EP0073847A1 - Sac à sang ayant un système de connexion - Google Patents

Sac à sang ayant un système de connexion Download PDF

Info

Publication number
EP0073847A1
EP0073847A1 EP81106885A EP81106885A EP0073847A1 EP 0073847 A1 EP0073847 A1 EP 0073847A1 EP 81106885 A EP81106885 A EP 81106885A EP 81106885 A EP81106885 A EP 81106885A EP 0073847 A1 EP0073847 A1 EP 0073847A1
Authority
EP
European Patent Office
Prior art keywords
bag
blood
break
blood bag
connecting piece
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP81106885A
Other languages
German (de)
English (en)
Other versions
EP0073847B1 (fr
Inventor
Wolfram H Dr. Dipl.-Chem. Walker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biotest AG
Original Assignee
Biotest Serum Institut GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotest Serum Institut GmbH filed Critical Biotest Serum Institut GmbH
Priority to EP81106885A priority Critical patent/EP0073847B1/fr
Priority to AT81106885T priority patent/ATE23271T1/de
Publication of EP0073847A1 publication Critical patent/EP0073847A1/fr
Application granted granted Critical
Publication of EP0073847B1 publication Critical patent/EP0073847B1/fr
Expired legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means

Definitions

  • the invention relates to blood bags with a connection system.
  • Blood bags are used for the collection, storage, preparation and transfusion of blood and blood components.
  • One of the advantages of blood bags over blood bottles made of glass is that with multiple blood bag systems, blood preparations in a closed, i.e. sterile system are possible.
  • the production of blood preparations is becoming increasingly important as part of "hemotherapy made to measure”.
  • Multi-bag systems as currently on the market consist of 2 or more bag systems, in which a primary bag generally stabilizes the blood contains sator solution and serves to absorb the blood.
  • the secondary or satellite bag or the satellite bag system which is connected to the primary bag with a tube system, is used to prepare the blood components, such as plasma, factor VIII concentrate, platelet concentrate, etc.
  • the primary bag carries a connection system which, after opening, allows the preparation to pass from the primary into the secondary bag.
  • connection system There are various design options for this connection system.
  • connection system which consists of a ball which is pressed into a flexible hose. A free passage is possible after pushing the ball out of the hose.
  • This system has the disadvantage that under extreme conditions, such as excess pressure, centrifugation, mechanical change in the tube diameter, etc., there is no hermetic seal.
  • Tube has been narrowed or glued permanently before use of the bag, so that no free flow is guaranteed after opening the clamp.
  • U.S. Patent 3,110,308 describes a connection system consisting of p iner membrane which is perforated with a cannula-like mandrel. This system often complains about the complicated and time-consuming manipulation.
  • break-off systems are known in which a free passage is possible by breaking off a plastic part in a hose system.
  • Such systems are located outside of a blood bag in the connecting tube between the primary and secondary bags.
  • This has the disadvantage that a clean and optimal separation of the blood preparations according to e.g. Centrifugation is not possible and the preparation is contaminated.
  • the manufacture and assembly of such systems is complex and costly.
  • the object of the invention was therefore to provide a connection system which shows the advantages of the break-off system, but which is at the same time flush with the blood bag, so that contamination of the secondary bag, e.g. after centrifugation is not possible, the manufacture and handling of the system should be as simple and safe as possible.
  • the connecting system contains a connecting piece (5) consisting of connecting part (7), break-off part (8), predetermined breaking point (9). and if necessary.
  • Collar (6) the connecting piece (5) being connected directly to the blood bag (1) in such a way that it is located directly on the upper edge of the bag and is essentially flush with it; the break-off part (8) protruding into the bag so that the break-off part (8) is present inside the bag after the break-off.
  • Fig. 1 shows the blood bag (1) (primary bag) with the blood collection tube (4), which is connected to the blood bag (2) (secondary bag) by a connecting tube (3).
  • the blood bag (1) is sealed liquid-tight by the connecting piece (5).
  • the connecting piece (5) is opened, the preparation can flow over the connecting tube (3) into the secondary bag (2).
  • part of the connecting piece (5) lies in a recess (1c).
  • a tube (1b) is also shown, which according to one embodiment is located between the blood bag (1) and the connecting piece (5).
  • Fig. 2 shows a detailed enlargement of the connector (5) used as a connection system. It consists of a collar (6), connecting part (7), break-off part (8) and predetermined breaking point (9).
  • the collar (6) When installed in the blood bag, the collar (6) is connected to the connecting tube (3), the connecting part (7) is hermetically connected to the blood bag (1), and the breaking part (8) is connected to the connecting part (7) via the breaking or predetermined breaking point (9 ) connected.
  • the predetermined breaking point (9) is designed so that when the connection part (7) is broken off, it receives a free flow which corresponds to or approximately corresponds to the lumen of the connection part (7). If the transfer hose (3) is glued inside the collar (6), then after breaking off the demolition part (8) there is a free flow through the complete system, which has approximately the lumen of the connecting hose (3).
  • the break-off part (8) After opening the connection system, the break-off part (8) remains in the primary bag (1). So that this part in the embodiment in which it falls freely into the bag, in the transfusion or preparation when the preparation runs through the tube (3) or any other outlet connection does not lead to a closure of the flow, the break-off part (8) has a structured one Surface that allows the liquid to flow past.
  • Fig. 3 shows a cross section of a preferred surface structure of the break-off part (8), which is composed of 4 semicircles in a rosette shape.
  • Fig. 4 shows an embodiment in which the connecting piece (5), consisting of connecting part (7). and break-off part (8) is welded directly into the bag.
  • the connecting hose (3) is glued directly into the open part of the system after the part has been welded in.
  • the connecting piece (5) is connected to the blood bag via connecting part (7) (Fig. 2), the connecting piece (5) being connected to the bag (1) via a tube (1b) (as in Fig. 1) or directly to the bag (as shown in Fig. 4).
  • Hose (3) and connecting part (7) of the connecting system (5) can also be designed such that hose (3) is inserted into the connecting part (7).
  • connection of the hose (3) with connecting piece (5) and bag (1) can be by gluing or welding or by other known joining techniques, such as ..
  • Ultrasonic welding or rotary welding are carried out.
  • Connection piece (5) is made of a transparent or colored plastic, which shows optimal properties both in steam sterilization and when breaking off.
  • a slight through pressure on the break-off part (8) results in a free passage, wherein the predetermined breaking point (9) can be structured in such a way that part (8) still adheres to part (7), but preferably breaks off completely.
  • Plastics such as hard PVC or Makrolon are suitable for this application.
  • the part can also be made of materials with a density less than 1; this will cause it to float on the blood or blood preparation after separation.
  • connecting piece (5) is that it is almost flush with the upper edge of the blood bag (1) and therefore no contamination of the preparation can take place.
  • the upper edge of the blood bag can also be designed such that the connecting piece (5) is located in a recess (1c) of the bag. This facilitates manipulation of the breaking off, because blood components of the bag (1) are not stirred up.
  • Recess (1c) can also be designed as a bag, so that the break-off part (8) does not fall freely into the bag (1), but is retained in the bag.

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
EP81106885A 1981-09-03 1981-09-03 Sac à sang ayant un système de connexion Expired EP0073847B1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP81106885A EP0073847B1 (fr) 1981-09-03 1981-09-03 Sac à sang ayant un système de connexion
AT81106885T ATE23271T1 (de) 1981-09-03 1981-09-03 Blutbeutel mit einem verbindungssystem.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP81106885A EP0073847B1 (fr) 1981-09-03 1981-09-03 Sac à sang ayant un système de connexion

Publications (2)

Publication Number Publication Date
EP0073847A1 true EP0073847A1 (fr) 1983-03-16
EP0073847B1 EP0073847B1 (fr) 1986-11-05

Family

ID=8187893

Family Applications (1)

Application Number Title Priority Date Filing Date
EP81106885A Expired EP0073847B1 (fr) 1981-09-03 1981-09-03 Sac à sang ayant un système de connexion

Country Status (2)

Country Link
EP (1) EP0073847B1 (fr)
AT (1) ATE23271T1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2142240A (en) * 1983-06-27 1985-01-16 Terumo Corp Blood bag apparatus
EP0175274A2 (fr) * 1984-09-13 1986-03-26 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Méthode de séparation des constituants du sang
US5071570A (en) * 1986-01-24 1991-12-10 Terumo Corporation Method for separation of blood components and apparatus thereof
EP1121921A1 (fr) * 2000-01-31 2001-08-08 Okamoto Rodney Systeme pour perfusion intraveineuse de solution nutritive
FR2820029A1 (fr) * 2001-01-26 2002-08-02 Pascal Lecointe Sachet et bande de sachets de conditionnement de substance, a canule et embout integres
WO2004028692A3 (fr) * 2002-09-23 2004-07-29 Prisma Diagnostika Gmbh Element de support pour analyses diagnostiques

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2819805A (en) * 1953-10-05 1958-01-14 Price Battery Corp Battery component assembling machines
AT203145B (de) * 1956-10-30 1959-04-25 Vifor Sa Vorrichtung zur Infusion von Flüssigkeiten
US3158165A (en) * 1961-06-20 1964-11-24 Torrington Co Valve assembly and method of making it
US3470893A (en) * 1968-03-04 1969-10-07 Illinois Tool Works Fluid distribution unit
US3482572A (en) * 1964-05-13 1969-12-09 Lab Vifor Sa Apparatus for the infusion of liquids into a body
DE7719528U1 (de) * 1977-06-22 1978-03-16 Knoll Ag, 6700 Ludwigshafen Infusionsbeutel
US4181140A (en) * 1978-02-10 1980-01-01 Baxter Travenol Laboratories, Inc. Frangible resealable closure for a flexible tube having hold open means
WO1981001105A1 (fr) * 1979-10-18 1981-04-30 Baxter Travenol Lab Vanne cassable

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2098873A5 (fr) * 1970-07-30 1972-03-10 Labaz Laboratoires

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2819805A (en) * 1953-10-05 1958-01-14 Price Battery Corp Battery component assembling machines
AT203145B (de) * 1956-10-30 1959-04-25 Vifor Sa Vorrichtung zur Infusion von Flüssigkeiten
US3158165A (en) * 1961-06-20 1964-11-24 Torrington Co Valve assembly and method of making it
US3482572A (en) * 1964-05-13 1969-12-09 Lab Vifor Sa Apparatus for the infusion of liquids into a body
US3470893A (en) * 1968-03-04 1969-10-07 Illinois Tool Works Fluid distribution unit
DE7719528U1 (de) * 1977-06-22 1978-03-16 Knoll Ag, 6700 Ludwigshafen Infusionsbeutel
US4181140A (en) * 1978-02-10 1980-01-01 Baxter Travenol Laboratories, Inc. Frangible resealable closure for a flexible tube having hold open means
WO1981001105A1 (fr) * 1979-10-18 1981-04-30 Baxter Travenol Lab Vanne cassable

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2142240A (en) * 1983-06-27 1985-01-16 Terumo Corp Blood bag apparatus
US4846795A (en) * 1983-06-27 1989-07-11 Terumo Kabushiki Kaisha Blood bag system
EP0175274A2 (fr) * 1984-09-13 1986-03-26 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Méthode de séparation des constituants du sang
EP0175274A3 (en) * 1984-09-13 1986-06-11 Terumo Corp Apparatus for separation of blood components
US5071570A (en) * 1986-01-24 1991-12-10 Terumo Corporation Method for separation of blood components and apparatus thereof
US6491679B1 (en) 1997-10-20 2002-12-10 Rodney Okamoto System for infusing intravenous nutrition solutions
EP1121921A1 (fr) * 2000-01-31 2001-08-08 Okamoto Rodney Systeme pour perfusion intraveineuse de solution nutritive
FR2820029A1 (fr) * 2001-01-26 2002-08-02 Pascal Lecointe Sachet et bande de sachets de conditionnement de substance, a canule et embout integres
WO2004028692A3 (fr) * 2002-09-23 2004-07-29 Prisma Diagnostika Gmbh Element de support pour analyses diagnostiques

Also Published As

Publication number Publication date
ATE23271T1 (de) 1986-11-15
EP0073847B1 (fr) 1986-11-05

Similar Documents

Publication Publication Date Title
DE2331687C3 (de) Für medizinische Geräte geeignete Kupplung
EP0454178B1 (fr) Appareil d'autotransfusion
DE60207683T2 (de) Verbindungsstück, Behälter mit solchem Verbindungsstück und Flüssigkeitaufbereitungsvorrichtung mit passendem Verbindungsstück für einen solchen Behälter
DE2206076A1 (de) Dauerkatheter mit flexiblem Schlauch
DE2917767C2 (de) Flüssigkeitssammelgerät
DE4409842C2 (de) Verfahren zum Erhalten einer Blutprobe aus der Nabelschnur eines neugeborenen Kindes
EP0808148B1 (fr) Dispositif de transfert
DE69822495T2 (de) Nadellose injektionsstelle
DE60032008T3 (de) Saugbeutelanordnung
DE7933323U1 (de) Schlauchkupplung
DE2349484A1 (de) Probenbehaelter
DE2439392A1 (de) Vorrichtung und verfahren zum aseptischen sammeln von fluiden durch unterdruck
DE2647624A1 (de) Verschluss mit halterung fuer einen behaelter
DE2824588A1 (de) Einweg-stopfen fuer vakuumroehrchen
DE2452858A1 (de) Sterile kupplung
DE2628719A1 (de) Verbindungsstueck zur entnahme von fluessigkeitsproben aus einer geschlossenen anordnung zur ableitung einer fluessigkeit
DE2215486C3 (de) Meßgefäßanordnung für ein Teilchenmeßgerät
GB2104044A (en) Bag and valve assembley for medical use
EP0390898A1 (fr) Recipient pour la conservation separee et sterile d'au moins deux substances et pour leur melange.
DE19958952B4 (de) Entnahmesystem für medizinische Lösungen und Behälter mit einem derartigen Entnahmesystem
US4435179A (en) Blood bags with interconnecting system
EP2391328B1 (fr) Récipient pour plasma sanguin
DE102014013892A1 (de) Vorrichtung zum Anschluss einer Durchstechflasche an einen Behälter oder an eine Fluidleitung und Überführung des Inhaltes einer Durchstechflasche in einen Behälter oder in eine Fluidleitung, sowie Verfahren hierzu und Verwendung einer solchen Vorichtung
DE3136791A1 (de) "antiseptische vorrichtung zur vollstaendigen parenteralen ernaehrung"
EP0073847B1 (fr) Sac à sang ayant un système de connexion

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Designated state(s): AT BE FR GB NL

17P Request for examination filed

Effective date: 19830721

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE FR GB NL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Effective date: 19861105

REF Corresponds to:

Ref document number: 23271

Country of ref document: AT

Date of ref document: 19861115

Kind code of ref document: T

ET Fr: translation filed
PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AT

Effective date: 19870903

26N No opposition filed
REG Reference to a national code

Ref country code: FR

Ref legal event code: CN

NLS Nl: assignments of ep-patents

Owner name: BIOTEST AKTIENGESELLSCHAFT TE FRANKFORT A.D. MAIN,

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 19900928

Year of fee payment: 10

Ref country code: GB

Payment date: 19900928

Year of fee payment: 10

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NL

Payment date: 19900930

Year of fee payment: 10

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Effective date: 19910903

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Effective date: 19920401

GBPC Gb: european patent ceased through non-payment of renewal fee
NLV4 Nl: lapsed or anulled due to non-payment of the annual fee
PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Effective date: 19920529

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST