ZA892720B - Amino acid derivatives - Google Patents

Amino acid derivatives

Info

Publication number
ZA892720B
ZA892720B ZA892720A ZA892720A ZA892720B ZA 892720 B ZA892720 B ZA 892720B ZA 892720 A ZA892720 A ZA 892720A ZA 892720 A ZA892720 A ZA 892720A ZA 892720 B ZA892720 B ZA 892720B
Authority
ZA
South Africa
Prior art keywords
amino acid
acid derivatives
derivatives
amino
acid
Prior art date
Application number
ZA892720A
Inventor
Peter Raddatz
Raddatz Peter
Joachim Gante
Gante Joachim
Johannes Sombroek
Sombroek Johannes
Claus J Schmitges
J Schmitges Claus
Klaus-Otto Minck
Minck Klaus-Otto
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of ZA892720B publication Critical patent/ZA892720B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
ZA892720A 1988-04-14 1989-04-13 Amino acid derivatives ZA892720B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3812328A DE3812328A1 (en) 1988-04-14 1988-04-14 AMINOSAEUREDERIVATE

Publications (1)

Publication Number Publication Date
ZA892720B true ZA892720B (en) 1989-12-27

Family

ID=6351910

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA892720A ZA892720B (en) 1988-04-14 1989-04-13 Amino acid derivatives

Country Status (12)

Country Link
EP (1) EP0337334A3 (en)
JP (1) JPH026449A (en)
KR (1) KR890016062A (en)
CN (1) CN1037155A (en)
AU (1) AU618335B2 (en)
DE (1) DE3812328A1 (en)
DK (1) DK177789A (en)
FI (1) FI891761A (en)
HU (1) HU206888B (en)
NZ (1) NZ228707A (en)
PT (1) PT90273B (en)
ZA (1) ZA892720B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3717631A1 (en) * 1987-05-26 1988-12-15 Merck Patent Gmbh AMINO ACID DERIVATIVES
AU6633490A (en) * 1989-10-27 1991-05-31 Upjohn Company, The Method for treating hiv and other retroviruses and compounds useful therefor
TW209870B (en) * 1990-01-18 1993-07-21 Pfizer
EP0483403A1 (en) * 1990-10-31 1992-05-06 Hoechst Aktiengesellschaft Derivatives of amino acids as inhibitors of renin, methods for their preparation, medicaments containing them and their use
US5442044A (en) * 1991-01-04 1995-08-15 Pfizer Inc. Orally active renin inhibitors
WO1993009132A1 (en) * 1991-11-01 1993-05-13 Smithkline Beecham Corporation Hiv protease inhibitors containing guanidine
JP6326232B2 (en) 2011-02-08 2018-05-16 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ Aminostatin derivatives for the treatment of arthropathy
US9624264B2 (en) 2012-07-24 2017-04-18 Merck Patent Gmbh Hydroxystatin derivatives for the treatment of arthrosis

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL81234A (en) * 1986-01-16 1992-09-06 Abbott Lab Peptidylaminodiols,process for their preparation and pharmaceutical compositions comprising them
DE3601248A1 (en) * 1986-01-17 1987-07-23 Hoechst Ag SUBSTITUTED 4-AMINO-3-HYDROXYBUTTERIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THESE AGENTS AND THEIR USE
ATE116994T1 (en) * 1986-06-10 1995-01-15 Merck Patent Gmbh RENIN-INHIBITING AMINO ACID DERIVATIVES.
DE3721855A1 (en) * 1987-03-12 1988-09-22 Merck Patent Gmbh AMINO ACID DERIVATIVES

Also Published As

Publication number Publication date
AU3255589A (en) 1989-10-19
PT90273A (en) 1989-11-10
HUT52786A (en) 1990-08-28
DE3812328A1 (en) 1989-10-26
EP0337334A3 (en) 1992-05-20
FI891761A (en) 1989-10-15
DK177789A (en) 1989-10-15
DK177789D0 (en) 1989-04-13
JPH026449A (en) 1990-01-10
CN1037155A (en) 1989-11-15
PT90273B (en) 1994-07-29
EP0337334A2 (en) 1989-10-18
AU618335B2 (en) 1991-12-19
KR890016062A (en) 1989-11-28
NZ228707A (en) 1992-03-26
FI891761A0 (en) 1989-04-13
HU206888B (en) 1993-01-28

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