EP0131259A2 - Procédé de lavage d'un récipient réacteur pour des tests d'immunologie - Google Patents

Procédé de lavage d'un récipient réacteur pour des tests d'immunologie Download PDF

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Publication number
EP0131259A2
EP0131259A2 EP84107835A EP84107835A EP0131259A2 EP 0131259 A2 EP0131259 A2 EP 0131259A2 EP 84107835 A EP84107835 A EP 84107835A EP 84107835 A EP84107835 A EP 84107835A EP 0131259 A2 EP0131259 A2 EP 0131259A2
Authority
EP
European Patent Office
Prior art keywords
washing
washing liquid
reaction vessel
immunological tests
wall
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP84107835A
Other languages
German (de)
English (en)
Other versions
EP0131259A3 (fr
Inventor
Hans-Detlef Dr. Dopatka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Publication of EP0131259A2 publication Critical patent/EP0131259A2/fr
Publication of EP0131259A3 publication Critical patent/EP0131259A3/fr
Withdrawn legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto 
    • B08B9/08—Cleaning containers, e.g. tanks
    • B08B9/093—Cleaning containers, e.g. tanks by the force of jets or sprays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L13/00—Cleaning or rinsing apparatus
    • B01L13/02—Cleaning or rinsing apparatus for receptacle or instruments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se

Definitions

  • the invention relates to a method for washing the reaction vessels for immunological tests using washing liquid.
  • a special feature of the immunological tests such as the enzyme-linked immunosorbent assay (ELISA) is that *) at certain intermediate steps during the execution of the test, non-specifically bound material must be removed by washing with suitable washing liquids. If the effectiveness of the washing process is inadequate, certain non-specificity reactions, a reduction in sensitivity and a deterioration in the reproducibility of the results can be determined after the end of the test. * ) that
  • the effectiveness of washing in immunological tests is determined by a number of factors, for example detergent content of the washing liquid, number of successive washing cycles, shape of the reaction vessel or speed of suctioning off the washing liquid.
  • the most important parameter, however, is the length of time the washing solution remains in the individual reaction vessels before aspiration.
  • the washing liquid stays in the reaction vessel for approx. 40 seconds with four washing cycles.
  • Increasing the number of wash cycles generally does not improve wash effectiveness.
  • tests with sample material of high consistency for example protruding from stool samples, generally require a longer residence time of the washing solution, which would, however, greatly reduce the capacity of the washing devices. Additional washing Runs have been shown to bring no improvement in these tests, but rather worsen test costs due to the increased detergent consumption.
  • the aim of the invention is therefore to get by with the usual washing cycles and dwell times, even in the case of difficult sample material, without deterioration in the test result.
  • the object is achieved by the invention in that the washing liquid is passed at an angle (o J ) of 50 ° to 80 ° onto the wall of the reaction vessels.
  • An improvement can still be achieved if the washing liquid is directed onto the wall eccentrically with respect to the longitudinal axis of the reaction vessels.
  • FIG. 1 shows the supply of the washing liquid in a side view and FIG. 2 in a top view.
  • the washing liquid (1) is applied to the wall of the reaction vessel (4) by means of a nozzle (2) at an angle d at point (3). headed.
  • the acentric supply of the washing liquid as shown in FIG. 2 is particularly advantageous.

Landscapes

  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Cleaning By Liquid Or Steam (AREA)
  • Detergent Compositions (AREA)
EP84107835A 1983-07-09 1984-07-05 Procédé de lavage d'un récipient réacteur pour des tests d'immunologie Withdrawn EP0131259A3 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19833324825 DE3324825A1 (de) 1983-07-09 1983-07-09 Verfahren zum waschen der reaktionsgefaesse fuer immunologische tests
DE3324825 1983-07-09

Publications (2)

Publication Number Publication Date
EP0131259A2 true EP0131259A2 (fr) 1985-01-16
EP0131259A3 EP0131259A3 (fr) 1987-05-06

Family

ID=6203589

Family Applications (1)

Application Number Title Priority Date Filing Date
EP84107835A Withdrawn EP0131259A3 (fr) 1983-07-09 1984-07-05 Procédé de lavage d'un récipient réacteur pour des tests d'immunologie

Country Status (4)

Country Link
EP (1) EP0131259A3 (fr)
JP (1) JPS6038076A (fr)
AU (1) AU3037284A (fr)
DE (1) DE3324825A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0411377A2 (fr) * 1989-08-03 1991-02-06 ORTMANN + HERBST Maschinen- und Anlagenbau GmbH Corps de buse pour le nettoyage intérieur des bouteilles
DE4024932A1 (de) * 1990-08-06 1992-02-20 Henning Berlin Gmbh Verfahren zum waschen von traegern mit immobilisierten reaktionsprodukten oder reaktionspartnern, die bei immundiagnostischen bestimmungsverfahren gebildet oder verwendet werden, sowie vorrichtung zur durchfuehrung dieses verfahrens
EP0644426A1 (fr) * 1993-09-17 1995-03-22 F. Hoffmann-La Roche Ag Analyseur comprenant un dispositif pour la suspension de particules, et méthode de suspension
EP1015892A1 (fr) * 1997-06-25 2000-07-05 CLMP, Inc. Double injecteur pour systeme d'immunoanalyse par chimioluminescence

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2887525B1 (fr) † 2005-06-24 2007-09-07 Sidel Sas Installation produisant des bouteilles steriles par soufflage a partir de preformes sterilisees

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3897002A (en) * 1974-08-14 1975-07-29 Baxter Laboratories Inc Liquid wash injector
GB1597867A (en) * 1978-05-31 1981-09-16 Projectus Ind Produkter Ab Device for washing machine parts

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3897002A (en) * 1974-08-14 1975-07-29 Baxter Laboratories Inc Liquid wash injector
GB1597867A (en) * 1978-05-31 1981-09-16 Projectus Ind Produkter Ab Device for washing machine parts

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0411377A2 (fr) * 1989-08-03 1991-02-06 ORTMANN + HERBST Maschinen- und Anlagenbau GmbH Corps de buse pour le nettoyage intérieur des bouteilles
EP0411377A3 (en) * 1989-08-03 1992-08-05 Apv Ortmann & Herbst Gmbh Nozzle assembly for the internal cleaning of bottles
DE4024932A1 (de) * 1990-08-06 1992-02-20 Henning Berlin Gmbh Verfahren zum waschen von traegern mit immobilisierten reaktionsprodukten oder reaktionspartnern, die bei immundiagnostischen bestimmungsverfahren gebildet oder verwendet werden, sowie vorrichtung zur durchfuehrung dieses verfahrens
EP0644426A1 (fr) * 1993-09-17 1995-03-22 F. Hoffmann-La Roche Ag Analyseur comprenant un dispositif pour la suspension de particules, et méthode de suspension
US5482864A (en) * 1993-09-17 1996-01-09 Hoffman-La Roche Inc. Method for suspending particles
US5482863A (en) * 1993-09-17 1996-01-09 Hoffmann-La Roche Inc. Apparatus for suspending particles
EP1015892A1 (fr) * 1997-06-25 2000-07-05 CLMP, Inc. Double injecteur pour systeme d'immunoanalyse par chimioluminescence
EP1015892A4 (fr) * 1997-06-25 2007-01-10 Quest Diagnostics Invest Inc Double injecteur pour systeme d'immunoanalyse par chimioluminescence

Also Published As

Publication number Publication date
EP0131259A3 (fr) 1987-05-06
AU3037284A (en) 1985-01-10
JPS6038076A (ja) 1985-02-27
DE3324825A1 (de) 1985-01-17

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Inventor name: DOPATKA, HANS-DETLEF, DR.