EP1017422A4 - CLONING USING DONOR CORES FROM DIFFERENTIATED CELLS WITHOUT SERUM DEFICIENCY - Google Patents

CLONING USING DONOR CORES FROM DIFFERENTIATED CELLS WITHOUT SERUM DEFICIENCY

Info

Publication number
EP1017422A4
EP1017422A4 EP19980931400 EP98931400A EP1017422A4 EP 1017422 A4 EP1017422 A4 EP 1017422A4 EP 19980931400 EP19980931400 EP 19980931400 EP 98931400 A EP98931400 A EP 98931400A EP 1017422 A4 EP1017422 A4 EP 1017422A4
Authority
EP
European Patent Office
Prior art keywords
cloning
serum
extracted
differentiated cells
donor nuclei
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19980931400
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1017422A1 (en
Inventor
Steven L Stice
Jose Cibelli
James M Robl
Paul Golueke
De Leon F Abel Ponce
D Joseph Jerry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Massachusetts Boston
University of Massachusetts Amherst
Original Assignee
University of Massachusetts Boston
University of Massachusetts Amherst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Massachusetts Boston, University of Massachusetts Amherst filed Critical University of Massachusetts Boston
Publication of EP1017422A1 publication Critical patent/EP1017422A1/en
Publication of EP1017422A4 publication Critical patent/EP1017422A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • C12N15/877—Techniques for producing new mammalian cloned embryos
    • C12N15/8771—Bovine embryos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2517/00—Cells related to new breeds of animals
    • C12N2517/02—Cells from transgenic animals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2517/00—Cells related to new breeds of animals
    • C12N2517/04—Cells produced using nuclear transfer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Psychology (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
EP19980931400 1997-07-03 1998-06-24 CLONING USING DONOR CORES FROM DIFFERENTIATED CELLS WITHOUT SERUM DEFICIENCY Withdrawn EP1017422A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88828397A 1997-07-03 1997-07-03
US888283 1997-07-03
PCT/US1998/012800 WO1999001163A1 (en) 1997-07-03 1998-06-24 Cloning using donor nuclei from non-serum starved, differentiated cells

Publications (2)

Publication Number Publication Date
EP1017422A1 EP1017422A1 (en) 2000-07-12
EP1017422A4 true EP1017422A4 (en) 2002-10-29

Family

ID=25392916

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19980931400 Withdrawn EP1017422A4 (en) 1997-07-03 1998-06-24 CLONING USING DONOR CORES FROM DIFFERENTIATED CELLS WITHOUT SERUM DEFICIENCY

Country Status (9)

Country Link
EP (1) EP1017422A4 (https=)
JP (1) JP2001509361A (https=)
CN (2) CN1265599A (https=)
AU (1) AU8154398A (https=)
BR (1) BR9811657A (https=)
CA (1) CA2294916A1 (https=)
IL (1) IL133786A0 (https=)
NZ (1) NZ502129A (https=)
WO (1) WO1999001163A1 (https=)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6235969B1 (en) * 1997-01-10 2001-05-22 University Of Massachusetts Cloning pigs using donor nuclei from non-quiescent differentiated cells
CA2259368C (en) * 1998-01-16 2010-10-05 Agrobiogen Gmbh Efficient nucleus transfer with foetal fibroblasts
US6331659B1 (en) 1998-01-21 2001-12-18 University Of Hawaii Cumulus cells as nuclear donors
WO1999046982A1 (en) * 1998-03-16 1999-09-23 Relag Pty Ltd Porcine nuclear transfer
AUPP294898A0 (en) * 1998-04-15 1998-05-07 Monash University Method of nuclear transfer
WO2000025578A2 (en) * 1999-04-26 2000-05-11 Trustees Of Tufts College Methods for cloning animals
EP1375654A3 (en) * 1998-11-02 2008-01-16 GTC Biotherapeutics, Inc. Transgenic and cloned mammals
EP1818397A1 (en) * 1998-11-02 2007-08-15 Trustees Of Tufts College Methods for cloning animals
US6781030B1 (en) 1998-11-02 2004-08-24 Trustee Of Tufts College, Ballou Hall Methods for cloning mammals using telophase oocytes
NZ514620A (en) 1999-03-04 2004-04-30 Ppl Therapeutics Scotland Ltd Genetic modification of somatic cells and uses thereof
RU2205536C2 (ru) * 1999-06-30 2003-06-10 Воо-Сук ХВАНГ Способ получения клонированной коровы
CN1304445A (zh) * 1999-06-30 2001-07-18 黄禹锡 一种通过用种间核转移技术生产克隆虎的方法
CN1304444A (zh) * 1999-06-30 2001-07-18 黄禹锡 一种通过用种间核转移技术生产人类克隆胚胎的方法
WO2001029206A1 (en) * 1999-10-15 2001-04-26 Advanced Cell Technology, Inc. Methods of producing differentiated progenitor cells and lineage-defective embryonic stem cells
GB2380202A (en) * 2000-06-08 2003-04-02 Trostner Jens Method for the genetic reconstruction of human organs
EA013564B1 (ru) 2000-08-03 2010-06-30 Терапеутик Хьюман Поликлоналз Инк. Гуманизированный иммуноглобулин и содержащая его фармацевтическая композиция
FR2814642B1 (fr) 2000-10-03 2005-07-01 Ass Pour Le Dev De La Rech En Souris transgenique pour la recombinaison ciblee mediee par la cre-er modifiee
AU2001297880B2 (en) * 2000-11-30 2007-05-31 Stemron Inc. Isolated homozygous stem cells differentiated cells derived therefrom and materials and methods for making and using same
EP1217071B1 (en) 2000-12-22 2010-04-28 Institut National De La Recherche Agronomique Position-independent and tissue specific expression of a transgene in milk of transgenic animals
MXPA03005624A (es) * 2000-12-22 2004-12-03 Vaurox Llc Metodos para clonar mamiferos usando cromatina reprogramada del donador o celulas donadoras.
JP4381139B2 (ja) 2001-08-13 2009-12-09 エンブレクス，インコーポレイテッド 鳥類の卵の処理方法
JP2005528095A (ja) * 2002-04-01 2005-09-22 ジーティーシー バイオセラピューティックス インコーポレイテッド 哺乳類種における核移植に使用するための細胞株を選択する方法
US7612250B2 (en) 2002-07-29 2009-11-03 Trustees Of Tufts College Nuclear transfer embryo formation method
RU2308281C1 (ru) * 2006-04-05 2007-10-20 ГУ Научно-исследовательский институт фармакологии Томского научного центра Сибирского отделения Российской академии медицинских наук (ГУ НИИ фармакологии ТНЦ СО РАМН) Способ клонирования in vitro регионарных стволовых клеток поджелудочной железы
PE20081216A1 (es) 2006-09-01 2008-09-04 Therapeutic Human Polyclonals Inc Expresion mejorada de la inmunoglobulina humana o humanizada en animales transgenicos no humanos
EP2267153A1 (en) 2009-05-26 2010-12-29 Université Claude Bernard Lyon 1 Identification of netrin-1 receptor unc5c gene mutation in solid cancers
US10865383B2 (en) 2011-07-12 2020-12-15 Lineage Cell Therapeutics, Inc. Methods and formulations for orthopedic cell therapy
JP2023131904A (ja) * 2022-03-10 2023-09-22 国立大学法人愛媛大学 細胞の移植方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995017500A1 (en) * 1993-12-23 1995-06-29 Abs Global, Inc. Embryonic stem cells as nuclear donors and nuclear transfer techniques to produce chimeric and transgenic animals
WO1997007669A1 (en) * 1995-08-31 1997-03-06 Roslin Institute (Edinburgh) Quiescent cell populations for nuclear transfer
WO1999036510A1 (de) * 1998-01-16 1999-07-22 Agrobiogen Gmbh Effizienter kerntransfer mit fetalen fibroblasten

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9517779D0 (en) 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
US5945577A (en) 1997-01-10 1999-08-31 University Of Massachusetts As Represented By Its Amherst Campus Cloning using donor nuclei from proliferating somatic cells

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995017500A1 (en) * 1993-12-23 1995-06-29 Abs Global, Inc. Embryonic stem cells as nuclear donors and nuclear transfer techniques to produce chimeric and transgenic animals
WO1997007669A1 (en) * 1995-08-31 1997-03-06 Roslin Institute (Edinburgh) Quiescent cell populations for nuclear transfer
WO1999036510A1 (de) * 1998-01-16 1999-07-22 Agrobiogen Gmbh Effizienter kerntransfer mit fetalen fibroblasten

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
CIBELLI J B ET AL: "CLONED TRANSGENIC CALVES PRODUCED FROM NON QUIESCENT FETAL FIBROBLASTS", SCIENCE,US,AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, vol. 280, 22 May 1998 (1998-05-22), pages 1256 - 1258, XP000786003, ISSN: 0036-8075 *
CIBELLI J B ET AL: "PRODUCTION OF GERMLINE CHIMERIC BOVINE FETUSES FROM TRANSGENIC EMBRYONIC STEM CELLS", THERIOGENOLOGY, LOS ALTOS, CA, US, vol. 47, no. 1, 1 December 1996 (1996-12-01), pages 241, XP002062127, ISSN: 0093-691X *
CIBELLI J B ET AL: "TRANSGENIC BOVINE CHIMERIC OFFSPRING PRODUCED FROM SOMATIC CELL-DERIVED STEM-LIKE CELLS", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, vol. 16, no. 7, July 1998 (1998-07-01), pages 642 - 646, XP001018987, ISSN: 1087-0156 *
COLLAS P ET AL: "NUCLEAR TRANSPLANTATION BY MICROINJECTION OF INNER CELL MASS AND GRANULOSA CELL NUCLEI", MOLECULAR REPRODUCTION AND DEVELOPMENT, LISSS, NEW YORK, NY, US, vol. 38, no. 3, 1 July 1994 (1994-07-01), pages 264 - 267, XP002067033, ISSN: 1040-452X *
HYTTINEN J-M ET AL: "GENERATION OF TRANSGENIC DAIRY CATTLE FROM TRANSGENE-ANALYZED AND SEXED EMBRYOS PRODUCED IN VITRO", BIO/TECHNOLOGY, NATURE PUBLISHING CO. NEW YORK, US, vol. 12, 12 June 1994 (1994-06-12), pages 606 - 608, XP002914460, ISSN: 0733-222X *
KATO Y ET AL: "NUCLEAR TRANSFER OF INNER CELL MASS CELLS AND FETAL GERM CELLS AT DIFFERENT CELL CYCLES INTO ENUCLEATED ZYGOTES AT THE M PHASE IN THE MOUSE", JOURNAL OF REPRODUCTION AND DEVELOPMENT, FUCHU, JP, vol. 41, no. 4, 1995, pages 345 - 351, XP000764043, ISSN: 0916-8818 *
SCHNIEKE A E ET AL: "HUMAN FACTOR IX TRANSGENIC SHEEP PRODUCED BY TRANSFER OF NUCLEI FROM TRANSFECTED FETAL FIBROBLASTS", SCIENCE,US,AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, vol. 278, no. 5346, 19 December 1997 (1997-12-19), pages 2130 - 2133, XP002067036, ISSN: 0036-8075 *
See also references of WO9901163A1 *
SIMS M M ET AL: "PRODUCTION OF FETUSES FROM TOTIPOTENT CULTURED BOVINE INNER CELL MASS CELLS", THERIOGENOLOGY, LOS ALTOS, CA, US, vol. 39, 1993, pages 313, XP000607230, ISSN: 0093-691X *

Also Published As

Publication number Publication date
CN101003800A (zh) 2007-07-25
BR9811657A (pt) 2000-09-05
CN1265599A (zh) 2000-09-06
AU8154398A (en) 1999-01-25
JP2001509361A (ja) 2001-07-24
WO1999001163A1 (en) 1999-01-14
CA2294916A1 (en) 1999-01-14
EP1017422A1 (en) 2000-07-12
NZ502129A (en) 2005-02-25
IL133786A0 (en) 2001-04-30

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