EP1017422A4 - Klonierung unter Verwendung von Spender-Kernen aus Serum-entzogenen, differenzierten Zellen - Google Patents

Klonierung unter Verwendung von Spender-Kernen aus Serum-entzogenen, differenzierten Zellen

Info

Publication number
EP1017422A4
EP1017422A4 EP19980931400 EP98931400A EP1017422A4 EP 1017422 A4 EP1017422 A4 EP 1017422A4 EP 19980931400 EP19980931400 EP 19980931400 EP 98931400 A EP98931400 A EP 98931400A EP 1017422 A4 EP1017422 A4 EP 1017422A4
Authority
EP
European Patent Office
Prior art keywords
cloning
differentiated cells
serum starved
donor nuclei
nuclei
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19980931400
Other languages
English (en)
French (fr)
Other versions
EP1017422A1 (de
Inventor
Steven L Stice
Jose Cibelli
James M Robl
Paul Golueke
De Leon F Abel Ponce
D Joseph Jerry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Massachusetts UMass
Original Assignee
University of Massachusetts UMass
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Massachusetts UMass filed Critical University of Massachusetts UMass
Publication of EP1017422A1 publication Critical patent/EP1017422A1/de
Publication of EP1017422A4 publication Critical patent/EP1017422A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • C12N15/877—Techniques for producing new mammalian cloned embryos
    • C12N15/8771—Bovine embryos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2517/00—Cells related to new breeds of animals
    • C12N2517/02—Cells from transgenic animals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2517/00—Cells related to new breeds of animals
    • C12N2517/04—Cells produced using nuclear transfer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Psychology (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pathology (AREA)
  • Rheumatology (AREA)
EP19980931400 1997-07-03 1998-06-24 Klonierung unter Verwendung von Spender-Kernen aus Serum-entzogenen, differenzierten Zellen Withdrawn EP1017422A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88828397A 1997-07-03 1997-07-03
US888283 1997-07-03
PCT/US1998/012800 WO1999001163A1 (en) 1997-07-03 1998-06-24 Cloning using donor nuclei from non-serum starved, differentiated cells

Publications (2)

Publication Number Publication Date
EP1017422A1 EP1017422A1 (de) 2000-07-12
EP1017422A4 true EP1017422A4 (de) 2002-10-29

Family

ID=25392916

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19980931400 Withdrawn EP1017422A4 (de) 1997-07-03 1998-06-24 Klonierung unter Verwendung von Spender-Kernen aus Serum-entzogenen, differenzierten Zellen

Country Status (9)

Country Link
EP (1) EP1017422A4 (de)
JP (1) JP2001509361A (de)
CN (2) CN1265599A (de)
AU (1) AU8154398A (de)
BR (1) BR9811657A (de)
CA (1) CA2294916A1 (de)
IL (1) IL133786A0 (de)
NZ (1) NZ502129A (de)
WO (1) WO1999001163A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6235969B1 (en) * 1997-01-10 2001-05-22 University Of Massachusetts Cloning pigs using donor nuclei from non-quiescent differentiated cells
JP4102450B2 (ja) * 1998-01-16 2008-06-18 アグロバイオジェン ゲーエムベーハー 胎仔線維芽細胞による効率的な核移入
US6331659B1 (en) 1998-01-21 2001-12-18 University Of Hawaii Cumulus cells as nuclear donors
WO1999046982A1 (en) * 1998-03-16 1999-09-23 Relag Pty Ltd Porcine nuclear transfer
AUPP294898A0 (en) * 1998-04-15 1998-05-07 Monash University Method of nuclear transfer
US6781030B1 (en) 1998-11-02 2004-08-24 Trustee Of Tufts College, Ballou Hall Methods for cloning mammals using telophase oocytes
WO2000025578A2 (en) * 1999-04-26 2000-05-11 Trustees Of Tufts College Methods for cloning animals
EP1818397A1 (de) * 1998-11-02 2007-08-15 Trustees Of Tufts College Verfahren zur Klonierung von Tieren
EP1375654A3 (de) * 1998-11-02 2008-01-16 GTC Biotherapeutics, Inc. Transgen- und klonierte Saugentiere
DK1159415T3 (da) 1999-03-04 2010-05-03 Revivicor Inc Genetisk modifikation af somatiske celler og anvendelse deraf
US6590139B1 (en) * 1999-06-30 2003-07-08 Woo-Suk Hwang Method for producing cloned cows
CA2334953A1 (en) * 1999-06-30 2001-01-04 Woo-Suk Hwang Method for producing human cloned embryos by employing inter-species nuclear transplantation technique
CA2334954A1 (en) * 1999-06-30 2001-01-04 Woo-Suk Hwang A method for producing cloned tigers by employing inter-species nuclear transplantation technique
CN1413250A (zh) * 1999-10-15 2003-04-23 先进细胞技术公司 用于生成分化祖细胞和谱系缺陷型胚胎干细胞的方法
DE10084883D2 (de) * 2000-06-08 2004-04-29 Trostner Jens Verfahren zur genetischen Rekonstruktion von menschlichen Organen
CA2634294A1 (en) 2000-08-03 2002-02-14 Therapeutic Human Polyclonals, Inc. Production of humanized antibodies in transgenic animals
FR2814642B1 (fr) 2000-10-03 2005-07-01 Ass Pour Le Dev De La Rech En Souris transgenique pour la recombinaison ciblee mediee par la cre-er modifiee
US20020168763A1 (en) * 2000-11-30 2002-11-14 Yan Wen Liang Isolated homozygous stem cells, differentiated cells derived therefrom, and materials and methods for making and using same
ATE466089T1 (de) 2000-12-22 2010-05-15 Agronomique Inst Nat Rech Positionsunabhängige und gewebespezifische expression eines transgens in der milch eines transgen-tieres
ATE502106T1 (de) * 2000-12-22 2011-04-15 Kyowa Hakko Kirin Co Ltd Verfahren zur klonierung von nichtmenschliche säugern unter verwendung von reprogrammiertem donorchromatin oder donorzellen
WO2003025159A1 (en) 2001-08-13 2003-03-27 Embrex, Inc. Methods for injecting avian eggs
AU2003230725A1 (en) * 2002-04-01 2003-10-20 Gtc Biotherapeutics, Inc. A method for selecting cell lines to be used for nuclear transfer in mammalian species
US7612250B2 (en) 2002-07-29 2009-11-03 Trustees Of Tufts College Nuclear transfer embryo formation method
CN101506235B (zh) 2006-09-01 2012-07-25 人类多细胞株治疗学公司 人或人源化免疫球蛋白在非人转基因动物中增强的表达
EP2267153A1 (de) 2009-05-26 2010-12-29 Université Claude Bernard Lyon 1 Identifizierung der Netrin-1-Rezeptor-unc5c-Genmutation bei festen Krebsen
US10865383B2 (en) 2011-07-12 2020-12-15 Lineage Cell Therapeutics, Inc. Methods and formulations for orthopedic cell therapy

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995017500A1 (en) * 1993-12-23 1995-06-29 Abs Global, Inc. Embryonic stem cells as nuclear donors and nuclear transfer techniques to produce chimeric and transgenic animals
WO1997007669A1 (en) * 1995-08-31 1997-03-06 Roslin Institute (Edinburgh) Quiescent cell populations for nuclear transfer
WO1999036510A1 (de) * 1998-01-16 1999-07-22 Agrobiogen Gmbh Effizienter kerntransfer mit fetalen fibroblasten

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9517779D0 (en) 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
US5945577A (en) 1997-01-10 1999-08-31 University Of Massachusetts As Represented By Its Amherst Campus Cloning using donor nuclei from proliferating somatic cells

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995017500A1 (en) * 1993-12-23 1995-06-29 Abs Global, Inc. Embryonic stem cells as nuclear donors and nuclear transfer techniques to produce chimeric and transgenic animals
WO1997007669A1 (en) * 1995-08-31 1997-03-06 Roslin Institute (Edinburgh) Quiescent cell populations for nuclear transfer
WO1999036510A1 (de) * 1998-01-16 1999-07-22 Agrobiogen Gmbh Effizienter kerntransfer mit fetalen fibroblasten

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
CIBELLI J B ET AL: "CLONED TRANSGENIC CALVES PRODUCED FROM NON QUIESCENT FETAL FIBROBLASTS", SCIENCE,US,AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, vol. 280, 22 May 1998 (1998-05-22), pages 1256 - 1258, XP000786003, ISSN: 0036-8075 *
CIBELLI J B ET AL: "PRODUCTION OF GERMLINE CHIMERIC BOVINE FETUSES FROM TRANSGENIC EMBRYONIC STEM CELLS", THERIOGENOLOGY, LOS ALTOS, CA, US, vol. 47, no. 1, 1 December 1996 (1996-12-01), pages 241, XP002062127, ISSN: 0093-691X *
CIBELLI J B ET AL: "TRANSGENIC BOVINE CHIMERIC OFFSPRING PRODUCED FROM SOMATIC CELL-DERIVED STEM-LIKE CELLS", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, vol. 16, no. 7, July 1998 (1998-07-01), pages 642 - 646, XP001018987, ISSN: 1087-0156 *
COLLAS P ET AL: "NUCLEAR TRANSPLANTATION BY MICROINJECTION OF INNER CELL MASS AND GRANULOSA CELL NUCLEI", MOLECULAR REPRODUCTION AND DEVELOPMENT, LISSS, NEW YORK, NY, US, vol. 38, no. 3, 1 July 1994 (1994-07-01), pages 264 - 267, XP002067033, ISSN: 1040-452X *
HYTTINEN J-M ET AL: "GENERATION OF TRANSGENIC DAIRY CATTLE FROM TRANSGENE-ANALYZED AND SEXED EMBRYOS PRODUCED IN VITRO", BIO/TECHNOLOGY, NATURE PUBLISHING CO. NEW YORK, US, vol. 12, 12 June 1994 (1994-06-12), pages 606 - 608, XP002914460, ISSN: 0733-222X *
KATO Y ET AL: "NUCLEAR TRANSFER OF INNER CELL MASS CELLS AND FETAL GERM CELLS AT DIFFERENT CELL CYCLES INTO ENUCLEATED ZYGOTES AT THE M PHASE IN THE MOUSE", JOURNAL OF REPRODUCTION AND DEVELOPMENT, FUCHU, JP, vol. 41, no. 4, 1995, pages 345 - 351, XP000764043, ISSN: 0916-8818 *
SCHNIEKE A E ET AL: "HUMAN FACTOR IX TRANSGENIC SHEEP PRODUCED BY TRANSFER OF NUCLEI FROM TRANSFECTED FETAL FIBROBLASTS", SCIENCE,US,AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, vol. 278, no. 5346, 19 December 1997 (1997-12-19), pages 2130 - 2133, XP002067036, ISSN: 0036-8075 *
See also references of WO9901163A1 *
SIMS M M ET AL: "PRODUCTION OF FETUSES FROM TOTIPOTENT CULTURED BOVINE INNER CELL MASS CELLS", THERIOGENOLOGY, LOS ALTOS, CA, US, vol. 39, 1993, pages 313, XP000607230, ISSN: 0093-691X *

Also Published As

Publication number Publication date
BR9811657A (pt) 2000-09-05
CA2294916A1 (en) 1999-01-14
NZ502129A (en) 2005-02-25
WO1999001163A1 (en) 1999-01-14
IL133786A0 (en) 2001-04-30
EP1017422A1 (de) 2000-07-12
JP2001509361A (ja) 2001-07-24
AU8154398A (en) 1999-01-25
CN101003800A (zh) 2007-07-25
CN1265599A (zh) 2000-09-06

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Inventor name: GOLUEKE, PAUL

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