EP0302575A1 - Ein zur mehrmaligen Verwendung bestimmter Kopfteil eines Behältnisses - Google Patents

Ein zur mehrmaligen Verwendung bestimmter Kopfteil eines Behältnisses Download PDF

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Publication number
EP0302575A1
EP0302575A1 EP88201691A EP88201691A EP0302575A1 EP 0302575 A1 EP0302575 A1 EP 0302575A1 EP 88201691 A EP88201691 A EP 88201691A EP 88201691 A EP88201691 A EP 88201691A EP 0302575 A1 EP0302575 A1 EP 0302575A1
Authority
EP
European Patent Office
Prior art keywords
head
container
head according
contents
passage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP88201691A
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English (en)
French (fr)
Inventor
Jan Lambert Van Os
Peter Buchan
Johannes Marinus De Man
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gist Brocades NV
Original Assignee
Gist Brocades NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades NV filed Critical Gist Brocades NV
Publication of EP0302575A1 publication Critical patent/EP0302575A1/de
Withdrawn legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/20—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge
    • B65D47/2018—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure
    • B65D47/2031—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure the element being formed by a slit, narrow opening or constrictable spout, the size of the outlet passage being able to be varied by increasing or decreasing the pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/20—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge
    • B65D47/2018—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure
    • B65D47/205—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure the valve being formed by a tubular flexible sleeve surrounding a rod-like element provided with at least one radial passageway which is normally closed by the sleeve
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/20—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge
    • B65D47/2018—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure
    • B65D47/2056—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure lift valve type
    • B65D47/2062—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure lift valve type in which the deformation raises or lowers the valve stem
    • B65D47/2075—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure lift valve type in which the deformation raises or lowers the valve stem in which the stem is raised by the pressure of the contents and thereby opening the valve

Definitions

  • This invention relates to novel heads for different types of containers, whose contents are intended to be discharged as separate aliquots.
  • Another option is to prevent contamination by measures taken at the outlet of the container.
  • DE-OS-1,586,758 discloses a tube with a closing device to prevent drying out of the tube contents in which point closure is effected by contact between the lips of a tubular member attached to the tube itself.
  • GB 417,793 is directed to an opening and closing device which prevents the oxidation of the contents in a tube, and comprises a number of displaceable members held together by a ring which separate to form an aperture when the tube is squeezed.
  • GB 326,683 discloses a valve-type closing device for a tube where the opening through which the tube contents are extruded is very short.
  • the passage length is no less than 3 mm and is preferably no less than 5 mm, and its width when closed is a maximum of 1 mm, preferably of 0.1 mm.
  • the head according to the invention is not to be removed, but stays in its place while the container is being used.
  • the head may be fitted with a cap for cover and protection, e.g. against desiccation, which cap must be removed before each use.
  • the containers may be of any type known in the art, in particular those in which the volume is reduced and no air is introduced as the contents are extruded.
  • Such containers are those provided with a plunger and collapsible tubes, in combination with which the heads of the invention are particularly suitable.
  • the contents of the containers for which the heads of the invention are intended may be any of those materials which are susceptible to deterioration by microbial infection, such as pharmaceuticals, cosmetics or foodstuffs.
  • the contents should pass readily through the narrow opening or openings of the head, therefore they will be semisolid or liquid.
  • the heads may contain certain anti-microbial agents. Also, when a removable cap is used to cover the head, this cap may contain an anti-microbial agent.
  • An anti-bacterial agent incorporated in the head or cap according to the present invention has to meet quite different requirements as compared with an anti-bacterial agent which is incorporated in the contents.
  • the anti-bacterial agent When the anti-bacterial agent is incorporated in the head or cap, its anti-bacterial effect has to be built up very quickly (due to the frequent transit of fresh contents) in a very small volume of contents, which is consequently unlikely to affect the user in any undesired way.
  • the embodiment illustrated in Figures 4A, 4B and 4C comprises a housing (11) which may be screwed onto the top of a container (2), and which is provided with a plurality of, in this case, four, openings (13) which extend into the body of the housing.
  • the inner surface of the housing extends cylindrically from its upper end for between a quarter and a third of its total length and then tapers radially inwards to meet the top of the container.
  • the frusto-conical cavity described by the tapering inner surface is provided with a plug (15) which is made from an elastic material and which comprises an upper stem (15 a ) that is attached inside the central cavity of the housing (16) ending flush with the end surface of the housing.
  • the plug stem (15 a ) When the container is squeezed the plug stem (15 a ) is compressed such that its shoulders end flush with the lower surface of the central cavity (17). A narrow elongate channel (18) is thereby formed between the tapering plug tip (15 b ) and the tapering inner surface of the housing through which the container contents are extruded.
  • the channel (17) has a length of at least 5 mm, preferably 10 mm and the separation between its walls is no more than 0.1 mm when the passage is closed.
  • the embodiment illustrated in Figures 5A and 5B comprises a housing (22) formed from a rigid material, the inner surface of which tapers inwards for about a quarter of its total length and then extends cylindrically to meet the top of the container to which it is attached.
  • the housing comprises a central part (24) which is separated from the cylindrical inner surface of the housing by an annular channel (23) and into which the stem (21 a ) of a frusto-conical plug (21) is secured.
  • the plug is made from an elastic material and, when the container is not in use, it is in contact with the tapering inner surface of the housing.
  • the plug is joined to the stem by a neck section (25) and when the container is squeezed, the pressure caused by the contents in the channel (23) causes elongation of the neck which in turn allows the plug (21) to lift and thereby form an extended elongate channel between the housing and the plug through which the container contents are extruded.
  • the channel has a length of at least 5 mm, preferably 10 mm and the separation between its walls is no more than 0.1 mm wide when the passage is closed.
  • the invention includes heads as hereinbefore described, provided with anti-microbial agents, as hereinbefore described.
  • Cream II is useful for indicating bacterial mutiplication by changing its colour at the place of multiplication to yellow due to acidic metabolism products. Preliminary experiments have ascertained, that the addition of phenol red and sodium hydroxide to cream II does not affect the growth and motility of Staphylococcus or Enterobacter as compared to cream I.
  • Example 2 Substantially the same experimental design was employed as in Example 1, the difference being that here infection of every head was done only once, followed by an incubation period at 30°C of 7 or 28 days.
  • Example 2 Substantially the same experimental design was employed as in Example 1, the difference being that here Staphylococcus aureus (chosen because it is a common pathogen) was used as the test bacterium. For infecting the free ends of the elastic tubes, about 5x105 CFU were used each time.
  • Example 2 The same heads and dummy heads as in Example 1 were employed, and also the same microorganism.
  • the heads or dummy heads were attached to disposable plastic 5 ml injection syringes, and the combination was filled with the sterile broth.
  • Control for bacterial colonisation within the syringe was performed visually (in the liquid broth, multiplication of bacteria is readily evident by the development of turbidity) and by culturing samples.
  • Example 4 Substantially the same experimental design was employed as in Example 4, the difference being that here Staphylococcus aureus was used as the test bacterium for infecting (105 CFU/ml) the broth in the vessel. (The bacterial contents of this organism did not drop below 108 CFU/ml for the duration of the experiment).
  • the head according to the first described embodiment ( Figure 1) was used for testing against ingrowth of six different micro-organisms.
  • the heads were mounted on the open ends of 30 ml collapsible tubes, filled with the sterile nutritive cream I of Example 1.
  • Infection of the tested combination was performed by inserting a liquid culture of Enterobacter aerogenes, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Candida albicans or Aspergillus niger into the free end of the head. Subsequently the combinations were incubated at 30°C for 24 hours.
  • Table 2 Bacterial colonisation after single infection of the free end of dummy or complete third-model heads with Enterobacter aerogenes. Heads tested Incubation period (days) Bacterial colonisation indicated by Number of heads tested Number of heads with colonisation Dummy 7 phenolred discoloration 3 3 " " culturing samples 3 3 " 28 phenolred discoloration 3 3 " “ culturing samples 3 3 Complete 7 phenolred discoloration 10 0 " " culturing samples 10 0 " 28 phenolred discoloration 10 0 “ “ culturing samples 10 0 Table 3 Bacterial ingrowth after repeatedly infecting the free end of dummy or complete third-model heads with staphylococcus aureus.
  • Heads Bacterial colonisation indicated Number of heads tested Number of heads with colonisation Total percentage heads with colinisation First day Second day Third day Sixth day Seventh day Dummy visually 5 5 5 5 5 5 100 " by culturing samples 5 5 100 complete visually 5 0 0 0 0 0 0 " by culturing samples 5 0 0 Table 5 Bacterial colonitation after placing the free end of dummy or complete third model heads in broth infected with Staphylococcus aureus.
  • Heads Bacterial colonisation indicated number of heads tested Number of heads with colonisation Total percentage heads with colonisations First day Second day Third day Seventh day Eight day Dummy visually 5 3 5 5 5 5 5 92 " by culturing samples 5 5 100 complete visually 5 0 0 0 0 0 0 " by culturing samples 5 0 0 Table 6 Microbial colonisation after infection of free end of first model heads.
  • test - microorganism starting infection (CFU) number of combinations infected Number of microbiologically positives after 24 hours incubation at 30 ⁇ C before the clip behind the clip Enterobacter aerogenes 2.2x107 2 2 0 Escherichia coli 1.3x106 1 1 0 1.0x103 1 1 0 Pseudomonas aeroginosa 1.4x105 1 1 0 2.2x102 1 1 0 Staphylococcus aureus 2.4x105 1 1 0 1.7x103 1 1 0 Candida albicans 4.8x103 1 1 0 2.0x102 1 1 0 Aspergillus niger 1x104 1 1 0 1x103 1 1 0

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
EP88201691A 1987-08-05 1988-08-04 Ein zur mehrmaligen Verwendung bestimmter Kopfteil eines Behältnisses Withdrawn EP0302575A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP87201488 1987-08-05
EP87201488 1987-08-05

Publications (1)

Publication Number Publication Date
EP0302575A1 true EP0302575A1 (de) 1989-02-08

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EP88201691A Withdrawn EP0302575A1 (de) 1987-08-05 1988-08-04 Ein zur mehrmaligen Verwendung bestimmter Kopfteil eines Behältnisses

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2738555A1 (fr) * 1995-09-13 1997-03-14 Sofab Perfectionnements apportes a un dispositif de distribution pour produit ophtalmologique
FR2804846A1 (fr) * 2000-02-16 2001-08-17 Oreal Dispositif de conditionnement et d'application comportant une structure poreuse incorporant un agent biocide
WO2003029085A3 (en) * 2001-10-03 2004-01-22 Hunter Group Inc Collapsible dispensing system
EP1391392A3 (de) * 2002-08-20 2004-04-07 Masuda Masatoshi Ventilmechanismus für Flüssigkeitstube
US7077296B2 (en) 1991-12-06 2006-07-18 Aptargroup, Inc. Dispensing valve
US7186045B2 (en) 2000-02-16 2007-03-06 L'oreal S.A. Device and method for applying a cosmetic product
EP1842787A3 (de) * 2006-04-05 2008-10-08 Coltène/Whaledent GmbH + Co. KG Spender für viskose Medien mit Spenderbehälter, Ausdrückmechanismus und Spenderkanüle
WO2011044531A1 (en) * 2009-10-09 2011-04-14 Py Daniel C Device with co-molded closure, one-way valve and variable-volume storage chamber, and related method
EP1948522A4 (de) * 2005-11-03 2011-10-19 Reseal Internat Ltd Partnership Kontinuierlich abdichtende einwegeventilanordnung und fluidabgabesystem sowie formulierungen zur verwendung darin

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR834140A (fr) * 1937-02-24 1938-11-14 Embout amovible à obturation automatique
DE834524C (de) * 1950-08-02 1952-03-20 Bela Seregi Als Lippenventil ausgebildeter Tubenverschluss
FR1092480A (fr) * 1953-10-26 1955-04-21 Bouchon automatique pour récipients genre tubes à produits pâteux
US2753091A (en) * 1953-01-09 1956-07-03 Albert M Herzig Closure for collapsible tubes

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR834140A (fr) * 1937-02-24 1938-11-14 Embout amovible à obturation automatique
DE834524C (de) * 1950-08-02 1952-03-20 Bela Seregi Als Lippenventil ausgebildeter Tubenverschluss
US2753091A (en) * 1953-01-09 1956-07-03 Albert M Herzig Closure for collapsible tubes
FR1092480A (fr) * 1953-10-26 1955-04-21 Bouchon automatique pour récipients genre tubes à produits pâteux

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7077296B2 (en) 1991-12-06 2006-07-18 Aptargroup, Inc. Dispensing valve
FR2738555A1 (fr) * 1995-09-13 1997-03-14 Sofab Perfectionnements apportes a un dispositif de distribution pour produit ophtalmologique
WO1997010160A1 (fr) * 1995-09-13 1997-03-20 Sofab Dispositif de distribution pour produit ophtalmologique ou similaire
FR2804846A1 (fr) * 2000-02-16 2001-08-17 Oreal Dispositif de conditionnement et d'application comportant une structure poreuse incorporant un agent biocide
EP1136056A1 (de) * 2000-02-16 2001-09-26 L'oreal Vorrichtung zum Aufbewahren und Auftragen mit einer porösen Anordnung welcher ein Biozid enthalt
JP2001315860A (ja) * 2000-02-16 2001-11-13 L'oreal Sa 滅菌剤を取り入れた多孔構造体を具備する収容且つ供給装置
US7186045B2 (en) 2000-02-16 2007-03-06 L'oreal S.A. Device and method for applying a cosmetic product
WO2003029085A3 (en) * 2001-10-03 2004-01-22 Hunter Group Inc Collapsible dispensing system
GB2396684A (en) * 2001-10-03 2004-06-30 Hunter Group Inc Collapsible dispensing system
GB2396684B (en) * 2001-10-03 2006-02-22 Hunter Group Inc One-way valve assembly for dispensing flowable materials
US7140517B2 (en) 2002-08-20 2006-11-28 Masatoshi Masuda Valve mechanism for tube shaped fluid container
EP1391392A3 (de) * 2002-08-20 2004-04-07 Masuda Masatoshi Ventilmechanismus für Flüssigkeitstube
CN100391805C (zh) * 2002-08-20 2008-06-04 增田胜利 用于管式流体容器的阀机构
EP1948522A4 (de) * 2005-11-03 2011-10-19 Reseal Internat Ltd Partnership Kontinuierlich abdichtende einwegeventilanordnung und fluidabgabesystem sowie formulierungen zur verwendung darin
EP1842787A3 (de) * 2006-04-05 2008-10-08 Coltène/Whaledent GmbH + Co. KG Spender für viskose Medien mit Spenderbehälter, Ausdrückmechanismus und Spenderkanüle
WO2011044531A1 (en) * 2009-10-09 2011-04-14 Py Daniel C Device with co-molded closure, one-way valve and variable-volume storage chamber, and related method
CN102666300A (zh) * 2009-10-09 2012-09-12 丹尼尔·皮 具有共模制的封闭件、单向阀和可变容积储存室的设备以及相关方法
CN102666300B (zh) * 2009-10-09 2014-12-17 丹尼尔·皮 单向阀、包括该单向阀的设备及制造该设备的方法
US8998034B2 (en) 2009-10-09 2015-04-07 Dr. Py Institute Llc Device with co-molded closure, one-way valve and variable-volume storage chamber, and related method
US10131474B2 (en) 2009-10-09 2018-11-20 Dr. Py Institute Llc Apparatus and method for sealing with a liquid sealant

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