EP0814849A1 - Magnetisch markierte chemoattraktanten zur verwendung als kontrastmitel während der nmr-bilderzeugung von lebenden geweben - Google Patents
Magnetisch markierte chemoattraktanten zur verwendung als kontrastmitel während der nmr-bilderzeugung von lebenden gewebenInfo
- Publication number
- EP0814849A1 EP0814849A1 EP96932764A EP96932764A EP0814849A1 EP 0814849 A1 EP0814849 A1 EP 0814849A1 EP 96932764 A EP96932764 A EP 96932764A EP 96932764 A EP96932764 A EP 96932764A EP 0814849 A1 EP0814849 A1 EP 0814849A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- mmol
- peptides
- water
- solution
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
- A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
- A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
- A61K49/1833—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule
- A61K49/1839—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule the small organic molecule being a lipid, a fatty acid having 8 or more carbon atoms in the main chain, or a phospholipid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
- A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
- A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
- A61K49/1866—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle the nanoparticle having a (super)(para)magnetic core coated or functionalised with a peptide, e.g. protein, polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1896—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes not provided for elsewhere, e.g. cells, viruses, ghosts, red blood cells, virus capsides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US566995P | 1995-10-19 | 1995-10-19 | |
US5669P | 1995-10-19 | ||
PCT/IB1996/001103 WO1997014443A1 (en) | 1995-10-19 | 1996-10-18 | Magnetically labeled chemoattractants as targeted contrast agents in the nmr imaging of living tissues |
Publications (1)
Publication Number | Publication Date |
---|---|
EP0814849A1 true EP0814849A1 (de) | 1998-01-07 |
Family
ID=21717087
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP96932764A Withdrawn EP0814849A1 (de) | 1995-10-19 | 1996-10-18 | Magnetisch markierte chemoattraktanten zur verwendung als kontrastmitel während der nmr-bilderzeugung von lebenden geweben |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0814849A1 (de) |
JP (1) | JPH10511701A (de) |
WO (1) | WO1997014443A1 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002500242A (ja) * | 1997-12-24 | 2002-01-08 | ヘンケル・コマンディットゲゼルシャフト・アウフ・アクチエン | 過酸素化合物の漂白効果を強化するためのデンドリマー配位子を有する遷移金属錯体の使用 |
US6872536B1 (en) * | 1998-11-10 | 2005-03-29 | Bracco Imaging S.P.A. | Chemotactic peptide antagonists for imaging sites of inflammation |
JP4511075B2 (ja) * | 2001-04-23 | 2010-07-28 | レンゴー株式会社 | 含硫ウレタン系デンドリマー及びその製造方法 |
ATE382632T1 (de) * | 2002-09-27 | 2008-01-15 | Nihon Mediphysics Co Ltd | An leukozyten bindende verbindung und diese verbindung im markierten zustand als wirkstoff enthaltende medizinische zusammensetzung |
WO2007031910A2 (en) | 2005-09-13 | 2007-03-22 | Philips Intellectual Property & Standards Gmbh | Multiple contrast agent injection for imaging |
KR20140144312A (ko) * | 2006-08-30 | 2014-12-18 | 지이 헬스케어 에이에스 | 동적 핵 분극화 방법 및 이러한 방법에서 사용되는 화합물 및 조성물 |
US8414926B1 (en) | 2006-09-12 | 2013-04-09 | University Of South Florida | Nanoparticles with covalently bound surfactant for drug delivery |
EP2906260B1 (de) | 2012-10-09 | 2019-06-26 | Case Western Reserve University | Stabförmige pflanzenvirusnanopartikel als kontrastmittelplattformen |
WO2014113203A1 (en) | 2013-01-17 | 2014-07-24 | Case Western Reserve University | Viral nanoparticle multimers |
WO2015123654A1 (en) | 2014-02-17 | 2015-08-20 | The Cleveland Clinic Foundation | Amine passivated nanoparticles for cancer treatment and imaging |
EP3487527A4 (de) | 2016-07-21 | 2020-03-11 | Case Western Reserve University | Pflanzenvirus- oder virusähnliche partikelkonstrukte |
WO2021195716A1 (en) * | 2020-04-02 | 2021-10-07 | Monash University | Antibiotic conjugates |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4554088A (en) * | 1983-05-12 | 1985-11-19 | Advanced Magnetics Inc. | Magnetic particles for use in separations |
US4827945A (en) * | 1986-07-03 | 1989-05-09 | Advanced Magnetics, Incorporated | Biologically degradable superparamagnetic materials for use in clinical applications |
NZ233601A (en) * | 1989-05-09 | 1997-06-24 | Gen Hospital Corp | N-terminal acylated peptides having an initial sequence met (or nle) -leu-phe and having a detectable label bound through dtpa or edta to a c-terminal lys or pu residue |
DE3919873A1 (de) * | 1989-06-19 | 1990-12-20 | Behringwerke Ag | Magnetische protein-konjugate, verfahren zu ihrer herstellung und ihre verwendung |
EP0565930A1 (de) * | 1992-03-27 | 1993-10-20 | Nihon Medi-Physics Co., Ltd. | Tetracyclododecan-Tetraessigsäurederivate und ihre Verwendung als diagnostische Mittel |
-
1996
- 1996-10-18 EP EP96932764A patent/EP0814849A1/de not_active Withdrawn
- 1996-10-18 JP JP9515662A patent/JPH10511701A/ja active Pending
- 1996-10-18 WO PCT/IB1996/001103 patent/WO1997014443A1/en not_active Application Discontinuation
Non-Patent Citations (1)
Title |
---|
See references of WO9714443A1 * |
Also Published As
Publication number | Publication date |
---|---|
JPH10511701A (ja) | 1998-11-10 |
WO1997014443A1 (en) | 1997-04-24 |
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Legal Events
Date | Code | Title | Description |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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17P | Request for examination filed |
Effective date: 19971024 |
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AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
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19U | Interruption of proceedings before grant |
Effective date: 19980903 |
|
19W | Proceedings resumed before grant after interruption of proceedings |
Effective date: 19991001 |
|
17Q | First examination report despatched |
Effective date: 20000623 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20010104 |