the possible stereocenters at positions 7 and 13 may have the (R) configuration or the (S) configuration or both, i.e. a mixture of stereoisomers is present .
- the present invention also provides the salts of compounds of formula 1.
- the salts are, typically, physiologically tolerable or pharmaceutically acceptable salts formed with suitable inorganic or organic acids.
- inorganic acids are, for instance, hydrochloric and sulfuric acid
- organic acids may be mono-, di- and tricarboxylic acids, like, for examples, acetic, trifluoroacetic, tartaric or citric acid, and sulfonic acids like, for example, methanesulfonic or p- toluensulphonic acid.
- Compounds of formula 1, wherein R 1; R 3 , R 4/ R 5 and R 6 are as defined above and R 2 is hydrogen or hydroxy can be prepared by the following procedures:
- R l t and R 3 are as defined above and R 2 is hydrogen or hydroxy, with a compound of formula 3_
- a compound of formula 1, wherein R lf R 3 and R 6 are as defined above, R 2 is hydrogen or hydroxy and R 4 and R 5 taken together represent a carbonyl group, is obtained according to procedure a) by reacting a compound of formula 2 with a compound of formula 3 in a proper organic solvent like dichloromethane, chloroform, acetone, dioxane or dimethylformamide at a temperature ranging from -10 °C to room temperature and for a period of from 6 to 48 hours.
- An organic base such as diethylamine or ethyl-diisopropylamine may be present.
- Preferred reaction conditions encompass the use of equimolar amounts of compound 2 and 3_ and ethyl- diisopropylamine in dichloromethane at room temperature for a period of 6 to 24 hours.
- R x and R 3 are as defined above and R 2 is hydrogen or hydroxy, in analogy to known procedures reported in the literature (see, for instance, T. H. Smith et al . , J. Org. Chem . 1977, vol. 42, p. 3653).
- a compound of formula 1, wherein R 1; R 2 , R 3 and R 6 are as defined above and R 4 and R 5 taken together represent a carbonyl group can be converted into a compound of formula 1, wherein R lf R 2 , R 3 and R 6 are as defined above, R 4 represents hydroxy and R 5 represents hydrogen by reduction with sodium borohydride or sodium cyanoborohydride .
- a compound of formula 1, wherein R 1; R 3 and R 6 are as defined above, and either R 2 represents hydroxy and R 4 and R 5 are taken together represent a carbonyl group, or R 2 and R 4 represent hydroxy and R 5 represents hydrogen can be converted into a compound of formula 1, wherein R l7 R 3 and R 6 are as defined above, and either R 2 represents hydrogen and R 4 and R 5 taken together represent a carbonyl group, or R 4 represents hydroxy and R 2 and R 5 represent hydrogen, by treatment with sodium dithionite.
- a compound of formula 1, wherein R x and R 6 are as defined above, R 2 and R 5 represent hydrogen and R 3 and R 4 represent hydroxy can be converted into a compound of formula 1, wherein R x and R 6 are as defined above, R 2 and R 5 represent hydrogen, R 3 and R 4 taken together represent a group of formula
- R 8 and R 9 are as above defined, by condensation with a compound of the formula R 8 COR 9 or R 8 C (OCH 3 ) 2 OR 9 wherein R 8 and R 9 are as above defined, for example acetone or 2 , 2-dimethoxy propane, in the presence of an acid catalyst.
- a compound of formula 1 wherein R- L , R 3 and R 6 are as defined above, R 4 and R 5 are taken together to represent a carbonyl group and R 2 represents diethylamino, piperidino, tetrahydropyridino or morpholino, can be prepared by reacting a compound of formula 1, wherein R 1# R 3 and R 6 are as defined above, R 2 represents hydroxy, R 4 and R 5 taken together represent a carbonyl group, by reaction with ethylchlorocarbonate to give an intermediate compound of formula 5.
- R 1; R 3 and R 6 are as defined above in analogy to a procedure described in the literature (see: L. Bernardi et al . II Far aco Ed. Sc . 1979, vol. 34, p. 884), followed by substitution with excess diethylamine, piperidine, tetrahydropyridine or morpholine.
- Compounds of formula 1 obtained according to procedures a) or b) can be transformed into pharmaceutically acceptable salts thereof by dissolving the free base in a proper organic solvent like dichloromethane, methanol, ethanol or dioxane and adding a solution of a pharmaceutically acceptable inorganic or organic acid in methanol, ethanol or dioxane.
- a proper organic solvent like dichloromethane, methanol, ethanol or dioxane
- the resulting salt of compound 1 is obtained by evaporation or concentration of the salt solution or the salt is precipitated by addition of diethyl ether to the salt solution.
- the compounds of the present invention can be used in the treatment of amyloidoses as they are characterized by high inhibitory activity on the formation of amyloid deposits by amyloidogenic proteins and are able to induce the degradation of existing amyloid deposits.
- amyloidoses indicates a group of diseases whose common characteristic is the presence, in the extracellular space, of amyloid deposits.
- Amyloidogenic proteins are proteins that have the tendency to aggregate and precipitate as amyloid.
- Proteins that precipitate as amyloid are both normal proteins, or truncated forms thereof, and mutated proteins, where one or more of the amino acid residues occurring at certain positions of the normal protein sequence are replaced by a different amino acid.
- Amyloid deposits are composed of insoluble fibrils, also referred to as amyloid fibrils. Amyloid fibrils cause cellular degeneration and organ failure that, in turn, result in different pathologies depending on the tissues and organs involved.
- amyloidosis The basis for the activity of the compounds of the present invention in different types of amyloidosis is to be found in the common ultrastructural organization of amyloid fibrils despite the fact that they can be formed from a variety of widely differing proteins (see: Glenner G.G., New England J. Med. 1980, vol 302, p. 1283 and p. 1333) .
- the compounds of the present invention are characterized by an acceptable toxicity and can be used to make medicaments useful to prevent, to arrest or to slow down the formation of or to induce the degradation of amyloid deposits that are formed by different amyloidogenic proteins. Therefore, the compounds of the present invention can be used in the prevention and in the treatment of different types of amyloidotic diseases such as systemic amyloidoses and amyloidoses of the peripheral and central nervous system. Amyloidoses of the central nervous system include, for example,
- Alzheimer's disease Down Syndrome
- spongiform encephalopathies such as Creutzfeld-Jacob disease and the like.
- amyloid ⁇ -protein the protein that is found in amyloid deposits
- a ⁇ protein the protein that is found in amyloid deposits
- a ⁇ protein encompasses proteins of different length.
- prion protein PrP
- the compounds disclosed in the present invention interfere with the aggregation of monomeric A ⁇ l-40 peptide stimulated by a seed of A ⁇ l-40 amyloid fibrils.
- the activity of the compounds was assessed according to the procedure reported below.
- An A ⁇ l-40 peptide monomer stock solution was prepared by dissolving the peptide in dimethylsulfoxide at a concentration of 33.33 mg/ml. The stock solution was further diluted 11.5 times with dimethylsulfoxide . This solution was then diluted with 10 mM phosphate buffer pH 7.4 containing
- test solution 150 mM sodium chloride to prepare the test solution.
- the activity is expressed as the percent of inhibition of the aggregation of a 20 ⁇ M A ⁇ l-40 monomer solution stimulated by 4 ⁇ M, based on the A ⁇ l-40 monomer content, pre-formed sonicated A ⁇ l-40 fibrils.
- the compounds of formula 1 of the present invention are characterized by a better activity than the compounds disclosed in our previous PCT Patent Application WO 96/04895.
- a pharmaceutical composition comprising a compound of formula 1 or a pharmaceutically acceptable salt thereof, as active ingredient, in association with a pharmaceutically acceptable carrier, excipient or other additive, if necessary.
- a compound of formula 1, as defined above, or a pharmaceutically acceptable salt thereof, for use in the treatment of the human or animal body is also provided.
- the present invention provides the use of a compound of formula 1, or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in the treatment of an amyloidotic disease .
- compositions containing a compound of formula 1 or salts thereof may be prepared in a conventional way by employing conventional non-toxic pharmaceutical carriers or diluents in a variety of dosage forms and ways of administration.
- the compounds of the formula 1 can be administered:
- compositions intended for oral use may be prepared according to any method known in the art for the manufacture of pharmaceutical compositions and such compositions may contain one or more agents selected from the group consisting of sweetening agents, flavoring agents, coloring agents and preserving agents in order to provide pharmaceutically elegant and palatable preparations .
- Tablets contain the active ingredient in admixture with non-toxic pharmaceutically acceptable excipients which are suitable for the manufacture of tablets.
- excipients may be for example, inert diluents, such as calcium carbonate, sodium carbonate, lactose, calcium phosphate or sodium phosphate; granulating and disintegrating agents, for example, maize starch or alginic acid; binding agents, for example maize starch, gelatin or acacia, and lubricating agents, for example magnesium stearate or stearic acid or talc.
- the tablets may be uncoated or they may be coated by known techniques to delay disintegration and absorption in the gastrointestinal tract and thereby provide a sustained action over a longer period.
- a time delay material such as glyceryl monostearate or glyceryl distearate may be employed.
- Formulation for oral use may also be presented as hard gelatin capsules wherein the active ingredient is mixed with an inert solid diluent, for example, calcium carbonate, calcium phosphate or kaolin, or soft gelatin capsules wherein the active ingredient is mixed with water or an oil medium, for example, peanut oil, liquid paraffin or olive oil.
- Aqueous suspensions contain the active materials in admixture with excipients suitable for the manufacture of aqueous suspensions.
- excipients are suspending agents, for example, sodium carboxymethylcellulose, methylcellulose, hydroxy, propylmethyl cellulose, sodium alginate, polyvinylpyrrolidone, gum tragacanth and gum acacia; dispersing or wetting agents may be naturally occurring phosphatides, for example lecithin, or condensation products of an alkylene oxide with fatty acids, for example polyoxyethylene stearate, or condensation products of ethylene oxide with long chain aliphatic alcohols, for example heptadecaethyleneoxycetanol, or condensation products of ethylene oxide with partial esters derived from fatty acids and a hexitol such as polyoxyethylene sorbitol onooleate, or condensation products of ethylene oxide with partial esters derived from fatty acids and a hexitol anhydrides, for example polyoxyethylene sorbitan monooleate.
- dispersing or wetting agents may be naturally occurring phosphatides, for example lecithin, or condensation products of an al
- the said aqueous suspensions may also contain one or more preservatives, for example, ethyl or n-propyl p- hydroxybenzoate, one or more coloring agents, one or more flavoring agents, or one or more sweetening agents, such as sucrose or saccharin.
- Oily suspension may be formulated by suspending the active ingredient in a vegetable oil, for example arachis oil, olive oil, sesame oil or coconut oil or in a mineral oil such as liquid paraffin.
- the oily suspensions may contain a thickening agent, for example beeswax, hard paraffin or cetyl alcohol. Sweetening agents, such as those set forth above, and flavoring agents may be added to provide a palatable oral preparation.
- compositions may be preserved by the addition of an antioxidant such as ascorbic acid.
- Dispersible powders and granules suitable for preparation of an aqueous suspension by the addition of water provide the active ingredient in admixture with a dispersing or wetting agent, a suspending agent and one or more preservatives. Suitable dispersing or wetting agents and suspending agents are exemplified by those already mentioned above. Additional excipients, for example sweetening, flavoring and agents, may also be present.
- compositions of the invention may also be in the form of oil-in-water emulsions.
- the oily phase may be a vegetable oil, for example olive oil or arachis oil, or a mineral oil for example liquid paraffin or mixtures of these.
- Suitable emulsifying agents may be naturally-occurring gums, for example gum acacia or gum tragacanth, naturally- occurring phosphatides, for example soy bean, lecithin, and esters or partial esters derived from fatty acids and hexitol anhydrides, for example sorbitan mono-oleate, and condensation products of the said partial esters with ethylene oxide, for example polyoxy ethylene sorbitan monooleate.
- the emulsion may also contain sweetening and flavoring agents. Syrups and elixirs may be formulated with sweetening agents, for example glycerol, sorbitol or sucrose. Such formulations may also contain a demulcent, a preservative and flavoring and coloring agents .
- compositions may be in the form of a sterile injectable aqueous or oleaginous suspensions.
- This suspension may be formulated according to the known art using those suitable dispersing or wetting agents and suspending agents which have been described above.
- the sterile injectable preparation may also be a sterile injectable solution or suspension in a non-toxic parenterally-acceptable diluent or solvent for example, as a solution in 1,3-butane diol .
- acceptable vehicles and solvents that may be employed are water, Ringer's solution and isotonic sodium chloride solution.
- sterile, fixed oils are conventionally employed as a solvent or suspending medium.
- any bland fixed oils may be conventionally employed including synthetic mono- or diglycerides.
- fatty acids such as oleic acid find use in the preparation of injectables.
- the present invention further provides a method of treating a human or animal, e.g. a mammal, suffering from or susceptible to an amyloidotic disease which method comprises administering thereto a non-toxic and therapeutically effective amount of a compound of the formula 1 or a pharmaceutically acceptable salt thereof .
- a typical daily dose is from about 0.1 to about 50 mg per kg of body weight, according to the activity of the specific compound, the age, weight and conditions of the subject to be treated, the type and the severity of the disease, and the frequency and route of administration; preferably, daily dosage levels are in the range of 5 mg to 2 g.
- the amount of active ingredient that may be combined with the carrier materials to produce a single dosage form will vary depending upon the host treated and the particular mode of administration.
- a formulation intended for the oral may contain from 5 mg to 2 g of active agent compounded with an appropriate and convenient amount of carrier material which may vary from about 5 to about
- Dosage unit forms will generally contain between from about 5 mg to about 500 mg of the active ingredient .
- the compound la was transformed into its hydrochloride salt according to the following procedure.
- a solution of 1.08 g of la in 20 ml of dichloromethane was treated, under stirring, with 1.25 ml of 2N HC1 in isopropanol . Diethyl ether was then added dropwise and stirring was continued for 15 minutes.
- the precipitated salt was filtered, washed extensively with diethyl ether and dried under vacuum at 30°C to give 1.13 g of a red solid, m.p. 188-190°C (dec).
- the title compound was prepared as described in example 1 starting from (9R) -4-demethoxy-7-deoxy-14-bromodaunomycinone which was obtained by bromination, according to a literature procedure (see: T.H. Smith et al . , J. Org. Chem . 1977, vol. 42, p. 3653), of (9R) -4-demethoxy-7-deoxy-daunomycinone .
- the starting material (9R) -4-demethoxy-7-deoxy-daunomycinone was obtained following the procedure described in CM. Wong et al. Can . J. Chem . 1971, vol.49, p. 2712.
- Tablets containing the following ingredients may be produced in a conventional manner:
- Capsules containing the following ingredients may be produced in a conventional manner:
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9805080 | 1998-03-10 | ||
GBGB9805080.0A GB9805080D0 (en) | 1998-03-10 | 1998-03-10 | Amino anthracyclinone derivatives |
PCT/EP1999/001300 WO1999046254A2 (en) | 1998-03-10 | 1999-02-25 | Amino anthracyclinone derivatives and their use in the treatment of amyloidosis |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1062206A2 true EP1062206A2 (de) | 2000-12-27 |
EP1062206B1 EP1062206B1 (de) | 2004-04-14 |
Family
ID=10828304
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP99910304A Expired - Lifetime EP1062206B1 (de) | 1998-03-10 | 1999-02-25 | Aminoanthracyclinonderivate und ihre verwendung zur behandlung von amyloidosis |
Country Status (23)
Country | Link |
---|---|
US (1) | US6268362B1 (de) |
EP (1) | EP1062206B1 (de) |
JP (1) | JP2002506066A (de) |
KR (1) | KR100603798B1 (de) |
CN (1) | CN1113867C (de) |
AR (1) | AR019831A1 (de) |
AT (1) | ATE264302T1 (de) |
AU (1) | AU755754B2 (de) |
BR (1) | BR9908057A (de) |
CA (1) | CA2321834A1 (de) |
DE (1) | DE69916438D1 (de) |
EA (1) | EA003333B1 (de) |
GB (1) | GB9805080D0 (de) |
HU (1) | HUP0101046A3 (de) |
ID (1) | ID26084A (de) |
IL (1) | IL137677A (de) |
NO (1) | NO317260B1 (de) |
NZ (1) | NZ506945A (de) |
PL (1) | PL193245B1 (de) |
TW (1) | TW528751B (de) |
UA (1) | UA51838C2 (de) |
WO (1) | WO1999046254A2 (de) |
ZA (1) | ZA991839B (de) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITRM20110264A1 (it) * | 2011-05-27 | 2012-11-28 | Univ Degli Studi Milano | Nuovi composti triciclici glicofusi, procedimento per la loro produzione e loro impiego quali ligandi dei peptidi ss amiloidi (ass). |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL110289A (en) | 1993-08-06 | 1998-01-04 | Policlinico San Matteo Istitut | Pharmaceutical preparations containing 4-iodo-4-deoxydoxorubicin for the treatment of amyloidosis |
GB9416007D0 (en) | 1994-08-08 | 1994-09-28 | Erba Carlo Spa | Anthracyclinone derivatives |
GB9516349D0 (en) | 1995-08-09 | 1995-10-11 | Pharmacia Spa | Aza-anthracyclinone derivatives |
GB9613433D0 (en) | 1996-06-26 | 1996-08-28 | Pharmacia Spa | Fluoro labelled anthracyclinone and anthracycline derivatives |
-
1998
- 1998-03-10 GB GBGB9805080.0A patent/GB9805080D0/en not_active Ceased
-
1999
- 1999-02-11 TW TW088102135A patent/TW528751B/zh not_active IP Right Cessation
- 1999-02-25 IL IL13767799A patent/IL137677A/xx not_active IP Right Cessation
- 1999-02-25 EP EP99910304A patent/EP1062206B1/de not_active Expired - Lifetime
- 1999-02-25 CA CA002321834A patent/CA2321834A1/en not_active Abandoned
- 1999-02-25 PL PL344086A patent/PL193245B1/pl not_active IP Right Cessation
- 1999-02-25 HU HU0101046A patent/HUP0101046A3/hu unknown
- 1999-02-25 JP JP2000535634A patent/JP2002506066A/ja not_active Withdrawn
- 1999-02-25 EA EA200000922A patent/EA003333B1/ru not_active IP Right Cessation
- 1999-02-25 NZ NZ506945A patent/NZ506945A/en unknown
- 1999-02-25 ID IDW20001707A patent/ID26084A/id unknown
- 1999-02-25 CN CN99803596A patent/CN1113867C/zh not_active Expired - Fee Related
- 1999-02-25 BR BR9908057-5A patent/BR9908057A/pt not_active Application Discontinuation
- 1999-02-25 WO PCT/EP1999/001300 patent/WO1999046254A2/en not_active Application Discontinuation
- 1999-02-25 AT AT99910304T patent/ATE264302T1/de not_active IP Right Cessation
- 1999-02-25 UA UA2000105718A patent/UA51838C2/uk unknown
- 1999-02-25 AU AU29308/99A patent/AU755754B2/en not_active Ceased
- 1999-02-25 US US09/622,921 patent/US6268362B1/en not_active Expired - Fee Related
- 1999-02-25 DE DE69916438T patent/DE69916438D1/de not_active Expired - Lifetime
- 1999-02-25 KR KR1020007009971A patent/KR100603798B1/ko not_active IP Right Cessation
- 1999-03-08 ZA ZA9901839A patent/ZA991839B/xx unknown
- 1999-03-08 AR ARP990100974A patent/AR019831A1/es unknown
-
2000
- 2000-09-04 NO NO20004406A patent/NO317260B1/no unknown
Non-Patent Citations (1)
Title |
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See references of WO9946254A2 * |
Also Published As
Publication number | Publication date |
---|---|
ZA991839B (en) | 1999-12-22 |
EA200000922A1 (ru) | 2001-04-23 |
KR20010041737A (ko) | 2001-05-25 |
NO317260B1 (no) | 2004-09-27 |
EP1062206B1 (de) | 2004-04-14 |
CN1113867C (zh) | 2003-07-09 |
NO20004406L (no) | 2000-10-30 |
NO20004406D0 (no) | 2000-09-04 |
US6268362B1 (en) | 2001-07-31 |
ID26084A (id) | 2000-11-23 |
JP2002506066A (ja) | 2002-02-26 |
WO1999046254A3 (en) | 1999-10-21 |
ATE264302T1 (de) | 2004-04-15 |
GB9805080D0 (en) | 1998-05-06 |
AU755754B2 (en) | 2002-12-19 |
HUP0101046A2 (hu) | 2001-08-28 |
IL137677A (en) | 2005-08-31 |
CN1291977A (zh) | 2001-04-18 |
DE69916438D1 (de) | 2004-05-19 |
AU2930899A (en) | 1999-09-27 |
PL193245B1 (pl) | 2007-01-31 |
EA003333B1 (ru) | 2003-04-24 |
HUP0101046A3 (en) | 2002-12-28 |
TW528751B (en) | 2003-04-21 |
NZ506945A (en) | 2002-06-28 |
IL137677A0 (en) | 2001-10-31 |
UA51838C2 (uk) | 2002-12-16 |
BR9908057A (pt) | 2000-10-31 |
CA2321834A1 (en) | 1999-09-16 |
WO1999046254A2 (en) | 1999-09-16 |
AR019831A1 (es) | 2002-03-20 |
KR100603798B1 (ko) | 2006-07-25 |
PL344086A1 (en) | 2001-09-24 |
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