EP0000825A1 - Dérivés de l'indène à deux substituants géminaux, leurs procédés de préparation et compositions pharmaceutiques les contenant - Google Patents

Dérivés de l'indène à deux substituants géminaux, leurs procédés de préparation et compositions pharmaceutiques les contenant Download PDF

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Publication number
EP0000825A1
EP0000825A1 EP7878300226A EP78300226A EP0000825A1 EP 0000825 A1 EP0000825 A1 EP 0000825A1 EP 7878300226 A EP7878300226 A EP 7878300226A EP 78300226 A EP78300226 A EP 78300226A EP 0000825 A1 EP0000825 A1 EP 0000825A1
Authority
EP
European Patent Office
Prior art keywords
compound
indene
formula
ethanol
cyclopentane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP7878300226A
Other languages
German (de)
English (en)
Other versions
EP0000825B1 (fr
Inventor
Aake Nils Joensson
Tomas Goeran Kempe
Lembit Mikiver
Bengt Aake Sparf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Phadia AB
Original Assignee
Kabi AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi AB filed Critical Kabi AB
Publication of EP0000825A1 publication Critical patent/EP0000825A1/fr
Application granted granted Critical
Publication of EP0000825B1 publication Critical patent/EP0000825B1/fr
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/38—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/40—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton with quaternised nitrogen atoms bound to carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/38—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
    • C07C47/453—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/93—Spiro compounds
    • C07C2603/94—Spiro compounds containing "free" spiro atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP78300226A 1977-08-05 1978-08-01 Dérivés de l'indène à deux substituants géminaux, leurs procédés de préparation et compositions pharmaceutiques les contenant Expired EP0000825B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB3294777 1977-08-05
GB3294777 1977-08-05

Publications (2)

Publication Number Publication Date
EP0000825A1 true EP0000825A1 (fr) 1979-02-21
EP0000825B1 EP0000825B1 (fr) 1982-04-14

Family

ID=10346367

Family Applications (1)

Application Number Title Priority Date Filing Date
EP78300226A Expired EP0000825B1 (fr) 1977-08-05 1978-08-01 Dérivés de l'indène à deux substituants géminaux, leurs procédés de préparation et compositions pharmaceutiques les contenant

Country Status (16)

Country Link
US (1) US4218472A (fr)
EP (1) EP0000825B1 (fr)
JP (1) JPS5444651A (fr)
AT (1) AT367018B (fr)
AU (1) AU527825B2 (fr)
CA (1) CA1109066A (fr)
DE (1) DE2861735D1 (fr)
DK (1) DK150538C (fr)
ES (1) ES472291A1 (fr)
FI (1) FI71724C (fr)
IE (1) IE47716B1 (fr)
IT (1) IT1099587B (fr)
NO (1) NO147420C (fr)
NZ (1) NZ188037A (fr)
PT (1) PT68383A (fr)
ZA (1) ZA784349B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4331549A (en) * 1980-04-21 1982-05-25 The Dow Chemical Company Hydraulic fluids containing cyano derivatives of ketones
KR100595963B1 (ko) * 2004-04-13 2006-07-05 한국화학연구원 인덴 유도체 및 이의 제조방법
KR101959636B1 (ko) * 2017-10-25 2019-07-04 경북대학교 산학협력단 인데엔 화합물을 유효성분으로 함유하는 골 재생 및 골 질환 예방 또는 치료용 조성물

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE955594C (de) * 1953-11-15 1957-01-03 Schering Ag Verfahren zur Herstellung von 3-Aminoindanen
GB1154506A (en) * 1965-12-30 1969-06-11 Merck & Co Inc 0-Substituted-3-Indenyl Aliphatic Amines and their preparation
GB1187255A (en) * 1966-12-01 1970-04-08 Mead Johnson & Co 0-(2-Dimethylaminoethyl)-1-Phenylindene-N-Oxide, Acid Addition Salts thereof, and Process for Preparing the same
DE2314636A1 (de) * 1972-03-24 1973-10-04 Kabi Ab Pharmakodynamisch aktive, basisch substituierte indanderivate
FR2363327A1 (fr) * 1976-08-31 1978-03-31 Continental Pharma Nouveaux amino-alcools heterocycliques, leurs sels et leur procede de preparation

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2532292A (en) * 1947-12-12 1950-12-05 Searle & Co Diarylmethyl ethers of amino alkanols
US2914561A (en) * 1957-08-06 1959-11-24 Wm S Merrell Co Amine derivatives of triphenylethylene
US2987442A (en) * 1959-02-17 1961-06-06 Smith Kline French Lab Method of treating hypertension with [2-(2, 6-dimethylphenoxy)-propyl]-trimethyl ammonium salts
US2971001A (en) * 1959-10-21 1961-02-07 Wm S Merrell Co Quaternary salts of triphenylethanols, -ethylenes, and -ethanes
US3205136A (en) * 1962-12-24 1965-09-07 Smith Kline French Lab Antidepressant phenyloxyalkylamines
US3255249A (en) * 1963-04-26 1966-06-07 Ici Ltd 2-branched lower alkyl-amino-1-(indan-, hydrogenated indan- and hydrogenated naphth-2-yl) lower alkanols
GB1059968A (en) * 1964-01-20 1967-02-22 Ici Ltd Naphthalene derivatives
CH540221A (de) * 1968-03-20 1973-08-15 Hoffmann La Roche Verfahren zur Herstellung von tricyclischen Verbindungen
US4136116A (en) * 1968-05-03 1979-01-23 Hoffmann-La Roche Inc. Tricyclic compounds
US4127675A (en) * 1968-11-12 1978-11-28 Yamanouchi Pharmaceutical Co., Ltd. 4-(Alkylamino-2-hydroxypropoxy)-indenes and method of use
US3940443A (en) * 1973-06-07 1976-02-24 The United States Of America As Represented By The Secretary Of The Navy Amino ethanol-indane and tetrahydronaphthalene derivatives

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE955594C (de) * 1953-11-15 1957-01-03 Schering Ag Verfahren zur Herstellung von 3-Aminoindanen
GB1154506A (en) * 1965-12-30 1969-06-11 Merck & Co Inc 0-Substituted-3-Indenyl Aliphatic Amines and their preparation
GB1187255A (en) * 1966-12-01 1970-04-08 Mead Johnson & Co 0-(2-Dimethylaminoethyl)-1-Phenylindene-N-Oxide, Acid Addition Salts thereof, and Process for Preparing the same
DE2314636A1 (de) * 1972-03-24 1973-10-04 Kabi Ab Pharmakodynamisch aktive, basisch substituierte indanderivate
FR2363327A1 (fr) * 1976-08-31 1978-03-31 Continental Pharma Nouveaux amino-alcools heterocycliques, leurs sels et leur procede de preparation

Also Published As

Publication number Publication date
DE2861735D1 (en) 1982-05-27
JPS5444651A (en) 1979-04-09
PT68383A (en) 1978-09-01
DK344778A (da) 1979-02-06
EP0000825B1 (fr) 1982-04-14
AT367018B (de) 1982-05-25
IT7826404A0 (it) 1978-08-02
ZA784349B (en) 1979-07-25
NO147420B (no) 1982-12-27
CA1109066A (fr) 1981-09-15
DK150538C (da) 1987-10-12
AU3857878A (en) 1980-02-07
FI71724C (fi) 1987-02-09
NO147420C (no) 1983-04-06
NO782651L (no) 1979-02-06
ES472291A1 (es) 1979-02-16
DK150538B (da) 1987-03-23
ATA563378A (de) 1981-10-15
FI71724B (fi) 1986-10-31
FI782382A (fi) 1979-02-06
NZ188037A (en) 1984-07-06
AU527825B2 (en) 1983-03-24
IE47716B1 (en) 1984-05-30
IT1099587B (it) 1985-09-18
IE781561L (en) 1979-02-05
JPS6344737B2 (fr) 1988-09-06
US4218472A (en) 1980-08-19

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