EP0211822A2 - Appareil électromédical pour thérapie - Google Patents

Appareil électromédical pour thérapie Download PDF

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Publication number
EP0211822A2
EP0211822A2 EP86890210A EP86890210A EP0211822A2 EP 0211822 A2 EP0211822 A2 EP 0211822A2 EP 86890210 A EP86890210 A EP 86890210A EP 86890210 A EP86890210 A EP 86890210A EP 0211822 A2 EP0211822 A2 EP 0211822A2
Authority
EP
European Patent Office
Prior art keywords
current
treatment
herpes
therapy device
pulses
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP86890210A
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German (de)
English (en)
Other versions
EP0211822A3 (fr
Inventor
Eugen Franz Dietheim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hepax Ltd
Original Assignee
Hepax Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hepax Ltd filed Critical Hepax Ltd
Publication of EP0211822A2 publication Critical patent/EP0211822A2/fr
Publication of EP0211822A3 publication Critical patent/EP0211822A3/fr
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36021—External stimulators, e.g. with patch electrodes for treatment of pain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/326—Applying electric currents by contact electrodes alternating or intermittent currents for promoting growth of cells, e.g. bone cells

Definitions

  • the invention relates to an electromedical therapy device with a unit for constant current generation, which generates a sequence of monopolar current pulses of approximately rectangular shape, which can be fed to the skin surface of a patient via two electrodes connected to the secondary winding of a pulse transformer.
  • a therapy device of the type mentioned in which rectangular pulses of a certain frequency, pulse duration and intensity are supplied to a patient for the purpose of sleep therapy.
  • the usable frequency of these square-wave pulses is between 5 and 100 Hz, while the pulse length should be 0.4 to 2 ms. It turns out that it is important in sleep therapy, among other things, to create clear and constant conditions with regard to frequency, pulse duration and intensity of the pulses, whereby any reaction to the rectangular pulses from the electrode circuit should be excluded as far as possible. Measures are proposed in the aforementioned DE-OS whereby a unit for constant current generation is realized.
  • the invention is based on the observation that herpes viruses can be inactivated by electrotherapy.
  • the object of the present invention is to develop a stimulation current device of the type mentioned at the outset so that its use leads to the desired inactivating effect on herpes viruses in organic tissue.
  • the frequency of the current pulses is between 25 and 35 Hz and the pulse duration is between 0.1 and 0.3 ms, and in that the current intensity is "60 mA, depending on the values that can be specified via an input device, so that Herpesviruses are inactivated in organic tissue
  • herpes summarizes all viral diseases of the skin and mucous membrane, which are due to infection with the herpes simplex virus (herpes simplex) and infection with the varicella virus (herpes zoster).
  • herpes simplex The usual medicinal treatment for herpes simplex is mostly only symptomatic, mostly lengthy and especially unsatisfactory with recurrent forms.
  • virostatics in solution and ointment form are used, the use of which is recommended over a period of a few weeks.
  • drying and disinfecting measures are available to treat the affected skin.
  • a satisfactory therapy for herpes zoster is also not known. Although the pain is treated symptomatically with analgesics, the success of any causal therapy is controversial. A major problem is the treatment of neuralgias, whereby psychotropic drugs and tranquilizers are also prescribed, and in extreme cases the severing of the affected nerve pathways is recommended.
  • the therapy device according to the invention is suitable for the treatment of all forms of herpes, the healing taking place with minimal physical and psychological stress on the patient The process is significantly accelerated and a hospital stay that may be necessary is considerably shortened. In addition, the occurrence of recurrences is effectively suppressed.
  • the frequency of the pulses is varied here between 4 and 50 Hz, while in the present invention there is a fixed frequency value for the duration of the treatment, which is between 25 and 35 Hz.
  • the current strength (mA) should be set during the treatment or should be carried out by the patient himself so that he feels a clear but not painful pulsation on the skin. After about five minutes, it is usually necessary to increase the intensity to counteract habituation processes and to reach the original starting position.
  • the trigeminal nerve with its three branches is treated electrically according to the affected half of the face.
  • the anode being placed as a single one on the ganglion gasseri.
  • the cathodes are placed as far as possible from the anode of the diseased dermatome. If several dermatomes on the same side of the face are affected, only one anode and several cathodes can be used.
  • a corresponding number of anodes can be placed, but the cathode, on the other hand, is homolaterally attached to the stomach.
  • the therapy device according to the invention can be used both for acute outbreaks with or without efflorescences and for the treatment of post-herpetic pain.
  • the treatment is continued until the lesions have healed or the pain has ceased or has decreased significantly.
  • it will be necessary to administer analgesics to the patient at the beginning of the treatment, but only until the analgesia has reached its full effect through the treatment.
  • treatment should be started as soon as possible, with the recommendation that the expected relapses were to be treated on fourteen consecutive days, for example, even if no outbreak (pain and / or efflorescences) was observed at this time.
  • the paravertebral anode In the treatment of genital herpes and progenital herpes, the paravertebral anode is placed transcutaneously either on the right or left of the second sacral segment. If there are visible efflorescences around the genitals, it is necessary to include the corresponding dermatomes.
  • the treatment should always be carried out with electrodes of different sizes, the anode being relatively small in order to get enough current to the nerve due to the field line density.
  • the cathode must be relatively large in order to distribute the cathodal stimulus so that the patient does not feel any sensations or unpleasant stimuli.
  • Electrodes with a round contact surface are used for the treatment in the area of the head, the anode having a diameter of approximately 13 mm and the cathode measuring approximately 29 mm.
  • the electrode used on the head as the cathode is used on the body as the anode. In this case, the cathode is to be distributed over a large area, e.g. formed as a rectangle with the dimensions 120 x 70 mm.
  • Treatment for generalized herpes is given here as an example. It can be observed that the outbreak or visible efflorescences always begin with local herpes and only then widen. The original local herpes is then treated (e.g. with herpes zoster intercostalis, the electrodes are placed according to the paravertebral dermatome). The treatment is carried out three times a day, 20 minutes at five hour intervals and until the efflorescences, pain, etc. disappear.
  • herpes outbreaks after marrow transplants can occur in patients with leukemia.
  • the body defense after the transplantation has been deliberately reduced pharmacologically, it is recommended to start the herpes treatment according to the invention prophylactically immediately after the transplantation.
  • the patient In order to achieve a particularly effective, rapidly effective treatment, the patient should be kept as far as possible of any kind of stress during the treatment period.
  • NiCd batteries e.g. 8 NiCd batteries with 1.2 volts and 600 mA each.
  • the treatment flow can be gradually increased or decreased using a keypad.
  • the unit for constant current generation controlled by the microprocessor, forms and delivers the current pulses necessary for the treatment with the current intensity previously entered via the keypad.
  • the therapy device has a device for measuring current with a peak-hold circuit for measuring current peaks of individual current pulses, the device generating a control signal which, with the interposition of a microprocessor in the unit for constant current generation, leads to current shutdown.
  • a peak-hold circuit for measuring current peaks of individual current pulses
  • the device generating a control signal which, with the interposition of a microprocessor in the unit for constant current generation, leads to current shutdown.
  • the control signal of the device for current measurement can be fed, preferably with the interposition of the microprocessor, to a preferably acoustic display and warning device for indicating the end of treatment or for an error message.
  • This display device for example in the form of a piezo buzzer integrated in the device or a small loudspeaker, is used primarily to indicate the end of a 20-minute treatment.
  • warning functions can also be taken over by this device, for example the indication of a power interruption due to poor electrode contact or the undervoltage in the power supply of the device.
  • optical display and warning devices for example flashing light-emitting diodes.
  • a charge state control which generates a signal for switching off the device in the event of undervoltage.
  • the frequency of the pulses is 30 Hz and their pulse duration is 0.2 ms. Frequencies below 5 Hz can be unpleasantly noticeable (electrical shocks). It should be noted that motor nerves could be blocked by frequencies above 180 Hz.
  • a storage unit for storing the pulse data preferably the frequency and the pulse duration.
  • a ROM can preferably be used, which reads all the data required for pulse generation, such as frequency, pulse duration and pulse shape, into the microprocessor.
  • microprocessor which stores the patient's treatment data, preferably the number and duration of the treatments. This allows specific data of the respective patient to be called up before each treatment, so that the desired treatment rhythm can be better adhered to.
  • the central component is the microprocessor 17, which is used to control the entire device, namely for pulse control, reading the key commands which are to be entered via the keypad 21 and for controlling the display unit 22.
  • the power supply 16 of the device can be either by a battery pack or by a Power supply can be realized.
  • the microprocessor 17 controls a unit 18 for constant current generation, which finally delivers the current pulses required for the treatment to the patient via the electrodes.
  • a device 19 is used on the output side for current measurement, the measured values being digitized and fed to the microprocessor 17 via a feedback 20.
  • the device also has a storage unit 43 and a charge status control 45.
  • the microprocessor 17, for example an R65 01Q from Rockwell, is fed via its supply line and operated at a clock frequency (quartz 23) of 4 MHz.
  • the current strength of the treatment current can be increased or decreased via the keys 24 or 25 of the keypad 21.
  • the key 26 is used to switch the display unit to display the treatment duration, a tip switch 27 'to switch off the device.
  • the LEDs 28, 29 indicate the operating state of the display unit (current measurement or time measurement).
  • the circuit 51 (power-up reset) at the reset input 50 of the microprocessor 17 ensures that the device only begins to work when the microprocessor has reached its predetermined clock frequency.
  • the components of the circuit designated by 30 are digital inverters.
  • the device also has an acoustic display and warning device 31, which performs a wide variety of functions. For example, the expiry of the treatment time, the interruption of the current flow, by falling electrodes etc. or internal errors of the device can be acoustically reported. If no electricity through the electrical that flows, the warning device responds and the power is switched off, the device remains switched on.
  • the display unit 22 of the device comprises an LC display 32, for example LD-H 7980 AZ from Epson, which is controlled by two LCD drivers 33 (74 HC 4543 National). This is also where BCD is decoded to 7 segments.
  • An oscillator 34 ensures the generation of a square-wave voltage of approximately 60 Hz to supply the LC display 32.
  • a digital-to-analog converter 37 (ZN 428 from Ferranti) is connected to the microprocessor 17 via the digital data line 35. This serves to convert the digital current specification into analog form and to control the constant current output stage 38 with an operational amplifier 39, a power transistor 49 (Darlington MPSU 45) and a pulse transformer 40, which is connected on the secondary side to the electrodes 46, 47 and in the It is able to transmit steep pulse edges as undistorted as possible.
  • the unit for current measurement 19 has a peak-hold circuit 41 for the detection of current peaks which may occur and for continuous current measurement, as well as an analog-digital converter 42, for example ADC 0804 from National, connected to the microprocessor 17 via the digital data line 35 Conversion of the analog measured value into digital form and forwarding to the microprocessor.
  • the components of the circuit 41, designated 39, are operational amplifiers (LM 2902 from National).
  • the device also has a memory unit 43 which has a program memory 44, for example an MBM 27C32 A from Fujitsu, which is connected to the microprocessor 17 via the digital data line 35 and the address line 36.
  • This ROM contains all parameters for pulse control, such as frequency, pulse duration, etc.
  • the device has a charge status control 45, which has a comparator circuit 48 for detecting undervoltage.
  • the display is carried out via the light-emitting diode 53.
  • the charge status control is connected to the microprocessor 17 and triggers an acoustic alarm signal in the event of undervoltage, after which the device switches off automatically.
  • a component 52 (74HC123 from National) with a so-called watchdog circuit represents a safety device which monitors and controls the microprocessor 17. An interruption or deviation in the program sequence leads to the device being switched off.
  • Herpes zoster Anode B on segment T3 right or left, cathode B 'opposite on the thorax, homolateral.
  • Herpes progenitalis anode C on segment L1 right or left, cathode C 'opposite on the thorax or abdomen, homolateral.
  • Herpes analis anode D on segment S5 alternately on the right and left, cathode D 'opposite, across the symphysis, median.
  • Fig. 3 the location on the head surface under which the ganglion trigeminal (gasseri) lies is designated by G. From this ganglion the three branches of the nerve nerve minus extend. These are the ophthalmic nerve I, the maxillary nerve II and the mandibular nerve III.
  • the electrodes are placed as shown in FIG. 4.
  • the anode G ' whose contact surface has a diameter of about 13 mm, comes to lie above the ganglion gasseri.
  • the cathode - Klbis K3, which have a diameter of about 29 mm, are at the locations designated in Figure 4 digits..
  • the dermatomes supplied by the three branches of the trigeminal nerve are designated by the numbers 1 to 3.
  • the corresponding dermatome (second and / or third) must be treated depending on the involvement of the upper or lower lip.
  • the anode G ' is to be placed on the ganglion gasseri and the cathode or the cathodes in each case on the designated electrode layers K2 and / or K3 (FIG. 4). If the infestation also includes the first segment, it will be necessary to fix another cathode Kl in front of the respective eyebrow. It is possible to treat the face with one anode and three cathodes.
  • the same dermatomes are also treated in the oral cavity if the oral mucosa is affected.
  • Monopolar approximately rectangular current pulses of the pulse shape shown in FIG. 6 are delivered to the patient via the electrodes 46, 47 to be attached to the diseased dermatome.
  • the pulse duration is 0.2 msec and the current intensity is 50 mA, for example.
  • the latter can be varied from 0 to 60 mA and is regulated and kept constant depending on the patient's skin resistance.
  • the frequency of the pulses is 30 Hz. Care must be taken to achieve the steepest possible pulse edges (small ot) with little over- or undershoot.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Electrotherapy Devices (AREA)
EP86890210A 1985-07-31 1986-07-15 Appareil électromédical pour thérapie Withdrawn EP0211822A3 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0225785A AT385664B (de) 1985-07-31 1985-07-31 Elektromedizinisches therapiegeraet
AT2257/85 1985-07-31

Publications (2)

Publication Number Publication Date
EP0211822A2 true EP0211822A2 (fr) 1987-02-25
EP0211822A3 EP0211822A3 (fr) 1988-05-11

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EP86890210A Withdrawn EP0211822A3 (fr) 1985-07-31 1986-07-15 Appareil électromédical pour thérapie

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US (1) US4913148A (fr)
EP (1) EP0211822A3 (fr)
KR (1) KR870000943A (fr)
CN (1) CN86105722A (fr)
AT (1) AT385664B (fr)

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DE3829082A1 (de) * 1988-08-27 1990-03-01 Wieland Edelmetalle Vorrichtung zur ermittlung der individuellen empfindlichkeitsschwelle gegenueber galvanischen spannungen in der mundhoehle
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US8532758B2 (en) 2000-11-29 2013-09-10 Leon M. Silverstone Method and apparatus for treatment of viral diseases

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US5676648A (en) 1996-05-08 1997-10-14 The Aps Organization, Llp Iontophoretic drug delivery apparatus and method for use
US6385487B1 (en) 1996-05-08 2002-05-07 Biophoretic Therapeutic Systems, Llc Methods for electrokinetic delivery of medicaments
USRE37796E1 (en) 1997-12-16 2002-07-23 Biophoretic Therapeutic Systems, Llc Methods for iontophoretic delivery of antiviral agents
CN1084634C (zh) * 1998-07-02 2002-05-15 周靖人 红外治疗仪
US6148231A (en) * 1998-09-15 2000-11-14 Biophoretic Therapeutic Systems, Llc Iontophoretic drug delivery electrodes and method
US6594527B2 (en) * 1998-09-18 2003-07-15 Nexmed Holdings, Inc. Electrical stimulation apparatus and method
EP1022034A1 (fr) * 1999-01-19 2000-07-26 Manfred Dr. Leubner Procédé et dispositif pour la stimulation des muscles ou des tissus nerveux
US6477410B1 (en) * 2000-05-31 2002-11-05 Biophoretic Therapeutic Systems, Llc Electrokinetic delivery of medicaments
US6792306B2 (en) * 2000-03-10 2004-09-14 Biophoretic Therapeutic Systems, Llc Finger-mounted electrokinetic delivery system for self-administration of medicaments and methods therefor
US7127285B2 (en) * 1999-03-12 2006-10-24 Transport Pharmaceuticals Inc. Systems and methods for electrokinetic delivery of a substance
RU2162353C1 (ru) * 1999-05-17 2001-01-27 Карасев Александр Александрович Электронейроадаптивный стимулятор
MXPA02010211A (es) 2000-04-17 2003-05-23 Nexmed Holdings Inc Aparato y metodo para estimulacion electrica.
US7228184B2 (en) * 2003-02-22 2007-06-05 Chester Heath Viral-inhibiting method
US7584001B2 (en) * 2003-07-17 2009-09-01 Beck Kent F Electrical epidermal stimulation device
US20050125040A1 (en) * 2003-12-09 2005-06-09 Peter Lathrop Method and apparatus for treating viral diseases
US7983747B2 (en) 2008-10-28 2011-07-19 Silverstone Leon M Non-invasive method and apparatus for the treatment of viral infections
DE102012010262B4 (de) * 2012-05-25 2014-07-03 Albrecht Molsberger Therapeutisch anwendbare Gleichstromabgabevorrichtung
US9858773B2 (en) 2014-02-19 2018-01-02 Microsoft Technology Licensing, Llc Wearable computer having a skin-stimulating interface
US10307082B2 (en) * 2015-06-02 2019-06-04 Htc Corporation Method and apparatus for herpes zoster diagnosis and recording medium using the method
EP3548136A4 (fr) 2016-12-01 2020-07-08 Thimble Bioelectronics, Inc. D/B/A Enso Dispositif de neuromodulation et son procédé d'utilisation
CN106580673A (zh) * 2016-12-03 2017-04-26 潍坊大地医疗器械有限公司 一种操作简便的电子经络治疗仪
CN106580672A (zh) * 2016-12-03 2017-04-26 潍坊大地医疗器械有限公司 一种安全可靠的电子经络治疗仪

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H. KRESSE "Kompendium Elektro-Medizin", 3. Auflage, 1982 Verlag Siemens Aktiengesellschaft, Berlin und Munchen seiten 185-191 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0290126A2 (fr) * 1987-03-25 1988-11-09 Hisamitsu Pharmaceutical Co., Inc. Appareil de guérison à basse fréquence applicable directement à l'organisme
EP0290126A3 (en) * 1987-03-25 1990-02-07 Kabushiki Kaisya Advance Low frequency curing apparatus applicable directly to organism
EP0298268A1 (fr) * 1987-06-10 1989-01-11 Sterimed Gesellschaft Mbh Dispositif de ponction et/ou cathétérisme avec une aiguille de ponction pour des opérations de recherche de nerfs
DE3829082A1 (de) * 1988-08-27 1990-03-01 Wieland Edelmetalle Vorrichtung zur ermittlung der individuellen empfindlichkeitsschwelle gegenueber galvanischen spannungen in der mundhoehle
GB2240275A (en) * 1990-01-12 1991-07-31 Solar Wide Ind Ltd Bactericidal device
GB2240275B (en) * 1990-01-12 1994-06-01 Solar Wide Ind Ltd Bactericidal device
WO1993018819A1 (fr) * 1990-04-12 1993-09-30 A California Partnership Consisting Of: Gloria Kent, Peter A. Lathrop And Steve K. Johnston Procede et appareil pour le traitement de l'herpes simplex 1 et 2
US8532758B2 (en) 2000-11-29 2013-09-10 Leon M. Silverstone Method and apparatus for treatment of viral diseases

Also Published As

Publication number Publication date
ATA225785A (de) 1987-10-15
EP0211822A3 (fr) 1988-05-11
CN86105722A (zh) 1987-01-28
AT385664B (de) 1988-05-10
KR870000943A (ko) 1987-03-10
US4913148A (en) 1990-04-03

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