EP0193249A3 - Benzoylharnstoffderivate mit Antikrebs-Wirkung - Google Patents
Benzoylharnstoffderivate mit Antikrebs-Wirkung Download PDFInfo
- Publication number
- EP0193249A3 EP0193249A3 EP86200300A EP86200300A EP0193249A3 EP 0193249 A3 EP0193249 A3 EP 0193249A3 EP 86200300 A EP86200300 A EP 86200300A EP 86200300 A EP86200300 A EP 86200300A EP 0193249 A3 EP0193249 A3 EP 0193249A3
- Authority
- EP
- European Patent Office
- Prior art keywords
- urea derivatives
- benzoyl urea
- ati
- tumor activity
- benzoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/46—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylureas
- C07C275/48—Y being a hydrogen or a carbon atom
- C07C275/54—Y being a carbon atom of a six-membered aromatic ring, e.g. benzoylureas
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/63—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/22—Nitrogen and oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
- C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyridine Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL8500572 | 1985-03-01 | ||
NL8500572 | 1985-03-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0193249A2 EP0193249A2 (de) | 1986-09-03 |
EP0193249A3 true EP0193249A3 (de) | 1988-03-16 |
Family
ID=19845602
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP86200300A Withdrawn EP0193249A3 (de) | 1985-03-01 | 1986-02-27 | Benzoylharnstoffderivate mit Antikrebs-Wirkung |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0193249A3 (de) |
JP (1) | JPS61218569A (de) |
AU (1) | AU601145B2 (de) |
DK (1) | DK88186A (de) |
ES (1) | ES8801896A1 (de) |
GR (1) | GR860542B (de) |
IE (1) | IE860511L (de) |
PH (1) | PH23163A (de) |
ZA (1) | ZA861446B (de) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8546429B2 (en) | 2003-07-11 | 2013-10-01 | Arena Pharmaceuticals, Inc. | 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto |
US8933083B2 (en) | 2003-01-14 | 2015-01-13 | Arena Pharmaceuticals, Inc. | 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0223741A3 (de) * | 1985-11-22 | 1988-05-25 | Ciba-Geigy Ag | Benzoylharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung in der Schädlingsbekämpfung |
DE3545569A1 (de) * | 1985-12-21 | 1987-06-25 | Hoechst Ag | Neue pyridin-derivate, verfahren zu ihrer herstellung, sie enthaltene mittel und ihre verwendung als schaedlingsbekaempfungsmittel |
EP0324521A3 (de) * | 1988-01-11 | 1991-11-27 | Duphar International Research B.V | Methode zur Behandlung hämatologischer Krankheiten und dafür anzuwendende pharmazeutische Zusammensetzungen |
US5166180A (en) * | 1988-01-11 | 1992-11-24 | Duphar International Research B.V. | Method of treating hematologic diseases and pharmaceutical composition to be used therefor |
EP0336888A1 (de) * | 1988-03-18 | 1989-10-11 | Ciba-Geigy Ag | Mittel zur Schädlingsbekämpfung |
EP0333659A3 (de) * | 1988-03-18 | 1990-12-05 | Ciba-Geigy Ag | Substituierte Thioharnstoffderivate |
JPH029855A (ja) * | 1988-03-31 | 1990-01-12 | Ishihara Sangyo Kaisha Ltd | 置換ベンゼン誘導体、それらの製造方法及びそれらを含有する抗癌性組成物 |
US5302608A (en) * | 1988-11-18 | 1994-04-12 | Takeda Chemical Industries, Ltd. | Age formation inhibitors |
EP0369453A3 (de) * | 1988-11-18 | 1990-10-24 | Takeda Chemical Industries, Ltd. | Inhibitoren der AGE-Bildung |
GB8829817D0 (en) * | 1988-12-21 | 1989-02-15 | Shell Int Research | Benzamide compounds,their preparation and their use as pesticides |
NZ234551A (en) * | 1989-07-28 | 1991-10-25 | Ishihara Sangyo Kaisha | Benzoylurea derivatives and antitumour compositions |
IL98784A0 (en) * | 1990-07-17 | 1992-07-15 | Lilly Co Eli | Heterocyclyl sulfonamide derivatives,process for their preparation and pharmaceutical compositions containing them |
DE69408598T2 (de) * | 1993-06-08 | 1998-09-17 | Vertex Pharmaceuticals Inc Cam | Pyridazine als Interleukin-1-beta Verwandlungsenzym Inhibitoren |
US6316503B1 (en) | 1999-03-15 | 2001-11-13 | Tularik Inc. | LXR modulators |
JP4434745B2 (ja) | 2002-01-30 | 2010-03-17 | アムジェン インコーポレイテッド | 複素環式アリールスルホンアミドベンジル化合物 |
WO2003063576A2 (en) | 2002-01-30 | 2003-08-07 | Tularik Inc. | Arylsulfonamidobenzylic compounds |
IL164249A0 (en) * | 2002-04-11 | 2005-12-18 | Aventis Pharma Gmbh | Acyl-3-carboxphenylurea derivatives, processes forpreparing them and their use |
US7223796B2 (en) | 2002-04-11 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Acyl-4-carboxyphenylurea derivatives, processes for preparing them and their use |
US7078404B2 (en) | 2002-04-11 | 2006-07-18 | Sanofi-Aventis Deutschland Gmbh | Acyl-3-carboxyphenylurea derivatives, processes for preparing them and their use |
DE10225635C1 (de) * | 2002-06-07 | 2003-12-24 | Aventis Pharma Gmbh | N-Benzoylureido-Zimtsäurederivate, Verfahren zu deren Herstellung und deren Verwendung |
US7049341B2 (en) | 2002-06-07 | 2006-05-23 | Aventis Pharma Deutschland Gmbh | N-benzoylureidocinnamic acid derivatives, processes for preparing them and their use |
EP1521577A1 (de) * | 2002-06-13 | 2005-04-13 | QLT, Inc. | Verfahren zur verwendung von isothiazolderivaten zur behandlung von krebs oder entzündungen |
PL373329A1 (en) | 2002-07-12 | 2005-08-22 | Sanofi-Aventis Deutschland Gmbh | Heterocyclically substituted benzoylureas, method for their production and their use as medicaments |
DE10246434B4 (de) * | 2002-10-04 | 2005-08-04 | Aventis Pharma Deutschland Gmbh | Carboxyalkoxy-substituierte Acyl-carboxyphenyl-harnstoffderivate und ihre Verwendung als Arzneimittel |
US20040157922A1 (en) | 2002-10-04 | 2004-08-12 | Aventis Pharma Deutschland Gmbh | Carboxyalkoxy-substituted acyl-carboxyphenylurea derivatives and their use as medicaments |
DE10302452B4 (de) * | 2003-01-23 | 2005-02-24 | Aventis Pharma Deutschland Gmbh | Carbonylamino-substituierte Acyl-phenyl-harnstoffderivate, Verfahren zu deren Herstellung und deren Verwendung |
MY148521A (en) | 2005-01-10 | 2013-04-30 | Arena Pharm Inc | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto |
DOP2006000010A (es) | 2005-01-10 | 2006-07-31 | Arena Pharm Inc | Procedimiento para preparar eteres aromáticos |
EP1907367A4 (de) * | 2005-04-18 | 2011-05-11 | Saeed R Khan | Entwicklung und synthese neuer tubulinpolymerisationsinhibitoren: benzoylphenylharnstoff- (bpu-) schwefelanaloga |
DE602007010664D1 (de) | 2006-09-04 | 2010-12-30 | Univ Dundee | P53 aktivierende benzoylharnstoff- und benzoylthioharnstoff-verbindungen |
GB0909912D0 (en) | 2009-06-09 | 2009-07-22 | Univ Dundee | Compounds |
CN101863856A (zh) * | 2010-06-12 | 2010-10-20 | 利尔化学股份有限公司 | 双(4-甲基-1,2,3-噻二唑-5-甲酰脲)类化合物及其制备方法和用途 |
CN101973959B (zh) * | 2010-06-12 | 2016-06-01 | 利尔化学股份有限公司 | 4-甲基-1,2,3-噻二唑-5-甲酰脲类化合物及其制备方法和用途 |
EP3323818A1 (de) | 2010-09-22 | 2018-05-23 | Arena Pharmaceuticals, Inc. | Modulatoren des gpr119-rezeptors und behandlung von damit assoziierten erkrankungen |
KR102386952B1 (ko) * | 2013-03-15 | 2022-04-18 | 데시페라 파마슈티칼스, 엘엘씨. | 항암 및 항-증식 활성을 나타내는 n-아실-n'-(피리딘-2-일) 우레아 및 유사체 |
CN107405332A (zh) | 2015-01-06 | 2017-11-28 | 艾尼纳制药公司 | 治疗与s1p1受体有关的病症的方法 |
KR102603199B1 (ko) | 2015-06-22 | 2023-11-16 | 아레나 파마슈티칼스, 인크. | S1p1 수용체-관련 장애에서의 사용을 위한 (r)-2-(7-(4-시클로펜틸-3-(트리플루오로메틸)벤질옥시)-1,2,3,4-테트라히드로시클로-펜타[b]인돌-3-일)아세트산 (화합물 1)의 결정성 l-아르기닌 염 |
US20220296363A1 (en) | 2019-08-19 | 2022-09-22 | Akkolens International B.V. | Accommodative Intraocular Lens Combination with Independent Fixed and Variable Power Lens Sections |
NL2027301B1 (en) | 2020-01-13 | 2021-10-26 | Akkolens Int B V | Mechanical means for accommodative intraocular lens |
Citations (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB986811A (en) * | 1961-01-23 | 1965-03-24 | Parke Davis & Co | Salts of substituted 1,2-dihydro-s-triazines |
NL7105350A (en) * | 1971-04-21 | 1972-10-24 | Substd benzoyl and thiobenzoyl ureas and thioureas - insecticides | |
US3860648A (en) * | 1970-03-02 | 1975-01-14 | Rorer Inc William H | 1-(p-trifluoromethoxyphenyl)-biguanide |
US4148902A (en) * | 1977-05-13 | 1979-04-10 | The Dow Chemical Company | N-[(optionally substituted phenylamino)carbonyl] pyridine carboxamides and insecticidal use thereof |
US4160037A (en) * | 1977-09-30 | 1979-07-03 | The Upjohn Company | Compounds, compositions and methods of combatting pest employing thioureas |
US4160834A (en) * | 1977-03-09 | 1979-07-10 | Eli Lilly And Company | 1-(Substituted benzoyl)-3-(substituted pyrazinyl)ureas |
DE2926480A1 (de) * | 1978-07-06 | 1980-01-24 | Duphar Int Res | Neue harnstoff- und thioharnstoffverbindungen, verfahren zur herstellung der neuen verbindungen sowie insektizidpraeparate auf basis dieser verbindungen |
EP0008768A1 (de) * | 1978-09-11 | 1980-03-19 | BASF Aktiengesellschaft | Aroylharnstoffe, Verfahren zu ihrer Herstellung sowie ihre Verwendung in insektiziden und akariziden Mitteln |
EP0009762A1 (de) * | 1978-10-07 | 1980-04-16 | Bayer Ag | Substituierte N-Benzoyl-N'-tert.-alkoxycarbonylphenyl-(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung als Insektizide |
EP0025363A1 (de) * | 1979-09-11 | 1981-03-18 | Ishihara Sangyo Kaisha Ltd. | N-Benzoyl-N'-pyridyloxyphenyl-Harnstoffe, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische und insektizide Zusammensetzungen |
EP0035084A1 (de) * | 1980-03-05 | 1981-09-09 | Ciba-Geigy Ag | Substituierte N-Fluorphenyl-N'-halogenbenzoylharnstoffe, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Mittel und ihre Verwendung zur Bekämpfung von Schädlingen |
EP0042732A1 (de) * | 1980-06-19 | 1981-12-30 | Eli Lilly And Company | 1-Benzoyl-3-substituierte Harnstoffe und Thioharnstoffe, ihre Herstellung, insektizide Zusammensetzungen, die sie enthalten, und ihre Verwendung als Insektizide |
EP0056124A2 (de) * | 1981-01-14 | 1982-07-21 | BASF Aktiengesellschaft | N-Benzoyl-N'-phenylharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Bekämpfung von Insekten |
EP0060071A1 (de) * | 1981-03-03 | 1982-09-15 | Eli Lilly And Company | 1-Benzoyl-3-(arylpyridyl)harnstoffverbindungen |
EP0107214A2 (de) * | 1982-09-02 | 1984-05-02 | Duphar International Research B.V | Pharmazeutische Zusammensetzungen mit Gehalt an Benzoyl-Phenylharnstoffen mit tumorhemmender Wirkung |
EP0116728A1 (de) * | 1983-01-24 | 1984-08-29 | Duphar International Research B.V | Aktive Kompositionen gegen Motten, weisse Fliegen und Holzwürmer, pharmazeutische Kompositionen und Benzoylharnstoffderivaten |
EP0116729A2 (de) * | 1983-01-24 | 1984-08-29 | Duphar International Research B.V | Benzoylharnstoffderivate und diese Verbindungen enthaltende pestizide Kompositionen |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57109721A (en) * | 1980-12-27 | 1982-07-08 | Ishihara Sangyo Kaisha Ltd | Carcinostatic agent |
JPS5959617A (ja) * | 1982-09-02 | 1984-04-05 | デユフアル・インテルナチオナル・レセ−ルフ・ベ−・ヴエ− | 制癌作用を有する医薬組成物 |
DE3478573D1 (en) * | 1983-09-01 | 1989-07-13 | Duphar Int Res | Benzoyl urea derivatives having anti-tumor activity |
-
1986
- 1986-02-26 IE IE860511A patent/IE860511L/xx unknown
- 1986-02-26 ZA ZA861446A patent/ZA861446B/xx unknown
- 1986-02-26 AU AU54108/86A patent/AU601145B2/en not_active Ceased
- 1986-02-26 DK DK88186A patent/DK88186A/da not_active Application Discontinuation
- 1986-02-26 GR GR860542A patent/GR860542B/el unknown
- 1986-02-26 ES ES552432A patent/ES8801896A1/es not_active Expired
- 1986-02-27 EP EP86200300A patent/EP0193249A3/de not_active Withdrawn
- 1986-02-27 PH PH33457A patent/PH23163A/en unknown
- 1986-03-01 JP JP61042838A patent/JPS61218569A/ja active Pending
Patent Citations (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB986811A (en) * | 1961-01-23 | 1965-03-24 | Parke Davis & Co | Salts of substituted 1,2-dihydro-s-triazines |
US3860648A (en) * | 1970-03-02 | 1975-01-14 | Rorer Inc William H | 1-(p-trifluoromethoxyphenyl)-biguanide |
NL7105350A (en) * | 1971-04-21 | 1972-10-24 | Substd benzoyl and thiobenzoyl ureas and thioureas - insecticides | |
US4160834A (en) * | 1977-03-09 | 1979-07-10 | Eli Lilly And Company | 1-(Substituted benzoyl)-3-(substituted pyrazinyl)ureas |
US4148902A (en) * | 1977-05-13 | 1979-04-10 | The Dow Chemical Company | N-[(optionally substituted phenylamino)carbonyl] pyridine carboxamides and insecticidal use thereof |
US4160037A (en) * | 1977-09-30 | 1979-07-03 | The Upjohn Company | Compounds, compositions and methods of combatting pest employing thioureas |
DE2926480A1 (de) * | 1978-07-06 | 1980-01-24 | Duphar Int Res | Neue harnstoff- und thioharnstoffverbindungen, verfahren zur herstellung der neuen verbindungen sowie insektizidpraeparate auf basis dieser verbindungen |
EP0008768A1 (de) * | 1978-09-11 | 1980-03-19 | BASF Aktiengesellschaft | Aroylharnstoffe, Verfahren zu ihrer Herstellung sowie ihre Verwendung in insektiziden und akariziden Mitteln |
EP0009762A1 (de) * | 1978-10-07 | 1980-04-16 | Bayer Ag | Substituierte N-Benzoyl-N'-tert.-alkoxycarbonylphenyl-(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung als Insektizide |
EP0025363A1 (de) * | 1979-09-11 | 1981-03-18 | Ishihara Sangyo Kaisha Ltd. | N-Benzoyl-N'-pyridyloxyphenyl-Harnstoffe, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische und insektizide Zusammensetzungen |
EP0035084A1 (de) * | 1980-03-05 | 1981-09-09 | Ciba-Geigy Ag | Substituierte N-Fluorphenyl-N'-halogenbenzoylharnstoffe, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Mittel und ihre Verwendung zur Bekämpfung von Schädlingen |
EP0042732A1 (de) * | 1980-06-19 | 1981-12-30 | Eli Lilly And Company | 1-Benzoyl-3-substituierte Harnstoffe und Thioharnstoffe, ihre Herstellung, insektizide Zusammensetzungen, die sie enthalten, und ihre Verwendung als Insektizide |
EP0056124A2 (de) * | 1981-01-14 | 1982-07-21 | BASF Aktiengesellschaft | N-Benzoyl-N'-phenylharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Bekämpfung von Insekten |
EP0060071A1 (de) * | 1981-03-03 | 1982-09-15 | Eli Lilly And Company | 1-Benzoyl-3-(arylpyridyl)harnstoffverbindungen |
EP0107214A2 (de) * | 1982-09-02 | 1984-05-02 | Duphar International Research B.V | Pharmazeutische Zusammensetzungen mit Gehalt an Benzoyl-Phenylharnstoffen mit tumorhemmender Wirkung |
EP0116728A1 (de) * | 1983-01-24 | 1984-08-29 | Duphar International Research B.V | Aktive Kompositionen gegen Motten, weisse Fliegen und Holzwürmer, pharmazeutische Kompositionen und Benzoylharnstoffderivaten |
EP0116729A2 (de) * | 1983-01-24 | 1984-08-29 | Duphar International Research B.V | Benzoylharnstoffderivate und diese Verbindungen enthaltende pestizide Kompositionen |
Non-Patent Citations (7)
Title |
---|
CHEMICAL ABSTRACTS, vol. 94, no. 23, 8th June 1981, page 652, abstract no. 192334q, Columbus, Ohio, US; R. RAI et al.: "A novel route to the synthesis of 3-(arylimino)-5-substituted-1,2,4-dithiazoles. Part I: Oxidative debenzylation and cyclization of S-benzyliso-N-(arylthiocarbamoyl)thioacetamides"; & J.INDIAN.CHEM.SOC. 1980, 57(12), 1166-9 * |
CHEMICAL ABSTRACTS, vol. 96, no. 13, 29th March 1982, page 700, abstract no. 104147b, Columbus, Ohio, US; Yu.L. YAGUPOL'SKII et al.: "1,4-diaryl-1,3-diaza-1,3-butadiene derivatives"; & ZH.ORG.KHIM. 1981, 17(8), 1720-5 * |
CHEMICAL ABSTRACTS, vol. 98, no. 13, 28th March 1983, page 67, abstract no. 101190r, Columbus, Ohio, US; & JP-A-57 109 721 (ISHIHARA SANGYO KAISHA) 08-07-1982 * |
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 21, no. 6, November/December 1973, pages 993-998, Washington, DC, US; K. WELLINGA et al.: "Synthesis and laboratory evaluation of 1-(2,6-disubstituted benzoyl)-3-phenylureas a new class of insecticides. II. Influence of the acyl moiety on insecticidal activity" * |
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 24, no. 1, January/February 1976, pages 134-136, Washington, DC, US; C.C. YU et al.: "Synthesis and insecticidal activity of substituted 1-phenyl-3-benzoylureas and 1-phenyl-3-benzoyl-2-thioureaus" * |
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 26, no. 1, January/February 1978, pages 164-166, Washington, DC, US; A.B. MILO et al.: "Heterocyclic analogues of diflubenzuron and growth and reproduction inhibitors of the fall armyworm and housfly" * |
MONATSHEFTE FUR CHEMIE, vol. 108, pages 367-379, 1977, Springer-Verlag, Vienna, AT; W. STADLBAUER et al.: "Zur Synthese 3,5,6-substituierter s-Triazin-2,4-dione" * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8933083B2 (en) | 2003-01-14 | 2015-01-13 | Arena Pharmaceuticals, Inc. | 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia |
US8546429B2 (en) | 2003-07-11 | 2013-10-01 | Arena Pharmaceuticals, Inc. | 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto |
Also Published As
Publication number | Publication date |
---|---|
PH23163A (en) | 1989-05-19 |
IE860511L (en) | 1986-09-01 |
ES552432A0 (es) | 1988-03-01 |
GR860542B (en) | 1986-06-25 |
DK88186D0 (da) | 1986-02-26 |
AU5410886A (en) | 1986-09-04 |
ES8801896A1 (es) | 1988-03-01 |
ZA861446B (en) | 1986-10-29 |
DK88186A (da) | 1986-09-02 |
EP0193249A2 (de) | 1986-09-03 |
JPS61218569A (ja) | 1986-09-29 |
AU601145B2 (en) | 1990-09-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0193249A3 (de) | Benzoylharnstoffderivate mit Antikrebs-Wirkung | |
AU4869185A (en) | Gadolinium chelates as nmr contrast agents | |
AU516264B2 (en) | Phthalazin-4-ylacetic acid derivatives | |
AU520784B2 (en) | Interphenylene 9-thia-oxo-12-azaprostand acid derivatives | |
AU532839B2 (en) | Ascorbic acid test composition | |
AU6176280A (en) | Substituted n-benzoylanthranilic acid derivatives | |
AU551079B2 (en) | Glycidyliso cyanuric acid derivatives | |
ZA783353B (en) | A-acetylenic amino acid derivatives | |
AU4004278A (en) | Pyrimido (2,1-a) isoquinoline derivatives | |
AU584403B2 (en) | Diagnostic testing for micro-onganisms | |
AU518251B2 (en) | L-halomethyl amino acid derivatives | |
AU521514B2 (en) | 6-azaoligocycloakyl-methylene amino-penicillanic acid derivatives | |
AU522514B2 (en) | 7p-acylamido-3-cephem-4-carboxylic acid derivatives | |
AU524985B2 (en) | O-aminodeoxyclayulanic acid derivatives | |
ES552563A0 (es) | Un procedimiento para la preparacion de nuevos derivados de siraxina. | |
AU528013B2 (en) | Pyrazolo(1,5-c)quinazoline derivatives | |
AU5863380A (en) | Acid derivatives | |
IE40847L (en) | Pyridazine derivatives | |
AU2301677A (en) | Phenoxyphenoxy-alkanecarboxylic acid derivatives | |
AU513904B2 (en) | 2-trichloromethyl-4-nitrobenzenesulfenic acid derivatives | |
AU519473B2 (en) | Oxaminic acid derivatives | |
AU533620B2 (en) | Pyrrolidinyl-sulfamoylbenzoic acid derivatives | |
AU537900B2 (en) | Dihydronicotinic acid derivatives | |
GB1516271A (en) | Glycyrrhetinic acid derivatives | |
AU5758980A (en) | Clauulanic acid derivatives |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE CH DE FR GB IT LI LU NL SE |
|
PUAL | Search report despatched |
Free format text: ORIGINAL CODE: 0009013 |
|
AK | Designated contracting states |
Kind code of ref document: A3 Designated state(s): AT BE CH DE FR GB IT LI LU NL SE |
|
17P | Request for examination filed |
Effective date: 19880831 |
|
17Q | First examination report despatched |
Effective date: 19900131 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 19900811 |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: BROUWER, MARIUS S. Inventor name: VAN HES, ROELOF |