EP0623011B1 - Zerstäubungsvorrichtung von therapeutischen Substanzen - Google Patents

Zerstäubungsvorrichtung von therapeutischen Substanzen Download PDF

Info

Publication number
EP0623011B1
EP0623011B1 EP93901076A EP93901076A EP0623011B1 EP 0623011 B1 EP0623011 B1 EP 0623011B1 EP 93901076 A EP93901076 A EP 93901076A EP 93901076 A EP93901076 A EP 93901076A EP 0623011 B1 EP0623011 B1 EP 0623011B1
Authority
EP
European Patent Office
Prior art keywords
animal
nebulizer
seal
particles
nebulizers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP93901076A
Other languages
English (en)
French (fr)
Other versions
EP0623011A1 (de
Inventor
Pierre Lekeux
Luc Mestach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agritronics International SA
Original Assignee
Agritronics International SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agritronics International SA filed Critical Agritronics International SA
Publication of EP0623011A1 publication Critical patent/EP0623011A1/de
Application granted granted Critical
Publication of EP0623011B1 publication Critical patent/EP0623011B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • A61D7/04—Devices for anaesthetising animals by gases or vapours; Inhaling devices

Definitions

  • the invention relates to a new device for nebulizing therapeutic substances, intended for the treatment of infections and / or respiratory disorders.
  • aerosol therapy allows rapid obtaining, at the level of the deep respiratory tract, of a maximum concentration of therapeutic substances while avoiding the systemic effects of this substance.
  • the aerosol can be defined as a two-phase system consisting of a continuous gas phase (usually air) and a discontinuous phase (usually liquid) of individual particles.
  • the majority of aerosols are heterodispersed or polydispersed aerosols, the size of the particles of which is generally not uniform.
  • the size of the particles generated by this system conditions the penetration and deposition of these particles in the respiratory system. Depending on their size, the particles can reach different sites in the respiratory system.
  • DAMM Aerodynamic Diameter Massal Median Deposits in the respiratory system DAMM> 100 Impossible passage in the airways 100> DAMM ⁇ 10 Nasal cavities 10> DAMM ⁇ 5 Trachea, bronchi, bronchioles 5> DAMM ⁇ 1 Alveoli Stable particles - weak 1> DAMM ⁇ 0.1 deposit DAMM ⁇ 0.1 Large deposit
  • This table shows that the site at which the particles are deposited is deeper than the size of these particles is small. Furthermore, the filtration function performed by the nasal cavities is so marked that it is exerted on any particle with a diameter greater than 10 ⁇ m. Consequently, in an animal in oral respiration, this filtration function is partially destroyed.
  • endotracheal intubation and tracheostomy are techniques which, in human medicine, make it possible to avoid the filtration process carried out by the nasal cavities, but which cannot be easily applied to veterinary medicine (Brain et al., Aerosols in Medecine, Chapter 5, Moren F., Newhouse MT, Dolovich MB, Elsevier, 1985, 336).
  • the first two types of aerosolizers are known in human medicine, but unusable in rural veterinary medicine.
  • nebulizers a distinction is made between ultrasonic nebulizers and pneumatic nebulizers.
  • the ultrasonic nebulizer includes a piezoelectric transducer which vibrates at high frequency under the effect of an alternating electric field produced by an electronic oscillator. By successive contiguity, these vibrations are transmitted to the solution to be nebulized. When the vibration intensity is high enough, it will forms a column of liquid, from which a cloud of particles is emitted.
  • Pneumatic nebulizers such as the Hudson® type nebulizer
  • a capillary tube immerses in a liquid and the pearl drop at the top of the capillary is sprayed (Venturi action) by a jet of air or oxygen relaxing at high flow.
  • the diameter of the particles generated by the pneumatic nebulizer is inversely proportional to the gas flow. For most pneumatic nebulizers, a minimum flow of 6 l.min -1 is necessary to ensure a high quality / duration of treatment ratio.
  • the flow rate as well as the particle size may also depend on the speed at which the patient inhales.
  • these nebulizers are directly and individually connected to a source of compressed air and allow inhalation of the treating product in only one nostril of the animal at a time.
  • Patent application GB-A-211,838 describes a device for inhaling therapeutic substances for horses.
  • This device includes a completely hermetic mask placed on the nostrils of the animal and preventing it from breathing through the mouth.
  • An ultrasonic atomizer placed on the mask, projects therapeutic substance into the animal's nostrils at the rate of its breathing.
  • Such a device has the drawback, by preventing the animal from breathing through the mouth, greatly reducing its comfort and making the administration of therapeutic substances more difficult.
  • this device does not make it possible to adjust certain parameters (particle size, inhalation speed, etc.) adapted to the different types of infections or respiratory disorders to be treated.
  • Such a device is therefore unsuitable for treating animals suffering from serious disorders such as respiratory distress, requiring nebulization in the nostrils of the animal of particles of size less than 1 ⁇ m; or perform treatment by mouth, upper respiratory tract (particles larger than 10 ⁇ m).
  • US Pat. No. 2,843,119 describes a device intended for the administration of oxygen to an animal via a mask placed hermetically around the mouth and the nostrils thereof.
  • This device includes a nebulization system intended for the post-operative administration of therapeutic substances and connected via a flexible tube to the mask.
  • this nebulization system connected via a long pipe to the mask, does not allow the administration of therapeutic substances into the deep respiratory tract.
  • the invention aims to provide a simple device, quick to set up and inexpensive allowing optimal nebulization of therapeutic substance (s) directly in the nostrils and / or in the mouth of an animal to treat, while preserving the comfort thereof.
  • the purpose of the device according to the invention is to nebulize optimally at the level of the mouth and / or the nostrils of an animal one or more therapeutic substances in the form of particles whose average nasal aerodynamic diameter is between 100 and 0, 01 ⁇ m.
  • the object of the invention is to provide a device which does not hamper breathing through the mouth and / or the nostrils of the animal during its treatment.
  • the invention also aims to provide a device for using several nebulizers connected together to a single source of compressed air supply.
  • a complementary object of the invention consists in providing a device adaptable to any animal head which it is desired to treat.
  • the invention relates to a device for nebulizing therapeutic substance (s), comprising a facial mask connected by a pneumatic line to a source of compressed air such as a dry and transportable air compressor, and a nebulizing chamber. disposed in the mask, comprising at least one nebulizer connected to the pneumatic line; wherein the connection between the pneumatic line and the nebulizer (s) consists of a cover obstructing the nebulization chamber and comprising at least one end piece connected by a seal to the nebulizers, so that by closing the cover or the nebulization, each nebulizer is connected to a nozzle.
  • the nebulization chamber comprises at least two nebulizers.
  • the seal consists of a rubber membrane disposed between the nebulization chamber and its housing.
  • the seal consists of a plastic or rubber teat fixed on the end of the end piece, preferably by screwing.
  • the seal is held on the nozzle and / or on the lower end of the nebulizer by a fixing O-ring.
  • the facial mask includes a deformation for housing an interchangeable lining adapted to the head of the animal and the attachment straps.
  • the pneumatic line of the device according to the invention comprises a flow regulator disposed between the mask and the source of compressed air.
  • This facial mask also has one or more openings for breathing through the nostrils and / or the mouth and / or for the saliva flow from the animal.
  • the therapeutic substances are nebulized by the device according to the invention in the form of particles whose median aerodynamic mass diameter is between 100 and 0.01 ⁇ m.
  • the device according to the invention shown in FIG. 1 comprises a facial mask 1 connected by a pneumatic line 2 to an air compressor 3.
  • facial mask is meant a mask completely covering the mouth and nostrils of the animal to be treated.
  • a nebulization chamber 4 comprising two nebulizers 5 connected to a pneumatic line 2, is arranged in the facial mask 1.
  • the arrangement of the spray chamber 4 in the facial mask 1 advantageously solves the problems caused by the movements of the animal when the spray chamber is connected to the transportable dry air compressor (not lubricated).
  • the device according to the invention allows optimization of the therapeutic effects of the nebulized substance since it is dispersed directly in the nostrils and / or in the mouth of the treated animal and the size of the particles generated by these nebulizers as well as the flow rate of these undergo small variations whatever the movements of the animal.
  • This device thus allows the administration of effective and constant doses to the treated animal.
  • These Hudson® type nebulizers 5 may include deflectors whose presence and position make it possible to increase the fraction of optimal particles in the respiratory tract.
  • the use of two nebulizers is particularly advantageous because it allows the simultaneous administration of different therapeutic substances.
  • the two nebulizers 5 are connected to the pneumatic line 2 and to the air compressor 3 by a hollow cover 6 obstructing the nebulization chamber 4.
  • the cover 6 has two end pieces 7 connected by a seal 8 to the two nebulizers 5 so that by closing the cover 6 or the nebulization chamber 4 opening according to a hinge 23, each nebulizer 5 is connected to an end piece 7.
  • the seal according to the invention consists, for example, of a rubber membrane arranged as shown in FIG. 2, between the nebulization chamber 4 and its cover 6.
  • An alternative embodiment of the invention shown in Figure 3 includes a plastic or rubber nipple 10 fixed on the end of the nozzle 7, so that when the cover 6 is closed on the chamber nebulization 4, each nebulizer 5 pierces with its lower end 12 the upper part 13 of the nipple 10 and thus seals the compressed air duct.
  • the seal 8 is advantageously held on the endpiece by a fixing O-ring 11.
  • the seal is fixed to the nozzle 7 by screwing and the lower end 12 of the nebulizer 11 is held in the seal 8 by an O-ring of fixing 11.
  • Such an arrangement advantageously allows the administration of therapeutic substance (s) by minimizing the risks of contamination of the environment, in particular by not unnecessarily and detrimentally dispersing the therapeutic agents on healthy animals.
  • the facial mask 1 made of reinforced polyester, PVC or any other plastic material, is designed to conform to the shape of the head of the animal to be treated.
  • this mask comprises, facing its opening 14, a deformation 15 intended for housing an interchangeable lining 20 adapted to the head of the animal.
  • This closed cell foam filling increases the comfort of the animal and prevents any contamination of the external environment by the nebulized product.
  • the facial mask 1 is quickly placed on the animal thanks to a system of straps 16 attached using carabiners 17 to a chain placed at the neck of the animal.
  • the device according to the invention also includes other elements which contribute to the comfort of the animal and / or which make it possible to facilitate its treatment.
  • the facial mask can in particular be equipped with openings (21, 22) for breathing through the nostrils and / or the mouth and / or for the flow of the animal's saliva and a window (not shown) allowing to check whether all the liquid phase contained in the nebulizer has been nebulized in the nostrils of the animal.
  • the pneumatic line 2 also comprises disposed between the air compressor 3 and the facial mask 1, a flow regulator 18 as well as a pressure gauge 19, making it possible to control the pressure and the air flow supplying the facial mask.
  • a flow regulator 18 as well as a pressure gauge 19, making it possible to control the pressure and the air flow supplying the facial mask.
  • the appended figures represent the particle size distribution ( ⁇ m) and their speed (m / s) following the nebulization of physiological water at a pressure of 6 bars (12 liters per minute [ Figures 5 and 6]) and 2 bars (4.5 liters per minute [ Figures 7 and 8]).
  • the device according to the invention therefore allows to adapt according to the type of animal and / or the type of infection or respiratory disorders to be treated, the size of the nebulized particles as well as the rate of aspiration of the therapeutic substances by the animal.
  • this device also makes it possible to treat serious disorders such as pulmonary distress which requires providing suitable delivery rates (50 l / minute) in the best conditions of comfort.
  • the air compressor can also be equipped with a heating resistor which advantageously makes it possible to use the device according to the invention in the open air and at low temperatures.
  • the device of the invention can be advantageously used in the treatment of certain respiratory ailments such as chronic obstructive bronchial diseases of the horse or Acute Respiratory Distress Syndrome of cattle.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Preparation (AREA)

Claims (10)

  1. Vorrichtung zur Zerstäubung einer therapeutischen Substanz (von therapeutischen Substanzen), die eine Gesichtsmaske (1) umfaßt, die über eine pneumatische Leitung (2) mit einer Druckluftquelle (3) verbunden ist, dadurch gekennzeichnet, daß eine Zerstäubungskammer (4) in der Maske (1) angeordnet ist und mindestens einen mit der pneumatischen Leitung verbundenen Zerstäuber (5) umfaßt, die Verbindung zwischen der pneumatischen Leitung (2) und dem Zerstäuber oder den Zerstäubern (5) aus einem Deckel (6) besteht, der die Zerstäubungskammer (4) verschließt und mindestens ein Ansatzstück (7) umfaßt, das über eine Dichtung (8) mit dem Zerstäuber (den Zerstäubern) (5) so verbunden ist, daß beim Schließen des Deckels (6) oder der Zerstäubungskammer (4) jeder Zerstäuber (5) mit einem Ansatzstück (7) verbunden wird.
  2. Vorrichtung gemäß Anspruch 1, dadurch gekennzeichnet, daß die Dichtung (8) aus einer Gummimembran (9) besteht, die zwischen der Zerstäubungskammer (4) und ihrem Gehäuse (6) angeordnet ist.
  3. Vorrichtung gemäß Anspruch 1, dadurch gekennzeichnet, daß die Dichtung (8) aus einer Tülle (10) besteht, die auf dem Ende des Ansatzstücks (7) vorzugsweise durch Aufschrauben befestigt ist.
  4. Vorrichtung gemäß irgendeinem der vorhergehenden Ansprüche, dadurch gekennzeichnet, daß die Dichtung (8) auf dem Ansatzstück (7) und/oder auf dem unteren Ende (12) des Zerstäubers durch eine O-Ring-Dichtung (11) festgehalten wird.
  5. Vorrichtung gemäß irgendeinem der vorhergehenden Ansprüche, dadurch gekennzeichnet, daß die Gesichtsmaske (1) eine Formänderung (15) für den Sitz einer an den Kopf des Tieres angepaßten, auswechselbaren Dichtungsmanschette (20), und Befestigungsgurte (16) umfaßt.
  6. Vorrichtung gemäß irgendeinem der vorhergehenden Ansprüche, dadurch gekennzeichnet, daß die pneumatische Leitung einen zwischen der Gesichtsmaske (1) und der Druckluftquelle (3) angeordneten Strömungsratenregler (18) umfaßt.
  7. Vorrichtung gemäß irgendeinem der vorhergehenden Ansprüche, dadurch gekennzeichnet, daß die Gesichtsmaske (1) eine oder mehrere Öffnungen (20, 21) für die Atmung durch die Nasenlöcher und/oder das Maul, und/oder für den Abfluß des Speichels des Tieres umfaßt.
  8. Vorrichtung gemäß irgendeinem der vorhergehenden Ansprüche, dadurch gekennzeichnet, daß die Zerstäubungskammer (4) mindestens zwei Zerstäuber (5) umfaßt.
  9. Vorrichtung gemäß irgendeinem der vorhergehenden Ansprüche, dadurch gekennzeichnet, daß die therapeutischen Substanzen in Form von Partikeln zerstäubt werden, deren mittlerer aerodynamischer Massendurchmesser zwischen 100 und 0,01 µm liegt.
  10. Vorrichtung gemäß irgendeinem der vorhergehenden Ansprüche, dadurch gekennzeichnet, daß die Druckluftquelle ein transportierbarer Trockenluft-Kompressor ist.
EP93901076A 1992-01-21 1993-01-21 Zerstäubungsvorrichtung von therapeutischen Substanzen Expired - Lifetime EP0623011B1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
BE9200057A BE1006103A3 (fr) 1992-01-21 1992-01-21 Dispositif de nebulisation de substance(s) therapeutiques.
BE9200057 1992-01-21
PCT/BE1993/000004 WO1993013730A1 (fr) 1992-01-21 1993-01-21 Dispositif de nebulisation de substances therapeutiques

Publications (2)

Publication Number Publication Date
EP0623011A1 EP0623011A1 (de) 1994-11-09
EP0623011B1 true EP0623011B1 (de) 1997-07-23

Family

ID=3886102

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93901076A Expired - Lifetime EP0623011B1 (de) 1992-01-21 1993-01-21 Zerstäubungsvorrichtung von therapeutischen Substanzen

Country Status (5)

Country Link
EP (1) EP0623011B1 (de)
BE (1) BE1006103A3 (de)
DE (1) DE69312473T2 (de)
DK (1) DK0623011T3 (de)
WO (1) WO1993013730A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7077126B2 (en) 2003-05-19 2006-07-18 Pari Gmbh Spezialisten Fur Effektive Inhalation Inhalation therapy mask and device for animals

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69430196T2 (de) * 1993-06-29 2002-10-31 Ponwell Entpr Ltd Spender
DE10260636A1 (de) * 2002-12-19 2004-07-08 Nagel, Jochen Inhalationsvorrichtung für Tiere, insbesondere Pferde zur speziellen Anwendung am bewegten Tier
DE102017008459A1 (de) * 2017-06-20 2018-12-20 Stefan Marx Inhalator für Pferde
FR3104381B1 (fr) 2019-12-16 2021-11-05 Ab7 Innovation Dispositif piézoélectrique pour la diffusion ciblée de matière active chez l’animal
FR3104382B1 (fr) 2019-12-16 2022-07-22 Ab7 Innovation Dispositif piézoélectrique pour la diffusion ciblée de matière active

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2843119A (en) * 1955-09-14 1958-07-15 Max E Glasser Respirators for animals
CH653244A5 (de) * 1981-12-22 1985-12-31 Georg Feierabend Inhalationsgeraet fuer tiere.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7077126B2 (en) 2003-05-19 2006-07-18 Pari Gmbh Spezialisten Fur Effektive Inhalation Inhalation therapy mask and device for animals

Also Published As

Publication number Publication date
BE1006103A3 (fr) 1994-05-10
DE69312473D1 (de) 1997-09-04
EP0623011A1 (de) 1994-11-09
WO1993013730A1 (fr) 1993-07-22
DK0623011T3 (da) 1998-02-16
DE69312473T2 (de) 1998-02-05

Similar Documents

Publication Publication Date Title
US8336545B2 (en) Methods and systems for operating an aerosol generator
AU2006227168B2 (en) Methods and systems for operating an aerosol generator
US7201167B2 (en) Method and composition for the treatment of lung surfactant deficiency or dysfunction
Pillow et al. Innovation in surfactant therapy II: surfactant administration by aerosolization
JP5021616B2 (ja) 計量供給及び乾式噴霧のための装置
CA2561403C (en) Aerosol delivery apparatus for pressure assisted breathing
CA2610334C (en) Nebulizer mask for delivery of aerosolized and nebulized medications
JP6640832B2 (ja) 薬剤送達用陽圧吸入装置
EP1674122B1 (de) Vorrichtung zum Verabreichen eines medizinischen Aerosols
BRPI1016186B1 (pt) "dispositivo (1) para dosar e tratar por aerossol material em forma de aerossol e sistema para dosar e nebulizar a seco material nebulizável
TW201127427A (en) Method for nasal irrigation and drug delivery
AU2006244478A1 (en) Ultrasonic aerosol generator
MX2008002560A (es) Pieza en "t" con valvulas y pieza en "t" con sello propio.
EP0623011B1 (de) Zerstäubungsvorrichtung von therapeutischen Substanzen
CN113768910A (zh) 包含富马酸福莫特罗吸入溶液的药物组件及其用途
JP2013539784A (ja) 嚢胞性線維症の吸入デヌホソルでの治療方法
CZ287114B6 (en) Therapeutic preparation in the form of aerosol and use of gas mixture
WO2023099842A1 (fr) Système de nébulisation par masque facial
WO2006108557A1 (en) Dry nebulizer

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19940811

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): DE DK FR GB IT

GRAG Despatch of communication of intention to grant

Free format text: ORIGINAL CODE: EPIDOS AGRA

17Q First examination report despatched

Effective date: 19960913

GRAH Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOS IGRA

GRAH Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOS IGRA

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): DE DK FR GB IT

REF Corresponds to:

Ref document number: 69312473

Country of ref document: DE

Date of ref document: 19970904

GBT Gb: translation of ep patent filed (gb section 77(6)(a)/1977)

Effective date: 19970909

ITF It: translation for a ep patent filed

Owner name: STUDIO TORTA S.R.L.

REG Reference to a national code

Ref country code: DK

Ref legal event code: T3

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed
PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DK

Payment date: 20010123

Year of fee payment: 9

REG Reference to a national code

Ref country code: GB

Ref legal event code: IF02

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20020121

REG Reference to a national code

Ref country code: DK

Ref legal event code: EBP

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20030213

Year of fee payment: 11

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20040121

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20040121

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES;WARNING: LAPSES OF ITALIAN PATENTS WITH EFFECTIVE DATE BEFORE 2007 MAY HAVE OCCURRED AT ANY TIME BEFORE 2007. THE CORRECT EFFECTIVE DATE MAY BE DIFFERENT FROM THE ONE RECORDED.

Effective date: 20050121

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20080115

Year of fee payment: 16

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20080131

Year of fee payment: 16

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20090801

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

Effective date: 20091030

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20090202