US3482572A - Apparatus for the infusion of liquids into a body - Google Patents

Apparatus for the infusion of liquids into a body Download PDF

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Publication number
US3482572A
US3482572A US454860A US3482572DA US3482572A US 3482572 A US3482572 A US 3482572A US 454860 A US454860 A US 454860A US 3482572D A US3482572D A US 3482572DA US 3482572 A US3482572 A US 3482572A
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pipette
closing device
reservoir
duct
liquid
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US454860A
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Rene Grosclaude
Pierre Andrey
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LAB VIFOR SA
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LAB VIFOR SA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A61M39/221—Frangible or pierceable closures within tubing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/1407—Infusion of two or more substances
    • A61M5/1409—Infusion of two or more substances in series, e.g. first substance passing through container holding second substance, e.g. reconstitution systems

Definitions

  • An apparatus for injecting liquids into a living body having a reservoir for the liquid to be injected.
  • a conduit is connected at one end of the reservoir and a closing device is connected to the other end of such conduit.
  • a joining device connects a pipette to the closing device and a second conduit connects the pipette to an injection member.
  • the closing device is of glass and has a break able portion at a point adjacent the arriving liquid to the pipette.
  • the joining device is releasably connected to the second conduit whereby a plurality of reservoirs may be attached to the injection device without disturbing the injection needle.
  • Apparatus for the infusion of liquids into a body, of which the reservoir, the pipette device and the injection needle form a single unit, which are sterilized during their manufacture, and which are, without further ado, ready for use. They are further equipped with a closing device, liable to be broken from the outside, to allow a passage for the liquid.
  • These apparatus offer the advantage that it is not necessary to expose their contents or their interior to outer contact in order to causethem to operate since the release of the flow of liquid is effected by breakage of the closing device from their outside.
  • the present invention permits this replacement.
  • It has for object an apparatus for the infusion of liquids into a body comprising a reservoir for the liquid to be infused, a duct connecting this reservoir to a pipette device, a closing device breakable at a definite point, closing said duct and a joint removably connecting the duct to the pipette device.
  • This apparatus is characterized in that the said closing device is secured in the end of the duct connected to the pipette device, and in that the portion of said closing device releasable by the break is upstream of that remaining fixed to the duct.
  • the portion of the closing device released by the break is held in said duct by the portion of the closing device remaining fixed to the duct.
  • the reservoir, the duct and all the broken closing device may be removed from the rest of the apparatus and replaced by another reservoir associated with a duct closed by a closing device still intact.
  • the breaking of the closing device may be effected from the outside, once the reservoir and its duct are connected to the pipette device.
  • the interchangeable reservoir with its duct and the closing device form a single unit during their manufacture.
  • FIGURE 1 is a view in elevation of the complete apparatus and FIGURE 2 is a section on a larger scale of the portion of the apparatus constituted by the closing device, the pipette device and the joint connecting the end of the duct to the pipette device.
  • the apparatus shown comprises a reservoir 10, of flexible plastic material, adapted to contain the liquid to be infused, for example a physiological solution of sodium chloride.
  • This reservoir has an attachment member 11 of one piece therewith, permitting of suspending the same. It is welded opposite the attachment member to a duct 12, also of plastic material.
  • This duct 12 encloses, at its end opposite to the reservoir 10, a closing device 13; it is connected in a'removable manner to a pipette device 14 by a joint 15.
  • a flexible duct 16 connects the pipette device 14 to the injection member 17 the essential part of which is an injection needle (not visible in FIG. 1) and protected, before use, by an elastic cap 18.
  • the closing device 13 is secured by friction in the end of the tube 12.
  • This closing device is in glass; it comprises a full portion 19 and a recessed portion 20. This latter, of larger diameter than the portion 19, is forced into the end of the tube 12 and is secured therein.
  • the recess of the portion 20 is conical adjacent to the full portion 19, so that the closing device has a weak part at 21, which is the breaking part.
  • the closing device has, at its portion adjacent to the pipette device 14, a shoulder 22. This latter is capped by an inwardly tapped collet 23. This collet is screwed on a downstream element 24 and forms, with the latter and with the closing device 13 and its shoulder 22, the joint between the duct 12 and the pipette device 14.
  • the shoulder 22 form a washer; the downstream element 24 has an axial duct 25 as an extension of the recess of the portion 20 of the closing device.
  • the down-stream element 24 is secured to the chamber 26 of the pipette device; it is provided, of one piece therewith, with a pipette tube 27 extending into the chamber 26.
  • This latter which is of rigid transparent material, has an extension 28 at its lower end, on which is secured the duct 16.
  • the reservoir 10 being suspended by the attachment member 11, the glass closing member 13 is broken at 21 by a bending effort exerted from the outside of the duct 12. From this moment, the liquid contained in the reservoir 10 flows to the pipette tube 27, where drops are formed which fall into the chamber 26. From there, the liquid flows to the injection member 17 the needle of which has been exposed by removal of the cap 18. The liquid reaching the needle, the latter may be inserted in a vein of the patient.
  • portion 19 of the closing device which has been released by the 'break, is up-strearn of the portion 20 remaining secured to the duct 12.
  • this portion 19 remains held in the duct 12, without hindering the flow of the liquid and without the risk of falling into the pipette device.
  • the reservoir 10 may be replaced by another reservoir by unscrewing the collet 23 to free it from the down-stream element 24.
  • the reservoir 10, the duct 12, the broken closing device 13 and the collet 23 form a unit which may be discarded and replaced by a similar unit, of which the closing device is still intact and the reservoir filled with liquid.
  • This replacement is very rapid because it is sufiicient to screw the collet 23 of the new unit on the threaded portion of the element 24.
  • This latter together with the chamber 26 of the pipette device, the duct 16 and the injection member 17 have remained in communication with the body of the patient, the injection needle not having been withdrawn from the spot where it had been inserted.
  • the replacement of a reservoir by another may be effected as many times as required, while leaving the injection needle in the same place in the body of the patient.
  • Apparatus for the infusion of liquids in a living body comprising a reservoir for the liquid to be infused, a first conduit connected at one end to said reservoir for drawing off liquid from said resrevoir, a closing device connected to the other end of said conduit, a pipette, a joining device connecting said closing device and said pipette, a second conduit connected to said pipette for drawing off said liquid from said pipette, an injection member connected to said second conduit, said closing device having a breakable portion at a joint adjacent the arriving liquid to said pipette for permitting a free flow of said liquid, said closing device comprising a glass tube secured to the end of said first conduit having said breakable portion which is solid and of smaller diameter than that portion of said glass tube secured to said conduit, and said glass tube having a conical recess adjacent said breakable portion.
  • Apparatus for the infusion of liquids in-a living body comprising a reservoir for the liquid to be infused, a first conduit connected at one end to said reservoir for drawing off liquid from siad reservoir, a closing device connected to the other end of said conduit, a pipette, a joining device connecting said closing device and said pipette, a second conduit connected to said pipette for drawing off said liquid from said pipette, an injection member connected to said second conduit, said closing device having a breakable portion at a point adjacent the arriving liquid to said pipette for permitting a free flow of said liquid, said closing device comprising a glass tube secured in the end of said first conduit having said breakable portion, said glass tube having an annular shoulder situated outside said first conduit adjacent said pipette, and said pipette comprising a cylindrical chamber having a cap with an axial duct, said cap being rigidly secured to the inlet end of said chamber and adapted to be releasably secured to said joining device, said axial duct having

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Sampling And Sample Adjustment (AREA)

Description

Dec. 9, 1969 APPARATUS FOR THE INFUSION OF LIQUIDS INTO A BODY R. GROSCLAUDE E AL Filed May 11. 1965 United States Patent US. Cl. 128-214 2 Claims ABSTRACT OF THE DISCLOSURE An apparatus for injecting liquids into a living body having a reservoir for the liquid to be injected. A conduit is connected at one end of the reservoir and a closing device is connected to the other end of such conduit. A joining device connects a pipette to the closing device and a second conduit connects the pipette to an injection member. The closing device is of glass and has a break able portion at a point adjacent the arriving liquid to the pipette. The joining device is releasably connected to the second conduit whereby a plurality of reservoirs may be attached to the injection device without disturbing the injection needle.
When infusing liquidS, such as physiological solutions, into a living body, by means of an injection needle connected to a reservoir containing the liquid to be infused, it is frequently necessary to be able to replace the reservoir by another. This operation should be possible without withdrawing the needle from the body in which it is fixed, in order to avoid injuring the vein utilized for the infusion, by repeated punctures or having to puncture the patient successively in several places.
Apparatus are known for the infusion of liquids into a body, of which the reservoir, the pipette device and the injection needle form a single unit, which are sterilized during their manufacture, and which are, without further ado, ready for use. They are further equipped with a closing device, liable to be broken from the outside, to allow a passage for the liquid. These apparatus offer the advantage that it is not necessary to expose their contents or their interior to outer contact in order to causethem to operate since the release of the flow of liquid is effected by breakage of the closing device from their outside.
When the different parts (reservoir, pipette, closing device and needle) of these apparatus are inseparable one from the other, they do not permit the replacement of their reservoir by another without withdrawing the injection needle from the body in which it is fixed.
The present invention permits this replacement.
It has for object an apparatus for the infusion of liquids into a body, comprising a reservoir for the liquid to be infused, a duct connecting this reservoir to a pipette device, a closing device breakable at a definite point, closing said duct and a joint removably connecting the duct to the pipette device.
This apparatus is characterized in that the said closing device is secured in the end of the duct connected to the pipette device, and in that the portion of said closing device releasable by the break is upstream of that remaining fixed to the duct.
In this apparatus, the portion of the closing device released by the break is held in said duct by the portion of the closing device remaining fixed to the duct. Thus, after use, the reservoir, the duct and all the broken closing device may be removed from the rest of the apparatus and replaced by another reservoir associated with a duct closed by a closing device still intact.
3,482,572 Patented Dec. 9, 1969 The breaking of the closing device may be effected from the outside, once the reservoir and its duct are connected to the pipette device. The interchangeable reservoir with its duct and the closing device form a single unit during their manufacture.
One embodiment of the apparatus according to the invention is shown in the accompanying drawing, in which:
FIGURE 1 is a view in elevation of the complete apparatus and FIGURE 2 is a section on a larger scale of the portion of the apparatus constituted by the closing device, the pipette device and the joint connecting the end of the duct to the pipette device.
With reference to FIG. 1, the apparatus shown comprises a reservoir 10, of flexible plastic material, adapted to contain the liquid to be infused, for example a physiological solution of sodium chloride. This reservoir has an attachment member 11 of one piece therewith, permitting of suspending the same. It is welded opposite the attachment member to a duct 12, also of plastic material.
This duct 12 encloses, at its end opposite to the reservoir 10, a closing device 13; it is connected in a'removable manner to a pipette device 14 by a joint 15.
A flexible duct 16 connects the pipette device 14 to the injection member 17 the essential part of which is an injection needle (not visible in FIG. 1) and protected, before use, by an elastic cap 18.
With reference to FIG. 2, the closing device 13 is secured by friction in the end of the tube 12. This closing device is in glass; it comprises a full portion 19 and a recessed portion 20. This latter, of larger diameter than the portion 19, is forced into the end of the tube 12 and is secured therein. The recess of the portion 20 is conical adjacent to the full portion 19, so that the closing device has a weak part at 21, which is the breaking part. The closing device has, at its portion adjacent to the pipette device 14, a shoulder 22. This latter is capped by an inwardly tapped collet 23. This collet is screwed on a downstream element 24 and forms, with the latter and with the closing device 13 and its shoulder 22, the joint between the duct 12 and the pipette device 14.
The shoulder 22 form a washer; the downstream element 24 has an axial duct 25 as an extension of the recess of the portion 20 of the closing device.
The down-stream element 24 is secured to the chamber 26 of the pipette device; it is provided, of one piece therewith, with a pipette tube 27 extending into the chamber 26. This latter, which is of rigid transparent material, has an extension 28 at its lower end, on which is secured the duct 16.
The operation of the apparatus which has been described in the following:
The reservoir 10 being suspended by the attachment member 11, the glass closing member 13 is broken at 21 by a bending effort exerted from the outside of the duct 12. From this moment, the liquid contained in the reservoir 10 flows to the pipette tube 27, where drops are formed which fall into the chamber 26. From there, the liquid flows to the injection member 17 the needle of which has been exposed by removal of the cap 18. The liquid reaching the needle, the latter may be inserted in a vein of the patient.
It will be noted that the portion 19 of the closing device, which has been released by the 'break, is up-strearn of the portion 20 remaining secured to the duct 12. Thus, this portion 19 remains held in the duct 12, without hindering the flow of the liquid and without the risk of falling into the pipette device.
Once the reservoir 10 is empty, it may be replaced by another reservoir by unscrewing the collet 23 to free it from the down-stream element 24. In fact, the reservoir 10, the duct 12, the broken closing device 13 and the collet 23 form a unit which may be discarded and replaced by a similar unit, of which the closing device is still intact and the reservoir filled with liquid. This replacement is very rapid because it is sufiicient to screw the collet 23 of the new unit on the threaded portion of the element 24. This latter, together with the chamber 26 of the pipette device, the duct 16 and the injection member 17 have remained in communication with the body of the patient, the injection needle not having been withdrawn from the spot where it had been inserted.
The replacement of a reservoir by another may be effected as many times as required, while leaving the injection needle in the same place in the body of the patient.
What we claim is:
. 1. Apparatus for the infusion of liquids in a living body, comprising a reservoir for the liquid to be infused, a first conduit connected at one end to said reservoir for drawing off liquid from said resrevoir, a closing device connected to the other end of said conduit, a pipette, a joining device connecting said closing device and said pipette, a second conduit connected to said pipette for drawing off said liquid from said pipette, an injection member connected to said second conduit, said closing device having a breakable portion at a joint adjacent the arriving liquid to said pipette for permitting a free flow of said liquid, said closing device comprising a glass tube secured to the end of said first conduit having said breakable portion which is solid and of smaller diameter than that portion of said glass tube secured to said conduit, and said glass tube having a conical recess adjacent said breakable portion.
2. Apparatus for the infusion of liquids in-a living body, comprising a reservoir for the liquid to be infused, a first conduit connected at one end to said reservoir for drawing off liquid from siad reservoir, a closing device connected to the other end of said conduit, a pipette, a joining device connecting said closing device and said pipette, a second conduit connected to said pipette for drawing off said liquid from said pipette, an injection member connected to said second conduit, said closing device having a breakable portion at a point adjacent the arriving liquid to said pipette for permitting a free flow of said liquid, said closing device comprising a glass tube secured in the end of said first conduit having said breakable portion, said glass tube having an annular shoulder situated outside said first conduit adjacent said pipette, and said pipette comprising a cylindrical chamber having a cap with an axial duct, said cap being rigidly secured to the inlet end of said chamber and adapted to be releasably secured to said joining device, said axial duct having a drop counting opening extending inside said chamber, the end of said first conduit having a collet for urging said end against said cap.
I References Cited FOREIGN PATENTS 1,129,284 9/ 1956 France.
882,381 11/1961 Great Britain. 402,286 5/ 1966 Switzerland.
DALTON L. TRULUCK, Primary Examiner U.S. Cl. X.R. 222-54l
US454860A 1964-05-13 1965-05-11 Apparatus for the infusion of liquids into a body Expired - Lifetime US3482572A (en)

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CH624864A CH401363A (en) 1964-05-13 1964-05-13 Apparatus for infusing liquids into a body

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BE (1) BE663822A (en)
CH (1) CH401363A (en)
DE (1) DE1288751B (en)
GB (1) GB1046684A (en)
NL (1) NL6505909A (en)
SE (1) SE312404B (en)

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1981001105A1 (en) * 1979-10-18 1981-04-30 Baxter Travenol Lab Breakaway valve
US4270534A (en) * 1979-08-08 1981-06-02 Baxter Travenol Laboratories, Inc. Frangible valve assembly for blood bags and the like
US4294247A (en) * 1977-07-25 1981-10-13 Baxter Travenol Laboratories, Inc. Frangible, resealable closure for a flexible tube
EP0073847A1 (en) * 1981-09-03 1983-03-16 Biotest-Serum-Institut GmbH Blood bag with a connection unit
US4386622A (en) * 1979-10-18 1983-06-07 Baxter Travenol Laboratories, Inc. Breakaway valve
US4439188A (en) * 1980-09-15 1984-03-27 Baxter Travenol Laboratories, Inc. Tube connector
US4465488A (en) * 1981-03-23 1984-08-14 Baxter Travenol Laboratories, Inc. Collapsible multi-chamber medical fluid container
US5374263A (en) * 1992-10-13 1994-12-20 Automatic Liquid Packaging Full withdrawal container and method
US5699936A (en) * 1995-09-08 1997-12-23 Sercomp Corporation Liquid dispensing system
EP0819440A2 (en) * 1996-07-19 1998-01-21 B. Braun Melsungen Ag Infusion set
US6106502A (en) * 1996-12-18 2000-08-22 Richmond; Frank M. IV sets with needleless fittings and valves
EP1358905A1 (en) * 2002-04-30 2003-11-05 Haemopharm Industry Ag Device for the administration of drugs
US20080308166A1 (en) * 2005-10-20 2008-12-18 Richmond Frank M Connector/Device with Reflux Valves
US7955418B2 (en) 2005-09-12 2011-06-07 Abela Pharmaceuticals, Inc. Systems for removing dimethyl sulfoxide (DMSO) or related compounds or odors associated with same
US8435224B2 (en) 2005-09-12 2013-05-07 Abela Pharmaceuticals, Inc. Materials for facilitating administration of dimethyl sulfoxide (DMSO) and related compounds
US8480797B2 (en) 2005-09-12 2013-07-09 Abela Pharmaceuticals, Inc. Activated carbon systems for facilitating use of dimethyl sulfoxide (DMSO) by removal of same, related compounds, or associated odors
US8673061B2 (en) 2005-09-12 2014-03-18 Abela Pharmaceuticals, Inc. Methods for facilitating use of dimethyl sulfoxide (DMSO) by removal of same, related compounds, or associated odors
US9427419B2 (en) 2005-09-12 2016-08-30 Abela Pharmaceuticals, Inc. Compositions comprising dimethyl sulfoxide (DMSO)
US9839609B2 (en) 2009-10-30 2017-12-12 Abela Pharmaceuticals, Inc. Dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) formulations to treat osteoarthritis

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS607833U (en) * 1983-06-27 1985-01-19 テルモ株式会社 blood bag device
NL9500382A (en) * 1995-02-27 1996-10-01 Nutricia Nv Enteral / parental substance administration system.
CN104436337B (en) * 2014-12-31 2016-08-24 郑州迪奥医学技术有限公司 Safe drainage bag or bottle jointing

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1129284A (en) * 1955-07-28 1957-01-17 Equipment for transfusions and injections
GB882381A (en) * 1959-07-13 1961-11-15 Ampins Ltd Improvements in catheters
CH402286A (en) * 1963-05-17 1965-11-15 Hera Ag Infusion device

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT203145B (en) * 1956-10-30 1959-04-25 Vifor Sa Device for infusing liquids

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1129284A (en) * 1955-07-28 1957-01-17 Equipment for transfusions and injections
GB882381A (en) * 1959-07-13 1961-11-15 Ampins Ltd Improvements in catheters
CH402286A (en) * 1963-05-17 1965-11-15 Hera Ag Infusion device

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4294247A (en) * 1977-07-25 1981-10-13 Baxter Travenol Laboratories, Inc. Frangible, resealable closure for a flexible tube
US4270534A (en) * 1979-08-08 1981-06-02 Baxter Travenol Laboratories, Inc. Frangible valve assembly for blood bags and the like
WO1981001105A1 (en) * 1979-10-18 1981-04-30 Baxter Travenol Lab Breakaway valve
US4340049A (en) * 1979-10-18 1982-07-20 Baxter Travenol Laboratories, Inc. Breakaway valve
US4386622A (en) * 1979-10-18 1983-06-07 Baxter Travenol Laboratories, Inc. Breakaway valve
US4439188A (en) * 1980-09-15 1984-03-27 Baxter Travenol Laboratories, Inc. Tube connector
US4465488A (en) * 1981-03-23 1984-08-14 Baxter Travenol Laboratories, Inc. Collapsible multi-chamber medical fluid container
EP0073847A1 (en) * 1981-09-03 1983-03-16 Biotest-Serum-Institut GmbH Blood bag with a connection unit
US5374263A (en) * 1992-10-13 1994-12-20 Automatic Liquid Packaging Full withdrawal container and method
US5699936A (en) * 1995-09-08 1997-12-23 Sercomp Corporation Liquid dispensing system
EP0819440A2 (en) * 1996-07-19 1998-01-21 B. Braun Melsungen Ag Infusion set
EP0819440A3 (en) * 1996-07-19 1998-09-09 B. Braun Melsungen Ag Infusion set
US6106502A (en) * 1996-12-18 2000-08-22 Richmond; Frank M. IV sets with needleless fittings and valves
EP1358905A1 (en) * 2002-04-30 2003-11-05 Haemopharm Industry Ag Device for the administration of drugs
US8480797B2 (en) 2005-09-12 2013-07-09 Abela Pharmaceuticals, Inc. Activated carbon systems for facilitating use of dimethyl sulfoxide (DMSO) by removal of same, related compounds, or associated odors
US7955418B2 (en) 2005-09-12 2011-06-07 Abela Pharmaceuticals, Inc. Systems for removing dimethyl sulfoxide (DMSO) or related compounds or odors associated with same
US8298320B2 (en) 2005-09-12 2012-10-30 Abela Pharmaceuticals, Inc. Systems for removing dimethyl sulfoxide (DMSO) or related compounds, or odors associated with same
US8435224B2 (en) 2005-09-12 2013-05-07 Abela Pharmaceuticals, Inc. Materials for facilitating administration of dimethyl sulfoxide (DMSO) and related compounds
US8440001B2 (en) 2005-09-12 2013-05-14 Abela Pharmaceuticals, Inc. Systems for removing dimethyl sulfoxide (DMSO) or related compounds, or odors associated with same
US8673061B2 (en) 2005-09-12 2014-03-18 Abela Pharmaceuticals, Inc. Methods for facilitating use of dimethyl sulfoxide (DMSO) by removal of same, related compounds, or associated odors
US9186472B2 (en) 2005-09-12 2015-11-17 Abela Pharmaceuticals, Inc. Devices for removal of dimethyl sulfoxide (DMSO) or related compounds or associated odors and methods of using same
US9186297B2 (en) 2005-09-12 2015-11-17 Abela Pharmaceuticals, Inc. Materials for facilitating administration of dimethyl sulfoxide (DMSO) and related compounds
US9427419B2 (en) 2005-09-12 2016-08-30 Abela Pharmaceuticals, Inc. Compositions comprising dimethyl sulfoxide (DMSO)
US20080308166A1 (en) * 2005-10-20 2008-12-18 Richmond Frank M Connector/Device with Reflux Valves
US9839609B2 (en) 2009-10-30 2017-12-12 Abela Pharmaceuticals, Inc. Dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) formulations to treat osteoarthritis
US9855212B2 (en) 2009-10-30 2018-01-02 Abela Pharmaceuticals, Inc. Dimethyl sulfoxide (DMSO) or DMSO and methylsulfonylmethane (MSM) formulations to treat infectious diseases
US10596109B2 (en) 2009-10-30 2020-03-24 Abela Pharmaceuticals, Inc. Dimethyl sulfoxide (DMSO) or DMSO and methylsulfonylmethane (MSM) formulations to treat infectious diseases

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Publication number Publication date
DE1288751B (en) 1969-02-06
NL6505909A (en) 1965-11-15
CH401363A (en) 1965-10-31
BE663822A (en) 1965-09-01
GB1046684A (en) 1966-10-26
SE312404B (en) 1969-07-14

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