GB986811A - Salts of substituted 1,2-dihydro-s-triazines - Google Patents
Salts of substituted 1,2-dihydro-s-triazinesInfo
- Publication number
- GB986811A GB986811A GB2325/62A GB232562A GB986811A GB 986811 A GB986811 A GB 986811A GB 2325/62 A GB2325/62 A GB 2325/62A GB 232562 A GB232562 A GB 232562A GB 986811 A GB986811 A GB 986811A
- Authority
- GB
- United Kingdom
- Prior art keywords
- salts
- hydrogen
- triazines
- trifluoromethyl
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003839 salts Chemical class 0.000 title abstract 4
- RMQOXNXLVICLNK-UHFFFAOYSA-N 1,4-dihydro-1,3,5-triazine Chemical class C1NC=NC=N1 RMQOXNXLVICLNK-UHFFFAOYSA-N 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 150000003918 triazines Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- ALKYHXVLJMQRLQ-UHFFFAOYSA-N 3-Hydroxy-2-naphthoate Chemical compound C1=CC=C2C=C(O)C(C(=O)O)=CC2=C1 ALKYHXVLJMQRLQ-UHFFFAOYSA-N 0.000 abstract 1
- -1 4,41-methylene Chemical group 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 abstract 1
- 229940123208 Biguanide Drugs 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- NAFSLMFLGYXGIF-UHFFFAOYSA-N [n'-[n'-(4-chlorophenyl)carbamimidoyl]carbamimidoyl]azanium;chloride Chemical compound Cl.NC(N)=NC(N)=NC1=CC=C(Cl)C=C1 NAFSLMFLGYXGIF-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- QGBSISYHAICWAH-UHFFFAOYSA-N dicyandiamide Chemical compound NC(N)=NC#N QGBSISYHAICWAH-UHFFFAOYSA-N 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 201000004792 malaria Diseases 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/10—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
- C07D251/18—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with nitrogen atoms directly attached to the two other ring carbon atoms, e.g. guanamines
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises salts of triazines of formula <FORM:0986811/C2/1> with 4,41-methylene bis(3-hydroxy-2-napthoic acid); where X is hydrogen, halogen, methyl or trifluoromethyl, each of Y and Z is hydrogen, halogen, lower (i.e. 1-4 C) alkyl, lower alkoxy, lower alkylthio, trifluoromethyl or benzyloxy, at least one of X, Y and Z being hydrogen; R1 is lower alkyl and R2 is hydrogen or methyl; the salts are prepared by reaction of the components or salts thereof in a solvent. Triazines I may be prepared by reaction of the X,Y,Z-aniline with dicyandiamide and a compound R1R2.CO in the presence of a strong acid: if the compound R1R2.CO is reacted in a second step a biguanide of formula <FORM:0986811/C2/2> (e.g. p-chlorophenylbiguanide hydrochloride) is first obtained. Pharmaceutical compositions containing the above triazine salts are mentioned for parenteral administration (as suspensions) against bacteria and malaria. Reference has been directed by the Comptroller to Specification 709,906.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8390961A | 1961-01-23 | 1961-01-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB986811A true GB986811A (en) | 1965-03-24 |
Family
ID=22181439
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2325/62A Expired GB986811A (en) | 1961-01-23 | 1962-01-22 | Salts of substituted 1,2-dihydro-s-triazines |
Country Status (7)
| Country | Link |
|---|---|
| BR (1) | BR6235803D0 (en) |
| CH (1) | CH397708A (en) |
| DE (1) | DE1171439B (en) |
| DK (1) | DK104411C (en) |
| ES (1) | ES273934A1 (en) |
| GB (1) | GB986811A (en) |
| SE (1) | SE301479B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0193249A2 (en) * | 1985-03-01 | 1986-09-03 | Duphar International Research B.V | Benzoyl urea derivatives having ati-tumor activity |
| CN114591256A (en) * | 2022-02-15 | 2022-06-07 | 上海奥萝拉医药科技有限公司 | Directional synthesis method of dihydrotriazine |
-
1962
- 1962-01-17 SE SE476/62A patent/SE301479B/xx unknown
- 1962-01-22 ES ES0273934A patent/ES273934A1/en not_active Expired
- 1962-01-22 BR BR135803/62A patent/BR6235803D0/en unknown
- 1962-01-22 GB GB2325/62A patent/GB986811A/en not_active Expired
- 1962-01-22 DK DK29162AA patent/DK104411C/en active
- 1962-01-22 DE DEP28646A patent/DE1171439B/en active Pending
- 1962-01-22 CH CH74062A patent/CH397708A/en unknown
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0193249A2 (en) * | 1985-03-01 | 1986-09-03 | Duphar International Research B.V | Benzoyl urea derivatives having ati-tumor activity |
| EP0193249A3 (en) * | 1985-03-01 | 1988-03-16 | Duphar International Research B.V | Benzoyl urea derivatives having ati-tumor activity |
| CN114591256A (en) * | 2022-02-15 | 2022-06-07 | 上海奥萝拉医药科技有限公司 | Directional synthesis method of dihydrotriazine |
| CN114591256B (en) * | 2022-02-15 | 2024-02-20 | 上海奥萝拉医药科技有限公司 | Directional synthesis method of dihydrotriazine |
Also Published As
| Publication number | Publication date |
|---|---|
| ES273934A1 (en) | 1962-06-16 |
| CH397708A (en) | 1965-08-31 |
| DE1171439B (en) | 1964-06-04 |
| BR6235803D0 (en) | 1973-05-24 |
| DK104411C (en) | 1966-05-16 |
| SE301479B (en) | 1968-06-10 |
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