EP0337334A3 - Dérivés d'acides aminés inhibant la rénine - Google Patents

Dérivés d'acides aminés inhibant la rénine Download PDF

Info

Publication number
EP0337334A3
EP0337334A3 EP19890106250 EP89106250A EP0337334A3 EP 0337334 A3 EP0337334 A3 EP 0337334A3 EP 19890106250 EP19890106250 EP 19890106250 EP 89106250 A EP89106250 A EP 89106250A EP 0337334 A3 EP0337334 A3 EP 0337334A3
Authority
EP
European Patent Office
Prior art keywords
amino acid
acid derivatives
renin
inhibiting amino
inhibiting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19890106250
Other languages
German (de)
English (en)
Other versions
EP0337334A2 (fr
Inventor
Peter Dr. Raddatz
Joachim Dr. Gante
Johannes Dr. Sombroek
Claus J. Dr. Schmitges
Klaus-Otto Dr. Minck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of EP0337334A2 publication Critical patent/EP0337334A2/fr
Publication of EP0337334A3 publication Critical patent/EP0337334A3/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
EP19890106250 1988-04-14 1989-04-08 Dérivés d'acides aminés inhibant la rénine Withdrawn EP0337334A3 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3812328A DE3812328A1 (de) 1988-04-14 1988-04-14 Aminosaeurederivate
DE3812328 1988-04-14

Publications (2)

Publication Number Publication Date
EP0337334A2 EP0337334A2 (fr) 1989-10-18
EP0337334A3 true EP0337334A3 (fr) 1992-05-20

Family

ID=6351910

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19890106250 Withdrawn EP0337334A3 (fr) 1988-04-14 1989-04-08 Dérivés d'acides aminés inhibant la rénine

Country Status (12)

Country Link
EP (1) EP0337334A3 (fr)
JP (1) JPH026449A (fr)
KR (1) KR890016062A (fr)
CN (1) CN1037155A (fr)
AU (1) AU618335B2 (fr)
DE (1) DE3812328A1 (fr)
DK (1) DK177789A (fr)
FI (1) FI891761A (fr)
HU (1) HU206888B (fr)
NZ (1) NZ228707A (fr)
PT (1) PT90273B (fr)
ZA (1) ZA892720B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3717631A1 (de) * 1987-05-26 1988-12-15 Merck Patent Gmbh Aminosaeurederivate
WO1991006561A1 (fr) * 1989-10-27 1991-05-16 The Upjohn Company Procede de traitement d'hvi et d'autres virus, et composes utiles a cet effet
TW209870B (fr) * 1990-01-18 1993-07-21 Pfizer
EP0483403A1 (fr) * 1990-10-31 1992-05-06 Hoechst Aktiengesellschaft Dérivés d'amino-acides ayant une activité d'inhibitrice de rénine, leur procédé de préparation et les médicaments les contenant
US5442044A (en) * 1991-01-04 1995-08-15 Pfizer Inc. Orally active renin inhibitors
AU3069192A (en) * 1991-11-01 1993-06-07 Smithkline Beecham Corporation Hiv protease inhibitors containing guanidine
CN103370331B (zh) 2011-02-08 2017-02-15 默克专利股份有限公司 用于治疗关节病的氨基他汀衍生物
WO2014015934A1 (fr) 2012-07-24 2014-01-30 Merck Patent Gmbh Dérivés d'hydroxystatine pour le traitement de l'arthrose

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0229667A2 (fr) * 1986-01-16 1987-07-22 Abbott Laboratories Peptidyl aminodiols
EP0230242A2 (fr) * 1986-01-17 1987-07-29 Hoechst Aktiengesellschaft Derivés substitués de l'acide 4-amino-3-hydroxy-butyrique, procédé pour leur production, médicaments les contenants, et leur application
EP0249096A2 (fr) * 1986-06-10 1987-12-16 MERCK PATENT GmbH Dérivés d'acides aminés inhibant la rénine
EP0286813A2 (fr) * 1987-03-12 1988-10-19 MERCK PATENT GmbH Dérivés d'acides aminés inhibant la rénine

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0229667A2 (fr) * 1986-01-16 1987-07-22 Abbott Laboratories Peptidyl aminodiols
EP0230242A2 (fr) * 1986-01-17 1987-07-29 Hoechst Aktiengesellschaft Derivés substitués de l'acide 4-amino-3-hydroxy-butyrique, procédé pour leur production, médicaments les contenants, et leur application
EP0249096A2 (fr) * 1986-06-10 1987-12-16 MERCK PATENT GmbH Dérivés d'acides aminés inhibant la rénine
EP0286813A2 (fr) * 1987-03-12 1988-10-19 MERCK PATENT GmbH Dérivés d'acides aminés inhibant la rénine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PEPTIDES, CHEMISTRY AND BIOLOGY, Proceedings of the 10th American Peptide Symposium, 23rd-28th May 1987, St. Louis, Missouri, pages 474-475; D.J. KEMPF et al.: "Renin inhibitors based on novel dipeptide analogs: Increased efficacy through systematic inclusion of polar functionality", Der ganze Artikel. *

Also Published As

Publication number Publication date
KR890016062A (ko) 1989-11-28
CN1037155A (zh) 1989-11-15
DK177789A (da) 1989-10-15
AU618335B2 (en) 1991-12-19
HUT52786A (en) 1990-08-28
ZA892720B (en) 1989-12-27
HU206888B (en) 1993-01-28
PT90273B (pt) 1994-07-29
PT90273A (pt) 1989-11-10
JPH026449A (ja) 1990-01-10
NZ228707A (en) 1992-03-26
DK177789D0 (da) 1989-04-13
EP0337334A2 (fr) 1989-10-18
AU3255589A (en) 1989-10-19
FI891761A0 (fi) 1989-04-13
DE3812328A1 (de) 1989-10-26
FI891761A (fi) 1989-10-15

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