Classifications

• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
  • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
  • C07D223/16—Benzazepines; Hydrogenated benzazepines
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
  • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P9/00—Drugs for disorders of the cardiovascular system
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P9/00—Drugs for disorders of the cardiovascular system
  • A61P9/08—Vasodilators for multiple indications
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
  • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
  • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
  • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
  • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
  • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
  • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
  • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
  • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
  • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
  • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
  • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
  • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
  • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
  • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
  • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
  • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
  • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Definitions

• the present invention relates to a vasopressin antagonist and oxytocin antagonist containing a benzoheterocyclic compound as an active ingredient.
• benzoheterocyclic compounds being used as the active ingredients in the vasopressin antagonists and oxytocin antagonists which are represented by the general formula (1) containing novel compounds.
• EP-A-0382185 A2 Publication Date: August 15, 1990
• WO 91/05549 Publication Date: May 2, 1991
• EP-A-0470514A1 Publication Date: February 12, 1992
• EP-A-0514667A1 discloses benzoheterocyclic compounds, and is known as the junior patent application of the present invention.
• R1 is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkanoyloxy group, an amino-lower alkoxy group which may have the substituents selected from the group consisting of lower alkyl group and lower alkanoyl group, a carboxy-substituted lower alkoxy group, a lower alkoxycarbonyl-substituted lower alkoxy group, or an aminocarbonyl-lower alkoxy group which may have lower alkyl groups as the substituents;
• R4 is a hydrogen atom, a group of the formula: (wherein R6 and R7 are the same or different, and are each a hydrogen atom, a lower alkyl group, a lower alkenyl group or a benzoyl group having halogen atoms as the substituents on the phenyl ring),
• each one of benzoheterocyclic compounds represented by the above-mentioned general formula (1) possess excellent vasopressin antagonistic activity and oxytocinantagonistic activity.
• vasopressin antagonists possess various pharmacological activities, for example, vasodilating activity, anti-hypertension, activity for inhibiting release of hepatic sugar, activity for inhibiting proliferation of mesangial cells, water diuretic activity, activity for inhibiting agglutination of platelets and antiemetic activity, thus they are useful as vasodilators, hypotensives, water diuretics and platelets agglutination inhibitors.
• the oxytocin antagonists according to the present invention possess activity for inhibiting contraction of the uterus smooth muscle, activity for inhibiting secretion of milk, activity for inhibiting synthesis and release of prostaglandins, vasodilation, thus, they are effective for prophylaxis and treatments of oxytocin related diseases, particularly early birth, prevention of birth before cesarean section, dysmenorrhea and the like.
• benzoheterocyclic compounds according to the present invention have the features in that they have less side-effects, while they sustain the pharmacological activities for long period of time.
• the lower alkoxy group there may be exemplified straight or branched alkoxy groups having 1 to 6 carbon atoms, for example, methoxy, ethoxy, propoxy, isopropoxy, butoxy, tert -butoxy, pentyloxy and hexyloxy groups, etc.
• the lower alkyl group there may be exemplified straight or branched alkyl groups having 1 to 6 carbon atoms, for example, methyl, ethyl, propyl, isoporpyl, butyl, tert -butyl, pentyl and hexyl groups, etc.
• halogen atom examples include fluorine, chlorine, bromine and iodine atoms.
• alkenyl group there may be exemplified straight or branched alkenyl groups having 2 to 6 carbon atoms, for example, vinyl, allyl, 2-butenyl, 3-butenyl, 1-methylallyl, 2-pentenyl and 2-hexenyl groups, etc.
• alkenyloxy group there may be exemplified straight or branched alkenyloxy groups having 2 to 6 carbon atoms, for example, vinyloxy, allyloxy, 2-butenyloxy, 3-butenyloxy, 1-methylallyloxy, 2-pentenyloxy and 2-hexenyloxy groups, etc.
• the lower alkylene group there may be exemplified straight chain or branched chain alkylene groups having 1 to 6 carbon atoms, for example, methylene, ethylene, trimethylene, 2-methyltrimethylene, 2,2-dimethyltrimethylene, 1-methyltrimethylene, methylmethylene, ethylmethylene, tetramethylene, pentamethylene and hexamethylene groups, etc.
• the lower alkanoyloxy group there may be exemplified straight chain or branched chain alkanoyloxy groups having 1 to 6 carbon atoms, for example, formyloxy, acetyloxy, propionyloxy, butyryloxy, isobutyryloxy, pentanoyloxy, tert -butylcarbonyloxy and hexanoyloxy groups, etc.
• hydroxy-substituted lower alkyl group there may be exemplified straight chain or branched chain alkyl groups having 1 to 6 carbon atoms which contains 1 to 3 hydroxy groups as substituent(s), for example, hydroxymethyl, 2-hydroxyethyl, 1-hydroxyethyl, 3-hydroxypropyl, 2,3-dihydroxyethyl, 4-hydroxybutyl, 3,4-dihydroxybutyl, 1,1-dimethyl-2-hydroxyethyl, 5-hydroxypentyl, 6-hydroxyhexyl, 2-methyl-3-hydroxypropyl and 2,3,4-trihydroxybutyl groups, etc.
• substituent(s) for example, hydroxymethyl, 2-hydroxyethyl, 1-hydroxyethyl, 3-hydroxypropyl, 2,3-dihydroxyethyl, 4-hydroxybutyl, 3,4-dihydroxybutyl, 1,1-dimethyl-2-hydroxyethyl, 5-hydroxypentyl, 6-hydroxyhexyl, 2-methyl-3-hydroxypropy
• aminocarbonyl-lower alkoxy group having a lowr alkyl group as a substituent(s) means straight chain or branched chain alkoxy groups having 1 to 6 carbon atoms which contains as substituent(s) one or two straight chain or branched chain alkyl groups having 1 to 6 carbon atoms, for example, methylaminocarbonylmethoxy, 1-ethylaminocarbonylethoxy, 2-propylaminocarbonylethoxy, 3-isopropylaminocarbonylpropoxy, 4-butylaminocarbonylbutoxy, 5-pentylaminocarbonylpentyloxy, 6-hexylaminocarbonylhexyloxy, dimethylaminocarbonylmethoxy, 3-diethylaminocarbonylpropoxy, diethylaminocarbonylmethoxy, (N-ethyl-N-propylamino)carbonylmethoxy and 2-(N-methyl-N-hexylamino
• the alkoxycarbonyl-substituted lower alkyl group there may be exemplified straight chain or branched chain alkoxycarbonylalkyl groups having 1 to 6 carbon atoms in which the alkoxycarbonyl moiety is a straight chain or branched chain alkoxycarbonyl group having 1 to 6 carbon atoms; specific examples are methoxycarbonylmethyl, 3-methoxycarbonylpropyl, ethoxycarbonylmethyl, 3-ethoxycarbonylpropyl, 4-ethoxycarbonylbutyl, 5-isopropoxycarbonylpentyl, 6-propoxycarbonylhexyl, 1,1-dimethyl-2-butoxycarbonylethyl, 2-methyl-3- tert -butoxycarbonylpropyl, 2-pentyloxycarbonylethyl and hexyloxycarbonylmethyl groups, etc.
• carboxy-substituted lower alkyl group there may be exemplified carboxyalkyl groups in which the alkyl moiety is a straight chain or branched chain alkyl group having 1 to 6 carbon atoms; for example, carboxymethyl, 2-carboxyethyl, 1-carboxyethyl, 3-carboxypropyl, 4-carboxybutyl, 5-carboxypentyl, 6-carboxyhexyl, 1,1-dimethyl-2-carboxyethyl and 2-methyl3-carboxypropyl groups, etc.
• phenyl-lower alkanoylamino group which contains as 1 to 3 substituent, on the phenyl ring, selected from the group consisting of a halogen atom, a lower alkoxy group, a lower alkyl group and nitro group
• phenylalkanoylamino groups which contain as 1 to 3 substituent(s), on the phenyl ring, selected from the group consisting of a straight chain or branched chain alkyl group having 1 to 6 carbon atoms, a straight chain or branched chain alkoxy group having 1 to 6 carbon atoms, a halogen atom and nitro group; for exmaple, 2-methoxyphenylacetylamino, 3-methoxyphenylacetylamino, 4-methoxyphenylacetylamino, 3-(2-ethoxyphenyl)propionylamino, 2-(3-ethoxyphenyl)propionylamino, 4-(
• lower alkoxycarbonyl-substituted lower alkylidene group there may be exemplified straight chain or branched chain alkylidene groups having 1 to 6 carbon atoms which are substituted with a straight chain or branched chain alkoxycarbonyl group having 1 to 6 carbon atoms; for example, ethoxycarbonylmethylidene, 2-methoxycarbonylethylidene, 3-isopropoxycarbonylpropylidene, 2-propoxycarbonylisopropylidene, 4-butoxycarbonylbutylidene, 5-pentyloxycarbonylpentylidene and 6-hexyloxycarbonylhexylidene groups, etc.
• pyrrolidinyl piperidinyl, piperazinyl, morpholino
• pyrrolyl imidazolyl, 1,2,4-triazolyl, 1,2,4-triazolyl, pyrazolyl, 2-pyrrolinyl, 2-imidazolinyl, imidazolidinyl, 2-pyrazolinyl, pyazolidinyl, 1,2-dihydropyridyl and 1,2,3,4-tetrahydropyridyl groups, etc.
• heterocyclic groups described above which are further substituted with a lower alkyl group there may be exemplified heterocyclic groups as described above which are substituted with 1 to 3 straight chain or branched chain alkyl groups having 1 to 6 carbon atoms; for example, 4-methylpiperazinyl, 3,4-dimethylpiperazinyl, 3-ethylpyrrolidinyl, 2-propylpyrrolidinyl, 3,4,5-trimethylpiperidinyl, 4-butylpiperidinyl, 3-pentylmorpholino, 4-hexylpiperazinyl, 2-methylimidazolyl, 3-methyl-1,2,4-triazolyl, 3-methylpyrrolyl, 3-methylpyrazolyl and 4-methyl-1,2-dihydropyridyl groups, etc.
• amino acid residue there may be exemplified alanyl-, ⁇ -alanyl, arginyl, cystationyl, cystyl, glycyl, histidyl, homoseryl, isoleucyl, lanthionyl, leucyl lysyl, methionyl, norleucyl, norvalyl, ornithyl, prolyl, sarcosyl, seryl, threonyl, tyronyl, tyrosyl, valyl, ⁇ -aspartyl, ⁇ -aspartyl, aspartoyl, asparaginyl, ⁇ -glutamyl, ⁇ -glutamyl, glutaminyl, cysteinyl, homocysteinyl, tryptophyl and dimethylglycyl groups, etc.
• amino-lower alkoxy group which may optionally contain as the substituents selected from the group consisting of a lower alkyl group and a lower alkanoyl group
• straight chain or branched chain alkoxy groups having 1 to 6 carbon atoms which may contain 1 to 2 substituents selected from the group consisting of a straight chain or branched chain alkyl group having 1 to 6 carbon atoms and a straight chain or branched chain alkanoyl group having 1 to 6 carbon atoms
• the alkoxycarbonyl-substituted lower alkoxy group there may be exemplified straight chain or branched chain alkoxycarbonylalkoxy groups having 1 to 6 carbon atoms in which the alkoxycarbonyl moiety is a straight chain or branched chain alkoxycarbonyl group having 1 to 6 carbon atoms; for example, methoxycarbonylmethoxy, 3-methoxycarbonylpropoxy, ethoxycarbonylmethoxy, 3-ethoxycarbonylpropoxy, 4-ethoxycarbonylbutoxy, 5-isopropoxycarbonylpentyloxy, 6-propoxycarbonylhexyloxy, 1,1-dimethyl-2-butoxycarbonylethoxy, 2-methyl-3- tert -butoxycarbonylpropoxy, 2-pentyloxycarbonylethoxy and hexyloxycarbonylmethoxy groups, etc.
• carboxy-substituted lower alkoxy group there may be exemplified carboxyalkoxy groups in which the alkoxy moiety is a straight chain or branched chain alkoxy group having 1 to 6 carbon atoms; for exmaple, carboxymethoxy, 2-carboxyethoxy, 1-carboxyethoxy, 3-carboxypropoxy, 4-carboxybutoxy, 5-carboxypentyloxy, 6-carboxyhexyloxy, 1,1-dimethyl-2-carboxyethoxy and 2-methyl-3-carboxypropoxy groups, etc.
• piperidinyl group which may optionally contain a phenyl-lower alkyl group on the piperidine ring
• piperidinyl groups which may optionally contain phenylalkyl groups on the piperidine ring and in which the alkyl moiety is a straight chain or branched chain alkyl group having 1 to 6 carbon atoms
• piperidinyl 1-benzyl-4-piperidinyl, 1-(2-phenylethyl)-3-piperidinyl, 1-(1-phenylethyl)-2-piperidinyl, 1-(3-phenylpropyl)-4-piperidinyl, 1-(4-phenylbutyl)-4-piperidinyl, 1-(5-phenylpentyl)-4-piperidinyl, 1-(6-phenylhexyl)-4-piperidinyl, 1-(1,1-dimethyl-2-phenylethyl)-3
• carbamoyl-substituted lower alkyl group there may be exemplified carbamoyl-substituted alkyl groups in which the alkyl moiety is a straight chain or branched chain alkyl group having 1 to 6 carbon atoms; for example, carbamoylmethyl, 2-carbamoylethyl, 1-carbamoylethyl, 3-carbamoylpropyl, 4-carbamoylbutyl, 5-carbamoylpentyl, 6-carbamoylhexyl, 1,1-dimethyl-2-carbamoylethyl and 2-methyl-3-carbamoylpropyl groups, etc.
• the lower alkanoyl group there may be exemplified straight chain or branched chain alkanoyl groups having 1 to 6 carbon atoms, for example, formyl, acetyl, propionyl, butyryl, isobutyryl, pentanoyl, tert -butylcarbonyl and hexanoyl groups, etc.
• amino group which may optionally contain as a substituent selected from the group consisting of a lower alkyl group and a lower alkanoyl group
• amino groups which may optionally contain 1 to 2 substituents selected from the group consisting of a straight chain or branched chain alkyl group having 1 to 6 carbon atoms and a straight chain or branched chain alkanoyl group having 1 to 6 carbon atoms; for exmaple, amino, methylamino, ethylamino, propylamino, isopropylamino, butylamino, tert -butylamino, pentylamino, hexylamino, dimethylamino, diethylamino, dipropylamino, dibutylamino, dipentylamino, dihexylamino, N-methyl-N-ethylamino, N-ethyl-N-propylamino, N-methyl-
• the alkoxycarbonyl-substituted lower alkyl group there may be exemplified straight chain or branched chain alkoxycarbonylalkyl groups having 1 to 6 carbon atoms in which the alkoxycarbonyl moiety is a straight chain or branched chain alkoxycarbonyl group having 1 to 6 carbon atoms; for exmaple, methoxycarbonylmethyl, 3-methoxycarbonylpropyl, ethoxycarbonylmethyl, 3-ethoxycarbonylpropyl, 4-ethoxycarbonylbutyl, 5-isopropxycarbonylpentyl, 6-propoxycarbonylhexyl, 1,1-dimethyl-2-butoxycarbonylethyl, 2-methyl-3- tert -butoxycarbonylpropyl, 2-pentyloxycarbonylethyl and hexyloxycarbonylmethyl groups etc.
• carboxy-substituted lower alkyl group there may be exemplified carboxyalkyl groups in which the alkyl moiety is a straight chain or branched chain alkyl group having 1 to 6 carbon atoms; for exmaple, carboxymethyl, 2-carboxy-ethyl, 1-carboxyethyl, 3-carboxypropyl, 4-carboxybutyl, 5-carboxypentyl, 6-carboxyhexyl, 1,1-dimethyl-2-carboxyethyl and 2-methyl-3-carboxypropyl groups, etc.
• piperidinyl group which may optionally contain a lower alkyl group on the piperidine ring
• piperidinyl groups which may optionally contain a straight chain or branched chain alkyl group having 1 to 6 carbon atoms; for example, piperidinyl, 1-methyl-4-piperidinyl, 1-ethyl-3-piperidinyl, 1-propyl-2-piperidinyl, 1-butyl-4-piperidinyl, 1-pentyl-4-piperidinyl and 1-hexyl-4-piperidinyl groups, etc.
• pyrrolidinylcarbonyl-lower alkoxy group which contains a lower alkoxycarbonyl group on the pyrrolidine ring
• pyrrolidinylcarbonylalkoxy groups which have a straight chain or branched chain alkoxycarbonyl group of 1 to 6 carbon atoms on the pyrrolidine ring and in which the alkoxy moiety is a straight chain or branched chain alkoxy group having 1 to 6 carbon atoms; for exmaple, 2-methoxycarbonyl-1-pyrrolidinylmethoxy, 1-(2-ethoxycarbonyl-1-pyrrolidinylcarbonyl)ethoxy, 2-(3-propoxycarbonyl-1-pyrrolidinylcarbonyl)ethoxy, 3-(2-butoxycarbonyl-1-pyrrolidinylcarbonyl)propoxy, 4-(3-pentyloxycarbonyl-1-pyrrolidinylcarbonyl)butoxy, 5-(
• the lower alkoxycarbonyl group there may be exemplified straight chain or branched chain alkoxycarbonyl groups having 1 to 6 carbon atoms, for example, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, butoxycarbonyl, tert -butoxycarbonyl, pentyloxycarbonyl and hexyloxycarbonyl groups, etc.
• alkanoyloxy groups which are substituted with a straight chain or branched chain alkoxy group having 1 to 6 carbon atoms and in which the alkanoyloxy moiety is a straight chain or branched chain alkanoyloxy group having 2 to 6 carbon atoms; for example, methoxyacetyloxy, 3-ethoxypropionyloxy, 2-propoxypropionyloxy, 4-butoxybutyryloxy, 2,2-dimethyl-3-pentyloxypropionyloxy, 5-hexyloxypentanoyloxy and 6-methoxyhexanoyloxy groups, etc.
• amino-substituted lower alkylidene group which may optionally contain lower alkyl groups as substituents
• amino-substituted alkylidene groups having 1 to 6 carbon atoms which may optionally contain 1 to 2 straight chain or branched chain alkyl groups having 1 to 6 carbon atoms as substituents; for example, aminomethylidene, 2-ethylaminoethylidene, 3-propylaminopropylidene, 2-isopropylaminopropylidene, 4-butylaminobutylidene, 5-pentylaminopentylidene, 6-hexylaminohexylidene, 3-dimethylaminopropylidene, 3-(N-methyl-N-butylamino)-propylidene, 2-dipentylaminoethylidene and 4-(N-methyl-N-hexylamino)butyliden
• cyano-substituted lower alkyl group there may be exemplified cyanoalkyl groups in which the alkyl moiety is a straight chain or branched chain alkyl group having 1 to 6 carbon atoms; for example, cyanomethyl, 2-cyanoethy, 1-cyanoethyl, 3-cyanopropyl, 4-cyanobutyl, 5-cyanopentyl, 6-cyanohexyl, 1,1-dimethyl-2-cyanoethyl and 2-methyl-3-cyanopropyl groups, etc.
• phthalimido-substituted lower alkyl group there may be exemplified phthalimido-substituted alkyl groups in which the alkyl moiety is a straight chain or branched chain alkyl group having 1 to 6 carbon atoms, for example, phthalimidomethyl, 2-phthalimidoethyl, 1-phthalimidoethyl, 3-phthalimidopropyl, 4-phthalimidobutyl, 5-phthalimidopentyl, 6-phthalimidohexyl, 1,1-dimethyl-2-phthalimidoethyl and 2-methyl-3-phthalimidopropyl groups, etc.
• the lower alkoxy group having a phenylsulfonyloxy group which may optionally contain a lower alkyl group as substituent(s) on the phenyl ring or having hydroxy group there may be exemplified straight chain or branched chain alkoxy groups having 1 to 6 carbon atoms and having a phenylsulfonyloxy group which may optionally contain 1 to 3 straight chain or branched chain alkyl groups having 1 to 6 carbon atoms as substituent(s) on the phenyl ring or having 1 to 3 hydroxy groups; for example, (2-methylphenylsulfonyloxy)methoxy, 2-(4-methylphenylsulfonyloxy)ethoxy, 3-(phenylsulfonyloxy)propoxy, 4-(3-methylphenylsulfonyloxy)butoxy, 5-(2-ethylphenylsulfonyloxy)pentyloxy, 6-(3-propyl
• phenylsulfonyloxy-substituted lower alkyl group which may optionally contain a lower alkyl group as substituent(s) on the phenyl ring
• phenylsulfonyloxy-substituted straight chain or branched chain alkyl groups having 1 to 6 carbon atoms which may optionally contain 1 to 3 straight chain or branched chain alkyl groups having 1 to 6 carbon atoms as substituent(s) on the phenyl ring; for example, (2-methylphenylsulfonyloxy)methyl, 2-(4-methylphenylsulfonyloxy)ethoxy, 3-(phenylsulfonyloxy)propyl, 4-(3-methylphenylsulfonyloxy)butyl, 5-(2-ethylphenylsulfonyloxy)pentyl, 6-(3-propylphenylsulfonyloxy)
• the 5- or 6-membered saturated heterocyclic group formed by combining R29 and R30 or R 23A and R 24A together with the adjacent nitrogen atom being bonded thereto, together with or without other nitrogen atom or oxygen atom there may be exemplified, pyrrolidinyl, piperidinyl, piperazinyl and morpholino groups, etc.
• the 5- to 7-membered saturated heterocyclic group formed by combining R11 and R12 together with the adjacent nitrogen atom being bonded thereto, together with or without other nitrogen atom or oxygen atom there may be exemplified, pyrrolidinyl, piperidinyl, piperazinyl, morpholino and homopiperazinyl groups, etc.
• heterocyclic groups described above which are substituted with a lower alkyl group, a lower alkoxycarbonyl group, an amino group which may optionally contain as substituent(s) selected from the group consisting of a lower alkyl group and a lower alkanoyl group, a lower alkoxycarbonyl-substituted lower alkyl group, a phenyl group which may optionally contain a halogen atom on the phenyl ring, a cyano-substituted lower alkyl group, a lower alkenyl group, an oxiranyl-substituted lower alkyl group, a carbamoyl-substituted lower alkyl group, a lower alkyl group having 1 to 2 substituents selected from the group consisting of hydroxy group and an amino group which may optionally contain a lower alkyl group, or a pyrrolidinylcarbonyl lower alkyl group, there may be exemplified heterocyclic
• the 5- to 10-membered monocyclic or bicyclic saturated or unsaturated heterocyclic group formed by combining R27 and R28 together with the adjacent nitrogen atom being bonded thereto, together with or without other nitrogen atom or oxygen atom there may be exemplified pyrrolidinyl, piperidinyl, piperazinyl, morpholino, imidazolyl, isoindolyl and 1,2,3,4,5,6,7-octahydroisoindolyl groups, etc.
• cyano-substituted lower alkylidene group there may be exemplified straight chain or branched chain alkylidene groups having 1 to 6 carbon atoms, for example, cyanomethylidene, 2-cyanoethylidene, 3-cyanopropylidene, 2-cyanopropylidene, 4-cyanobutylidene, 5-cyanopentylidene and 6-cyanohexylidene groups, etc.
• the lower alkanoylamino group there may be exemplified amino groups containing a straight chain or branched chain alkanoyl group having 1 to 6 carbon atoms, for example, acetylamino, propionylamino, isopropionylamino, butyrylamino, pentanoylamino, hexanoylamino and formylamino groups, etc.
• imidazolyl-substituted lower alkyl group there may be exemplified imidazolyl-substituted alkyl groups in which the alkyl moiety is a straight chain or branched chain alkyl group having 1 to 6 carbon atoms; for example, (1-imidazolyl)methyl, 2-(1-imidazolyl)ethyl, 1-(2-imidazolyl)ethyl, 3-(4-imidazolyl)propyl, 4-(5-imidazolyl)butyl, 5-(1-imidazolyl)pentyl, 6-(2-imidazolyl)hexyl, 1,1-dimethyl-2-(1-imidazolyl)ethyl and 2-methyl-3-(1-imidazlyl)propyl groups, etc.
• (1-imidazolyl)methyl 2-(1-imidazolyl)ethyl, 1-(2-imidazolyl)ethyl, 3-(
• 1,2,4-triazolyl-substituted lower alkoxy group there may be exemplified 1,2,4-triazolyl-substituted alkoxy groups in which the alkoxy moiety is a straight chain or branched chain alkoxy group having 1 to 6 carbon atoms; for example, (1-1,2,4-triazolyl)methoxy, 2-(1-1,2,4-triazolyl)ethoxy, 1-(1-2,4-triazolyl)ethoxy, 3-(3-1,2,4-triazolyl)propoxy, 4-(5-1,2,4-triazolyl)butoxy, 5-(1-1,2,4-triazolyl)pentyloxy, 6-(3-1,2,4-triazolyl)hexyloxy, 1,1-dimethyl-2-(5-1,2,4-triazolyl)ethoxy and 2-methyl-3-(1-1,2,4-triazolyl)propoxy groups, etc.
• 1,2,4-triazolyl-substituted lower alkyl group there may be exemplified 1,2,4-triazolyl-substituted alkyl groups in which the alkyl moiety is a straight chain or branched chain alkyl group having 1 to 6 carbon atoms; for exmaple, (1-1,2,4-triazolyl)methyl, 2-(1-1,2,4-triazolyl)ethyl, 1-(1-1,2,4-triazolyl)ethyl, 3-(3-1,2,4-triazolyl)propyl, 4-(5-1,2,4-triazolyl)butyl, 5-(1-1,2,4-triazolyl)pentyl, 6-(3-1,2,4,-triazolyl)hexyl, 1,1-dimethyl-2-(5-1,2,4-triazolyl)ethyl and 2-methyl-3-(1-1,2,4-triazolyl)propyl groups, etc.
• phenyl group which may optionally contain a halogen atom on the phenyl group
• phenyl groups which may optionally contain 1 to 3 halogen atoms as the substituents on the phenyl ring
• oxiranyl-substituted lower alkyl group there may be exemplified oxiranyl-substituted alkyl groups in which the alkyl moiety is a straight chain or branched chain alkyl group having 1 to 6 carbon atoms; for example, oxiranylmethyl, 2-oxiranylethyl, 1-oxiranylethyl, 3-oxiranylpropyl, 4-oxiranylbutyl, 5-oxiranylpentyl, 6-oxiranylhexyl, 1,1-dimethyl-2-oxiranylethyl and 2-methyl-3-oxiranylpropyl groups, etc.
• alkyl groups having 1 to 2 substituents selected from the group consisting of hydroxy group and an amino group which may optionaly contain a lower alkyl group there may be exemplified straight chain or branched chain alkyl groups having 1 to 6 carbon atoms and having 1 to 2 substituents selected from the group consisting of hydroxy group and an amino group which may optionally contain as substituent(s) 1 to 2 straight chain or branched chain alkyl groups having 1 to 6 carbon atoms; for examples, alkyl groups include hydroxymethyl, 2-hydroxyethyl, 1-hydroxyethyl, 3-hydroxypropyl, 2,3-dihydroxyethyl, 4-hydroxybutyl, 3,4-dihydrooxybutyl, 1,1-dimethyl-2-hydroxyethyl, 5,6-dihydroxyhexyl, 5-hydroxypentyl, 6-hydroxyhexyl, 2-methyl-3-hydroxypropyl, aminomethyl, 1-aminoethyl, 2-aminoethyl,
• imidazolyl-substituted lower alkoxy group there may be exemplified imidazolyl-substituted alkoxy groups in which the alkoxy moiety is a straight chain or branched chain alkoxy group having 1 to 6 carbon atoms; for example, (1-imidazolyl)methoxy, 2-(1-imidazolyl)ethoxy, 1-(2-imidazolyl)ethoxy, 3-(4-imidazolyl)propoxy, 4-(5-imidazolyl)butoxy, 5-(1-imidazolyl)pentyloxy, 6-(2-imidazolyl)hexyloxy, 1,1-dimethyl-2-(1-imidazolyl)ethoxy and 2-methyl-3-(1-imidazolyl)propoxy groups, etc.
• (1-imidazolyl)methoxy 2-(1-imidazolyl)ethoxy, 1-(2-imidazolyl)ethoxy, 3-(4-imi
• piperidinyl-lower alkoxy group having a lower alkanoylamino group on the piperidine ring there may be exemplified piperidinylalkoxy groups which contain an amino group having a straight chain or branched chain alkanoyl group of 1 to 6 carbon atoms on the piperidine ring in which the alkoxy moiety is a straight chain or branched chain alkanoyl group having 1 to 6 carbon atoms; examples include 3-(4-acetylamino-1-piperidinyl)propoxy, 2-(3-acetylamino-1-piperidinyl)ethoxy, (4-acetylamino-1-piperidinyl)methoxy, 1-(2-propionylamino-1-piperidinyl)ethoxy, 4-(4-butyrylamino-1-piperidinyl)butoxy, 5-(3-pentanoylamino-1-piperidinyl)pentyloxy, 6-
• ureido-substituted lower alkoxy group which may optionally contain a lower alkyl group
• straight chain or branched chain alkoxy groups having 1 to 6 carbon atoms which may optionally contain as substituent(s) 1 to 2 straight chain or branched chain alkyl groups having 1 to 6 carbon atoms; for example, ureidomethoxy, 2-ureidoethoxy, 1-ureidoethoxy, 3-ureidopropoxy, 4-ureidobutoxy, 5-ureidopentyloxy, 6-ureidohexyloxy, 1,1-dimethyl-2-ureidoethoxy, 2-methyl-3-ureidopropoxy, N'-methylureidomethoxy, 1-(N'-ethylureido)ethoxy, 2-(N'-propylureido)ethoxy, 3-(N'-isopropylureido)propoxy, 4-(N'--
• the alkoxycarbonyl-substituted lower alkoxy group there may be exemplified straight chain or branched chain alkoxycarbonylalkoxy groups in which the alkoxycarbonyl moiety is a straight chain or branched chain alkoxycarbonyl group having 1 to 6 carbon atoms; for example, methoxycarbonylmethoxy, 3-methoxycarbonylpropoxy, ethoxycarbonylmethoxy, 3-ethoxycarbonylpropoxy, 4-ethoxycarbonylbutoxy, 5-isopropoxycarbonylpentyloxy, 6-propoxycarbonylhexyloxy, 1,1-dimethyl-2-butoxycarbonylethoxy, 2-methyl-3- tert -butoxycarbonylpropoxy, 2-pentyloxycarbonylethoxy and hexyloxycarbonylmethoxy groups, etc.
• carboxy-substituted lower alkoxy there may be exemplified carboxyalkoxy groups in which the alkoxy moiety is a straight chain or branched chain alkoxy group having 1 to 6 carbon atoms; for example, carboxymethoxy, 2-carboxyethoxy, 1-carboxyethoxy, 3-carboxypropoxy, 4-carboxybutoxy, 5-carboxypentyloxy, 6-carboxyhexyloxy, 1,1-dimethyl-2-carboxyethoxy and 2-methyl-3-carboxypropoxy groups, etc.
• heterocyclic groups described above which are substituted with a lower alkyl group there may be exemplified those heterocyclic groups described above which are substituted with 1 to 3 straight chain or branched chain alkyl groups having 1 to 6 carbon atoms; examples include 4-methylpiperazinyl, 4-ethylpiperazinyl, 3,4-dimethylpiperazinyl, 3-ethylpyrrolidinyl, 2-propylpyrrolidinyl, 3,4,5-trimethylpiperidinyl, 4-butylpiperidinyl, 3-pentylmorpholino, 4-hexylpiperazinyl and 4-methylhomopiperazinyl groups, etc.
• heterocyclic groups described above which are substituted with a lower alkyl group there may be exemplified those heterocyclic groups described above which are substituted with 1 to 3 straight chain or branched chain alkyl groups having 1 to 6 carbon atoms; examples include 4-methylpiperazinyl, 3,4-dimethylpiperazinyl, 3-ethylpyrrolidinyl, 2-propylpyrrolidinyl, 1-methylpyrrolidinyl, 3,4,5-trimethylpiperidinyl, 4-butylpiperidinyl, 3-pentylmorpholino and 4-hexylpiperazinyl groups, etc.
• pyrazinyl-substituted lower alkyl group which may optionally contain a lower alkyl group as substituent(s) on the pyrazine ring
• pyrazinylalkyl groups which may optionally contain as a substituent(s) 1 to 3 straight chain or branched chain alkyl groups having 1 to 6 carbon atoms and in which the alkyl moety is a straight chain or branched chain alkyl group having 1 to 6 carbon atoms; for example, (2-pyrazinyl)methyl, 2-(3-pyrazinyl)ethyl, 1-(2-pyrazinyl)ethyl, 3-(2-pyrazinyl)propyl, 4-(3-pyrazinyl)butyl, 5-(2-pyrazinyl)pentyl, 6-(3-pyrazinyl)hexyl, 1,1-dimethyl-2-(2-pyrazinyl)ethyl, 2-
• aminothiocarbonyl group which may optionally contain a lower alkyl group as substituent(s)
• aminothiocarbonyl groups which may optionally contain as substituent(s) 1 to 2 straight chain or branched chain alkyl groups having 1 to 6 carbon atoms; for example, aminothiocarbonyl, methylaminothiocarbonyl, ethylaminothiocarbonyl, propylaminothiocarbonyl, isopropylaminothiocarbonyl, butylaminothiocarbonyl, tert -butylaminothiocarbonyl, pentylaminothiocarbonyl, hexylaminothiocarbonyl, dimethylaminothiocarbonyl, diethylaminothiocarbonyl, dipropylaminothiocarbonyl, dibutylaminothiocarbonyl, dipentylaminothiocarbonyl, dihexylaminothiothio
• aminocarbonyl group which may optionally contain as substituent(s) lower alkyl groups
• aminocarbonyl groups which may optionally contain as a substituent(s) one or two straight chain or branched chain alkyl groups having 1 to 6 carbon atoms; for example, aminocarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, isopropylaminocarbonyl, butylaminocarbonyl, tert -butylaminocarbonyl, pentylaminocarbonyl, hexylaminocarbonyl, dimethylaminocarbonyl, diethylaminocarbonyl, dipropylaminocarbonyl, dibutylaminocarbonyl, dipentylaminocarbonyl, dihexylaminocarbonyl, N-methyl-N-ethylaminocarbonyl, N-ethyl-N-propylamin
• imidazolylthio-substituted lower alkoxy group there may be exemplified imidazolylthio-substituted alkoxy groups in which the alkoxy moiety is a straight chain or branched chain alkoxy group having 1 to 6 carbon atoms; for exmaple, (2-imidazolyl)thiomethoxy, 2-(2-imidazolyl)thioethoxy, 1-(2-imidazolyl)thioethoxy, 3-(4-imidazolyl)thiopropoxy, 4-(5-imidazolyl)thiobutoxy, 5-(4-imidazolyl)thiopentyloxy, 6-(2-imidazolyl)thiohexyloxy, 1,1-dimethyl-2-(2-imidazolyl)thioethoxy and 2-methyl-3-(5-imidazolyl)thiopropoxy groups, etc.
• imidazolylsulfinyl-substituted lower alkoxy group there may be exemplified imidazlylsulfonyl-substituted alkoxy groups in which the alkoxy moiety is a straight chain or branched chain alkoxy group having 1 to 6 carbon atoms; for example, (2-imidazolyl)sulfinylmethoxy, 2-(2-imidazolyl)sulfinylethoxy, 1-(2-imidazolyl)sulfinylethoxy, 3-(4-imidazolyl)sulfinylpropoxy, 4-(5-imidazolyl)sulfinylbutoxy, 5-(4-imidazolyl)sulfinylpentyloxy, 6-(2-imidazolyl)sulfinylhexyloxy, 1,1-dimethyl-2-(2-imidazolyl)sulfinylethoxy and 2-methyl-3-(
• imidazolylsulfonyl-substituted lower alkoxy group there may be exemplified imidazolylsulfonyl-substituted alkoxy groups in which the alkoxy moiety is a straight chain or branched chain alkoxy group having 1 to 6 carbon atoms; for example, (2-imidazolyl)sulfonylmethoxy, 2-(2-imidazolyl)sulfonylethoxy, 1-(2-imidazolyl)sulfonylethoxy, 3-(4-imidazolyl)sulfonylpropoxy, 4-(5-imidazolyl)sulfonylbutoxy, 5-(4-imidazolyl)sulfonylpentyloxy, 6-(2-imidazolyl)sulfonylhexyloxy, 1,1-dimethyl-2-(2-imidazolyl)sulfonylethoxy and 2-methyl-3-(5
• pyrrolidinyl-substituted lower alkyl group there may be exemplified pyrrolidinylalkyl groups which may optionally contain as substituent(s) 1 to 3 straight chain or branched chain alkyl groups and in which the alkyl moiety is a straight chain or branched chain alkyl group having 1 to 6 carbon atoms; for example, (2-pyrrolidinyl)methyl, 2-(2-pyrrolidinyl)ethyl, 1-(3-pyrrolidinyl)ethyl, 3-(2-pyrrolidinyl)propyl, 4-(3-pyrrolidinyl)butyl, 5-(2-pyrrolidinyl)pentyl, 6-(3-pyrrolidinyl)hexyl, 1,1-dimethyl-2-(2-pyrrolidinyl)ethyl, 2-methyl-3-(3-pyrrolidinyl)propyl, (5-ethyl-2-pyrrolidin
• the compounds of the present invention can be produced by various processes.
• R1, R2, R3, R4, R5 and the bond between the 4- and 5-position carbons of the benzoazepine skeleton are the same as defined above.
• the process shown by the reaction formula 1 is a process in which a benzoheterocyclic compound of the general formula (2) is reacted with a carboxylic acid of the general formula (3) according to an ordinary amide-bond-formation reaction.
• the amide-bond-formation reaction the known conditions for amide-bond-formation reaction can be applied easily.
• the basic compound is a compound conventionally used in the Schotten-Baumann reaction and includes, for example, organic bases such as triethylamine, trimethylamine, pyridine, dimethylaniline, N-methylmorpholine, 1,5-diazabicyclo[4.3.0]nonene-5 (DBN), 1,8-diazabicyclo[5.4.0]undecene-7 (DBU), 1,4-diazabicyclo[2.2.2]octane (DABCO) and the like, and inorganic bases such as potassium carbonate, sodium carbonate, potassium hydrogencarbonate, sodium hydrogencarbonate and the like.
• organic bases such as triethylamine, trimethylamine, pyridine, dimethylaniline, N-methylmorpholine, 1,5-diazabicyclo[4.3.0]nonene-5 (DBN), 1,8-diazabicyclo[5.4.0]undecene-7 (DBU), 1,4-diazabicyclo[2.2.2]octane (
• the reaction is conducted generally at about -20°C to 100°C, preferably at about 0-50°C, and the reaction time is about 5 minutes to 10 hours, preferably about 5 minutes to 2 hours.
• the reaction of the resulting mixed acid anhydride with an amine (2) is conducted generally at about -20°C to 150°C, preferably at about 10-50°C, and the reaction time is about 5 minutes to 10 hours, preferably about 5 minutes to 5 hours.
• the mixed acid anhydride process (a) is conducted generally in a solvent.
• the alkylhalocarboxylic acid used in the mixed acid anhydride process (a) includes, for example, methyl chloroformate, methyl bromoformate, ethyl chloroformate, ethyl bromoformate and isobutyl chloroformate.
• the proportions of the carboxylic acid (3), the alkylhalocarboxylic acid and the amine (2) used in the process are generally equal moles. However, the carboxylic acid (3) and the alkylhalocarboxylic acid may be used each in an amount of about 1-1.5 moles per mole of the amine (2).
• the proportions of the amine (2) and the carboxylic acid halide used are not particularly restricted and can be appropriately selected from a wide range, but the carboxylic acid halide is used in an amount of generally at least about 1 mole, preferably about 1-5 moles per mole of the amine (2).
• the reaction is conducted generally at about -20°C to 180°C, preferably at about 0-150°C and is complete generally in about 5 minutes to 30 hours.
• the amide-bond-formation reaction shown by the reaction formula 1 can also be carried by a process which comprises reacting a carboxylic acid (3) with an amine (2) in the presence of a phosphorus compound as condensating agent.
• the phosphorus compound includes triphenylphosphine, diphenylphosphinyl chloride, phenyl N-phenylphosphoramide chloridate, diethyl chlorophosphate, diethyl cyanophosphate, diphenyl phosphoric azide, bis(2-oxo-3-oxazolidinyl)phosphinic chloride, etc.
• R14 is a group represented by the following formula (R13 and m are the same as defined above), a phenyl-lower alkanoyl group having, on the phenyl ring, 1-3 substituents selected from the group consisting of halogen atoms, lower alkoxy groups, lower alkyl groups and a nitro group, or a group represented by the following formula.
• the reaction of the compound (2a) with the compound (4) can be conducted under the same conditions as in the reaction of the reaction formula 1 between the compound (2) and the compound (3).
• R1, R2, R3, R6 and R7 are the same as defined above.
• the reaction for converting a compound (1c) into a compound (1d) can be conducted by a reduction reaction.
• the reduction can be preferably conducted using a hydride as a reducing agent.
• the hydride as reducing agent includes, for example, lithium aluminum hydride, lithium boron hydride, sodium boron hydride and diborane.
• the amount of the hydride used is at least 1 mole, preferably 1-15 moles per mole of the raw material.
• This reduction reaction is conducted generally using an appropriate solvent such as water, lower alcohol (e.g. methanol, ethanol or isopropanol), ether (e.g.
• tetrahydrofuran, diethyl ether, diisopropyl ether or diglyme) or mixture thereof generally at about -60°C to 150°C, preferably at -30°C to 100°C for about 10 minutes to 15 hours.
• an anhydrous solvent such as tetrahydrofuran, diethyl ether, diisopropyl ether or diglyme.
• the reduction for converting a compound (1c) into a compound (1e) is conducted in the absence of any solvent or in the presence of an appropriate solvent, in the presence or absence of a dehydrating agent.
• the solvent includes, for example, alcohols such as methanol, ethanol, isopropanol and the like; aromatic hydrocarbons such as benzene, toluene, xylene and the like; halogenated hydrocarbons such as dichloromethane, dichloroethane, chloroform, carbon tetrachloride and the like; aprotic polar solvents such as dimethylformamide, dimethylacetamide, N-methylpyrrolidone and the like; and mixtures thereof.
• the solvent includes, for example, water; alcohols such as methanol, ethanol, isopropanol and the like; hydrocarbons such as hexane, cyclohexane and the like; ethers such as diethylene glycol dimethyl ether, dioxane, tetrahydrofuran, diethyl ether and the like; esters such as ethyl acetate, methyl acetate and the like; aprotic polar solvents such as dimethylformamide and the like; and mixtures thereof.
• R1, R2, R3, R5 R6 and the bond between the 4- and 5-position carbons of the benzoazepine skeleton are the same as defined above.
• R 7a is a lower alkyl group or a lower alkenyl group.
• R15 and R16 are each a hydrogen atom or a lower alkyl group.
• X is a halogen atom.
• R 7b is a benzoyl group having halogen substituent(s) on the phenyl ring.
• reaction of the compound (1f) with the compound (6) is conducted generally in an appropriate inactive solvent in the presence or absence of a basic compound.
• the inactive solvent includes, for example, aromatic hydrocarbons such as benzene, toluene, xylene and the like; ethers such as tetrahydrofuran, dioxane, diethylene glycol dimethyl ether and the like; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride and the like; lower alcohols such as methanol, ethanol, isopropanol, butanol, tert -butanol and the like; acetic acid; ethyl acetate; acetone; acetonitrile; pyridine; dimethyl sulfoxide; dimethylformamide; hexamethylphosphoric triamide; and mixtures thereof.
• aromatic hydrocarbons such as benzene, toluene, xylene and the like
• ethers such as tetrahydrofuran, dioxane, diethylene glycol dimethyl ether and the like
• the basic compound includes, for example, carbonates such as sodium carbonate, potassium carbonate, sodium hydrogencarbonate, potassium hydrogencarbonate and the like; metal hydroxides such as sodium hydroxide, potassium hydroxide and the like; sodium hydride; potassium; sodium; sodium amide; metal alcoholates such as sodium methylate, sodium ethylate and the like; and organic bases such as pyridine, N-ethyldiisopropylamine, dimethylaminopyridine, triethylamine, 1,5-diazabicyclo-[4.3.0]nonene-5 (DBN), 1,8-diazabicyclo[5.4.0]undecene-7 (DBU), 1,4-diazabicyclo[2.2.2]octane (DABCO) and the like.
• carbonates such as sodium carbonate, potassium carbonate, sodium hydrogencarbonate, potassium hydrogencarbonate and the like
• metal hydroxides such as sodium hydroxide, potassium hydroxide and the like
• sodium hydride potassium
• the proportions of the compound (1f) and the compound (6) are not particularly restricted and can be appropriately selected from a wide range, but the compound (6) is used in an amount of preferably at least about 1 mole, more preferably about 1-10 moles per mole of the compound (1f).
• the reaction is conducted generally at about 0-200°C, preferably at about 0-170°C and is complete generally in about 30 minutes to 75 hours.
• an alkali metal halide e.g. sodium iodide or potassium iodide
• the reaction of the compound (1f) with the compound (7) is conducted in the absence of any solvent or in the presence of an appropriate solvent in the presence of a reducing agent.
• the solvent can be exemplified by water; alcohols such as methanol, ethanol, isopropanol and the like; acetonitrile; formic acid; acetic acid; ethers such as dioxane, diethyl ether, diglyme, tetrahydrofuran and the like; aromatic hydrocarbons such as benzene, toluene, xylene and the like; and mixtures thereof.
• the reducing agent can be exemplified by formic acid; alkali metal salts of fatty acids, such as sodium formate and the like; hydride reducing agents such as sodium borohydride, sodium cyanoborohydride, lithium aluminum hydride and the like; and catalytic reducing agents such as palladium black, palladium-carbon, platinum oxide, platinum black, Raney nickel and the like.
• the appropriate reaction temperature is generally about room temperature to 200°C, preferably about 50-150°C, and the reaction is complete in about 1-10 hours.
• the amount of formic acid used is preferably a large excess to the compound (1f).
• the appropriate reaction temperature is generally about -30°C to 100°, preferably about 0-70°C, and the reaction is complete in about 30 minutes to 12 hours.
• the appropriate amount of the reducing agent used is generally about 1-20 moles, preferably about 1-6 moles per mole of the compound (1f).
• an ether e.g. diethyl ether, dioxane, tetrahydrofuran or diglyme
• an aromatic hydrocarbon e.g. benzene, toluene or xylene
• reaction of the compound (1f) with the compound (30) can be conducted under the same conditions as in the reaction of the compound (2) with the compound (3) in the reaction formula-1.
• the appropriate amount of the compound (7) used is generally at least equimolar, preferably equimolar to a large excess to the compound (1f).
• R1, R2, R3, X, R5 and the bond between the 4- and 5-position carbons of the benzoazepine skeleton are the same as defined above.
• R18 is a lower alkanoyloxy group having halogen substituent(s), or a lower alkoxy-substituted lower alkanoyloxy group.
• R19 is a lower alkenyloxy group, a group -O-CO-A-NR8R9 (A, R8 and R9 are the same as defined above), a group -OACONR23R24 (A, R23 and R24 are the same as defined above), a pyrrolidinylcarbonyl-lower alkoxy group having lower alkoxycarbonyl group(s) on the pyrrolidine ring, a group -OANR27R28 (A, R27 and R28 are the same as defined above), a phenylsulfonyloxy group having lower alkyl substituent(s) on the phenyl ring, a hydroxyl group-containing lower alkoxy group, a 1,2,4-triazolyl-substituted lower alkoxy group, a 1,2,3,4-tetrazolyl-substituted lower alkoxy group, a 1,2,3,5-tetrazolyl-substituted lower alkoxy group,
• the reaction for converting the compound (1k) into a compound (1l) is conducted under the same conditions as in the reduction reaction in the reaction formula 3 for converting the compound (1c) into a compound (1e).
• a metal halide e.g. nickel chloride
• the reaction for converting the compound (1l) into a compound (1m) can be carried out in an appropriate solvent or in the absence of any solvent in the presence of an acid or a basic compound.
• the solvent includes, for example, water; lower alcohols such as methanol, ethanol, isopropanol and the like; ketones such as acetone, methyl ethyl ketone and the like; ethers such as dioxane, tetrahydrofuran, ethylene glycol dimethyl ether and the like; fatty acids such as acetic acid, formic acid and the like; and mixtures thereof.
• the acid includes, for example, mineral acids such as hydrochloric acid, sulfuric acid, hydrobromic acid and the like; and organic acids such as formic acid, acetic acid, aromatic sulfonic acids and the like.
• the basic compound includes, for example, metal carbonates such as sodium carbonate, potassium carbonate and the like; and metal hydroxides such as sodium hydroxide, potassium hydroxide, calcium hydroxide and the like.
• the reaction favorably proceeds generally at about room temperature to 200°C, preferably at about room temperature to 150°C, and is complete generally in about 10 minutes to 25 hours.
• R1, R2, R3, R5, R11, R12, A and the bond between the 4- and 5-position carbons of the benzoazepine skeleton are the same as defined above.
• R22 is a carboxy-substituted lower alkyl group.
• reaction of the compound (1n) with the compound (12) can be conducted under the same conditions as in the reaction of the compound (2) with the compound (3) in the reaction formula 1.
• R1, R2, R3, R5, R10 and the bond between the 4- and 5-position carbons of the benzoazepine skeleton are the same as defined above.
• the reaction of the compound (2) with the compound (14) can be conducted under the same conditions as in the reaction of the compound (2) with the compound (3) in the reaction formula-3.
• the solvent includes, for example, water; alcohols such as methanol, ethanol, isopropanol and the like; hydrocarbons such as hexane, cyclohexane and the like; ethers such as dioxane, tetrahydrofuran, diethyl ether, diethylene glycol dimethyl ether and the like; esters such as ethyl acetate, methyl acetate and the like; aprotic polar solvents such as N,N-dimethylformamide and the like; and mixtures thereof.
• alcohols such as methanol, ethanol, isopropanol and the like
• hydrocarbons such as hexane, cyclohexane and the like
• ethers such as dioxane, tetrahydrofuran, diethyl ether, diethylene glycol dimethyl ether and the like
• esters such as ethyl acetate, methyl acetate and the like
• the catalytic reduction catalyst includes, for example, palladium, palladium black, palladium-carbon, platinum, platinum oxide, copper chromite and Raney nickel.
• the appropriate amount of the catalyst used is generally about 0.02-1 time the amount of the starting material.
• the appropriate reaction temperature is generally about -20°C to 150°C, preferably about 0-100°C, the appropriate hydrogen pressure used is generally 1-10 atm.
• the reaction is complete generally in about 0.5-10 hours.
• An acid such as hydrochloric acid or the like may be used in the reaction.
• a mixture as a reducing agent there is used, as the reducing agent, a mixture between iron, zinc, tin or stannous chloride and a mineral acid (e.g. hydrochloric acid or sulfuric acid), or a mixture between iron, ferrous sulfate, zinc or tin and an alkali metal hydroxide (e.g. sodium hydroxide), a sulfide (e.g. ammonium sulfide), ammonia water or an ammonium salt (ammonium chloride).
• the inert solvent can be exemplified by water, acetic acid, methanol, ethanol and dioxane.
• the conditions for the reduction reaction can be appropriately selected depending upon the reducing agent used.
• the reaction is preferably conducted at about 0-80°C for about 0.5-10 hours.
• the reducing agent is used in an amount of at least 1 mole, generally 1-5 moles per mole of the raw material compound.
• the solvent includes, for example, water; lower alcohols such as methanol, ethanol, isopropyl alcohol and the like; ethers such as dioxane, tetrahydrofuran and the like; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride and the like; polar solvents such as acetonitrile and the like; and mixtures thereof.
• lower alcohols such as methanol, ethanol, isopropyl alcohol and the like
• ethers such as dioxane, tetrahydrofuran and the like
• halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride and the like
• polar solvents such as acetonitrile and the like; and mixtures thereof.
• reaction of the compound (1r) with the compound (16) is conducted under the same conditions as in the reaction of the compound (1p) with the compound (13) in the reaction formula 8.
• R37 is a lower alkoxy group having a phenylsulfonyloxy group which may have lower alkyl substituent(s) on the phenyl ring.
• R38 is a group -OANR27R28 (A, R27 and R28 are the same as defined above).
• the reaction of the compound (1h) with the compound (19) is conducted under the same conditions as in the reaction of the compound (1f) with the compound (6) in the reaction formula 4.
• the reaction for converting the compound (20) into a compound (1w) is conducted under the same conditions as in the reaction for converting the compound (1c) into a compound (1d) in the reaction formula 3.
• the reaction of the compound (1w) with the compound (17) is conducted under the same conditions as in the reaction of the compound (1f) with the compound (6) in the reaction formula 4.
• the reaction of the compound (1x) with the compound (21) is conducted also under the same conditions as in the reaction of the compound (1f) with the compound (6) in the reaction formula-4.
• R42 is a lower alkyl group or an amino group which may have lower alkyl substituent(s).], a carbamoyl group, a lower alkoxycarbonyl group, a cycloalkyl group, a phenyl-lower alkyl group which may have halogen substituent(s) on the phenyl ring, a cyano-substituted lower alkyl group, a halogen-substituted lower alkylsulfonyl group or a lower alkyl group having an amino substituent which may have lower alkyl group(s).
• R 28a is a lower alkyl group, a lower alkenyl group, a lower alkinyl group, a lower alkylsulfonyl group, a lower alkoxycarbonyl group, a cycloalkyl group, a phenyl-lower alkyl group which may have halogen substituent(s) on the phenyl ring, a cyano-substituted lower alkyl group, a halogen-substituted lower alkylsulfonyl group or a lower alkyl group having an amino substituent which may have lower alkyl group(s).
• R43 is a lower alkyl group.
• M is an alkali metal such as sodium, potassium or the like.
• the reaction of the compound (1z) with the compound (22) or the compound (7) can be conducted under the same conditions as in the reaction of the compound (1f) with the compound (6) or the compound (7) in the reaction formula-4.
• the reaction of the compound (1z) with the compound (23) is conducted in the presence or absence of a basic compound, preferably in the absence of any basic compound, in an appropriate solvent or in the absence of any solvent.
• the solvent and basic compound can be any solvent and basic compound used in the reaction of the carboxylic acid halide with the amine (2) in the reaction formula-1.
• the appropriate amount of the compound (23) used is generally about 1-5 moles, preferably about 1-3 moles per mole of the compound (1z).
• the reaction is conducted generally at about 0-200°C, preferably at room temperature to 150°C generally in about 5 minutes to 30 hours.
• a boron compound such as boron trifluoride ethyl etherate or the like may be used.
• the reaction of the compound (1z) with the compound (24) can be conducted in the presence of an acid in an appropriate solvent.
• the acid includes, for example, organic acids such as acetic acid, trifluoroacetic acid and the like and mineral acids such as hydrochloric acid, sulfuric acid and the like.
• the solvent can be any solvent used in the reaction of the carboxylic acid halide with the amine (2) in the reaction formula-1.
• reaction of the compound (1z) with the compound (25) can be conducted under the same conditions as in the above reaction of the compound (1z) with the compound (23).
• the reaction of the compound (1z) with the compound (26) can be conducted under the same conditions as in the above reaction of the compound (1z) with the compound (23).
• the product obtained thereby is reacted with a compound (27) without being isolated, whereby a compound (1ee) can be obtained.
• the reaction with the compound (27) can be conducted in the same solvent as used in the reaction of the compound (1z) with the compound (26), generally at 0-150°C, preferably at about 0-100°C generally in about 1-10 hours.
• the appropriate amount of the compound (27) used is at least 1 mole, generally 1-25 moles per mole of the compound (1z).
• the reaction of the compound (1z) with the compound (28) can be conducted under the same conditions as in the reaction of the carboxylic acid halide with the amine (2) in the reaction formula-1.
• R1, R2, R3, R5, M and the bond between the 4- and 5-position carbons of the benzoazepine skeleton are the same as defined above.
• R48 is a cyano-substituted lower alkyl group.
• R49 is a 1,2,3,4-tetrazolyl-substituted lower alkyl group.
• reaction of the compound (1gg) with the compound (29) can be conducted in an appropriate solvent in the presence of an ammonium halide such as ammonium chloride or the like.
• the appropriate amount of the compound (29) used is at least 1 mole, preferably 1-2 moles per mole of the compound (1gg).
• the reaction is conducted generally at room temperature to 200°C, preferably at room temperature to 150°C and is complete in about 1-10 hours.
• the compound of the general formula (1) is a compound of the general formula (1) wherein the R4 is an imidazolylthio-substituted lower alkoxy group or a pyridylthio-substituted lower alkoxy group
• the compound can be converted by oxidation into a compound of the general formula (1) wherein the R4 is an imidazolylsulfinyl-substituted lower alkoxy group or an imidazolylsulfonyl-substituted lower alkoxy group, or a pyridylsulfinyl-substituted lower alkoxy group or a pyridylsulfonyl-substituted lower alkoxy group.
• the oxidation reaction for converting the imidazolylthio-substituted lower alkoxy group into an imidazolylsulfinyl-substituted lower alkoxy group, the oxidation reaction for converting the imidazolylsulfinyl-substituted lower alkoxy group into an imidazolylsulfonyl-substituted lower alkoxy group, the oxidation reaction for converting the pyridylthio-substituted lower alkoxy group into a pyridylsulfinyl-substituted lower alkoxy group, and the oxidation reaction for converting the pyridylsulfinyl-substituted lower alkoxy group into a pyridylsulfonyl-substituted lower alkoxy group are conducted in an appropriate solvent in the presence of an oxidizing agent.
• the solvent can be exemplified by water; organic acids such as formic acid, acetic acid, trifluoroacetic acid and the like; alcohols such as methanol, ethanol and the like; halogenated hydrocarbons such as chloroform, dichloromethane and the like; and mixtures thereof.
• the oxidizing agent includes, for example, peracids such as performic acid, peracetic acid, trifluoroperacetic acid, perbenzoic acid, m-chloroperbenzoic acid, o-carboxyperbenzoic acid and the like; hydrogen peroxide; sodium metaperiodate; bichromic acid; bichromates such as sodium bichromate, potassium bichromate and the like; permanganic acid; permanganates such as potassium permanganate, sodium permanganate and the like; and lead salts such as lead tetraacetate and the like.
• the appropriate amount of the oxidizing agent used is at least 1 mole, preferably 1-2.5 moles per mole of the starting material.
• the appropriate amount of the oxidizing agent used is at least 2 moles, preferably 2-4 moles per mole of the oxidizing agent.
• the reaction is conducted generally at 0-150°C, preferably at about 0-100°C and is complete in about 10 minutes to 15 hours.
• the compound of the general formula (1) is a compound of the general formula (1) wherein the R2 is a lower alkoxy group
• the dealkylation can be conducted by heating said compound at 30-150°C, preferably at 50-120°C in a mixture of an acid (e.g. hydrobromic acid or hydrochloric acid) and a solvent(e.g. water, methanol, ethanol, isopropyl alcohol or acetic acid).
• an acid e.g. hydrobromic acid or hydrochloric acid
• a solvent e.g. water, methanol, ethanol, isopropyl alcohol or acetic acid.
• the dealkylation can be conducted by hydrolysis.
• the hydrolysis is conducted in an appropriate solvent in the presence of an acid.
• the solvent includes, for example, water; lower alcohols such as methanol, ethanol, isopropanol and the like; ethers such as dioxane, tetrahydrofuran and the like; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride and the like; polar solvents such as acetonitrile and the like; and mixtures thereof.
• the acid includes, for example, mineral acids such as hydrochloric acid, sulfuric acid, hydrobromic acid and the like; Lewis acids such as boron trifluoride, aluminum chloride, boron tribromide and the like; iodides such as sodium iodide, potassium iodide and the like; and mixtures of said Lewis acid and said iodide.
• the reaction proceeds favorably generally at room temperature to 150°C, preferably at room temperature to 100°C, and is complete generally in about 0.5-15 hours.
• those having an acidic group can each form a salt with a pharmacologically acceptable basic compound.
• the basic compound can be exemplified by metal hydroxides such as sodium hydroxide, potassium hydroxide, lithium hydroxide, calcium hydroxide and the like; alkali metal carbonates or bicarbonates such as sodium carbonate, sodium hydrogencarbonate and the like; and alkali metal alcoholates such as sodium methylate, potassium ethylate and the like.
• metal hydroxides such as sodium hydroxide, potassium hydroxide, lithium hydroxide, calcium hydroxide and the like
• alkali metal carbonates or bicarbonates such as sodium carbonate, sodium hydrogencarbonate and the like
• alkali metal alcoholates such as sodium methylate, potassium ethylate and the like.
• the acid can be exemplified by inorganic acids such as sulfuric acid, nitric acid, hydrochloric acid, hydrobromic acid and the like; and organic acids such as acetic acid, p-toluenesulfonic acid, ethanesulfonic acid, oxalic acid, maleic acid, fumaric acid, citric acid, succinnic acid, benzoic acid and the like.
• inorganic acids such as sulfuric acid, nitric acid, hydrochloric acid, hydrobromic acid and the like
• organic acids such as acetic acid, p-toluenesulfonic acid, ethanesulfonic acid, oxalic acid, maleic acid, fumaric acid, citric acid, succinnic acid, benzoic acid and the like.
• These salts can also be used as an active ingredient in the present invention, similarly to the compounds (1) of free form.
• the compounds (1) include stereoisomers and optical isomers and these isomers can
• Each of the intended compounds (1) obtained by the above reaction formulas can be separated from the reaction system by an ordinary means and can further be purified.
• Each of the thus obtained active ingredient compounds is effective as a vasopressin antagonist and is used in the form of ordinary pharmaceutical preparation.
• the pharmaceutical preparation is prepared by using diluents or excipients ordinarily used, such as filler, bulking agent, binder, humectant, disintegrator, surfactant, lubricant and the like.
• the pharmaceutical preparation can be used in various forms depending upon the purpose of remedy, and the typical forms include tables, pills, a powder, a solution, a suspension, an emulsion, granules, suppositories, an injection (e.g. solution or suspension), etc.
• various carriers conventionally known in the art can be used.
• the carriers can be exemplified by excipients such as lactose, white sugar, sodium chloride, glucose, urea, starch, calcium carbonate, kaolin, crystalline cellulose, silicic acid and the like; binders such as water, ethanol, propanol, simple syrup, glucose solution, starch solution, gelatin solution, carboxymethyl cellulose, shellac, methyl cellulose, potassium phosphate, polyvinylpyrrolidone and the like; disintegrators such as dry starch, sodium alginate, powdered agar, powdered laminarin, sodium hydrogencarbonate, calcium carbonate, polyoxyethylene sorbitan-fatty acid esters, sodium lauryl sulfate, stearic acid monoglyceride, starch, lactose and the like; disintegration inhibitors such as white sugar, stearin, cacao butter, hydrogenated oil and the like; absorption promoters such as quaternary ammonium salts, sodium lauryl sulfate
• the tablets can be prepared, as necessary, in the form of ordinary coated tablets, such as sugar-coated tablets, gelatin-coated tablets, enteric-coated tablets or film-coated tablets, or in the form of double-layered tablets or multi-layered tablets.
• various carriers conventionally known in the art can be used.
• the carriers can be exemplified by excipients such as glucose, lactose, starch, cacao butter, hardened vegetable oils, kaolin, talc and the like; binders such as powdered acacia, powdered tragacanth, gelatin, ethanol and the like; and disintegrators such as laminarin, agar and the like.
• various carriers conventionally known in the art can be used.
• the carriers can be exemplified by a polyethylene glycol, cacao butter, a higher alcohol, a higher alcohol ester, gelatin and a semi-synthetic glyceride.
• Capsules can be prepared generally by mixing the active ingredient compound with various carriers shown above and filling the mixture into a hard gelatin capsule or a soft capsule by an ordinary method.
• an injection solution, emulsion or suspension
• it is sterilized and is preferably made isotonic to the blood.
• the injection may contain sodium chloride, glucose or glycerine in an amount sufficient to make the injection isotonic, and may further contain a solubilizing agent, a buffer solution, a soothing agent, etc. all ordinarily used.
• the pharmaceutical preparation may furthermore contain, as necessary, a coloring agent, a preservative, a perfume, a flavoring agent, a sweetening agent and other drugs.
• the amount of the active ingredient compound to be contained in the vasopressin antagonist of the present invention is not particularly restricted and can be appropriately selected from a wide range, but the appropriate amount is generally about 1-70% by weight, preferably about 5-50% by weight in the pharmaceutical preparation.
• the method for administering the vasopressin antagonist of the present invention is not particularly restricted.
• the vasopressin antagonist can be administered in various methods depending upon the form of preparation, the age, sex and other conditions of patient, the disease condition of patient, etc. For example, tablets, pills, a solution, a suspension, an emulsion, granules or capsules are administered orally.
• An injection is intravenously administered singly or in admixture with an ordianry auxiliary solution of glucose, amino acids or the like, or, as necessary, is singly administered intramuscularly, intradermally, subcutaneously or intraperitoneally. Suppositories are administered intrarectally.
• the dose of the vasopressin antagonist of the present invention is appropriately selected depending upon the administration method, the age, sex and other conditions of patient, the disease condition of patient, etc., but the appropriate dose is generally about 0.6-50 mg per kg of body weight per day in terms of the amount of the active ingredient, i,e, the present compound of the general formula (1).
• the pharmaceutical prepartion contains about 10-1,000 mg of the active ingredient compound in each unit of administration form.
• the present invention is described in more detail below by showing Preparation Examples for preparing some of the vasopressin antagonists of the present invention, Reference Examples for producing some of the raw materials used for production of the active ingredient compounds to be contained in the vasopressin antagonists of the present invention, Examples for producing said active ingredient compounds, and Test Examples for examining the efficacies of said active ingredient compounds.
• the active ingredient compound of the present invention Avicel, corn starch and magnesium stearate are mixed and ground. Then, the mixture is made into tablets using a tablet machine of R 10 mm (sugar coating). The tablets are each covered with a coating film consisting of hydroxypropyl methyl cellulose, polyethylene glycol 6,000, castor oil and ethanol, to prepare film-coated tablets.
• the active ingredient compound of the present invention citric acid, lactose, dicalcium phosphate, Pluronic F-68 and sodium lauryl sulfate are mixed.
• the mixture is sifted using a No. 60 screen and then wet-pelletized using an alcoholic solution containing polyvinylpyrrolidone, Carbowax 1,500 and Carbowax 6,000.
• the mixture is made into a paste by adding ethanol.
• Corn starch is added, after which mixing is conducted until uniform particles are formed.
• the resulting mixture is sifted using a No. 10 screen and placed in a tray.
• the mixture in the tray is dried in an oven of 100°C for 12-14 hours.
• the dried particles are sifted using a No. 16 screen, then mixed with dry sodium lauryl sulfate and dry magnesium stearate, and compressed into desired forms using a tablet-making machine.
• each of the tablets obtained is treated with a varnish and then covered with talc for prevention of moisture absorption.
• An undercoating layer is formed on the surface of the core portion. Varnish coating is conducted a plurality of times for internal use. Further, an undercoating layer and smooth coating are applied in order to make completely round and smooth tablets. Color coating is conducted until a desired color is obtained. Then, drying and grinding are conducted in this order to obtain tablets of uniform lustre.
• the two parabens, sodium metabisulfite and sodium chloride are dissolved in distilled water for injection, of about half of the above amount at 80°C with stirring.
• the resulting solution is cooled to 40°C.
• the active ingredient compound of the present invention polyethylene glycol and polyoxyethylene sorbitan monooleate in this order.
• To the resulting solution is added the remaining amount of distilled water for injection.
• the solution is filtered for sterilization using an appropriate filter paper to prepare an injection.
• the resulting insolubles were removed by filtration.
• the filtrate was mixed with a 5% aqueous sodium hydrogensulfate solution, followed by extraction with dichloromethane.
• the dichloromethane layer was washed with a saturated aqueous sodium hydrogencarbonate solution and a saturated aqueous sodium chloride solution in this order and dried over magnesium sulfate.
• the resulting dichloromethane solution was concentrated for solvent removal.
• This crude product was dissolved in a mixed solvent consisting of 15 ml of acetic acid and 15 ml of ethyl acetate. To the solution was added 0.3 g of 5% Pd-C. The mixture was subjected to hydrogenolysis at normal temperature at normal pressure. Then, the catalyst was removed by filtration. The filtrate was concentrated.
• the dichloromethane layer was water-washed, then dried over magnesium sulfate and concentrated.
• the residue was purified by silica gel column chromatography (elutant: ethyl acetate) to obtain 0.34 g of an isomer A and 0.35 g of an isomer B both of 5-(L-methionyloxy)-7-chloro-1-[2-methoxy-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-benzoazepine.
• the aqueous layer was separated, then neutralized with a saturated aqueous sodium bicarbonate solution, and subjected to extraction with dichloromethane.
• the dichloromethane layer was washed with water, then dried and subjeced to distillation to remove the solvent.
• the resiude was mixed with hydrochloric acid-ethanol to form a hydrochloride and obtain 150 mg of 5-[2-(4-acetyl-1-piperazinyl)ethyl]-7-chloro-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-benzoazepine hydrochloride. Colorless and amorphous
• ethyl acetoimidate hydrochloride 0.129 g was added to 15 ml of a suspension of 0.5 g of 5-(2-amino-ethoxy)-7-chloro-1-[2-methoxy-4-(2-chlorobenzoylamino)-benzoyl]-2,3,4,5-tetrahydro-1H-benzoazepine in ethanol with ice-cooling. The mixture was stirred overnight at room temperature. Then, 0.163 g of ethyl acetoimidate hydrochloride was further added. The mixture was stirred at 50°C for 7 hours and then refluxed for 3 hours. After cooling, the reaction mixture was subjected to filtration to remove insolubles. The filtrate was concentrated.
• Test-1 V1 Recepter binding assay
• Rate of inhibitory effect (%) 100-[(C1-B1)/(C0-B1)] x 100 wherein,
• IC50 value is the concentration of the test compound required to achieve the inhitory effect in the rate of 50% and are shown in the following Table 156.
• Rate of the inhibitory effect (%) 100-[(C1-B1)/(C0-B1)] x 100 wherein,
• IC50 value which is the concentration of the test compound required to achieve the inhibitory effect in the rate of 50%, and are shown in the following Table 157.
• Test-3 Vasopressin antagonistic activity in vivo
• vasopressin antagonistic activity of the compound of the present invention when admistered orally to rats under awaking, the following experiment was conducted.
• Cannulas were inserted into the aorta abdominalis and the carotid arteries of male SD-rats (body weight: 300-450 g) under pentobarbital-anesthetization.
• vasopressin (30 mU/kg) was administered intravenously to the rats under awaking with measuring the blood pressure at the cannula inserted into the arorta abdominalis by a piezo-electric transducer.
• the test compound was dissolved in polyethylene glycol or water, or suspended in 5% gum arabic solution, and orally administered by force to the rats.
• the increase in the diastolic pressure of the rat was periodically measured at 30 minutes' interval after the administration of vasopressin for 8 hours.
• the rate of inhibitory effect (%) of the test compound on the increase in the diastolic pressure caused by vasopressin (30 mU/kg) was calculated based on the increase in the diastolic pressure when vasopressin (30 mU/kg) was intravenously administered without a test compound.
• ID50 value which is the oral dose of the test compound required to achieve the inhibitory effect in the rate of 50% and is shown in Table 158 as follows: Table 158 Test compound No. ID50 (mg/kg) 63 3.4
• Test-4 Anti-antidiuretic (water diuretic) activity in vivo
• test compound of the present invention was dissolved in polyethylene glycol 400 or water or suspended in 5% gum arabic aqueous solution, and the mixture was orally administered by force to male SD-rats (body weight: 300 to 400 g) under untreated and unrestrained. After administration the rats were kept in a metabolism cage and the amount of urine spontaneously excreted by the rats was measured at 2 hours' interval, during which the rats could freely be given feed and water.
• test results are expressed as ED3, which is the oral dose of the test compound which is required to increase the amount of the urine excreted from the rat in the test compound-treated group for the first 2 hours by time based on the amount of urine excreted from the rat for the first 2 hours in the control group.
• Table 159 Test compound No. ED3 (mg/kg) 41 1.4 63 3.2
• IC50 values which is the concentration of the test compound required to achieve the inhibitory effect in the rate of 50%.
• Table 160 The results are shown in Table 160 as follows:

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