EP1011567A1 - Drug delivery devices and methods for treatment of viral and microbial infections and wasting syndromes - Google Patents
Drug delivery devices and methods for treatment of viral and microbial infections and wasting syndromesInfo
- Publication number
- EP1011567A1 EP1011567A1 EP98926488A EP98926488A EP1011567A1 EP 1011567 A1 EP1011567 A1 EP 1011567A1 EP 98926488 A EP98926488 A EP 98926488A EP 98926488 A EP98926488 A EP 98926488A EP 1011567 A1 EP1011567 A1 EP 1011567A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- dmf
- therapeutic composition
- alkyl groups
- drug delivery
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
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- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
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- A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Definitions
- HIV-1 envelope proteins gpl60, gpl20, gp41
- gpl60, gpl20, gp41 have been shown to be the major antigens for anti-HIV antibodies present in
- the invention also extends to a vaccine prepared from antibodies that are obtained from the body of an animal after treatment with a composition of the invention for a viral infection. 4. BRIEF DESCRIPTION OF THE FIGURES
- FIGURE 4 illustrates the general condition of HIV infected patients before and after treatment with transdermal DMF, as assessed according to the Karnofsky performance scale. See text, Section 7, for details.
- R3 is selected from the group consisting of H, methyl, and saturated and unsaturated C2-C3 alkyl groups; or any agent selected from the group consisting of amides of the general formula in which
- each sticker requires about 7,064 g DMF to deliver the required amount, having a surface area of 6,36 evr (each sticker) .
- DMF absorption rate is 9,4 mg/cm 2 /hour.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US874425 | 1997-06-13 | ||
| US08/874,425 US5935597A (en) | 1995-12-15 | 1997-06-13 | Drug delivery devices and methods for treatment of viral and microbial infections and wasting syndromes |
| PCT/US1998/011956 WO1998056325A1 (en) | 1997-06-13 | 1998-06-09 | Drug delivery devices and methods for treatment of viral and microbial infections and wasting syndromes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP1011567A1 true EP1011567A1 (en) | 2000-06-28 |
| EP1011567A4 EP1011567A4 (en) | 2000-06-28 |
Family
ID=25363728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP98926488A Withdrawn EP1011567A4 (en) | 1997-06-13 | 1998-06-09 | DRUG DELIVERY DEVICES AND METHODS FOR TREATING VIRAL OR MICROBIAL INFECTIONS OR LOSS OF SYNDROME |
Country Status (34)
| Country | Link |
|---|---|
| EP (1) | EP1011567A4 (es) |
| JP (1) | JP4531141B2 (es) |
| KR (1) | KR20010013709A (es) |
| CN (1) | CN1260703A (es) |
| AP (1) | AP1629A (es) |
| AR (1) | AR012970A1 (es) |
| AU (1) | AU7831598A (es) |
| BG (1) | BG103997A (es) |
| BR (1) | BR9810095A (es) |
| CA (1) | CA2295176A1 (es) |
| CZ (1) | CZ298510B6 (es) |
| EA (1) | EA200000011A1 (es) |
| EE (1) | EE9900562A (es) |
| ES (1) | ES2161187B1 (es) |
| FI (1) | FI19992648A (es) |
| GB (1) | GB2341319B (es) |
| HU (1) | HUP0003034A2 (es) |
| ID (1) | ID23516A (es) |
| IL (2) | IL133396A0 (es) |
| IS (1) | IS5289A (es) |
| LT (1) | LT4714B (es) |
| LV (1) | LV12490B (es) |
| NO (1) | NO996117L (es) |
| NZ (1) | NZ501669A (es) |
| OA (1) | OA11307A (es) |
| PL (1) | PL196256B1 (es) |
| RO (1) | RO121252B1 (es) |
| SI (1) | SI20191A (es) |
| SK (1) | SK172299A3 (es) |
| TN (1) | TNSN98086A1 (es) |
| TR (1) | TR200000540T2 (es) |
| WO (1) | WO1998056325A1 (es) |
| YU (1) | YU66099A (es) |
| ZA (1) | ZA984649B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070212402A1 (en) * | 2003-12-05 | 2007-09-13 | Rooven Qainton V | Patch |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0399765A2 (en) * | 1989-05-22 | 1990-11-28 | Advanced Polymer Systems, Inc. | System for transdermal drug delivery |
| US5624912A (en) * | 1991-08-21 | 1997-04-29 | Burcoglu; Arsinur | Method of treating HIV infection and related secondary infections with defibrotide |
| WO1997022248A1 (en) * | 1995-12-15 | 1997-06-26 | Cryopreservation Technologies Cc | Composition for organ cryopreservation and treatment of viral and bacterial infections |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE60941B1 (en) * | 1986-07-10 | 1994-09-07 | Elan Transdermal Ltd | Transdermal drug delivery device |
| US4855294A (en) * | 1988-09-06 | 1989-08-08 | Theratech, Inc. | Method for reducing skin irritation associated with drug/penetration enhancer compositions |
| US5534260A (en) * | 1989-02-23 | 1996-07-09 | University Of Utah | Percutaneous drug delivery system |
| WO1993016992A1 (en) * | 1992-02-20 | 1993-09-02 | Merrell Dow Pharmaceuticals Inc. | Sulfonic acid derivatives in the treatment of viral diseases |
-
1998
- 1998-05-29 ZA ZA9804649A patent/ZA984649B/xx unknown
- 1998-06-09 ES ES009950072A patent/ES2161187B1/es not_active Expired - Lifetime
- 1998-06-09 CZ CZ0447399A patent/CZ298510B6/cs not_active IP Right Cessation
- 1998-06-09 AP APAP/P/1999/001708A patent/AP1629A/en active
- 1998-06-09 ID IDW20000042A patent/ID23516A/id unknown
- 1998-06-09 HU HU0003034A patent/HUP0003034A2/hu unknown
- 1998-06-09 IL IL13339698A patent/IL133396A0/xx active IP Right Grant
- 1998-06-09 EA EA200000011A patent/EA200000011A1/ru unknown
- 1998-06-09 CA CA002295176A patent/CA2295176A1/en not_active Abandoned
- 1998-06-09 AU AU78315/98A patent/AU7831598A/en not_active Abandoned
- 1998-06-09 NZ NZ501669A patent/NZ501669A/en unknown
- 1998-06-09 EE EEP199900562A patent/EE9900562A/xx unknown
- 1998-06-09 GB GB9929189A patent/GB2341319B/en not_active Expired - Fee Related
- 1998-06-09 SI SI9820040A patent/SI20191A/sl unknown
- 1998-06-09 YU YU66099A patent/YU66099A/sh unknown
- 1998-06-09 JP JP50311899A patent/JP4531141B2/ja not_active Expired - Fee Related
- 1998-06-09 WO PCT/US1998/011956 patent/WO1998056325A1/en active IP Right Grant
- 1998-06-09 CN CN98806085A patent/CN1260703A/zh active Pending
- 1998-06-09 PL PL338439A patent/PL196256B1/pl unknown
- 1998-06-09 BR BR9810095-5A patent/BR9810095A/pt not_active Application Discontinuation
- 1998-06-09 KR KR1019997011724A patent/KR20010013709A/ko not_active Application Discontinuation
- 1998-06-09 EP EP98926488A patent/EP1011567A4/en not_active Withdrawn
- 1998-06-09 SK SK1722-99A patent/SK172299A3/sk unknown
- 1998-06-09 RO RO99-01313A patent/RO121252B1/ro unknown
- 1998-06-09 TR TR2000/00540T patent/TR200000540T2/xx unknown
- 1998-06-11 AR ARP980102783A patent/AR012970A1/es not_active Application Discontinuation
- 1998-06-12 TN TNTNSN98086A patent/TNSN98086A1/fr unknown
-
1999
- 1999-12-08 IS IS5289A patent/IS5289A/is unknown
- 1999-12-09 FI FI992648A patent/FI19992648A/fi unknown
- 1999-12-09 IL IL133396A patent/IL133396A/en not_active IP Right Cessation
- 1999-12-10 NO NO996117A patent/NO996117L/no not_active Application Discontinuation
- 1999-12-10 OA OA9900279A patent/OA11307A/en unknown
- 1999-12-13 BG BG103997A patent/BG103997A/xx unknown
- 1999-12-20 LT LT99-148A patent/LT4714B/lt not_active IP Right Cessation
-
2000
- 2000-02-02 LV LVP-99-182A patent/LV12490B/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0399765A2 (en) * | 1989-05-22 | 1990-11-28 | Advanced Polymer Systems, Inc. | System for transdermal drug delivery |
| US5624912A (en) * | 1991-08-21 | 1997-04-29 | Burcoglu; Arsinur | Method of treating HIV infection and related secondary infections with defibrotide |
| WO1997022248A1 (en) * | 1995-12-15 | 1997-06-26 | Cryopreservation Technologies Cc | Composition for organ cryopreservation and treatment of viral and bacterial infections |
Non-Patent Citations (3)
| Title |
|---|
| See also references of WO9856325A1 * |
| VIZA, D. ET AL.: "HHV-6 inhibition by two polar compounds" ANTIVIRAL RESEARCH, vol. 18, no. 1, 1992, pages 27-38, XP000876979 * |
| VIZA, DIMITRI ET AL.: "chemical inducers of cell differentiation inhibit HIV in vitro" AIDS-FORSCHUNG, vol. 4, no. 7, 1989, pages 349-352, XP000876957 * |
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