EP0930870B1 - Zubereitung zum schutz der haut gegen mechanische reizung - Google Patents

Zubereitung zum schutz der haut gegen mechanische reizung Download PDF

Info

Publication number
EP0930870B1
EP0930870B1 EP97942061A EP97942061A EP0930870B1 EP 0930870 B1 EP0930870 B1 EP 0930870B1 EP 97942061 A EP97942061 A EP 97942061A EP 97942061 A EP97942061 A EP 97942061A EP 0930870 B1 EP0930870 B1 EP 0930870B1
Authority
EP
European Patent Office
Prior art keywords
skin
trimethylglycine
preparation
cosmetic
preparations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP97942061A
Other languages
English (en)
French (fr)
Other versions
EP0930870A1 (de
Inventor
Kirsti Jutila
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Finnfeeds Finland Ltd
Original Assignee
Finnfeeds Finland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Finnfeeds Finland Ltd filed Critical Finnfeeds Finland Ltd
Publication of EP0930870A1 publication Critical patent/EP0930870A1/de
Application granted granted Critical
Publication of EP0930870B1 publication Critical patent/EP0930870B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q9/00—Preparations for removing hair or for aiding hair removal
    • A61Q9/04—Depilatories
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q9/00—Preparations for removing hair or for aiding hair removal
    • A61Q9/02—Shaving preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/75—Anti-irritant

Definitions

  • the present invention relates to cosmetic preparations, particularly to skin care products, shaving preparations, and depilatory preparations ('lady shaving' preparations), which protect skin from mechanical irritation.
  • the active agent contained in the preparations is trimethylglycine.
  • the invention also relates to the use of trimethylglycine as a skin-protecting agent in different cosmetic preparations, and to a method of protecting skin from mechanical irritation.
  • Skin is subjected to mechanical irritation, i.e. it is scratched, abraded, chafed or cut, in many situations.
  • a razor or the blade of a shaver may scratch or cut the skin on the face despite the use of shaving lather or shaving soap.
  • Infants and persons using incontinence diapers have the problem that their skin often moistens and thereby becomes thinner, and the diaper chafes and damages the skin.
  • Shoes in turn, abrade the skin on the heels, ball of the foot, and toes, and the skin on the hands is easily abraded and scratched in agricultural and garden work.
  • the object of the present invention is to provide a preparation protecting skin from mechanical irritation.
  • Another object of the present invention is to provide a method of protecting skin from mechanical irritation.
  • mechanical irritation means external damage caused to epidermis by different objects, such as a shaver blade, a razor, shoes, a diaper, clothes, tools, or the like.
  • a cosmetic preparation here means different skin care products, such as skin creams, cleansers, tonics, and milks; hand creams; foot care products, such as foot creams, and foot baths; shaving preparations, such as after-shave lotions, shaving lathers, foams, gels, and balms; depilatory preparations; products of personal hygiene ('lady-shaving' preparations), and the like.
  • Preferred preparations according to the invention are foot care products, after-shave lotions, skin tonics, and baby care products.
  • trimethylglycine means a naturally occurring quaternary ammonium type compound having the formula which is present as an anhydride or a monohydrate.
  • the compound is commonly also called betaine, trimethylammonioacetate, 1-carboxy-N,N,N-trimethylmethaneaminium, inner salt, and glycine betaine.
  • betaine trimethylammonioacetate
  • 1-carboxy-N,N,N-trimethylmethaneaminium inner salt
  • glycine betaine In the pure form, it is a white, crystalline compound that is readily soluble in water, and in lower alcohols, such as methanol and ethanol. In plants it functions as an osmolyte and thereby protects cells from the effects of osmotic stress.
  • Trimethylglycine has a bipolar structure, and it contains several metabolically reactive methyl groups, which it can donate in enzyme catalyzed reactions. Most organisms are able to synthesize small amounts of trimethylglycine, e.g. for the methyl donor function, but are not able to produce it, nor store it, in large amounts.
  • trimethylglycine has been observed to protect plants particularly under stress conditions. It has been used as an agent improving the preservation characteristics of a plant, and as an agent improving the drought and chill resistance of a growing plant. To enhance growth, trimethylglycine has also been added to fertilizers. Further, trimethylglycine has been used as an additive in animal feed or fodder. It has also been observed to have pharmacological activity, e.g. it prevents detrimental effects of coccidiosis in broilers.
  • Synthetic long-chain alkyl ester, sulpho, and aluminium salt derivatives of trimethylglycine have long been used as amphoteric surfactants in cosmetic industry, that is, e.g. as foaming agents in shampoos, soaps, and cleansers.
  • Trimethylglycine instead, is not useful in the above-mentioned cosmetic applications, since its surface activity is completely different, and since it does not foam at all.
  • Trimethylglycine hydrochloride since it is strongly acidic - differs in its characteristics from trimethylglycine anhydride and trimethylglycine monohydrate, has also been used in cosmetic products.
  • Hungarian Patent T50,622 teaches a skin care composition that contains e.g. 0.3 to 0.6% of betaine hydrochloride.
  • EP 2,127 describes a shaving composition containing 'cosmetically acceptable betaine', which means particularly long-chain alkyl esters of glycine, the composition being stated to affect the root of a hair, so that the hair can be cut as close to the skin as possible, which improves the shaving result.
  • betaine' means particularly long-chain alkyl esters of glycine
  • Trimethylglycine is commercially available both as an anhydride and as a monohydrate from Cultor Oy, Finnsugar Bioproducts.
  • a cosmetic preparation according to the present invention protecting skin from mechanical irritation contains 0.1 to 20% by weight, preferably 2 to 10% by weight, particularly 2 to 6% by weight of trimethylglycine as an anhydride or as a monohydrate in an aqueous composition or cream base, which may be e.g. an oil-in-water or a water-in-oil emulsion, water, or a water/alcohol mixture.
  • the preparation also contains ingredients and additives that are commonly used in the cosmetic preparation concerned.
  • They may be, for example, skin care agents, softening agents, astringent agents, refreshing agents, anti-oxidation agents, emulsifying agents, viscosity increasing agents, moisturizing agents, stabilizing agents, colouring agents, perfumes, surfactants, and the like, as well as alcohols and/or water.
  • the cosmetic preparations according to the invention include, in particular, skin care products, shaving preparations, depilatory preparations, and products of personal hygiene, such as skin tonics and milks; skin creams and lotions; cleansing creams, milks and gels; liquid cleansers; foot creams and baths; hand creams; refresher and moisturizing tissues and sprays; after-shave lotions; shaving lathers, gels and balms; and foam preparations.
  • the preparation type is selected according to the need.
  • the preparations of the invention can be formulated by common methods well known to those skilled in the art.
  • trimethylglycine in the above preparations provides the products with characteristics that protect skin from mechanical irritation.
  • trimethylglycine also reduces the effect of any irritating agents contained in the cosmetic preparation, as described in EP 531,387, preparations containing trimethylglycine can be regarded as being particularly friendly to the skin.
  • a preparation according the invention can thus be applied to the skin at the very moment that the skin is subjected to irritation, or even before it.
  • a preferred preparation according to the invention might be a shaving lather or foam, to ensure that skin-protecting trimethylglycine is immediately present on the skin.
  • the preparation according to the invention is an after-shave lotion or a skin tonic, it will be applied to the skin immediately after shaving or cutting off of hairs.
  • a cream according to the invention can be applied to the skin before putting on a new diaper, or the skin can be washed or wiped with a cleanser or a moisturizing tissue according to the invention.
  • Foot or hand creams according to the invention can be used according to the need for symptomatic alleviation of irritation, or for preventing irritation.
  • test was conducted on two test groups, each one of which comprised six healthy female volunteers.
  • group 1 four cutaneous test areas were defined on the arm of each subject, and microcirculation was first measured for 30 minutes before the preparation was added. The skin was then cut by scraping in all the four areas, and onto the skin was pressed a filter paper into which a solution had been absorbed that contained 14 ⁇ l/cm 2 of 4% (weight/volume) trimethylglycine in distilled water, or only distilled water (placebo). Subsequently, microcirculation was measured for 60 minutes at the erythematous, damaged points on the skin, treated with the solution.
  • the subjects' microcirculation was measured at the erythema in the same way as above, but the irritation was here caused by 30-minute infrared irradiation (IR Philips 250 S lamps, spectrum 700 to 2500 nm, power 250 W, light energy 70 mW/cm 2 , irradiation area 14 cm 2 ) in the four cutaneous areas defined on the upper back.
  • 30-minute infrared irradiation IR Philips 250 S lamps, spectrum 700 to 2500 nm, power 250 W, light energy 70 mW/cm 2 , irradiation area 14 cm 2
  • the treated area means an area treated with a preparation containing trimethylglycine
  • untreated area 1 is an untreated area that is symmetric with the area treated with the preparation containing trimethylglycine
  • the placebo area means an area treated with a placebo
  • untreated area 2 is an untreated area that is symmetric with the area treated with the placebo.
  • the microcirculation does not vary 30 and 60 min after treatment. % Variation, group 2 t30 min t60 min treated area / untreated area 1 23.5 ⁇ 11.8 10.8 ⁇ 14.5 treated area / untreated area 2 19.7 ⁇ 8.2 -0.6 ⁇ 6.7
  • microcircuiation increased 30 min after the treatment (mean variation: +19.7 ⁇ 8.2), but 60 min after the treatment, no variation was observed in the microcirculation (mean variation: -0.6 ⁇ 6.7).
  • a preparation containing trimethylglycine diluted at a concentration of 4% (weight/volume) in water was effective against mechanical erythema (group 1) after normal application.
  • the effect was detected 60 min after the application.
  • the results show that the preparation is effective against skin irritation when the damage is relatively superficial.
  • cutting of the skin causes erythema and probably enhances penetration of the preparation, which in turn adds to the effect of the preparation.
  • Figs. 1A (group 1) and 1B (group 2) are diagrams drawn on the basis of the results.
  • Glyceryl monostearate S/E 10.0% Mineral oil 10.0% Vaseline 6.0% Tegiloxan 100 0.5% Lanolin 3.0% Cetyl alcohol 3.0% Glycerol 3.0% Citric acid 0.2% Potassium aluminium sulphate 0.1% Trimethylglycine 4.0% Water 60.2% Perfume q.s.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dental Preparations (AREA)
  • Materials For Medical Uses (AREA)

Claims (12)

  1. Nicht-therapeutische Verwendung von Trimethylglycin, wasserfrei oder als Monohydrat, in kosmetischen Zubereitungen zum Schutz der Haut vor mechanischer Reizung.
  2. Verwendung gemäß Anspruch 1,
    dadurch gekennzeichnet, dass
    das Trimethylglycin in einer Konzentration von 0,1 bis 20, vorzugsweise von 2 bis 10 und insbesondere von 2 bis 6 Gew.%, bezogen auf die Zubereitung, verwendet wird.
  3. Verwendung gemäß Anspruch 1 oder 2,
    dadurch gekennzeichnet, dass
    die kosmetische Zubereitung ein Haut-Pflegeprodukt, eine Zubereitung zur Rasur oder eine Zubereitung zur Enthaarung ist.
  4. Verwendung gemäß einem der Ansprüche 1 bis 3,
    dadurch gekennzeichnet, dass
    die kosmetische Zubereitung ein Fuß-Pflegeprodukt oder eine Handcreme ist.
  5. Verwendung gemäß einem der Ansprüche 1 bis 3,
    dadurch gekennzeichnet, dass
    die kosmetische Zubereitung ein Baby-Pflegeprodukt ist.
  6. Verwendung gemäß einem der Ansprüche 1 bis 3,
    dadurch gekennzeichnet, dass
    die kosmetische Zubereitung eine Nach-Rasur-Lotion oder ein Haut-Tonikum ist.
  7. Nicht-therapeutisches Verfahren zum Schutz der Haut vor mechanischer Reizung,
    dadurch gekennzeichnet, dass
    man auf die Haut eine kosmetische Zubereitung aufbringt, die Trimethylglycin, wasserfrei oder als Monohydrat, enthält.
  8. Verfahren gemäß Anspruch 7,
    dadurch gekennzeichnet, dass
    die kosmetische Zubereitung das Trimethylglycin in einer Konzentration von 0,1 bis 20, vorzugsweise von 2 bis 10 und insbesondere von 2 bis 6 Gew.%, bezogen auf die Zubereitung, in einer geeigneten herkömmlichen kosmetischen Grundlage enthält.
  9. Verfahren gemäß Anspruch 7 oder 8,
    dadurch gekennzeichnet, dass
    die kosmetische Zubereitung ein Haut-Pflegeprodukt oder eine Zubereitung zur Rasur oder zur Enthaarung ist.
  10. Verfahren gemäß einem der Ansprüche 7 bis 9,
    dadurch gekennzeichnet, dass
    die kosmetische Zubereitung ein Fuß-Pflegeprodukt oder eine Handcreme ist.
  11. Verfahren gemäß einem der Ansprüche 7 bis 9,
    dadurch gekennzeichnet, dass
    die kosmetische Zubereitung ein Baby-Pflegeprodukt ist.
  12. Verfahren gemäß einem der Ansprüche 7 bis 9,
    dadurch gekennzeichnet, dass
    die kosmetische Zubereitung eine Nach-Rasur-Lotion oder ein Haut-Tonikum ist.
EP97942061A 1996-09-26 1997-09-25 Zubereitung zum schutz der haut gegen mechanische reizung Expired - Lifetime EP0930870B1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FI963849A FI103711B (fi) 1996-09-26 1996-09-26 Trimetyyliglysiinin käyttö ihoa mekaaniselta ärsytykseltä suojaavana aineena
FI963849 1996-09-26
PCT/FI1997/000577 WO1998013021A1 (en) 1996-09-26 1997-09-25 Preparation protecting skin from mechanical irritation

Publications (2)

Publication Number Publication Date
EP0930870A1 EP0930870A1 (de) 1999-07-28
EP0930870B1 true EP0930870B1 (de) 2003-02-19

Family

ID=8546751

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97942061A Expired - Lifetime EP0930870B1 (de) 1996-09-26 1997-09-25 Zubereitung zum schutz der haut gegen mechanische reizung

Country Status (7)

Country Link
US (1) US6436385B2 (de)
EP (1) EP0930870B1 (de)
JP (1) JP2001500887A (de)
AT (1) ATE232718T1 (de)
DE (1) DE69719200T2 (de)
FI (1) FI103711B (de)
WO (1) WO1998013021A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8703212B2 (en) * 1999-09-03 2014-04-22 Viraj Shah, Varion Limited Base material for pharmaceutical and/or cosmetic cream (herbal composition for itchy or infected skin)
AU2176001A (en) * 1999-12-02 2001-06-12 Orion Corporation, Noiro Cosmetic composition
FI116826B (fi) * 2000-11-10 2006-03-15 Lumene Oy Siemenöljyä sisältävät kosmeettiset koostumukset
US7196022B2 (en) 2001-12-20 2007-03-27 Kimberly-Clark Worldwide, Inc. Products for controlling microbial generated odors
US7105691B2 (en) 2003-06-26 2006-09-12 Colgate-Palmolive Company Aluminum / zirconium / glycine antiperspirant actives stabilized with Betaine
JP2005029532A (ja) * 2003-07-09 2005-02-03 Asahi Kasei Chemicals Corp 皮膚洗浄料
US9675823B2 (en) * 2012-12-19 2017-06-13 Colgate-Palmolive Company Two component compositions containing zinc amino acid halide complexes and cysteine
US11147761B2 (en) * 2018-01-12 2021-10-19 Nicole Akmenkalns Topical supplement composition and method of use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69121405T2 (de) * 1990-06-05 1997-01-23 Cultor Oy Verfahren zur verminderung der reizenden eigenschaften von kosmetischen zusammensetzungen
JPH07309741A (ja) 1994-05-17 1995-11-28 Ajinomoto Co Inc 浴用剤組成物
JPH0820520A (ja) 1994-07-06 1996-01-23 Asahi Chem Ind Co Ltd 保湿力の高い皮膚外用剤
JP3577113B2 (ja) 1994-09-14 2004-10-13 小林製薬株式会社 皮膚外用剤

Also Published As

Publication number Publication date
EP0930870A1 (de) 1999-07-28
WO1998013021A1 (en) 1998-04-02
FI963849L (fi) 1998-03-27
US20020018788A1 (en) 2002-02-14
ATE232718T1 (de) 2003-03-15
FI103711B1 (fi) 1999-08-31
FI963849A0 (fi) 1996-09-26
DE69719200D1 (de) 2003-03-27
FI103711B (fi) 1999-08-31
US6436385B2 (en) 2002-08-20
DE69719200T2 (de) 2003-10-23
JP2001500887A (ja) 2001-01-23

Similar Documents

Publication Publication Date Title
DE69001730T2 (de) Pastenfoermige, waesserige pharmazeutische zusammensetzungen.
US4495079A (en) Facial skin cleanser capable of softening and removing sebum plaque
US4775530A (en) Method for treatment and prevention of pseudofolliculitis barbae
EP1005320B1 (de) Nicht-irritierende zusammensetzung zur behandlung des aknes und andere hautzustände
US4145413A (en) Artificial skin darkening composition and method of using the same
JP2001517607A (ja) ヘアースタイリング組成物
CN110638715B (zh) 一种男士洁面膏及其制备方法
EP1295593A1 (de) Hautreiniger mit einem Alterungsschutzmittel
EP0531387B1 (de) Verfahren zur verminderung der reizenden eigenschaften von kosmetischen zusammensetzungen
EP0930870B1 (de) Zubereitung zum schutz der haut gegen mechanische reizung
US5853709A (en) Shaving composition and method for preventing pseudofolliculitis barbae
US20030095991A1 (en) Treatment for skin
JPH09501665A (ja) ヒドロキシアルカノエート誘導体を含有する化粧品用組成物
WO2001001954A1 (en) Personal hygiene tablet composition
CN113318008B (zh) 一种沐浴组合物及其制备方法
EP1557161A1 (de) Methode zur Reinigung sensitiver Haut unter Verwendung eines Alkanolamins
JP2003012446A (ja) スベリヒユ科植物抽出物を含む刺激性が低減された組成物
KR19990077866A (ko) 외용 피부 치료 조성물
JPH0820521A (ja) 角化酵素活性促進剤及びこれを含有する化粧料
KR0153203B1 (ko) 피부의 보습 및 각질연화 조성물
JPH07149614A (ja) 養毛料
CN118975938A (zh) 一种含胶态硫温和控油除螨沐浴露及其制备方法
JP2001288042A (ja) 頭皮頭髪用組成物
JPS58125797A (ja) 皮膚刺戟を抑制した洗浄料
JPH0959141A (ja) 皮膚外用組成物

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19990326

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: DANISCO FINLAND OY

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: FINNFEEDS FINLAND OY

GRAG Despatch of communication of intention to grant

Free format text: ORIGINAL CODE: EPIDOS AGRA

17Q First examination report despatched

Effective date: 20020506

GRAG Despatch of communication of intention to grant

Free format text: ORIGINAL CODE: EPIDOS AGRA

GRAH Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOS IGRA

GRAH Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOS IGRA

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20030219

Ref country code: LI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20030219

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT;WARNING: LAPSES OF ITALIAN PATENTS WITH EFFECTIVE DATE BEFORE 2007 MAY HAVE OCCURRED AT ANY TIME BEFORE 2007. THE CORRECT EFFECTIVE DATE MAY BE DIFFERENT FROM THE ONE RECORDED.

Effective date: 20030219

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20030219

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20030219

Ref country code: CH

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20030219

Ref country code: BE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20030219

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20030219

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REF Corresponds to:

Ref document number: 69719200

Country of ref document: DE

Date of ref document: 20030327

Kind code of ref document: P

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20030519

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20030519

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20030519

NLV1 Nl: lapsed or annulled due to failure to fulfill the requirements of art. 29p and 29m of the patents act
PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20030828

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20030925

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20030925

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20030930

ET Fr: translation filed
PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20031120

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20160921

Year of fee payment: 20

Ref country code: DE

Payment date: 20160920

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20160816

Year of fee payment: 20

REG Reference to a national code

Ref country code: DE

Ref legal event code: R071

Ref document number: 69719200

Country of ref document: DE

REG Reference to a national code

Ref country code: GB

Ref legal event code: PE20

Expiry date: 20170924

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF EXPIRATION OF PROTECTION

Effective date: 20170924