EP0454593A1 - Tube pour le prélèvement du sang - Google Patents
Tube pour le prélèvement du sang Download PDFInfo
- Publication number
- EP0454593A1 EP0454593A1 EP91401125A EP91401125A EP0454593A1 EP 0454593 A1 EP0454593 A1 EP 0454593A1 EP 91401125 A EP91401125 A EP 91401125A EP 91401125 A EP91401125 A EP 91401125A EP 0454593 A1 EP0454593 A1 EP 0454593A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- anticoagulant
- blood collection
- collection tube
- supporting film
- blood
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/491—Blood by separating the blood components
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
- Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction
Definitions
- the invention relates to a blood collection tube in which an anticoagulant is enclosed.
- This blood collection tube comprises a bottomed tube whose open end is hermetically sealed by a plug and a porous support having an anticoagulant such as heparin sodium carried thereon, accomodated in said bottomed tube.
- the present invention is intended to carry a predetermined quantity of an anticoagulant on a support surely and easily, when the anticoagulant is carried on the support and charged in a tube.
- a blood collection tube according to the invention described in claim 1 comprises a bottomed tube whose open end is hermetically sealed by a plug, and a supporting film having an anticoagulant coated thereon, accomodated in said bottomed tube, wherein an anticoagulant-coated surface of said supporting film has a large number of fine convexes.
- the large number of said fine convexes are made such that 2 ⁇ 500 convexes with a height of 0.2 ⁇ m or more exist per a length of 1 mm, in the cross section of said film in the thickness direction.
- the bottomed tube accomodates further a thixotropy gel having a specific gravity of 1.03 ⁇ 1.60, and the specific gravity of said film is made heavier than that of said gel.
- heparin sodium or heparin lithium is used as said anticoagulant.
- a surfactant is contained in said anticoagulant.
- water-soluble silicone is used as said surfactant.
- a blood collection tube 10 comprises a bottomed tube 12 whose open end is hermetically sealed by a plug 11, and a supporting film 13 having an anticoagulant coated thereon, accomodated in said bottomed tube 12.
- the tube 12 is made of glass, plastic or the like.
- the plug 11 is composed of a gas barrier member 11A and a sealing member 11B.
- the gas barrier member 11A is made of an aluminium foil film or the like and is highly gas-tight before a hollow needle is pierced therein, and it closes the opening of the tube 12.
- the sealing member 11B is made of polyisoprene rubber or the like, and it is applied at least on an area of the gas barrier member 11A where the hollow needle will be punctured, and enables to plug a hole left after the punctured hollow needle has been removed therefrom.
- the supporting film 13 is made of polyethylene terephthalate film or the like, and subjected to an embossing treatment so as to have a large number of fine convexes on the anticoagulant-coated surface.
- the embossing treatment for giving these fine convexes is carried out by polishing methods, such as a sandblast, a shotblast, a molding method using a die mold having concaves and convexes formed thereon, an emboss-printing method, a etching or the other methods.
- the sandblast method is preferably used because of the adherence of the anticoagulant to the film and the stability of the anticoagulant.
- Sands and glass beads or the like are preferably used in the sandblast method.
- the roughness of the embossed surface is tested by the surface roughness gauge.
- the grade of the large number of said fine convexes formed on the supporting film 13 is preferably made such that 2 ⁇ 500 convexes with a height of 0.2 ⁇ m or more exist per a length of 1 mm in the cross section of the supporting film in the thickness direction.
- the anticoagulant can be surely carried on the supporting film 13, while it is not likely to be exfoliated therefrom.
- the tube 12 accomodates a thixotropy gel 14 having a specific gravity of 1,03 ⁇ 1.60, and the specific gravity of the supporting film 13 is set to be heavier than that of said gel 14.
- the thixotropy gel 14 is substantially hydrophobic and thixotropic, and is substantially inert to blood. It is necessary that the specific gravity of such thixotropy gel is medium between those of the blood-plasma component and blood-corpuscle component. It is preferably in an order of 1.03 ⁇ 1.035 which is lighter than that of the blood-platelet component.
- the specific gravity of a blood-plasma component is often heaveir, varying with blood donors, and in such a case, the gel may get out of an intermediate position between the blood-plasma component and blood-corpuscle component. It is, therefore, preferred that the specific gravity of the gel is suitably selected between 1.03 ⁇ 1.06, for the purpose of use.
- the gel when the blood collection tube 10 in which blood has been collected is set on a centrifuge, the gel exhibits a fluidity and immigrates to the border of the two components, and it provides a wall in a semi-solid state, i.e. in a non-flowable state which isolates the two components from each other, as centrifugal force is stopped.
- the thixotrophy gel 14 for instance, there are used a gel consisting mainly of an ⁇ -olefin-maleic acid diester copolymer having a viscosity of 10,000 ⁇ 80,000 cp (25°C) or a gel consisting mainly of silicone in which a viscosity modifier, a spesific gravity regulator and the like are added.
- the supporting film 13 Since the supporting film 13 has a specific gravity heavier than that of the thixotropy gel 14, it is not moved to the side of the blood-plasma component separated as mentioned above, and settles in the side of the blood-corpuscle component.
- heparin sodium, heparin lithium or the like is used for the anticoagulant coated on the supporting film 13.
- the coating quantity of the anticoagulant on the supporting film 13 is preferably as large as 20 ⁇ 100 units.
- the anticoagulant is coated on the supporting film 13, in addition, it is dried by heat drying or freez-drying or the other drying method so as to be carried on the supporting film 13 in a more stable state, or without being exfoliated therefrom.
- a surfactant is preferably contained.
- water-soluble silicone is used for the surfactant.
- the surfactant improves the wettability of the surface of the supporting film 13. Since the supporting film 13 is hydrophobic and the anticoagulant is hydrophilic, namely, the hydrophobic groups of the supporting film 13 and surfactant are attracting each other due to the hydrophobic interaction, and the hydrophilic groups of the anticoagulant and surfactant are attracting each other due to the hydrophilic interaction, and as a result, the anticoagulant can be surely carried on the supporting film 13.
- a evacuated blood collection tube was manufactured in the same manner as Example 1, except that the embossing treatment was not carried out. After drying, however, heparin lithium was exfoliated from the supporting film so that the blood collection tube was useless.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Ecology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2110401A JP2540649B2 (ja) | 1990-04-27 | 1990-04-27 | 採血管 |
JP110401/90 | 1990-04-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0454593A1 true EP0454593A1 (fr) | 1991-10-30 |
EP0454593B1 EP0454593B1 (fr) | 1994-03-02 |
Family
ID=14534869
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP91401125A Expired - Lifetime EP0454593B1 (fr) | 1990-04-27 | 1991-04-26 | Tube pour le prélèvement du sang |
Country Status (5)
Country | Link |
---|---|
US (1) | US5213765A (fr) |
EP (1) | EP0454593B1 (fr) |
JP (1) | JP2540649B2 (fr) |
AU (1) | AU637690B2 (fr) |
DE (1) | DE69101253T2 (fr) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994017108A1 (fr) * | 1993-01-27 | 1994-08-04 | American Home Products Corporation | Composition anticoagulante |
EP0609794A1 (fr) * | 1993-02-01 | 1994-08-10 | Becton, Dickinson and Company | Dispositif de collection de sang |
EP0730154A1 (fr) * | 1994-09-19 | 1996-09-04 | Sekisui Kagaku Kogyo Kabushiki Kaisha | Inhibiteur d'adherence des facteurs sanguins, accelerateur de coagulation sanguine, procede d'utilisation de ces agents, et recipient et support pour examens sanguins |
EP0755654A1 (fr) * | 1995-07-21 | 1997-01-29 | Becton, Dickinson and Company | Tube à essai pour la détermination de la vitesse de sédimentation des érythrocytes et agent tensioactif pour sa mise en oeuvre |
EP0766973A1 (fr) * | 1995-09-29 | 1997-04-09 | Becton, Dickinson and Company | Dispositif et méthode de prélèvement du sang pour la séparation du plasma |
US5745227A (en) * | 1995-07-21 | 1998-04-28 | Becton, Dickinson And Company | Method and apparatus for determining the erythrocyte sedimentation rate |
EP0875757A2 (fr) * | 1997-04-30 | 1998-11-04 | Becton, Dickinson and Company | Appareil et méthode pour la préparation de plasma |
US5914272A (en) * | 1996-06-19 | 1999-06-22 | Becton Dickinson And Company | Test method for determining the erythrocyte sedimentation rate and a surfactant for use therein |
US6974701B2 (en) | 2003-03-21 | 2005-12-13 | Hemovations, Llc | Erythrocyte sedimentation rate (ESR) test measurement instrument of unitary design and method of using the same |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5269927A (en) * | 1991-05-29 | 1993-12-14 | Sherwood Medical Company | Separation device for use in blood collection tubes |
US5326535A (en) * | 1993-04-30 | 1994-07-05 | Becton, Dickinson And Company | Tube having unitary blood coagulation activator and method for its preparation |
US5455009A (en) * | 1993-09-14 | 1995-10-03 | Becton, Dickinson And Company | Blood collection assembly including clot-accelerating plastic insert |
FI940823A0 (fi) * | 1994-02-22 | 1994-02-22 | Orion Yhtymae Oy | Analysatorkyvett foer turbidimetriska och nefelometriska bestaemningar av helblodsprov |
US5511558A (en) * | 1994-06-06 | 1996-04-30 | Becton, Dickinson And Company | Blood collection assembly having additive dispensing means and method for sample collection using same |
JP3410818B2 (ja) * | 1994-06-20 | 2003-05-26 | 愛知時計電機株式会社 | 電磁流量計と流管部 |
US6238578B1 (en) * | 1996-12-09 | 2001-05-29 | Sherwood Services Ag | Method for dispensing separator gel in a blood collection tube |
WO1998029126A1 (fr) * | 1996-12-27 | 1998-07-09 | Sherwood Medical Company | Composition anticoagulante |
US6077235A (en) * | 1999-02-23 | 2000-06-20 | Becton, Dickinson And Company | Blood collection assembly and method therefor |
CA2445204C (fr) | 2002-10-16 | 2014-08-12 | Streck Laboratories, Inc. | Methode et dispositif de prelevement et de conservation de cellules aux fins d'analyse |
WO2004096046A1 (fr) * | 2003-04-25 | 2004-11-11 | Sekisui Chemical Co., Ltd. | Procede et outil de filtrage d'eprouvettes utilisant un recipient d'echantillonnage d'eprouvettes, et recipient d'echantillonnage d'eprouvettes |
US20090036841A1 (en) * | 2007-08-01 | 2009-02-05 | Mckale James M | Coatings for blood and bone marrow-contacting devices |
US7947186B2 (en) | 2008-05-22 | 2011-05-24 | Statspin, Inc. | Centrifugal device and method for fluid component separation |
WO2010078194A1 (fr) * | 2008-12-30 | 2010-07-08 | Streck, Inc. | Procédé pour cribler du sang utilisant un conservateur qui peut être sous une forme à l'état sensiblement solide |
US11634747B2 (en) | 2009-01-21 | 2023-04-25 | Streck Llc | Preservation of fetal nucleic acids in maternal plasma |
DE202010018561U1 (de) | 2009-01-21 | 2017-08-28 | Streck Inc. | Blutsammelröhrchen |
DE202010018569U1 (de) | 2009-02-18 | 2017-09-26 | Streck Inc. | Konservierung zellfreier Nukleinsäuren |
ES2571104T3 (es) * | 2009-11-09 | 2016-05-24 | Streck Inc | Estabilización del ARN y extracción del ARN presente en células intactas dentro de una muestra de sangre |
US9956281B2 (en) | 2011-05-04 | 2018-05-01 | Streck, Inc. | Inactivated virus compositions and methods of preparing such compositions |
EP3024323B1 (fr) | 2013-07-24 | 2022-10-19 | Streck, Inc. | Compositions et méthodes de stabilisation de cellules tumorales circulantes |
US11168351B2 (en) | 2015-03-05 | 2021-11-09 | Streck, Inc. | Stabilization of nucleic acids in urine |
US20170145475A1 (en) | 2015-11-20 | 2017-05-25 | Streck, Inc. | Single spin process for blood plasma separation and plasma composition including preservative |
US11480559B2 (en) | 2016-01-07 | 2022-10-25 | Fujimori Kogyo Co., Ltd. | Blood collection tube, reagent, and method for analyzing blood characteristics using same |
WO2018022991A1 (fr) | 2016-07-29 | 2018-02-01 | Streck, Inc. | Composition de suspension pour contrôle d'analyse hématologique |
EP3903106A1 (fr) | 2018-12-27 | 2021-11-03 | Streck, Inc. | Procédés de préparation d'échantillons pour une analyse protéomique |
MX2023000136A (es) | 2020-07-01 | 2023-05-19 | Métodos para preparar muestras para análisis proteómico. |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4087567A (en) * | 1976-04-22 | 1978-05-02 | Corning Glass Works | Anticoagulant coating method |
EP0073551A2 (fr) * | 1981-08-27 | 1983-03-09 | Becton Dickinson and Company | Récipient pour la collection d'échantillons |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5110631U (fr) * | 1974-07-10 | 1976-01-26 | ||
US4308232A (en) * | 1979-07-09 | 1981-12-29 | Sherwood Medical Industries Inc. | Anticoagulant stopper coating |
DE3165646D1 (en) * | 1980-05-08 | 1984-09-27 | Terumo Corp | Apparatus for separating blood |
US4315892A (en) * | 1980-07-18 | 1982-02-16 | Sherwood Medical Industries, Inc. | Fluid collection device having phase partitioning means |
US4425235A (en) * | 1982-03-22 | 1984-01-10 | Sherwood Medical Company | Blood collection device with phase partitioning means |
JPS59149152A (ja) * | 1983-02-16 | 1984-08-27 | テルモ株式会社 | 血液採取器 |
US4844818A (en) * | 1987-10-23 | 1989-07-04 | Becton Dickinson & Company | Method for separating the cellular components of blood samples |
US4867887A (en) * | 1988-07-12 | 1989-09-19 | Becton Dickinson And Company | Method and apparatus for separating mononuclear cells from blood |
-
1990
- 1990-04-27 JP JP2110401A patent/JP2540649B2/ja not_active Expired - Lifetime
-
1991
- 1991-04-24 AU AU75952/91A patent/AU637690B2/en not_active Ceased
- 1991-04-26 EP EP91401125A patent/EP0454593B1/fr not_active Expired - Lifetime
- 1991-04-26 US US07/691,855 patent/US5213765A/en not_active Expired - Lifetime
- 1991-04-26 DE DE69101253T patent/DE69101253T2/de not_active Expired - Lifetime
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4087567A (en) * | 1976-04-22 | 1978-05-02 | Corning Glass Works | Anticoagulant coating method |
EP0073551A2 (fr) * | 1981-08-27 | 1983-03-09 | Becton Dickinson and Company | Récipient pour la collection d'échantillons |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU679498B2 (en) * | 1993-01-27 | 1997-07-03 | Wyeth | Anticoagulant composition |
WO1994017108A1 (fr) * | 1993-01-27 | 1994-08-04 | American Home Products Corporation | Composition anticoagulante |
EP0609794A1 (fr) * | 1993-02-01 | 1994-08-10 | Becton, Dickinson and Company | Dispositif de collection de sang |
EP0730154A4 (fr) * | 1994-09-19 | 2001-02-07 | Seikisui Chemical Co Ltd | Inhibiteur d'adherence des facteurs sanguins, accelerateur de coagulation sanguine, procede d'utilisation de ces agents, et recipient et support pour examens sanguins |
EP0730154A1 (fr) * | 1994-09-19 | 1996-09-04 | Sekisui Kagaku Kogyo Kabushiki Kaisha | Inhibiteur d'adherence des facteurs sanguins, accelerateur de coagulation sanguine, procede d'utilisation de ces agents, et recipient et support pour examens sanguins |
US6495367B1 (en) | 1994-09-19 | 2002-12-17 | Sekisui Kagaku Kogyo Kabushiki Kaisha | Method of accelerating blood coagulation using an antimicrobial metal |
US6300135B1 (en) | 1994-09-19 | 2001-10-09 | Sekisui Kagaku Kogyo Kabushiki Kaisha | Blood component deposition-preventing agent, methods using them, and blood test ware and matrixes |
US5745227A (en) * | 1995-07-21 | 1998-04-28 | Becton, Dickinson And Company | Method and apparatus for determining the erythrocyte sedimentation rate |
US5779983A (en) * | 1995-07-21 | 1998-07-14 | Becton, Dickinson & Company | Test tube for determining the erythrocyte sedimentation rate and a surfactant for use therein |
EP0755654A1 (fr) * | 1995-07-21 | 1997-01-29 | Becton, Dickinson and Company | Tube à essai pour la détermination de la vitesse de sédimentation des érythrocytes et agent tensioactif pour sa mise en oeuvre |
EP0766973A1 (fr) * | 1995-09-29 | 1997-04-09 | Becton, Dickinson and Company | Dispositif et méthode de prélèvement du sang pour la séparation du plasma |
US5914272A (en) * | 1996-06-19 | 1999-06-22 | Becton Dickinson And Company | Test method for determining the erythrocyte sedimentation rate and a surfactant for use therein |
EP0875757A2 (fr) * | 1997-04-30 | 1998-11-04 | Becton, Dickinson and Company | Appareil et méthode pour la préparation de plasma |
EP0875757A3 (fr) * | 1997-04-30 | 1999-06-02 | Becton, Dickinson and Company | Appareil et méthode pour la préparation de plasma |
US6974701B2 (en) | 2003-03-21 | 2005-12-13 | Hemovations, Llc | Erythrocyte sedimentation rate (ESR) test measurement instrument of unitary design and method of using the same |
Also Published As
Publication number | Publication date |
---|---|
AU7595291A (en) | 1992-03-05 |
JPH049143A (ja) | 1992-01-13 |
AU637690B2 (en) | 1993-06-03 |
DE69101253T2 (de) | 1994-07-07 |
JP2540649B2 (ja) | 1996-10-09 |
US5213765A (en) | 1993-05-25 |
EP0454593B1 (fr) | 1994-03-02 |
DE69101253D1 (de) | 1994-04-07 |
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