HU225878B1 - Intra-uterine contraceptive - Google Patents

Abstract

The intrauterine contraceptive device has plastic arms (1) with agent (2) including alloy of gold, copper and zinc, and nickel ions.

Description

BACKGROUND OF THE INVENTION The present invention relates to a contraceptive device for intrauterine delivery with plastic arms and a carrier body and a nickel-containing alloy.

The widespread use of intrauterine contraceptives dates back to the early sixties of the last century.

In the initial period, non-active contraceptive devices made of plastic were subsequently marketed and subsequently hormone-active contraceptives. From the nineteen-seventies onwards, they began to use types trained with more effective copper contraceptives that release contraceptive copper ions. They consist of three main units. It consists of a plastic carrier body with various shapes (for example, T, Y - shaped arms, metal on the carrier body, usually in helical copper wire, and a plastic marker thread attached to the end of the carrier body).

Devices are known where the metal active ingredient is copper (U.S. Patent Nos. 4,198,966 and 4,353,363) and devices in which the wire-shaped active ingredient is formed from an alloy of copper and / or zinc containing gold core wire (U.S. Pat. Nos. 200,2005, HU21,2696).

The disadvantage of each of these types is that the copper and zinc ions liberated from the active substance are excreted with varying intensity. Liver function, which is ideal for the selection of copper and zinc, occurs in the presence of optimal concentrations of nickel ions. Optimal conditions, depending on nutrition, are only more or less realized. Most are nickel depleted, which can lead to unwanted accumulation of toxic copper and zinc ions.

SUMMARY OF THE INVENTION It is an object of the present invention to provide an intrauterine contraceptive device which contains nickel ions required for the ideal function of the liver.

The inventive idea is based on the recognition that nickel ions can be supplied to the liver by forming a nickel-containing alloy of the metal active ingredient of the device with copper and / or zinc.

The alloy active ingredient of the intrauterine device thus formed is in contact with the electrolyte-containing uterine fluid to form a plurality of galvanic cells. The anode of the galvanic cells will be a more negative electrode potential component of the drug. During the operation of the galvanic cell, the components forming the anode dissolve, for example, in the formation of nickel and copper ions, while the cathode, such as gold, remains unchanged. By preferentially selecting the amount and proportions of the components in the alloy, the amount of dissolved ions can be varied (i.e., the body obtains the required amount of nickel ions while the device acts as a contraceptive through known effects (copper, zinc).

In one embodiment of the intrauterine device according to the invention, the active substance formed from a gold, copper / zinc alloy containing nickel is contained in a plastic carrier body, for example in the form of a ring (s) or a wire wrapped in a snail line.

The device according to the invention may also be formed by forming the active ingredient in gold, copper and / or zinc alloy containing nickel containing precious metal, for example in the form of a ring (s) or wire wrapped in a snail line.

The plastic carrier body of the present invention can be prepared by injection molding technology, melting the active ingredients, and melt-stretching and bending in a known manner.

The intrauterine device insertion tube and push rod of the present invention can be inserted into the uterus in a known manner. To remove the device from the uterus (5-7 years after insertion), the indicator thread is used to pull the arms of the device together and slide it easily through the uterus.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The invention will now be described in more detail with reference to the drawings, in which two examples are given. The attached drawings show

Figure 1 is a partially sectional view of a possible embodiment of the device according to the invention,

Figure 2 is a partial sectional view of another embodiment of the device according to the invention.

Example 1

In Figure 1, the active ingredient 2 is arranged in the form of an annular ring on a polyethylene carrier body 1 formed with arms. The composition of the rings by weight is as follows:

2a - 70 copper, 15 zinc, 8 nickel, 7 gold,

2b - 60 Copper, 20 Zinc, 6 Nickel, 14 Gold,

2c - 2 Copper, 1 Zinc, 2.7 Nickel, 94.3 Gold.

At the opposite end of the carrier body 1, a plastic indicator thread 3 is attached.

Example 2

In Figure 2, the lever-shaped polyethylene carrier body 1 is wound in a spiral line in two portions (2x, 2z). 2x active ingredient composition by weight: 79 copper, 17.5 zinc, 0.5 nickel, 3 gold, 2z active ingredient by weight: 70 copper, 15 zinc, 1 nickel, 14 gold. Active ingredient 2z gold includes 4 gold wires. At the opposite end of the carrier body 1, a plastic indicator thread 3 is attached.

The intrauterine devices shown in the examples release 5-15 µg of nickel in the form of ions per day, while having the same contraceptive capability as the known intrauterine devices (Pearl index 0.6-0.4).

Claims (2)

PATENT CLAIMS An intrauterine contraceptive device comprising a carrier body and arms attached to one end thereof, an active agent formed from a copper and / or zinc noble metal alloy containing 5 precious metals on the carrier body, and an indicator line attached to the other end of the carrier body, The active ingredient (2) contains 0.5 to 10% by weight of nickel (2a to 2c). The intrauterine contraceptive device according to claim 1, characterized in that the active ingredient (2) comprises gold (4).