EP1017422A4 - Klonierung unter Verwendung von Spender-Kernen aus Serum-entzogenen, differenzierten Zellen - Google Patents
Klonierung unter Verwendung von Spender-Kernen aus Serum-entzogenen, differenzierten ZellenInfo
- Publication number
- EP1017422A4 EP1017422A4 EP19980931400 EP98931400A EP1017422A4 EP 1017422 A4 EP1017422 A4 EP 1017422A4 EP 19980931400 EP19980931400 EP 19980931400 EP 98931400 A EP98931400 A EP 98931400A EP 1017422 A4 EP1017422 A4 EP 1017422A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- cloning
- differentiated cells
- serum starved
- donor nuclei
- nuclei
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
- C12N15/877—Techniques for producing new mammalian cloned embryos
- C12N15/8771—Bovine embryos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2517/00—Cells related to new breeds of animals
- C12N2517/02—Cells from transgenic animals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2517/00—Cells related to new breeds of animals
- C12N2517/04—Cells produced using nuclear transfer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Psychology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Developmental Biology & Embryology (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88828397A | 1997-07-03 | 1997-07-03 | |
US888283 | 1997-07-03 | ||
PCT/US1998/012800 WO1999001163A1 (en) | 1997-07-03 | 1998-06-24 | Cloning using donor nuclei from non-serum starved, differentiated cells |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1017422A1 EP1017422A1 (de) | 2000-07-12 |
EP1017422A4 true EP1017422A4 (de) | 2002-10-29 |
Family
ID=25392916
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19980931400 Withdrawn EP1017422A4 (de) | 1997-07-03 | 1998-06-24 | Klonierung unter Verwendung von Spender-Kernen aus Serum-entzogenen, differenzierten Zellen |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1017422A4 (de) |
JP (1) | JP2001509361A (de) |
CN (2) | CN1265599A (de) |
AU (1) | AU8154398A (de) |
BR (1) | BR9811657A (de) |
CA (1) | CA2294916A1 (de) |
IL (1) | IL133786A0 (de) |
NZ (1) | NZ502129A (de) |
WO (1) | WO1999001163A1 (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6235969B1 (en) * | 1997-01-10 | 2001-05-22 | University Of Massachusetts | Cloning pigs using donor nuclei from non-quiescent differentiated cells |
WO1999036510A1 (de) * | 1998-01-16 | 1999-07-22 | Agrobiogen Gmbh | Effizienter kerntransfer mit fetalen fibroblasten |
US6331659B1 (en) | 1998-01-21 | 2001-12-18 | University Of Hawaii | Cumulus cells as nuclear donors |
JP2002511234A (ja) * | 1998-03-16 | 2002-04-16 | リレグ ピーティーワイ リミテッド | ブタの核移植 |
AUPP294898A0 (en) * | 1998-04-15 | 1998-05-07 | Monash University | Method of nuclear transfer |
EP1375654A3 (de) * | 1998-11-02 | 2008-01-16 | GTC Biotherapeutics, Inc. | Transgen- und klonierte Saugentiere |
EP1818397A1 (de) * | 1998-11-02 | 2007-08-15 | Trustees Of Tufts College | Verfahren zur Klonierung von Tieren |
US6781030B1 (en) | 1998-11-02 | 2004-08-24 | Trustee Of Tufts College, Ballou Hall | Methods for cloning mammals using telophase oocytes |
WO2000025578A2 (en) * | 1999-04-26 | 2000-05-11 | Trustees Of Tufts College | Methods for cloning animals |
ES2338631T3 (es) | 1999-03-04 | 2010-05-11 | Revivicor, Inc. | Modificacion genetica de celulas somaticas y usos de las mismas. |
NZ508739A (en) * | 1999-06-30 | 2002-11-26 | Woo Suk Hwang | Method for producing cloned tigers by employing inter-species nuclear transplantation technique |
JP3652308B2 (ja) * | 1999-06-30 | 2005-05-25 | ソウル ナショナル ユニバーシティー インダストリー ファウンデーション | クローンウシの生産方法 |
AU5577600A (en) * | 1999-06-30 | 2001-01-31 | Woo-Suk Hwang | A method for producing human embryonic skin cells by employing an inter-species nuclear transplantation technique |
CN1413250A (zh) * | 1999-10-15 | 2003-04-23 | 先进细胞技术公司 | 用于生成分化祖细胞和谱系缺陷型胚胎干细胞的方法 |
DE10084883D2 (de) * | 2000-06-08 | 2004-04-29 | Trostner Jens | Verfahren zur genetischen Rekonstruktion von menschlichen Organen |
AU8470301A (en) | 2000-08-03 | 2002-02-18 | Wim-Van Schooten | Production of humanized antibodies in transgenic animals |
FR2814642B1 (fr) | 2000-10-03 | 2005-07-01 | Ass Pour Le Dev De La Rech En | Souris transgenique pour la recombinaison ciblee mediee par la cre-er modifiee |
US20020168763A1 (en) * | 2000-11-30 | 2002-11-14 | Yan Wen Liang | Isolated homozygous stem cells, differentiated cells derived therefrom, and materials and methods for making and using same |
ATE466089T1 (de) | 2000-12-22 | 2010-05-15 | Agronomique Inst Nat Rech | Positionsunabhängige und gewebespezifische expression eines transgens in der milch eines transgen-tieres |
EP1356035B1 (de) * | 2000-12-22 | 2011-03-16 | Kyowa Hakko Kirin Co., Ltd. | Verfahren zur klonierung von nichtmenschliche säugern unter verwendung von reprogrammiertem donorchromatin oder donorzellen |
JP4381139B2 (ja) | 2001-08-13 | 2009-12-09 | エンブレクス,インコーポレイテッド | 鳥類の卵の処理方法 |
EP1490487A4 (de) * | 2002-04-01 | 2007-08-29 | Gtc Biotherapeutics Inc | Verfahren zur selektion von für die zellkernübertragung in säugerspezies zu verwendenden zellinien |
US7612250B2 (en) | 2002-07-29 | 2009-11-03 | Trustees Of Tufts College | Nuclear transfer embryo formation method |
PE20081216A1 (es) | 2006-09-01 | 2008-09-04 | Therapeutic Human Polyclonals Inc | Expresion mejorada de la inmunoglobulina humana o humanizada en animales transgenicos no humanos |
EP2267153A1 (de) | 2009-05-26 | 2010-12-29 | Université Claude Bernard Lyon 1 | Identifizierung der Netrin-1-Rezeptor-unc5c-Genmutation bei festen Krebsen |
WO2013010045A1 (en) | 2011-07-12 | 2013-01-17 | Biotime Inc. | Novel methods and formulations for orthopedic cell therapy |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995017500A1 (en) * | 1993-12-23 | 1995-06-29 | Abs Global, Inc. | Embryonic stem cells as nuclear donors and nuclear transfer techniques to produce chimeric and transgenic animals |
WO1997007669A1 (en) * | 1995-08-31 | 1997-03-06 | Roslin Institute (Edinburgh) | Quiescent cell populations for nuclear transfer |
WO1999036510A1 (de) * | 1998-01-16 | 1999-07-22 | Agrobiogen Gmbh | Effizienter kerntransfer mit fetalen fibroblasten |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9517779D0 (en) | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
US5945577A (en) | 1997-01-10 | 1999-08-31 | University Of Massachusetts As Represented By Its Amherst Campus | Cloning using donor nuclei from proliferating somatic cells |
-
1998
- 1998-06-24 BR BR9811657-6A patent/BR9811657A/pt not_active Application Discontinuation
- 1998-06-24 CA CA002294916A patent/CA2294916A1/en not_active Abandoned
- 1998-06-24 IL IL13378698A patent/IL133786A0/xx unknown
- 1998-06-24 WO PCT/US1998/012800 patent/WO1999001163A1/en active Application Filing
- 1998-06-24 CN CN98807691A patent/CN1265599A/zh active Pending
- 1998-06-24 EP EP19980931400 patent/EP1017422A4/de not_active Withdrawn
- 1998-06-24 CN CNA2007100081920A patent/CN101003800A/zh active Pending
- 1998-06-24 AU AU81543/98A patent/AU8154398A/en not_active Abandoned
- 1998-06-24 NZ NZ502129A patent/NZ502129A/en unknown
- 1998-06-24 JP JP2000500926A patent/JP2001509361A/ja active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995017500A1 (en) * | 1993-12-23 | 1995-06-29 | Abs Global, Inc. | Embryonic stem cells as nuclear donors and nuclear transfer techniques to produce chimeric and transgenic animals |
WO1997007669A1 (en) * | 1995-08-31 | 1997-03-06 | Roslin Institute (Edinburgh) | Quiescent cell populations for nuclear transfer |
WO1999036510A1 (de) * | 1998-01-16 | 1999-07-22 | Agrobiogen Gmbh | Effizienter kerntransfer mit fetalen fibroblasten |
Non-Patent Citations (9)
Title |
---|
CIBELLI J B ET AL: "CLONED TRANSGENIC CALVES PRODUCED FROM NON QUIESCENT FETAL FIBROBLASTS", SCIENCE,US,AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, vol. 280, 22 May 1998 (1998-05-22), pages 1256 - 1258, XP000786003, ISSN: 0036-8075 * |
CIBELLI J B ET AL: "PRODUCTION OF GERMLINE CHIMERIC BOVINE FETUSES FROM TRANSGENIC EMBRYONIC STEM CELLS", THERIOGENOLOGY, LOS ALTOS, CA, US, vol. 47, no. 1, 1 December 1996 (1996-12-01), pages 241, XP002062127, ISSN: 0093-691X * |
CIBELLI J B ET AL: "TRANSGENIC BOVINE CHIMERIC OFFSPRING PRODUCED FROM SOMATIC CELL-DERIVED STEM-LIKE CELLS", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, vol. 16, no. 7, July 1998 (1998-07-01), pages 642 - 646, XP001018987, ISSN: 1087-0156 * |
COLLAS P ET AL: "NUCLEAR TRANSPLANTATION BY MICROINJECTION OF INNER CELL MASS AND GRANULOSA CELL NUCLEI", MOLECULAR REPRODUCTION AND DEVELOPMENT, LISSS, NEW YORK, NY, US, vol. 38, no. 3, 1 July 1994 (1994-07-01), pages 264 - 267, XP002067033, ISSN: 1040-452X * |
HYTTINEN J-M ET AL: "GENERATION OF TRANSGENIC DAIRY CATTLE FROM TRANSGENE-ANALYZED AND SEXED EMBRYOS PRODUCED IN VITRO", BIO/TECHNOLOGY, NATURE PUBLISHING CO. NEW YORK, US, vol. 12, 12 June 1994 (1994-06-12), pages 606 - 608, XP002914460, ISSN: 0733-222X * |
KATO Y ET AL: "NUCLEAR TRANSFER OF INNER CELL MASS CELLS AND FETAL GERM CELLS AT DIFFERENT CELL CYCLES INTO ENUCLEATED ZYGOTES AT THE M PHASE IN THE MOUSE", JOURNAL OF REPRODUCTION AND DEVELOPMENT, FUCHU, JP, vol. 41, no. 4, 1995, pages 345 - 351, XP000764043, ISSN: 0916-8818 * |
SCHNIEKE A E ET AL: "HUMAN FACTOR IX TRANSGENIC SHEEP PRODUCED BY TRANSFER OF NUCLEI FROM TRANSFECTED FETAL FIBROBLASTS", SCIENCE,US,AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, vol. 278, no. 5346, 19 December 1997 (1997-12-19), pages 2130 - 2133, XP002067036, ISSN: 0036-8075 * |
See also references of WO9901163A1 * |
SIMS M M ET AL: "PRODUCTION OF FETUSES FROM TOTIPOTENT CULTURED BOVINE INNER CELL MASS CELLS", THERIOGENOLOGY, LOS ALTOS, CA, US, vol. 39, 1993, pages 313, XP000607230, ISSN: 0093-691X * |
Also Published As
Publication number | Publication date |
---|---|
NZ502129A (en) | 2005-02-25 |
CN1265599A (zh) | 2000-09-06 |
CN101003800A (zh) | 2007-07-25 |
CA2294916A1 (en) | 1999-01-14 |
AU8154398A (en) | 1999-01-25 |
JP2001509361A (ja) | 2001-07-24 |
IL133786A0 (en) | 2001-04-30 |
WO1999001163A1 (en) | 1999-01-14 |
EP1017422A1 (de) | 2000-07-12 |
BR9811657A (pt) | 2000-09-05 |
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Legal Events
Date | Code | Title | Description |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
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17P | Request for examination filed |
Effective date: 20000112 |
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Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
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RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: JERRY, D., JOSEPH Inventor name: PONCE DE LEON, F., ABEL Inventor name: GOLUEKE, PAUL Inventor name: ROBL, JAMES, M. Inventor name: CIBELLI, JOSE Inventor name: STICE, STEVEN, L. |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: JERRY, D., JOSEPH Inventor name: PONCE DE LEON, F., ABEL Inventor name: GOLUEKE, PAUL Inventor name: ROBL, JAMES, M. Inventor name: CIBELLI, JOSE Inventor name: STICE,STEVEN, L., ASSOC.PROF. ANIMAL SCIE.RESEARCH |
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A4 | Supplementary search report drawn up and despatched | ||
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Free format text: 7C 12N 15/00 A, 7A 01K 67/027 B, 7A 61K 48/00 B, 7C 12N 5/10 B, 7C 12N 5/06 B |
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17Q | First examination report despatched |
Effective date: 20030606 |
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TPAC | Observations filed by third parties |
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RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: JERRY, D., JOSEPH Inventor name: PONCE DE LEON, F., ABEL Inventor name: GOLUEKE, PAUL Inventor name: ROBL, JAMES, M. Inventor name: CIBELLI, JOSE Inventor name: STICE,STEVEN, L. |
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RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: JERRY, D., JOSEPH Inventor name: PONCE DE LEON, F., ABEL Inventor name: GOLUEKE, PAUL Inventor name: ROBL, JAMES, M. Inventor name: CIBELLI, JOSE Inventor name: STICE,STEVEN, L. |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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18D | Application deemed to be withdrawn |
Effective date: 20070929 |