EP0512020A1 - Verfahren zur herstellung von homochiralen aminen sowie für dafür benötigte zwischenprodukte - Google Patents

Verfahren zur herstellung von homochiralen aminen sowie für dafür benötigte zwischenprodukte

Info

Publication number
EP0512020A1
EP0512020A1 EP19910903459 EP91903459A EP0512020A1 EP 0512020 A1 EP0512020 A1 EP 0512020A1 EP 19910903459 EP19910903459 EP 19910903459 EP 91903459 A EP91903459 A EP 91903459A EP 0512020 A1 EP0512020 A1 EP 0512020A1
Authority
EP
European Patent Office
Prior art keywords
phenyl
ethyl
preparing
glycidyl
isopropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP19910903459
Other languages
English (en)
French (fr)
Inventor
Lars Westfelt
Aina Westfelt
Bo Birgersson
Lena Andersson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nobel Chemicals AB
Original Assignee
Nobel Chemicals AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nobel Chemicals AB filed Critical Nobel Chemicals AB
Publication of EP0512020A1 publication Critical patent/EP0512020A1/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/04—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reaction of ammonia or amines with olefin oxides or halohydrins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP19910903459 1990-01-22 1991-01-15 Verfahren zur herstellung von homochiralen aminen sowie für dafür benötigte zwischenprodukte Ceased EP0512020A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9000206 1990-01-22
SE9000206A SE468211B (sv) 1990-01-22 1990-01-22 Flerstegsfoerfarande foer framstaellning av homokirala aminer

Publications (1)

Publication Number Publication Date
EP0512020A1 true EP0512020A1 (de) 1992-11-11

Family

ID=20378305

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19910903459 Ceased EP0512020A1 (de) 1990-01-22 1991-01-15 Verfahren zur herstellung von homochiralen aminen sowie für dafür benötigte zwischenprodukte

Country Status (7)

Country Link
EP (1) EP0512020A1 (de)
JP (1) JPH05506008A (de)
AU (1) AU638801B2 (de)
CA (1) CA2074075A1 (de)
FI (1) FI923305A (de)
SE (1) SE468211B (de)
WO (1) WO1991010642A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6057476A (en) * 1996-09-18 2000-05-02 Daiso Co., Ltd. Process for the preparation of 3-amino-2-hydroxy-1-propyl ethers
ATE252543T1 (de) * 1998-04-14 2003-11-15 Samsung Fine Chemicals Co Ltd Verfahren zur herstellung chiraler (s)-2,3- disubstituierter 1-propylamin-derivate
CN103739512A (zh) * 2014-01-24 2014-04-23 南京工业大学 一种制备(s)-阿替洛尔的方法
JP7108436B2 (ja) * 2018-03-22 2022-07-28 三井化学株式会社 ビフェニル骨格含有エポキシ化合物の製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1269776A (en) * 1968-08-29 1972-04-06 Ici Ltd Epoxides and halohydrins and conversion thereof to alkanolamine derivatives
GB1458392A (en) * 1973-11-09 1976-12-15 Ici Ltd Optically-active 1-aryloxy-2,3-epoxypropane derivatives
US4408063A (en) * 1978-06-27 1983-10-04 Merck & Co., Inc. Preparation of epihalohydrin enantiomers
WO1988000190A1 (en) * 1986-06-25 1988-01-14 Massachusetts Institute Of Technology Optically active derivatives of glycidol

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9110642A1 *

Also Published As

Publication number Publication date
SE9000206L (sv) 1991-07-23
SE9000206D0 (sv) 1990-01-22
JPH05506008A (ja) 1993-09-02
WO1991010642A1 (en) 1991-07-25
AU638801B2 (en) 1993-07-08
AU7224991A (en) 1991-08-05
SE468211B (sv) 1992-11-23
FI923305A0 (fi) 1992-07-20
CA2074075A1 (en) 1991-07-23
FI923305A (fi) 1992-07-20

Similar Documents

Publication Publication Date Title
US4582918A (en) Preparation of intermediates for (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols
JPH08504819A (ja) フロルフェニコール、チアンフェニコール、クロラムフェニコールおよびオキサゾリン中間体の不整製造方法
US6015903A (en) Method of resolving racemic mixtures
EP0249610B1 (de) Herstellung optisch aktiver aryloxypropanolamine und arylaethanolamine
HU186776B (en) Process for preparing new, optically active imidazolidin-2-one derivatives
EP0512020A1 (de) Verfahren zur herstellung von homochiralen aminen sowie für dafür benötigte zwischenprodukte
WO1987003583A1 (en) Synthesis of aryloxypropanolamines and arylethanolamines
EP1008590B1 (de) Verfahren zur Herstellung von optisch aktiven Oxazolidinonderivate
KR100519691B1 (ko) 알킬옥시 퓨라논 유도체의 제조방법, 상기 방법으로 얻은화합물 및 상기 화합물의 용도
EP0930291B1 (de) Verfahren zur herstellung von 3-amino-2-hydroxy-1-propylethern
US6387692B1 (en) Process for the preparation of optically active amines
KR19980079310A (ko) (r) 및 (s)-알파-메틸-3(트리플로로메틸)벤젠에탄아민의 제조방법
US4515977A (en) Process for preparing optically active [S]-2-acetyl-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran and salts thereof
EP1375474B1 (de) Zwischenverbindung zur Herstellung von Carvedilol
US4677214A (en) Intermediates for preparation of (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols
US4897409A (en) 5-aminoethyloxazolidin-2-one derivatives
CA2217880C (en) Synthesis of optically active aminoindanol
EP0239122A2 (de) Verfahren zur enzymatischen Auftrennung von racemischen 2-Amino-1-alkanolen
JP4001388B2 (ja) ３―アミノ―２―ヒドロキシ―１―プロピルエーテルの製造法
KR20110086167A (ko) γ-아미노-α,β-불포화 카르복실산 유도체의 거울상이성질체선택적 합성
KR100469946B1 (ko) 키랄(s)-2,3-치환-1-프로필아민유도체의제조방법
JPH0977723A (ja) 光学活性１，２−ジフェニルエチレンジアミン類の製造方法
JPH0566940B2 (de)
JPH06733B2 (ja) 光学活性３−ハイドロキシ−４−ハロゲノ−ブチロニトリルの製造法
JPH0959265A (ja) 光学活性オキサゾリジノン、その製造方法、製造の中間体および不斉補助基としての利用

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19920629

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE

17Q First examination report despatched

Effective date: 19940211

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED

18R Application refused

Effective date: 19950318