EP0462110A1 - Intrauterine contraceptive device - Google Patents
Intrauterine contraceptive deviceInfo
- Publication number
- EP0462110A1 EP0462110A1 EP90901868A EP90901868A EP0462110A1 EP 0462110 A1 EP0462110 A1 EP 0462110A1 EP 90901868 A EP90901868 A EP 90901868A EP 90901868 A EP90901868 A EP 90901868A EP 0462110 A1 EP0462110 A1 EP 0462110A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- active body
- contraceptive device
- set forth
- carrier means
- intrauterine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
- A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
- A61F6/14—Contraceptive devices; Pessaries; Applicators therefor for use by females intra-uterine type
- A61F6/142—Wirelike structures, e.g. loops, rings, spirals
- A61F6/144—Wirelike structures, e.g. loops, rings, spirals with T-configuration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
- A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
- A61F6/14—Contraceptive devices; Pessaries; Applicators therefor for use by females intra-uterine type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0039—Devices retained in the uterus for a prolonged period, e.g. intrauterine devices for contraception
Definitions
- the present invention refers to an intrauterine contraceptive device comprising an active body made of a metallic substance of contraceptive activity and carrier means made of a. biologically inert substance for supporting the active body in an intrauterine environment, wherein the carrier means are generally made of a plastic and connected with an indicator thread.
- the contraceptive effectiveness of some intrauretine devices has been known since many years. They have found application from the end of the sixties, when the approp ⁇ riate plastics were prepared and investigated. Since that time the intrauterine devices have become applicable in a wide selection of different shapes, configurations and ma ⁇ terials.
- the process of the development of the intrauterine contraceptive devices can be shared into three periods. The first of them is marked by the application of the app ⁇ ropriate plastics (see e.g. US-PS 3.937.217), completed in the second period by a steroid-releasing substance. The third period is characterized in introducing copper for preparing the active body.
- the intrauterine devices based on copper comprise carrier means, generally made in T-shape from plastic (e.g. polyethylene) material, an active body made in form of a copper wire contacting the carrier means, further an indicator thread fixed on the carrier means.
- carrier means generally made in T-shape from plastic (e.g. polyethylene) material
- an active body made in form of a copper wire contacting the carrier means
- an indicator thread fixed on the carrier means.
- the active body is a coil shaped element and the indicator thread is a flexible line made of plastic (e.g. polyamid).
- the pregnancy rate was 5 % for the women using in ⁇ trauterine devices including copper, 8 % in the women po- 5 pulation taking oral contraceptives, 18 % in that applying mechanical contraceptives (condoms) and 40 % in the women population making no use of contraceptives.
- 20 body is as high as 94 to 95 % and this is a relatively low level when compared to 100 % assigned to the full , safety. An improvement of the effectiveness is therefore highly desired.
- the copper material of the active body is slowly dissolving and consequently the active body during its presence in the human body fragmentates.
- the fragmen- tated copper wire can harm thereby the tissues and has shortened life period.
- the contraceptive effect of the intrauterine devices comprising copper is supposed to be attributed even to copper.
- the dissolution process of copper i.e. the speed of producing copper ions by the device is uneven, and therefore the known devices have a not stabilized influence on the physiological processes taking place in the human body (i.e. the enzyme processes, glycogen metabolism, absorption of estrogens, activity of the uterine muscles, changes in the composition of the fluids etc.), the influence on the mechanism of preventing the pregnancy, the implantation of the fertilized ovum.
- the present invention is intended to creating an intrauterine contraceptive device of high contraceptive ef- fectiveness reaching at least 99 % based on a metallic substance.
- the intrauterine device proposed by the inven ⁇ tion should preserve its original shape during the whole period of application and ensure a uniform deliberation of the ions having contraceptive effect.
- the invention is based on the recognition that the active body of the intrauterine device should be made of an appropriate metal composition containing at least two metals forming one with .mother a galvanic cell in the intrauterine environment.
- an intra ⁇ uterine contraceptive device which comprises an active body consisting of a metallic substance of contraceptive activity and carrier means made of a biologically inert substance for supporting the active body in an intrauterine en vironment, wherein according to the -5-
- the active body is made of a metallic substance including at least two metals forming a plurality of local galvanic cells in the intrauterine environment.
- the active body is advantageously made at least partially of an alloy of the at least two metals.
- the plurality of the galvanic cells is advanta ⁇ geously consisted of a copper-gold or a copper-z ⁇ nc-silver alloy.
- a copper-gold or a copper-z ⁇ nc-silver alloy can be applied, too, and it is especially desirable to prepare the active body from copper and at least one metal of higher electropositivity, when copper forms the anode of the galvanic cell and the other metal, e.g. gold or silver constitutes the cathode thereof.
- Some other metal composition are: nickel and gold, copper, silver and zinc, silver and cadmium, silver and palladium.
- the basic feature of the intrauterine device of the invention is that the active body includes a plurality of small, in most cases microscopic galvanic cells wherefrom the ions of the anode, generally the copper ions can be dissolved with higher concentration than from the intra ⁇ uterine devices of known designs.
- the active body of the intrauterine contraceptive device proposed by the invention can preferably be made in the shape of a coil consisting of the mixture of more metals (e.g. copper is completed with zinc and silver), wherein the mixture can constitute an alloy, too, if re ⁇ quired.
- more metals can be present in ionic form and in controlled amounts, whereby the potential dif ⁇ ference between the electrodes of the galvanic cells is stepwise increased and the effectiveness of the contra ⁇ ceptive activity possibly based on inactivating the sperma ⁇ tozoa is increased.
- Another preferred embodiment of the active body is when prepared in tubular shape, wherein one or more tubular elements are applied. In the case of more tubular elements they can be divided by ring shaped elements.
- FIG. 1 is a schematic view of a proposed contracep ⁇ tive device with coil shaped active body
- FIG. 2 is the schematic view of an intrauterine con ⁇ traceptive device including a tubular shaped active body made from an alloy sheet
- FIG. 3 is the schematic view of an intrauterine con- traceptive device with an active body in form of two tubular and three ring form elements.
- the proposed intrauterine contraceptive device of the invention con ⁇ sists of carrier means 1 made of plastic, an active body 2 of required activity exerted e.g. by inactivating spermato ⁇ zoa in an intrauterine environment and an indicator thread 3 connected to the carrier means 1 (FIGs. 1, 2 and 3.)
- the carrier means 1 consist generally of an approp ⁇ riate plastic which usually has no physiological activity in the intrauterine environment.
- the feature that the carrier means 1 are biological inert is, however, not a feature following from the contraceptive effectiveness of the active body 2 and if required, the carrier means 1 can be completed by further substances of appropriate acti ⁇ vity.
- the carrier means 1 is generally a T-shaped, two arm element which can be arranged in the uterus of a woman and is intended to support the active body 2.
- the carrier means 1 generally consist of two stems 10 and 11 connected to one another in a loop 14 carrying the indicator thread 3 and continued in respective arms 12 and 13 (FIG. 1).
- the active body 2 of the proposed intrauterine device is generally produced in form of a coil 4 wound a- round the two stems 10 and 11 of the carrier means 2 (FIG. 1).
- the coil 4 can be also a double helix prepared from a wire by the means of known mechanical technologies.
- the simple coil 4 or the double helix, i.e. a coil wound from another coil prepared from a wire offer high surface area.
- FIG. 2 Another possibility of shaping the active body 2 is shown in FIG. 2. , wherein the active body 2 consists of a tube 5 surrounding the two stems 10 and 11 from the loop 14 up to the beginning of the arms 12 and 13.
- the tube 5 can be produced by forming a metallic sheet to a tubular ele ⁇ ment and closing, e.g. by welding the metallic sheet along the lines of connecting the edges of the sheet to one an ⁇ other.
- FIG. 3 wherein an active body 2 is divided into more parts: the stems 10 and 11 are partly covered by tubular elements 7 and a ring 6 arranged therebetween.
- the active body 2 consists of sheet- and wire-like elements with inhomogenized surface layer including the at least two metals forming microscopic or small galvanic cells as re ⁇ quired by the invention.
- the two or more metal composition is also a requirement against the coil 4 and the tube 5, made in whole volume or at least on the outer surface of at least two metals.
- the active body 2 includes copper and at least one further metal of higher electroposi ivity. e.g. gold or silver. These metals can form either a mixture or an alloy. A third and further metal can be applied, too, and in this way a series of galvanic cells of different voltages is applied.
- Other preferred selections for prepar ⁇ ing the active body 2 are listed up in the examples given below, however, it is not intended to be limited by the ex ⁇ amples.
- the proposed contra ⁇ ceptive device forms a plurality of galvanic cells with electrodes in the active body 2.
- the electrolyte is the biologic fluid of the uterus. If the active body is made of a given first metal, e.g. copper and a more noble metal, e.g. gold the rules of the electrochemical corrosion pre ⁇ dict that the anodes are at the "isles" formed by the first metal, i.e. copper and the cathodes at the parts consisted of the nobler metal, i.e. gold.
- the dissolution process re ⁇ sults in removing first metal from the active body 2 and the cathodes remain practically without change on their original places, their fragmentation can not be observed.
- the concentration of the first metal ions i.e. the copper ions is higher than in the environ ⁇ ment of the known intrauterine devices.
- the cathodes or cathode isles ensure retaining the original shape of the active body 2 and the problems linked with the fragmentation of the active body 2 resulting in rough, splintered outer surface thereof in the known devices can be avoided.
- the composition of the mixture or .alloy of the active body 2 can be selected in a wide range including more orders of magnitudes.
- the proposed intrauterine contraceptive devices operate in the following way:
- the small or microscopic gal ⁇ vanic cells created by the component metals of the active body 2 are capable not only of deliberating the required active ions in the intrauterine environment but also of generating an electric field. Therefore the contraceptive activity supposed to be based on chemical effects is inten- sively improved by the electric field.
- the spermatozoa have electric charge and this results in their migration to the cathodes and anodes of the galvanic cells, respectively, according to their electric charges. Thereby the inactivating process of the spermatozoa shows higher effectiveness than in the known devices.
- a further advantage of the proposed intrauterine contraceptive devices lies in the fact that during the excitation accompanying the sexual intercourse, when the temperature of the human body exceeds the normal level, the intensity of deliberating ions in the galvanic cells in ⁇ creases what results in higher activity of the proposed in ⁇ trauterine contraceptive device when this is especially re ⁇ quired.
- the active body 2 of the intrauterine device pro ⁇ posed by the invention is a coil 4 (FIG. 1.) consisting of 85 parts copper and 15 parts gold.
- the coil 4 is wound from a wire and surrounds the carrier means 1 made of poly ⁇ ethylene.
- the carrier means 1 are connected with a poly- amide thread 3-
- the active body 2 of the intrauterine ' device pro ⁇ posed by the invention is a coil 4 (FIG. 1.) consisting of an alloy including 30 parts zinc and 70 parts copper.
- the coil 4 is wound from a wire and surrounds the carrier means 1 made of polyethylene.
- the carrier means 1 are connected with a polyamide thread 3- EXAMPLE 3.
- the active body 2 of the intrauterine device pro ⁇ posed by the invention is a coil 4 (FIG, 1.) consisting of an alloy including 40 parts palladium and 70 parts silver.
- the coil 4 is wound from a wire and surrounds the carrier means 1 made of polyethylene.
- the carrier means 1 are connected with a polyamide thread 3-
- the active body 2 of the intrauterine device pro- posed by the invention is a coil 4 (FIG. 1.) consisting of an alloy including 18 parts nickel and 82 parts gold.
- the coil 4 is wound from a wire and surrounds the carrier means 1 made of polyethylene.
- the carrier means 1 are connected with a polyamide thread 3- EXAMPLE 5.
- the active body 2 is a tube 5 (FIG- 2.) made of an alloy consisting of 40 parts copper, 25 parts silver and 35 parts zinc
- the tube 5 is prepared by welding from a metal sheet.
- the carrier means 1 made of plastic are connected with a polyamide thread 3.
- the active body 2 is made of a copper wire and a copper sheet with having surface layer including gold mixed with copper.
- the wires are prepared in the form of the rings 6 and 8, the sheet is closed to constitute the tub ⁇ ular elements 7 (FIG. 3).
- the carrier means 1 made of plastic are connected with a thread 3 consisting of a fle ⁇ xible plastic. EXAMPLE 1.
- the active body 2 is made of a wire and a sheet made of an alloy consisting of 90 parts silver and 10 parts cad ⁇ mium.
- the wires are prepared in the form of the rings 6 and 8, the sheet is closed to constitute the tubular ele ⁇ ments 7 (FIG. 3).
- the carrier means 1 made of plastic ,are connected with a thread 3 consisting of a flexible p-jastic.
- the intrauterine contraceptive devices of the inven ⁇ tion were investigated in conditions near to the physiolo ⁇ gical. According to the observations the effective life is more than 20 years and the contraceptive effectivenes is as high as at least 99 %• The device can be applied in d fully similar way to the known devices.
Landscapes
- Health & Medical Sciences (AREA)
- Reproductive Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU89569A HU200905B (en) | 1989-02-07 | 1989-02-07 | Electrochemical contraceptive device |
HU56989 | 1989-02-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
EP0462110A1 true EP0462110A1 (en) | 1991-12-27 |
Family
ID=10950196
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP90901868A Withdrawn EP0462110A1 (en) | 1989-02-07 | 1990-01-23 | Intrauterine contraceptive device |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0462110A1 (no) |
KR (1) | KR910700032A (no) |
CN (1) | CN1018521B (no) |
AU (1) | AU4941590A (no) |
BR (1) | BR9007098A (no) |
CS (1) | CS30890A2 (no) |
DD (1) | DD291243A5 (no) |
DE (1) | DE4090201T (no) |
FI (1) | FI913721A0 (no) |
HU (1) | HU200905B (no) |
PL (1) | PL162833B1 (no) |
RO (1) | RO107542B1 (no) |
WO (1) | WO1990009158A1 (no) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4311812A1 (de) * | 1993-04-13 | 1995-01-26 | Christian Kossack | Vorrichtung zur elektrolytischen Deaktivierung von Spermien zum Einsatz beim Mann |
DE19542386A1 (de) * | 1995-11-01 | 1997-05-15 | Hamann Bernd Dr Med Habil | Intrauterines Pessar |
US7073504B2 (en) | 1996-12-18 | 2006-07-11 | Ams Research Corporation | Contraceptive system and method of use |
BE1011714A3 (fr) * | 1998-01-20 | 1999-12-07 | Wildemeersch Dirk | Dispositif intra-uterin a efficacite accrue. |
AU2005209871B2 (en) * | 2004-02-02 | 2010-06-17 | Conceptus, Inc. | Enhancing tissue ingrowth for contraception |
US9713549B2 (en) | 2004-02-02 | 2017-07-25 | Bayer Healthcare Llc | Contraceptive with permeable and impermeable components |
FI123188B (fi) * | 2005-04-05 | 2012-12-14 | Bayer Oy | Ultraäänellä havaittavissa oleva kohdunsisäinen järjestelmä |
WO2010112095A1 (en) * | 2009-04-03 | 2010-10-07 | Bio Material Systems Nv/Sa | Improvement to intrauterine copper contraceptive devices |
ITBO20110229A1 (it) * | 2011-04-28 | 2012-10-29 | Alberto Mazzanti | Dispositivo anticoncezionale intrauterino (iud) |
US9265652B2 (en) | 2012-08-14 | 2016-02-23 | Contramed, Llc | Intrauterine contraceptive device |
US9089418B2 (en) | 2012-08-14 | 2015-07-28 | Contramed, Llc | Intrauterine contraceptive device |
LT2945580T (lt) * | 2013-01-17 | 2020-08-10 | Pat&Co Bvba | Varį išskirianti hibridinė į gimdos ertmę įstatoma kontraceptinė priemonė su sulaikymo atšaka, prijungta prie berėmio korpuso |
US10918516B2 (en) | 2013-10-14 | 2021-02-16 | Sebela Vlc Limited | Intrauterine device with controlled copper ion elution |
US10188546B2 (en) * | 2013-10-14 | 2019-01-29 | Sebela Vlc Limited | Intrauterine device with controlled copper ion elution |
US9180040B2 (en) | 2013-10-18 | 2015-11-10 | Contramed, Llc | Intrauterine device with retrieval thread |
SI24779A (sl) * | 2014-08-28 | 2016-02-29 | CABALLUS CARNIOLUS & AMSTERDAMUS, veterinarsko tehnološki center in trgovina, uvoz - izvoz d.o.o. | Vstavek za ljudi in živali ter postopek izdelave le-tega |
CN112999433B (zh) * | 2021-02-23 | 2022-07-05 | 吴江永元生物科技有限公司 | 一种Cu-Zn复合材料宫内节育器及其制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2758037A1 (de) * | 1977-12-24 | 1979-06-28 | Kurt Dr Med Herten | Applikationseinheit aus pessar und einfuehreinrichtung |
ES239677Y (es) * | 1978-11-23 | 1979-06-16 | Sopena Quesada Angel | Espermicida intrauterino |
FI59720C (fi) * | 1980-04-02 | 1981-10-12 | Outokumpu Oy | Koppartraod foer livmoderinlaegg samt foerfarande foer framstaellning av densamma |
FR2536987B1 (fr) * | 1982-07-19 | 1985-10-31 | Serimed | Sterilet endo-uterin pour les animaux tels que les chiennes |
-
1989
- 1989-02-07 HU HU89569A patent/HU200905B/hu not_active IP Right Cessation
- 1989-12-29 DD DD89336761A patent/DD291243A5/de not_active IP Right Cessation
-
1990
- 1990-01-08 CN CN90100193A patent/CN1018521B/zh not_active Expired
- 1990-01-22 CS CS90308A patent/CS30890A2/cs unknown
- 1990-01-23 BR BR909007098A patent/BR9007098A/pt unknown
- 1990-01-23 RO RO148177A patent/RO107542B1/ro unknown
- 1990-01-23 EP EP90901868A patent/EP0462110A1/en not_active Withdrawn
- 1990-01-23 DE DE19904090201 patent/DE4090201T/de not_active Withdrawn
- 1990-01-23 AU AU49415/90A patent/AU4941590A/en not_active Abandoned
- 1990-01-23 KR KR1019900702017A patent/KR910700032A/ko not_active Application Discontinuation
- 1990-01-23 WO PCT/HU1990/000009 patent/WO1990009158A1/en not_active Application Discontinuation
- 1990-02-07 PL PL28366890A patent/PL162833B1/pl unknown
-
1991
- 1991-08-05 FI FI913721A patent/FI913721A0/fi not_active Application Discontinuation
Non-Patent Citations (1)
Title |
---|
See references of WO9009158A1 * |
Also Published As
Publication number | Publication date |
---|---|
DE4090201T (no) | 1992-03-12 |
PL162833B1 (en) | 1994-01-31 |
KR910700032A (ko) | 1991-09-12 |
BR9007098A (pt) | 1991-11-05 |
DD291243A5 (de) | 1991-06-27 |
CS30890A2 (en) | 1991-06-11 |
AU4941590A (en) | 1990-09-05 |
RO107542B1 (ro) | 1993-12-30 |
HU200905B (en) | 1990-09-28 |
CN1018521B (zh) | 1992-10-07 |
WO1990009158A1 (en) | 1990-08-23 |
CN1044758A (zh) | 1990-08-22 |
FI913721A0 (fi) | 1991-08-05 |
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Legal Events
Date | Code | Title | Description |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19910802 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB IT LI LU NL SE |
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17Q | First examination report despatched |
Effective date: 19930329 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 19930801 |