EP0351574B1 - Aufsteckbare Pipettenspitze in Form eines entsprechend einem Aufsteckkopfstück, insbesondere Konus einer Pipette, wenigstens abschnittsweise ausgeführten Gefässes - Google Patents

Aufsteckbare Pipettenspitze in Form eines entsprechend einem Aufsteckkopfstück, insbesondere Konus einer Pipette, wenigstens abschnittsweise ausgeführten Gefässes Download PDF

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Publication number
EP0351574B1
EP0351574B1 EP89111346A EP89111346A EP0351574B1 EP 0351574 B1 EP0351574 B1 EP 0351574B1 EP 89111346 A EP89111346 A EP 89111346A EP 89111346 A EP89111346 A EP 89111346A EP 0351574 B1 EP0351574 B1 EP 0351574B1
Authority
EP
European Patent Office
Prior art keywords
pipette tip
wall thickness
wall
pipette
sealing area
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP89111346A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP0351574A2 (de
EP0351574A3 (en
Inventor
Ernst Dipl.-Ing. Tennstedt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eppendorf SE
Original Assignee
Eppendorf Netheler Hinz GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eppendorf Netheler Hinz GmbH filed Critical Eppendorf Netheler Hinz GmbH
Priority to AT89111346T priority Critical patent/ATE95728T1/de
Publication of EP0351574A2 publication Critical patent/EP0351574A2/de
Publication of EP0351574A3 publication Critical patent/EP0351574A3/de
Application granted granted Critical
Publication of EP0351574B1 publication Critical patent/EP0351574B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0275—Interchangeable or disposable dispensing tips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids

Definitions

  • the invention relates to an attachable pipette tip according to the preambles of claims 1 and 8.
  • the invention relates to a form of such a pipette tip in the form of an at least partially conical vessel, in which the sealing region is designed with a smooth seat at a distance from the plug-on opening at the upper end of the pipette tip.
  • a cylindrical design in the area of the plug-on head piece is also reserved.
  • the reference to the smooth seat does not rule out roughening of the surface. In this respect, there can also be slight profiles which improve the seal on the working cone. Basically, a smooth seat is preferred.
  • the plug-on head piece of a pipette can represent a cone per se, which has a passage and is inserted into the conical wall part of the pipette tip.
  • the outwardly projecting push-on headpiece has a spherical surface in its ring-shaped seating area. This also creates a sealing seat, in particular on an elastic and resilient seat surface, of the pipette tip, the elasticity causing the pipette tip to fit tightly against the ring-shaped seat region of the plug-on head piece.
  • Pipette tips with a conical seat are known for example from DE-C-10 90 449.
  • the push-on cone is conical over its entire length.
  • a flexibility of the push-on tip itself is included, but only a small tolerance compensation between the cone of the tip and the push-on cone of the pipette is possible. Therefore, leaks have been repeatedly observed in the practical use of this arrangement.
  • Such ribs do not form a secure fit or a quasi smooth seating area.
  • This known version has, for example, only a peripheral edge web at the upper edge goes through with the same wall thickness over the major part of the pipette tip length. At most, the wall thickness is reduced in the area of the lower discharge opening.
  • a pipette tip according to US-A-4,349,109 is made up of several sections, the uppermost of which, as a truncated cone, has an inner surface with a conical shape, for example of 3 °, and forms a wedge seat on a pipette.
  • This section with the seat, which forms the sealing area, has the greatest wall thickness of the pipette tip and is therefore particularly unyielding.
  • the seat surface passes through an inclined step surface into the lower wall section of the pipette tip, which is offset with respect to the upper section with the seat surface in order to also make it possible for pipettes of smaller volume to find a seat.
  • the upper edge of the lower section is particularly firm and unyielding due to the outwardly projecting wall of the upper section. In this respect, there is no adaptability and, because of the wall offset with respect to a center line, there is also no overlap of wall contours.
  • a plug-on pipette tip of the type specified above which has a wall thickness weakening in the sealing area, so that an adaptation to the conical plug-on head piece can take place.
  • the pipette tip consists of a material, in particular plastic, which is particularly elastic, at least flexible, but preferably has certain recovery properties that are caused when it expands.
  • plastic which is particularly elastic, at least flexible, but preferably has certain recovery properties that are caused when it expands.
  • a rubber material for example Plastic, as it is on the market under the trade name polypropylene.
  • the wall thickness weakening already known in this sense has proven itself. This weakening of the wall thickness is arranged on the outside. It either runs around the circumference or is formed in places by groove-like depressions. In the case of the wall thickness weakening arranged on the outside, it is taken into account that this is made stronger at the upper edge of the sealing area than at the lower end of the pipette tip. It is taken into account that there is an annular step on the outside at the upper edge of the sealing area and that the wall thickness of the pipette tip in the sealing area decreases towards the top.
  • Such an embodiment in the arrangement on the outside is also preferably included because it is relatively easy to implement using appropriate injection molds. In practice, however, it has been shown that this measure can only be used to a limited extent from the point of view of demoldability by avoiding undercuts. Especially with slim pipette tips with low conicity, it is very difficult to find an adequate one To achieve wall thickness weakening in the sealing area and to carry out this wall thickness weakening evenly over the entire area of a defined sealing zone. Typically, the wall thickness changes over the sealing area. For this reason, the sealing area of such pipette tips is also poorly visible, which can lead to uncertainties for the user.
  • the present invention is therefore based on the object of creating a pipette tip in which the weakening of the wall thickness can be chosen as desired, the sealing area is clearly visible and can be produced without harmful undercuts impairing the demoldability. This applies in particular to slim pipette tips with low conicity up to at least approximately cylindrical designs.
  • the object is achieved in that an outer wall thickness weakening coming from below and an inner wall thickness weakening coming from above overlap in a defined sealing area.
  • the expression of a weakening of the wall thickness progressing to overlap arises in such a way that it starts directly from the wall and ultimately ends in one step in the weakening.
  • the step lies in the internal weakening of the wall thickness with respect to the insertion opening below and the outer wall thickness weakening above.
  • a preferred feature in an embodiment in which the wall thickness weakening increases from the outside upwards towards the push-on opening towards an upwardly widening step surface for the transition into the normal wall thickness is that the wall thickness weakening inside in the sealing region in the opposite sense from top to bottom increases at the bottom and has a retracted ring step at the lower end. It is expediently included that the inner conical ring step drawn in downwards has a slight slope of the order of 30 °.
  • the opposite wall thickness weakening which increases in the opposite direction, forms an essentially parallel wall section of the pipette tip in the sealing region between the outside and inside.
  • the inner ring step is preferably used as a stop for the conical plug-on head piece of the pipette tip, whereby the additional advantage of a defined, reproducible seat can be used.
  • the strength of the seat can advantageously be improved further by creating a wall section that runs obliquely to the wall center line of the conical pipette tip and that forms a cone around the central axis of the pipette tip, which forms from the top to the bottom extended and designed in the opposite direction to the cone of the continuous pipette tip wall.
  • the embodiment according to the invention with a wall thickness weakening inside and outside therefore has advantages and, in the preferred embodiment, also enables a particularly simple design of the manufacturing mold while avoiding slides or similar mechanisms that would be necessary for realizing undercuts.
  • the overlap of the outer and inner wall thickness weakening according to the invention arises after the corresponding design of the molding tools in a simple manner when joining the inner and outer shape in each injection cycle.
  • the pipette tip 1 has an upper attachment opening 2, which can be widened by an edge bevel.
  • the upper section is bordered by a relatively thick wall 3. This is reinforced on the outside by ribs 4, so that stability is present here. On this wall, a web 3 'running around can still be arranged on the upper edge outside.
  • This wall thickness continues up to area 5 and is uniform. This area ends at 6. Below the transverse line 6, the wall thickness decreases. A longitudinal section, which contains the sealing region 10, adjoins the transverse line 6. This sealing area extends to the transverse line 7. Below this, the pipette tip with essentially the same wall thickness, which is present above the transverse line 6, continues downwards to a lower receiving and dispensing opening 8. In addition, it is noted that also included becomes that the wall thickness can typically taper towards the lower discharge opening from the wall thickness below the sealing region 10.
  • the center surface of the wall of the conical body of the pipette tip 1 is designated with 9 on the whole and by the dash-dotted wall center line. It runs in the middle of the wall above cross line 6 and below cross line 7.
  • the sealing area 10 between the transverse lines 6 and 7 - the sealing area not having to extend exactly to these transverse lines, but rather being less in the axial length of the pipette tip - the wall thickness is reduced.
  • a wall thickness weakening 11 which has an inner axial lateral surface 12 which extends at an angle to the wall center line 9. It is at least less conical.
  • a wall thickness weakening 15 is now arranged on the inside. It starts approximately from the point of use of stage 14 and deepens downward approximately to the height of end 13, at which the external weakening of the wall thickness begins.
  • the inner wall thickness weakening 15 now increases downwards, it then passes through a conical ring ring 16 which contracts inwards into the wall 17 of the pipette tip which is of normal thickness.
  • the lower conical ring step 16 drawn in has, for example, a slope of 30 °.
  • outer wall thickness weakening 11 comes from below and the inner wall thickness weakening 15 comes from above with regard to the pipette tip, the top being determined by the plug-on opening 2. This direction results from the increasing thickness of the wall thickness weaknesses in their course, and it can also be seen that the two wall thickness weaknesses 11 and 15 overlap.
  • the wall section 18 between the wall thickness weakenings 11 on the outside and 15 on the inside has the same thickness over the length of the sealing region 10 if the surfaces forming the wall are parallel.
  • FIG. 2 shows an example of a cylindrical design of the pipette tip in the upper region.
  • the pipette tip has a wall 3 with normal, considerable wall thickness.
  • a cylindrical, inner wall thickness weakening 19 goes down to an annular step 20. This wall thickness weakening 19 comes from above.
  • a wall thickness weakening 21 comes from below and ends in an upper, downward ring step 22.
  • the sealing area 10 is arranged, in which the two wall thickness weakenings overlap and thus create a considerable wall thickness weakening becomes.
  • This weakening of the wall thickness can be achieved by appropriate dimensioning of the inner diameter 23 and the outer diameter 24, i.e. in the end can be made arbitrarily thin by designing the wall thickness weakenings.
  • FIG. 3 shows an embodiment in which a outer wall thickness weakening 25 coming from the outside ends in an upper conical ring step 26, while an inner wall thickness weakening 27 coming from above ends in a lower conical ring step 28.
  • a wall section 29 with a smaller wall thickness than above and below the sealing area, but the seat surface in the sealing area is conical, essentially with a cone tightening of 1:15.
  • This example is given in order to explain the possibility within the scope of the invention of setting an upwardly widening cone angle in the sealing area, the wall thickness being essentially constant even in the sealing area.
  • the wall section 29 has less conicity than the total wall of the pipette tip or the wall center line.
  • the upper wall 3 below the push-on opening 2 is made thicker than the wall in the sealing area and the pipette tip according to FIG. 3 also has a wall 17 of normal thickness below the sealing area.

Landscapes

  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Closures For Containers (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
EP89111346A 1988-07-21 1989-06-22 Aufsteckbare Pipettenspitze in Form eines entsprechend einem Aufsteckkopfstück, insbesondere Konus einer Pipette, wenigstens abschnittsweise ausgeführten Gefässes Expired - Lifetime EP0351574B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT89111346T ATE95728T1 (de) 1988-07-21 1989-06-22 Aufsteckbare pipettenspitze in form eines entsprechend einem aufsteckkopfstueck, insbesondere konus einer pipette, wenigstens abschnittsweise ausgefuehrten gefaesses.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3824767A DE3824767A1 (de) 1988-07-21 1988-07-21 Aufsteckbare pipettenspitze in form eines entsprechend einem aufsteckkopfstueck, insbesondere konus einer pipette, wenigstens abschnittsweise ausgefuehrten gefaesses
DE3824767 1988-07-21

Publications (3)

Publication Number Publication Date
EP0351574A2 EP0351574A2 (de) 1990-01-24
EP0351574A3 EP0351574A3 (en) 1990-11-14
EP0351574B1 true EP0351574B1 (de) 1993-10-13

Family

ID=6359207

Family Applications (1)

Application Number Title Priority Date Filing Date
EP89111346A Expired - Lifetime EP0351574B1 (de) 1988-07-21 1989-06-22 Aufsteckbare Pipettenspitze in Form eines entsprechend einem Aufsteckkopfstück, insbesondere Konus einer Pipette, wenigstens abschnittsweise ausgeführten Gefässes

Country Status (6)

Country Link
US (1) US4961350A (enrdf_load_stackoverflow)
EP (1) EP0351574B1 (enrdf_load_stackoverflow)
JP (1) JP2848632B2 (enrdf_load_stackoverflow)
AT (1) ATE95728T1 (enrdf_load_stackoverflow)
DD (1) DD283953A5 (enrdf_load_stackoverflow)
DE (2) DE3824767A1 (enrdf_load_stackoverflow)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5200151A (en) * 1990-05-21 1993-04-06 P B Diagnostic Systems, Inc. Fluid dispensing system having a pipette assembly with preset tip locator
US5192511A (en) * 1991-05-31 1993-03-09 Tri-Continent Scientific, Inc. Pipette tip and piston
US5232669A (en) * 1991-11-08 1993-08-03 Abbott Laboratories Pipette tip with self-aligning and self-sealing features
US5509319A (en) * 1994-06-21 1996-04-23 Geo-Microbial Technologies, Inc. Adapter for pipetter and hypodermic needle
DK0979146T3 (da) * 1997-05-02 2002-12-02 Gen Probe Inc Reaktionsbeholderapparat
US6499363B1 (en) * 1997-12-12 2002-12-31 The Sailor Pen Co., Ltd. Tip for pipette and pipette with the same
US6168761B1 (en) * 1998-11-06 2001-01-02 Rainin Instrument Co., Inc. Pipette with improved pipette tip and mounting shaft
US6197259B1 (en) * 1998-11-06 2001-03-06 Rainin Instrument Co., Inc. Easy eject pipette tip
BR9915136A (pt) * 1998-11-06 2001-08-07 Rainin Instr Co Inc Pipeta para deslocamento de ar, combinação em uma pipeta para deslocamento de ar, haste para montagem de ponta de pipeta, e, ponta de pipeta
PL192753B1 (pl) * 1998-11-06 2006-12-29 Rainin Instr Llc Pipeta z przemieszczaniem powietrza i połączenie w pipecie z przemieszczaniem powietrza
US6248295B1 (en) * 1998-11-06 2001-06-19 Rainin Instrument Co., Inc. Pipette with improved pipette tip and mounting shaft combination
DE19917375C2 (de) * 1999-04-16 2001-09-27 Hamilton Bonaduz Ag Bonaduz Pipettiereinheit
US6814936B1 (en) 1999-07-01 2004-11-09 Goran Enhorning Pipette assembly having a small volume disposable tip
US6596240B2 (en) 2001-01-12 2003-07-22 Porex Corporation Pipette tip for easy mounting and ejecting from a pipette
US6973845B2 (en) 2001-01-18 2005-12-13 Beckman Coulter, Inc. Low insertion force tip/mandrel
FI20010972A0 (fi) * 2001-05-09 2001-05-09 Thermo Labsystems Oy Kärkisäiliöpipetti
US6568288B2 (en) * 2001-06-29 2003-05-27 Rainin Instrument, Llc Pipette with improved pipette tip and mounting shaft
DE10135963B4 (de) * 2001-07-24 2005-09-29 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung zum Pipettieren einer Flüssigkeit
DE10222511B4 (de) * 2002-05-22 2005-03-17 Eppendorf Ag Pipettenspitze
US7517694B2 (en) * 2002-07-26 2009-04-14 Ortho-Clinical Diagnostics, Inc. Metering tip with internal features to control fluid meniscus and oscillation
US7641859B2 (en) * 2004-02-11 2010-01-05 Matrix Technologies Corporation Pipette tip mounting and ejection assembly and associated pipette tip
US20050255005A1 (en) * 2004-05-13 2005-11-17 Arta Motadel Stackable pipette tips having increased accuracy
CA2512353A1 (en) * 2004-07-16 2006-01-16 Stemcell Technologies Inc. Automated pipette machine
EP1862219B1 (de) * 2006-05-29 2018-02-07 Qiagen GmbH Vorrichtung zur halterung von pipettenspitzen sowie pipettiervorrichtung
US7662344B2 (en) 2006-10-24 2010-02-16 Viaflo Corporation Locking pipette tip and mounting shaft
US7662343B2 (en) 2006-10-24 2010-02-16 Viaflo Corporation Locking pipette tip and mounting shaft
US7794664B2 (en) 2006-11-16 2010-09-14 Idexx Laboratories, Inc. Pipette tip
US8277757B2 (en) * 2009-09-29 2012-10-02 Integra Biosciences Corp. Pipette tip mounting shaft
EP3831489A1 (en) * 2010-01-22 2021-06-09 Biotix, Inc. Pipette tips
US9486803B2 (en) 2010-01-22 2016-11-08 Biotix, Inc. Pipette tips
US11559802B2 (en) * 2011-07-20 2023-01-24 Avidien Technologies, Inc. Pipette tip adapter
US8795606B2 (en) 2012-05-30 2014-08-05 Biotix, Inc. Integrated pipette tip devices
CN114453042A (zh) 2017-05-17 2022-05-10 拜欧迪克斯公司 人体工学移液管吸头

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Publication number Priority date Publication date Assignee Title
US3732734A (en) * 1972-05-25 1973-05-15 Centaur Chemical Co Micropipette with disposable tips
DE2526296C3 (de) * 1975-06-12 1978-05-18 Eppendorf Geraetebau Netheler + Hinz Gmbh, 2000 Hamburg Aufsteckbare Pipettenspitze
US4349109A (en) * 1980-10-20 1982-09-14 Medical Laboratory Automation, Inc. Disposable pipette tips and trays therefor
FI843976L (fi) * 1983-10-13 1985-04-14 Cetus Corp Utbytbar pipettspets.
US4679446A (en) * 1985-09-09 1987-07-14 Baxter Travenol Laboratories, Inc. Multi-volume displacement pipette
US4748859A (en) * 1987-03-06 1988-06-07 Rainin Instrument Co., Inc. Disposable pipette tip

Also Published As

Publication number Publication date
DD283953A5 (de) 1990-10-31
DE3824767C2 (enrdf_load_stackoverflow) 1990-05-10
EP0351574A2 (de) 1990-01-24
US4961350A (en) 1990-10-09
JP2848632B2 (ja) 1999-01-20
DE3824767A1 (de) 1990-02-01
EP0351574A3 (en) 1990-11-14
DE58905889D1 (de) 1993-11-18
JPH0268148A (ja) 1990-03-07
ATE95728T1 (de) 1993-10-15

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