EP0182370A2 - Dispositif de conservation de sang - Google Patents

Dispositif de conservation de sang Download PDF

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Publication number
EP0182370A2
EP0182370A2 EP85114740A EP85114740A EP0182370A2 EP 0182370 A2 EP0182370 A2 EP 0182370A2 EP 85114740 A EP85114740 A EP 85114740A EP 85114740 A EP85114740 A EP 85114740A EP 0182370 A2 EP0182370 A2 EP 0182370A2
Authority
EP
European Patent Office
Prior art keywords
slide
blood
closure piece
collection tube
blood collection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP85114740A
Other languages
German (de)
English (en)
Other versions
EP0182370A3 (fr
Inventor
Walter Sarstedt
Dieter Korf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Walter Sarstedt Kunststoff Spritzgusswerk
Original Assignee
Walter Sarstedt Kunststoff Spritzgusswerk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Walter Sarstedt Kunststoff Spritzgusswerk filed Critical Walter Sarstedt Kunststoff Spritzgusswerk
Publication of EP0182370A2 publication Critical patent/EP0182370A2/fr
Publication of EP0182370A3 publication Critical patent/EP0182370A3/fr
Withdrawn legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs

Definitions

  • the invention relates to a blood storage device with a blood collection tube, which has a capillary-shaped mouthpiece at one end and an opening with a much larger diameter at the other end, which can be sealed with a removable cover.
  • the blood collection tube has a capillary-shaped mouthpiece for withdrawing the smallest amounts of blood.
  • a circular cylindrical tube adjoins the mouthpiece in one piece, which is expanded relative to the mouthpiece in such a way that it allows the insertion of a micropipette and which is designed to be closable at its enlarged end by means of a stopper.
  • the removable cover is preferably designed as a stopper.
  • the aim of the invention is to provide a blood storage device of the type mentioned in the introduction, in which if the blood collection tube is held at an angle, there is no need to fear the leakage of blood from the upper end, but nevertheless there is ventilation, and in that after the blood has been drawn a complete closure of the upper end of the blood collection tube can be brought about at any time without risk of blood spillage, but at which pressure equalization between the interior of the blood collection tube and the atmosphere is also possible for a desired time.
  • the invention provides that the lid consists of a sealing piece which is arranged close to and removable from the blood collection tube and a slide which is closed at the top by a cover plate, which is arranged in a cavity on the side of the closure piece facing away from the blood collection tube and between an opening and can be shifted to a closed position, the slide leaving a narrow passage, which serves only for ventilation, but does not let blood through when the blood collection tube is inclined, between the blood storage space and the atmosphere in the open state or closes tightly in the closed position.
  • the cover which consists of two parts, itself represents an externally actuable valve which allows the initially close connection between the interior of the blood collection tube and the atmosphere to be interrupted.
  • the passage opening initially present should be so small and arranged that when the tube is inclined, if blood would leak without a lid, this would be the case because of the arrangement and narrowness of the opening is avoided. So the opening should let air through but not blood. In principle, several small openings could also be provided next to one another.
  • the closure piece can be applied during manufacture, so that it does not interfere with the blood collection. If the interior of the blood collection tube is then to be hermetically sealed off from the outside, the valve is closed by pushing the slide into the closure piece.
  • a particularly good and hermetic closure of the lid after the blood withdrawal can be achieved if a pin is provided on the slide, which engages sealingly in the preferably central opening only when the slide is depressed.
  • An advantageous practical implementation of the invention is characterized in that the cavity is essentially circular-cylindrical and the slide is complementary thereto, in such a way that the slide can be displaced like a piston into the closed position.
  • This enables simple actuation of the valve according to the invention, since the slide can preferably be displaced in the axial direction like a piston within the closure piece into the closed position.
  • a further preferred embodiment is characterized in that the bottom wall of the closure piece delimiting the cavity from the interior contains a small opening, that a sealing projection extends axially into the cavity from the bottom wall at a radial distance from the peripheral wall of the closure piece, the outer wall of which when the slide is in the closed position with its inner wall in sealing engagement.
  • the slide has an annular bead radially on the inside in the lower end region of the inner wall.
  • At least one air duct is provided between the cylinder walls of the slide and the closure piece, which is in flow connection on the one hand with the atmosphere and on the other hand with the small opening of the closure piece adjacent to the interior, and between the slide in the open position between the sealing projection and the slide an air passage is present.
  • the small opening can also be arranged eccentrically in the closure piece, so that even larger inclination angles are possible before blood in the tube reaches the small opening.
  • a particularly preferred embodiment of the invention is designed in such a way that the slide is connected in a hinge-like manner to the upper end of the blood collection tube via a flexible tab. In this way, there is no risk that the slide is inadvertently pressed into the closed position before the blood is drawn, from which it is difficult, if at all, to be removed again. However, if the slide and the closure piece are sufficiently far apart from one another before and during blood withdrawal, as is made possible by the flexible tab, there is no risk of the valve closing prematurely.
  • a further embodiment is provided see that the cover plate of the slide, when it is in the closed position, does not protrude radially beyond the closure piece, such that the slide is no longer easily separable from the closure piece, but only the closure piece can be removed from the upper end of the blood collection tube .
  • a recess is provided in the upper surface of the closure piece, into which the cover plate of the slide enters in the closed position, in such a way that the operator no longer engages the cover plate after the closure piece has been assembled with the slide can be.
  • a mixing ball is loosely arranged in the interior of the blood collection tube, the diameter of which is larger than that of the small opening is in the closure piece. Due to the arrangement of the closure piece according to the invention, the mixing ball cannot fall out of the top of the same when the blood collection tube is shaken.
  • a further advantageous embodiment is characterized in that the capillary mouthpiece of the blood collection tube can be sealed tightly by an attached closure cap which is attached laterally to the closure piece or to the cover plate above a predetermined breaking point before use.
  • This design prevents the relatively small closure cap from being lost before use after the blood has been drawn, because it is firmly connected to a part of the cover.
  • the cover plate of the slide is flat and can be labeled on its upper side. With this design, the labels required for taking blood samples can easily be attached to the top of the cover plate.
  • a further embodiment is designed such that the blood collection tube is arranged in a centrifuge adapter tube in such a way that the closure cap rests on the bottom of the centrifuge adapter tube and a fastening ring sits on the upper end of the blood collection tube below an upper end flange on the upper end edge of the centrifuge adapter tube. This ensures that the blood collection tube is held securely within the centrifuge adapter tube.
  • the cavity 11 is essentially circular cylindrical, the axis 43 of this circular cylinder being aligned with the axis of the blood collection tube 20.
  • the slider 13 consists of an upper flat cover plate 36 which projects on all sides in a flange-like manner over the upper edge of the slider 13, but not radially beyond the edge of the closure piece 21. Furthermore, the slide 13 has a circular cylinder piece 37 which extends into the cavity 11 and which has at its lower end a radially inwardly projecting annular sealing bead 27 and a radially outwardly projecting stop bead 29 which, according to FIG. 2, is offset by 90 ° in relation to one another 33 owns.
  • the closure piece 21 has a circumferential wall 23 carrying the sealing bead 35 and at the top a circumferential flange 38 seated on the edge of the blood collection tube 20. At the bottom, the closure piece 21 is closed by a bottom wall 22 which, according to FIG. 1, has a small opening 14 in the middle, which connects the cavity 11 to the interior 17 of the blood collection tube 20.
  • the small opening 14 could also be arranged eccentrically at the dashed position 14 ', which would have the advantage that if the blood collection tube 20 is tilted to the left in FIG. 1, the blood contained in the tube only opens the opening 14' at a larger tilt angle. reached.
  • a sealing projection 24 / which has the shape of a circular cylinder extends centrally from the bottom wall 22 upwards.
  • the sealing projection 24 ends at about 1/3 of the total height of the closure piece 21.
  • the diameter of the cylinder wall 37 of the slide 13 is slightly smaller than the diameter of the cavity 11 in the upper region of the closure piece 21, so that at least when the slide 13 is in the open position (left half of FIG.
  • the outer wall 25 of the sealing projection 24 and the inner side 26 of the cylinder wall 37 are essentially aligned with one another.
  • the inner annular sealing bead 27 overlaps radially inwards somewhat with the outer wall 25, but the annular sealing bead 27 is slightly beveled at the bottom, so that it can slide along the outer wall 25 of the sealing projection 24 when the slide 13 is depressed, with slight radial compression.
  • the cavity 11 has a radially outwardly extending extension 28, which means that the cavity 11 extends downwards in a sudden step slightly above an annular step 39 in front of the sealing projection 24.
  • the stop bead 29 is arranged within this extension 28. Its radial extension to the outside is such that it overlaps with the inner wall 19 of the flange 38 of the closure piece 21 and is thus secured against being pulled out in the direction of arrow f in FIG. 1 by the ring step 39.
  • the interruptions 33 between the stop beads 29 serve to ensure air passage even when the slide 13 in FIG. 1 is pushed down into the closed position according to the right half of the figure. This is necessary so that the air can escape from the annular space 15 to the outside.
  • the stop bead 29 should have a small radial distance from the wall of the cavity 11, so that an air passage 32 is present between the wall and the stop bead 39 even at the points where there are no interruptions 33.
  • the closure piece 21 has on its flange 38 a tab 40, which is only partially shown and by means of which the closure piece can be fastened elastically and movably at a suitable location of the blood collection tube 20, but can also be omitted according to the invention, because the lid sits on the tube 20 from the start.
  • a handle 41 On the diametrically opposite side of the closure piece there is a handle 41 which facilitates the actuation and in particular the removal of the closure piece 21 from the blood collection tube 20.
  • the blood collection tube 20 is hermetically sealed, and the transport can now take place without the risk of blood leakage.
  • the closure piece 21 including the slide 13 is removed from the upper opening by means of the tab 41, whereupon the blood sample can then be poured off or pipetted in the usual manner.
  • a pin 42 on the slide 13 could be mounted, the tight manner in the closed state, the opening 14.
  • the slider 13 is connected to the closure plate 36 via a flexible tab 40 with the upper end of the blood collection tube 20, the tab 40 being in one piece with a ring 50 which is the radial end of the upper end of the blood collection tube 20 below surrounds outwardly projecting flange 51.
  • an annular disk-shaped recess 44 is provided in the upper surface of the closure piece 21, which is complementary to the shape of the cover plate 36.
  • the closure plate 36 is arranged in a recessed manner when the slide 13 is placed on the closure piece 21. It is therefore not possible to lift the closure plate 36 off the closure piece 21 again. Rather, it is necessary to open the closure piece 21 on the handle 41 to open it.
  • the closure piece 21 is removed from the blood receiving tube 20, the latter is connected to the tab 40 via the slide 13, so that the cover 12, which now consists of the two parts 13, 21, cannot be lost.
  • the capillary bore 14 is sufficient for ventilation, while the cylinder wall 37 can engage in a tight snap engagement with the closure piece 21 via locking ring beads 29 or 53.
  • the blood collection tube 20 is arranged in a centrifuge adapter tube 49, which can be suspended in a centrifuge (not shown) by means of an upper ring projection 52.
  • the ring 50 located below the flange 51 rests on the upper edge of the centrifuge adapter tube 49.
  • the capillary mouthpiece 46 located at the bottom of the blood collection tube 20 is sealed off by a hat-like closure cap 47 which is attached from below.
  • the closure cap 47 When inserted into the centrifuge adapter tube 49, the closure cap 47 is seated on the bottom of the centrifuge adapter tube 49. The blood collection tube 20 is thus properly supported for the centrifugation process.
  • a mixing ball 45 Inside the blood collection tube 20 there is a mixing ball 45, the diameter of which is significantly larger than that of the small opening 14, so that when the blood collection tube 20 is shaken, the ball mixes the contents of the blood collection tube 20 well but cannot escape from the tube.
  • the possibility of arranging the mixing ball 45 in the interior of the blood collection tube 20 represents a further essential advantage of the arrangement of the closure piece 21 during and after the blood withdrawal.
  • the closure cap 47 is first attached to the side of the cover plate 36 or preferably the closure piece 21 via a predetermined breaking point 48. The cap 47 is thus held captive until use. As soon as the blood withdrawal is complete, the closure cap 47 can be separated from the closure piece 21 by twisting or tearing and can be used to close the capillary mouthpiece 46.
  • the inside diameter of the capillary mouthpiece is 1.5 mm. As a result, better mixing is achieved;
  • the spherically rounded bottom of the centrifuge adapter tube 49 has proven particularly favorable.
  • the small vent hole 14 in the closure piece 21 has a diameter of about 1 mm.
  • a particular advantage of the small vent hole 14 is that the blood intake stops automatically when the blood collection tube 20 is filled with blood up to the vent hole.
  • the further blood intake which is also brought about by capillary action, is then automatically interrupted.
  • the interior of the cylindrical sealing projection 24 is at most filled with blood and it forms at the upper opening of the sealing projection 24, which is conically drawn in against the upper edge of the sealing projection 24
  • the inner diameter of the sealing projection 24 is significantly narrowed, but is still larger than the vent hole 14, an outwardly protruding blood dome, which then prevents any further blood flow due to surface tension effects.
  • the mixing ball 45 is made of high density plastic.
  • the cap 47 is first pushed onto the capillary mouthpiece 46. Only then is the slide 13 with the cover plate 36 to be inscribed inserted into the closure piece 21.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • External Artificial Organs (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
EP85114740A 1984-11-20 1985-11-19 Dispositif de conservation de sang Withdrawn EP0182370A3 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3442423 1984-11-20
DE3442423 1984-11-20

Publications (2)

Publication Number Publication Date
EP0182370A2 true EP0182370A2 (fr) 1986-05-28
EP0182370A3 EP0182370A3 (fr) 1987-12-09

Family

ID=6250780

Family Applications (1)

Application Number Title Priority Date Filing Date
EP85114740A Withdrawn EP0182370A3 (fr) 1984-11-20 1985-11-19 Dispositif de conservation de sang

Country Status (4)

Country Link
US (1) US4687479A (fr)
EP (1) EP0182370A3 (fr)
JP (1) JPS61203965A (fr)
CA (1) CA1253764A (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0420013A1 (fr) * 1989-09-26 1991-04-03 Walter Sarstedt Geräte und Verbrauchsmaterial für Medizin und Wissenschaft Dispositif de prélèvement sanguin
EP0627962A1 (fr) * 1992-02-28 1994-12-14 HSEI, Paul Dispositif de preparation d'echantillon
DE9418060U1 (de) * 1994-11-11 1996-03-14 SC - Sanguis Counting Kontrollblutherstellungs- und Vertriebs GmbH, 51588 Nümbrecht Probenröhre und Abschlußkappe, insesondere für Kapillar-Blutentnahme
DE29505652U1 (de) * 1995-04-01 1996-04-25 Boehringer Mannheim Gmbh, 68305 Mannheim Gefäß zur kontaminationsreduzierten Behandlung von Flüssigkeiten
AT514833A1 (de) * 2013-10-11 2015-04-15 Greiner Bio One Gmbh Abnahmebaugruppe, insbesondere für Blutproben

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5145646A (en) * 1991-06-03 1992-09-08 Abbott Laboratories Reagent bottle and cap
JPH0693907B2 (ja) * 1991-07-26 1994-11-24 川澄化学工業株式会社 血小板保存用器具
US5295599A (en) * 1992-07-20 1994-03-22 Innervision, Inc. Multiple cap seal for containers
FR2698375B1 (fr) * 1992-11-20 1995-02-17 Biopredic Sarl Dispositif pour le transport et le stockage de liquides utilisable, notamment, pour réaliser des kits pour test in vitro.
US5396899A (en) * 1993-04-28 1995-03-14 Duke University Spinal puncture fluid collection apparatus
DE19748749A1 (de) * 1997-11-05 1999-05-06 Roche Diagnostics Gmbh Gefäßverschluß mit Mitteln zur Vermeidung eines Austrages beim Öffnen
US20060018799A1 (en) * 2004-07-21 2006-01-26 Wong Cai Ne W Universal tissue homogenizer device and methods
BRPI0920586A2 (pt) 2008-10-31 2017-05-30 Bio Merieux Inc dispositivo de separacao para uso na separacao ,caracterizacao e/ou identificacao de micro-organismos.
IT1402876B1 (it) * 2010-11-19 2013-09-27 Copan Italia Spa Contenitore per il trasferimento selettivo di campioni di materiale biologico
JP6104480B2 (ja) * 2015-03-17 2017-04-05 株式会社エム・ビー・エス 試料採取分離器具
JP6558971B2 (ja) * 2015-06-17 2019-08-14 株式会社日立ハイテクノロジーズ 採血装置
JP6104440B1 (ja) * 2016-08-17 2017-03-29 株式会社エム・ビー・エス 血液採取器及び血液収容器を含む血液採取器具

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3288318A (en) * 1964-11-24 1966-11-29 John D Corbin Flexible plastic vial
US3419179A (en) * 1967-06-07 1968-12-31 Brunswick Corp Captive cap specimen vial
US4002275A (en) * 1975-11-12 1977-01-11 Vca Corporation Safety cap
US4007639A (en) * 1974-08-16 1977-02-15 Firma Walter Sarstedt Kunststoff-Spritzgusswerk Capillary vessel for blood removal
US4460101A (en) * 1982-12-28 1984-07-17 Tseng Bang Tsai Tortuous passage cover for flexible liquid container

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2388634A (en) * 1944-12-07 1945-11-06 Ace Glass Inc Container for aseptic filling and dispensing of sterile liquids
US3005455A (en) * 1955-06-24 1961-10-24 Baxter Laboratories Inc Container closure
US3047178A (en) * 1958-06-24 1962-07-31 Baxter Laboratories Inc Closure system
FR1545591A (fr) * 1967-05-19 1968-11-15 Baranne Soc Fermeture à double effet pour flacons, avec cape imperméable
US3944104A (en) * 1974-11-25 1976-03-16 Consumers Glass Company Limited Threaded wine bottle stopper
US4133462A (en) * 1977-10-19 1979-01-09 Lindstrom Alrik C Container closure
DE2943747A1 (de) * 1979-10-30 1981-05-07 Daimler-Benz Ag, 7000 Stuttgart Entlueftungsdose fuer hydraulische betriebsmittel enthaltende behaelter oder gehaeuse
US4328828A (en) * 1980-09-17 1982-05-11 The Kendall Company Drainage system with vent
US4377248A (en) * 1981-01-09 1983-03-22 Stull Morton B Dispensing cap construction
US4392055A (en) * 1981-08-24 1983-07-05 Owens-Illinois, Inc. Bottle finish and closure combination with venting slots

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3288318A (en) * 1964-11-24 1966-11-29 John D Corbin Flexible plastic vial
US3419179A (en) * 1967-06-07 1968-12-31 Brunswick Corp Captive cap specimen vial
US4007639A (en) * 1974-08-16 1977-02-15 Firma Walter Sarstedt Kunststoff-Spritzgusswerk Capillary vessel for blood removal
US4002275A (en) * 1975-11-12 1977-01-11 Vca Corporation Safety cap
US4460101A (en) * 1982-12-28 1984-07-17 Tseng Bang Tsai Tortuous passage cover for flexible liquid container

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0420013A1 (fr) * 1989-09-26 1991-04-03 Walter Sarstedt Geräte und Verbrauchsmaterial für Medizin und Wissenschaft Dispositif de prélèvement sanguin
EP0627962A1 (fr) * 1992-02-28 1994-12-14 HSEI, Paul Dispositif de preparation d'echantillon
EP0627962A4 (fr) * 1992-02-28 1995-02-08 Paul Hsei Dispositif de preparation d'echantillon.
DE9418060U1 (de) * 1994-11-11 1996-03-14 SC - Sanguis Counting Kontrollblutherstellungs- und Vertriebs GmbH, 51588 Nümbrecht Probenröhre und Abschlußkappe, insesondere für Kapillar-Blutentnahme
DE29505652U1 (de) * 1995-04-01 1996-04-25 Boehringer Mannheim Gmbh, 68305 Mannheim Gefäß zur kontaminationsreduzierten Behandlung von Flüssigkeiten
EP0734767A2 (fr) * 1995-04-01 1996-10-02 Roche Diagnostics GmbH Récepient pour le traitement à contamination réduite de liquides
EP0734767A3 (fr) * 1995-04-01 1998-06-03 Roche Diagnostics GmbH Récepient pour le traitement à contamination réduite de liquides
US5855852A (en) * 1995-04-01 1999-01-05 Boehringer Mannheim Gmbh Vessel for reducing contamination in the treatment of liquids
AT514833A1 (de) * 2013-10-11 2015-04-15 Greiner Bio One Gmbh Abnahmebaugruppe, insbesondere für Blutproben
AT514833B1 (de) * 2013-10-11 2015-07-15 Greiner Bio One Gmbh Abnahmebaugruppe, insbesondere für Blutproben
US10004444B2 (en) 2013-10-11 2018-06-26 Greiner Bio-One Gmbh Collection assembly, in particular for blood samples

Also Published As

Publication number Publication date
EP0182370A3 (fr) 1987-12-09
CA1253764A (fr) 1989-05-09
JPS61203965A (ja) 1986-09-09
US4687479A (en) 1987-08-18

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