EP0531387A1 - Methode permettant de reduire les proprietes irritantes d'une composition cosmetique. - Google Patents

Methode permettant de reduire les proprietes irritantes d'une composition cosmetique.

Info

Publication number
EP0531387A1
EP0531387A1 EP91910181A EP91910181A EP0531387A1 EP 0531387 A1 EP0531387 A1 EP 0531387A1 EP 91910181 A EP91910181 A EP 91910181A EP 91910181 A EP91910181 A EP 91910181A EP 0531387 A1 EP0531387 A1 EP 0531387A1
Authority
EP
European Patent Office
Prior art keywords
skin
cosmetic composition
properties
irritating
cosmetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP91910181A
Other languages
German (de)
English (en)
Other versions
EP0531387B1 (fr
Inventor
Kirsti Maarit Jutila
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Finnfeeds Finland Ltd
Original Assignee
Cultor Oyj
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cultor Oyj filed Critical Cultor Oyj
Publication of EP0531387A1 publication Critical patent/EP0531387A1/fr
Application granted granted Critical
Publication of EP0531387B1 publication Critical patent/EP0531387B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/75—Anti-irritant

Definitions

  • active ingredients may include emol ⁇ lients, barrier agents, healing agents, humectants, emulsifiers, preservatives, perfume oils, coloring agents, and/or surfactants, particularly anionic surfac ⁇ tants (e.g., sodium lauryl ether sulphates), and several compounds for skin cleansing (which contain kerosen ⁇ es, solvents and disinfectants in addition to hard surfac- tants) .
  • surfactants particularly anionic surfac ⁇ tants (e.g., sodium lauryl ether sulphates)
  • anionic surfac ⁇ tants e.g., sodium lauryl ether sulphates
  • surfactants particularly anionic surfac ⁇ tants (e.g., sodium lauryl ether sulphates)
  • anionic surfac ⁇ tants e.g., sodium lauryl ether sulphates
  • Other cosmetics such as deodorants containing ethanol are recognized as having potentially irritating or sensitizing properties. In addition,
  • Cationic compounds such as cetyltrimethyla - monium chloride, alkyldimethylbenzylammonium, alkyliso- quinidinium, and alkylpyridinium halides are commonly used as hair conditioners. In small amounts, these quaternary ammonium derivatives improve hair manage ⁇ ability.
  • One drawback of including quaternary ammonium compounds in cosmetics such as shampoos, hair condi ⁇ tioners, creams, lotions, etc. is the fact that great care must be taken when introducing them into commercial products, as most of these materials are known to be skin irritants. More particularly, it is known from the literature that the quaternary compounds of synthetic origin, particularly at higher concentrations (over 10 percent) , cause skin irritation and cauterization.
  • Quaternary ammonium salts have also previously been used at concentrations below 0.1 percent as anti ⁇ septics in preparations such as aftershave lotions and baby lotions and creams.
  • One hair treatment composition described in U.S. Patent No. 4,752,467 (Konrad et al.), contains 0.1-25 percent by weight betaine and 0.1-10 percent by weight of an aliphatic organic acid such as citric acid.
  • the combination of the betaine/aliphatic organic acid is said to provide synergistic conditioning properties which improve the condition of the hair structure, and act as an antioxidant and as a buffer.
  • DE-Patent No. 1911144 (Medisan Ab) describes a skin-treating composition for treating abnormal skin conditions or as a vehicle for other medicaments, com ⁇ prising an aqueous phase in which urea and lactic acid are dissolved.
  • the mode of operation of this composition relates to the skin-softening properties of urea and the keratolytic effect of lactic acid.
  • Optional components of this composition include emulsifiers and a ino acid derivatives such as betaine.
  • Other cosmetic formulations also include betai ⁇ ne.
  • Betaine is a general name for an organic tertiary amine with three free organic radicals.
  • Known formula ⁇ tions include betaines in which at least one of the free radicals is a long fatty acid derivative based radical.
  • U.S. Patent No. 4,490,355 (Desai) describes a mixture of cocoamidopropyl betaine and oleomidopropyl betaine which when included in cosmetics is said to improve thickening and foam boosting properties.
  • U.S. Patent No. 4,654,161 (Kollmeier et al.) describes the use of organopolysila- xanes that have betaine groups in hair cosmetics.
  • siloxane derivatives are said to provide improved compatibility with anionic additives (surfac ⁇ tants) and less irritation than prior organopolysiloxanes with quaternary ammonium groups.
  • EP-Patent No. 286261 (Redken Laboratories) describes the use of zwitterions such as taurines and betaines to increase the substantivity of hydrolysed proteins in keratinous tissues.
  • the present invention also relates to the method of reducing the skin irritating properties of a cosmetic composition.
  • the quaternary ammonium compound preferably obtained from natural sources, is ethanaminium, l-carboxy-N,N,N-trimethyl-,hydroxide inner salt monohydrate or the corresponding anhydride thereof (also referred to as trimethylglycine or trimethylglycine anhydride respectively) .
  • T ⁇ e present invention also relates to a cosmetic composition
  • a cosmetic composition comprising one or more cosmetic ingredients selected from the group consisting of an active agent, an emollient, a barrier agent, a healing agent, a humectant, an emulsifier, a preservative, a perfume oil, a coloring agent, a deodorizing agent, a surfactant, a solvent and mixtures of the above and one or more of the cosmetic ingredient having irritating properties when applied to human skin, and trimethylglycine or anhydride in an amount effective to substantially neutralize the skin-irritating properties of the cosmetic ingredient.
  • the dosage of trimethylglycine (or its anhydride) is from about 0.1 to about 50, preferably 1 - 15, percent by weight.
  • the cosmetic compositions of the present inven ⁇ tion include skin cleansers, body shampoos, hair condi- tioners, skin creams or lotions, deodorants, etc.
  • CH 3 has now surprisingly been found to reduce the skin irritation properties or sensitisation reactions of cosmetic compounds including irritating ingredients such as sodium lauryl ether sulphate, and other anionic surfactants, cetyltrimethylammonium chloride, alkyl ⁇ dimethylbenzylammonium, and alkylisoquinidinium, alkylpyridinium halides, solvents etc.
  • Trimethylglycine (or anhydride thereof) in question has been found to improve the skin compatibility and moisturizing characteristics of cosmetic compositions. Problems mentioned above are often found in products containing irritants, including skin and hand cleaners, skin lotions, skin creams, as well as medicated products.
  • the dosage of methanaminium, l-carboxy-N,N,N-trimethyl-, hydroxide, inner salt monohydrate or corresponding anhydride is between 0,1 and 50%, preferably 1 - 15 w/w.
  • the patch testing was conducted as follows. In each of these Examples, the test materials were applied on the upper outer arm and the application arm was occluded with a patch for an initial contact period of 24 hours. The patches were then removed and the skin reaction was assessed using a numerical scoring system one hour later.
  • Irritants have much stronger effect on dry skin; thus ingredients of cosmetic compounds should not cause any increasing normal TEWL.
  • the same cream containing 50% w/w trimethylglycine was applied under an occlusive patch at a different skin site.
  • blank occlusive patches were also applied to a third skin site.
  • the transepidermal water loss from skin (TEWL) was measured.
  • test subjects were twelve female volunteers between 18 and 65 years of age. Panelists were selected on the + criteria that they had normal healthy skin on their forearms and were able to provide stable TEWL values.
  • TEWL readings were taken from each skin site to provide normal untreated water loss levels. Treatment was made via 12 mm occlusive Finn chambers. A blank Finn chamber served as the control site. The lotion samples were applied by immersing Whatman 3MM filter paper discs in the sample, removing excess product against the edge of the container and placing the disc in the Finn chamber using forceps. Each chamber was applied to one of the marked sites on the forearm and held in position with Scanpor non-occulsive surgical tape. The pattern of application of treatments to sites was randomized and recorded.
  • Example 18 provides illustrative formulations including ingredient with irritating properties for a skin cream, body shampoo and skin cleanser in accordance with the invention.
  • Sodium lauryl ether sulphate is known to have a hard cleansing effect; thus because of the side effect (e.g. too effective fat removal from the skin and hair) it cannot be used as such in shampoos.
  • the addition of tri ⁇ methylglycine remarkably reduces the irritation effect.
  • Trimethyl glycine reduces the irritating properties of irritants.
  • N,N,N-trimethyl-,hydroxide inner salt monohydrate on skin tested by the Zeiss-spektrophotometer This formula was tested by using ten female volunteers. The body lotion was used for 8 days. The smoothness of the skin was measured by a Zeiss-spektrophotometer by 660 nm. The results show that the addition of trimethylglycine moder ⁇ ately improves the smoothness of the skin. Smoothness of skin was calculated by the follow ⁇ ing equation:
  • Example 20 Moisture Holding Capacity Using Corneometer
  • the same body lotion formula used in Example 19 was used in tests where the moisturizing effect of tri- methylglycine was measured by a Corneometer.
  • the moisture holding capacity in the skin was increased when the trimethylglycine level in the product increased from 0% to 2% to 6%.
  • Example 19 Medial part of skin of arms were used (5 x 2.5 cm 2). Different test areas for dif ⁇ ferent model products were used.
  • the subjects were acclimatized in a controlled atmosphere (vH 60 %, T° 24°C) for 30 minutes before 0-values of different skin areas were measured.
  • Body lotions were used twice daily (12 hr. intervals) . Duration of the trials was 8 days.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Cosmetics (AREA)

Abstract

On décrit une méthode permettant de réduire sensiblement l'irritation de la peau et d'améliorer les propriétés hydratantes de produits cosmétiques par incorporation d'une quantité efficace d'un composé de triméthylglycine, et des produits cosmétiques ainsi réalisés.
EP91910181A 1990-06-05 1991-06-05 Methode permettant de reduire les proprietes irritantes d'une composition cosmetique Expired - Lifetime EP0531387B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US533684 1983-09-19
US53368490A 1990-06-05 1990-06-05
PCT/FI1991/000176 WO1991018588A1 (fr) 1990-06-05 1991-06-05 Methode permettant de reduire les proprietes irritantes d'une composition cosmetique

Publications (2)

Publication Number Publication Date
EP0531387A1 true EP0531387A1 (fr) 1993-03-17
EP0531387B1 EP0531387B1 (fr) 1996-08-14

Family

ID=24127018

Family Applications (1)

Application Number Title Priority Date Filing Date
EP91910181A Expired - Lifetime EP0531387B1 (fr) 1990-06-05 1991-06-05 Methode permettant de reduire les proprietes irritantes d'une composition cosmetique

Country Status (5)

Country Link
EP (1) EP0531387B1 (fr)
AT (1) ATE141154T1 (fr)
DE (1) DE69121405T2 (fr)
ES (1) ES2093102T3 (fr)
WO (1) WO1991018588A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI103711B (fi) 1996-09-26 1999-08-31 Finnfeeds Finland Oy Trimetyyliglysiinin käyttö ihoa mekaaniselta ärsytykseltä suojaavana aineena
FI106923B (fi) * 1997-01-03 2001-05-15 Cultor Ltd Finnsugar Bioproduc Trimetyyliglysiinin käyttö kehon limakalvojen hygieniaan ja hoitoon tarkoitetuissa valmisteissa
WO2001039730A1 (fr) * 1999-12-02 2001-06-07 Orion Corporation, Noiro Composition cosmetique
FI116826B (fi) * 2000-11-10 2006-03-15 Lumene Oy Siemenöljyä sisältävät kosmeettiset koostumukset
WO2002087526A1 (fr) * 2001-05-02 2002-11-07 Finnfeeds Finland Oy Utilisation de la betaine pour le soin capillaire
EP1577373B1 (fr) * 2002-12-27 2006-11-29 Kao Corporation Composition detergente
PL1675559T3 (pl) 2003-04-04 2010-04-30 Colgate Palmolive Co Sole antyperspiracyjne z betainą wolne od glicyny do polepszonych produktów kosmetycznych
US7204976B2 (en) 2003-05-30 2007-04-17 Colgate-Palmolive Company High efficacy gel with low glycol content
US7105691B2 (en) 2003-06-26 2006-09-12 Colgate-Palmolive Company Aluminum / zirconium / glycine antiperspirant actives stabilized with Betaine
JP2005029532A (ja) * 2003-07-09 2005-02-03 Asahi Kasei Chemicals Corp 皮膚洗浄料
JP2006143636A (ja) * 2004-11-18 2006-06-08 Asahi Kasei Chemicals Corp 化粧下地料
US9789038B2 (en) 2007-02-02 2017-10-17 Colgate-Palmolive Company Antiperspirant/deodorant compositions
US7976828B2 (en) 2007-02-02 2011-07-12 Colgate-Palmolive Company Antiperspirant/deodorant composition
FI125107B (fi) * 2008-10-15 2015-06-15 Dupont Nutrition Biosci Aps Betaiinin käyttö
US20200046617A1 (en) 2017-04-24 2020-02-13 Tomcat International Limited Composition For Combating The Signs Of Ageing Of The Skin And Hair And Nails

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE325667B (fr) * 1968-03-06 1970-07-06 Medisan Ab
FR2303536A1 (fr) * 1975-03-11 1976-10-08 Rhone Poulenc Ind Nouveaux sels d'aluminium, leur preparation et les compositions qui les contiennent
DE2750731C3 (de) * 1977-11-12 1983-05-11 Rewo Chemische Werke Gmbh, 6497 Steinau Betaine und diese Verbindungen enthaltende Reinigungs-,Bade- und Desinfektionsmittel
DE3033929C2 (de) * 1980-09-10 1982-05-27 Th. Goldschmidt Ag, 4300 Essen Körperreinigungsmittel
DE3101011C2 (de) * 1981-01-15 1985-06-05 Wella Ag, 6100 Darmstadt Haarbehandlungsmittel
AU5078885A (en) * 1984-12-20 1986-06-26 Warner-Lambert Company Non-irritant detergent
DE3527974C2 (de) * 1985-08-03 1994-08-04 Wella Ag Saures Haarpflegemittel
FR2647342B1 (fr) * 1989-05-23 1994-05-27 Sanofi Sa Composition cosmetique s'opposant au vieillissement de la peau

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9118588A1 *

Also Published As

Publication number Publication date
EP0531387B1 (fr) 1996-08-14
ES2093102T3 (es) 1996-12-16
DE69121405D1 (de) 1996-09-19
DE69121405T2 (de) 1997-01-23
WO1991018588A1 (fr) 1991-12-12
ATE141154T1 (de) 1996-08-15

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