EP0000256B1 - Utilisation d'un sel de lanthane pour la préparation d'une composition aqueuse de nettoyage de dents - Google Patents

Utilisation d'un sel de lanthane pour la préparation d'une composition aqueuse de nettoyage de dents Download PDF

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Publication number
EP0000256B1
EP0000256B1 EP78300055A EP78300055A EP0000256B1 EP 0000256 B1 EP0000256 B1 EP 0000256B1 EP 78300055 A EP78300055 A EP 78300055A EP 78300055 A EP78300055 A EP 78300055A EP 0000256 B1 EP0000256 B1 EP 0000256B1
Authority
EP
European Patent Office
Prior art keywords
cation
teeth
plaque
lanthanum
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
EP78300055A
Other languages
German (de)
English (en)
Other versions
EP0000256A1 (fr
EP0000256B2 (fr
Inventor
Gunnar Rölla
Michael Roy Carlton Winters
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10241609&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP0000256(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of EP0000256A1 publication Critical patent/EP0000256A1/fr
Application granted granted Critical
Publication of EP0000256B1 publication Critical patent/EP0000256B1/fr
Publication of EP0000256B2 publication Critical patent/EP0000256B2/fr
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Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients

Definitions

  • This invention relates to dental hygiene, and more particularly it relates to a method of cleaning teeth.
  • tooth enamel may be remineralised by sequential application to the teeth of a cationic and an anionic component which react below the tooth surface to form an insoluble salt.
  • the cationic component are ions derived from barium, lanthanum, manganese, lead, tin, zinc, indium, zirconium, iron, titanium, vanadium and cadmium (UK Patent Specification No. 1,452,125, equivalent to French Patent No. 2,202,697).
  • French Patent No. 997,488 states that caries can be prevented by using an oxidising solution containing a metallic catalyst derived from iron, copper, manganese, zinc, silver or one of the 14 rare earth elements. This patent contains no Examples.
  • deposits such as dental plaque may be removed from the surface of teeth, or may be prevented from adhering thereto, by application of the lanthanum cation.
  • a method of cleaning plaque and/or stains from human teeth by applying thereto, as the sole oral hygiene agent, a non-oxidising aqueous composition which consists essentially of the unbound cation of the element lanthanum in the form of a water-soluble salt, said composition being free from any ingredients which precipitate the cation as a water-insoluble salt.
  • the method of the invention is particularly useful for cleaning teeth in human beings.
  • the efficient cleaning of teeth is, of course, of immense cosmetic value.
  • One of the substances routinely found on the surface of teeth is bacterial plaque and the method of this invention is particularly useful in removing plaque from teeth or in preventing its adhering thereto.
  • the method of the invention is also useful in removing various types of stain from teeth, for example the stain produced by smoking tobacco.
  • bacterial plaque is generally regarded as a dominant etiological factor in caries and periodontal disease and removal of plaque from teeth or prevention of its accumulation is known to have a beneficial effect in those conditions.
  • the cation is in the form of a water-soluble salt.
  • water soluble salts are the chloride, bromide, iodide, nitrate, acetate or sulphate.
  • the cation may also be used in the form of a salt with an antibacterial anion.
  • the preferred compound for use in the method of the invention is lanthanum chloride, LaCl 3 .
  • the amount of cation used in the method of the invention may vary from 0.01 m.moles to 1 m.moles of cation and preferably from 0.1 m.moles to 0.5 m.moles of cation, and it may be applied from once a week to 1 to 10 times per day.
  • a preferred regime is three times per day, after meals, or failing this, twice per day, night and morning.
  • the method of the invention achieves a satisfactory result simply by application of the cation to the teeth, for example in the form of a simple aqueous solution.
  • an improved degree of cleansing can be achieved if the method of the invention is combined with one or more of the normal mechanical methods of cleaning teeth, for example if combined with the use of a toothbrush, toothpick, dental floss, dental probe or rotary dental brush.
  • a particularly preferred adjunct to the method of the invention is the use of a toothbrush.
  • the cation for use in the method of the invention may be presented in the form of a composition such as a simple aqueous solution or suspension or in the form of a more sophisticated composition such as a mouthwash, toothpaste, prophylaxis paste, toothpowder, pastille, chewing gum or oral spray, or it may be incorporated into a beverage, nutritional substance or confection. It may also be incorporated into the public water supply.
  • a composition such as a simple aqueous solution or suspension
  • a more sophisticated composition such as a mouthwash, toothpaste, prophylaxis paste, toothpowder, pastille, chewing gum or oral spray, or it may be incorporated into a beverage, nutritional substance or confection. It may also be incorporated into the public water supply.
  • compositions described above are those which are well known to those skilled in this art. They may incorporate any of the ingredients normally used in such compositions, with the addition of the cation in the form of a salt.
  • a mouthwash or oral spray the cation is incorporated at the desired user concentration.
  • a toothpaste, prophylactic paste, toothpowder, lozenge or chewing gum it may be necessary, depending on the nature of the ingredients in the composition, to increase the concentration of the cation to above the level of the desired user concentration, for example by up to five times the desired user concentration, in order to allow for incomplete availability of the cation in use as a result of specific binding of the cation to one or more of the ingredients.
  • these formulations it is preferable to use ingredients which avoid precipitation of the cation in the form of an insoluble salt.
  • a typical mouthwash has an aqueous base and generally incorporates a thickener and a flavour.
  • a gel has an aqueous base and generally incorporates a gelling agent, a surfactant, a flavour and a preservative.
  • a toothpaste has an aqueous base and generally contains an abrasive, a binder, a thickener, a surfactant, a humectant, a flavouring agent and a sweetening agent.
  • a non-oxidising aqueous composition which consists essentially of the unbound cation of the element lanthanum in the form of a water soluble salt, said composition being free from any ingredients which precipitate the cation as a water insoluble salt, and being a mouthwash, oral spray, toothpaste or dental gel.
  • a preferred water soluble salt is lanthanum chloride.
  • the control group had a mean Plaque Index of 1.0 whereas the treated group had a mean Plaque Index of zero.
  • the very small amount of deposit which was present in the treated group was very loosely attached to the tooth surface and could be blown off with an air jet.
  • the panel was provided with new toothbrushes and instructed to brush their teeth each morning and evening for 30 seconds over a period of four days, according to each individual's own habits, with a 10 ml. test solution, and then to rinse the teeth with the remainder of the test solution.
  • the whole experiment was carried out under double blind conditions, each person using one of the test solutions in turn. Each person's Plaque Index was brought to zero before using a new test solution.
  • the results obtained were as follows:-
  • each group brushed their teeth with 20 ml. of either a 20 mM aqueous lanthanum acetate solution or water respectively with a new soft toothbrush dipped in the respective test solution. Rinsing for 1 minute was then carried out with the remainder of the test solution. No after-rinses with water were permitted.
  • a subject rinsed his mouth and teeth with 10 ml. of 20 mM aqueous LaCl 3 solution for 1 minute.
  • the solution tasted salty but was not unpleasant-there was no metallic taste.
  • After rinsing the subject spat out pieces of organic debris. His mouth and teeth felt much cleaner and in particular his teeth felt dry and clean.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Birds (AREA)
  • Inorganic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)
  • Detergent Compositions (AREA)

Claims (4)

1. Procédé pour enlever la plaque et/ou taches de dents humaines par application aux dents, comme unique agent d'hygiène buccale, d'une composition aqueuse non oxydante qui est essentiellement formée du cation non lié du lanthane élémentaire sous la forme d'une sel hydrosoluble ladite composition étant dépourvue de tous ingrédients qui précipitent le cation sous la forme d'un sel insoluble dans l'eau.
2. Procédé suivant la revendication 1, dans lequel le cation lanthane est présent sous la forme du chlorure.
3. Une composition aqueuse non oxydante qui comprend essentiellement le cation non lié du lanthane élémentaire sous la forme d'un sel soluble dans l'eau, ladite composition étant dépourvue de tous ingrédients qui précipitent le cation sous la forme d'un sel insoluble dans l'eau et étant sous la forme d'un bain de bouche, d'une composition pulvérisante orale, d'une pâte dentaire ou d'un gel dentaire.
4. Composition suivant la revendication 3, dans laquelle le cation lanthane est présent sous la forme du chlorure.
EP78300055A 1977-06-23 1978-06-20 Utilisation d'un sel de lanthane pour la préparation d'une composition aqueuse de nettoyage de dents Expired - Lifetime EP0000256B2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2630877 1977-06-23
GB2630877 1977-06-23

Publications (3)

Publication Number Publication Date
EP0000256A1 EP0000256A1 (fr) 1979-01-10
EP0000256B1 true EP0000256B1 (fr) 1983-04-13
EP0000256B2 EP0000256B2 (fr) 1991-09-25

Family

ID=10241609

Family Applications (1)

Application Number Title Priority Date Filing Date
EP78300055A Expired - Lifetime EP0000256B2 (fr) 1977-06-23 1978-06-20 Utilisation d'un sel de lanthane pour la préparation d'une composition aqueuse de nettoyage de dents

Country Status (19)

Country Link
US (1) US4218434A (fr)
EP (1) EP0000256B2 (fr)
JP (1) JPS5417137A (fr)
AT (1) AT376365B (fr)
AU (1) AU517737B2 (fr)
BE (1) BE868250A (fr)
CA (1) CA1226525A (fr)
CH (1) CH646603A5 (fr)
DE (2) DE2862228D1 (fr)
DK (1) DK155775C (fr)
ES (2) ES471084A1 (fr)
FI (1) FI69405C (fr)
FR (1) FR2395022A1 (fr)
IE (1) IE47251B1 (fr)
IL (1) IL54926A0 (fr)
IT (1) IT1098329B (fr)
NO (1) NO146839C (fr)
NZ (1) NZ187498A (fr)
ZA (1) ZA783241B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2493704A1 (fr) * 1980-11-07 1982-05-14 Lemouel Jean Composition pour la prophylaxie et les soins de la carie dentaire
US5340566A (en) * 1993-08-09 1994-08-23 Colgate-Palmolive Company Method for preventing the progression of gingivitis
US5875798A (en) * 1997-09-23 1999-03-02 Advanced Medical Instruments, Inc. Therapeutic toothpick for treating oral and systemic diseases
WO2007100541A2 (fr) * 2006-02-23 2007-09-07 Research Foundation Of The State University Of New York Procédé de traitement de la parodontite et de réduction de la sensibilité dentinaire
EP2219693B1 (fr) * 2007-11-20 2019-04-03 Sunkara, Nagendra Babu Formulation et procédé pour un traitement dentaire
US11110047B2 (en) * 2017-08-07 2021-09-07 Colgate-Palmolive Company Oral care compositions including cyclic anhydrides
US20230235248A1 (en) * 2022-01-24 2023-07-27 Inter-Med, Inc. Dental material compositions for cleansing and removal of anionic contaminants from substrates & their methods of use

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB654472A (en) * 1947-03-12 1951-06-20 Procter & Gamble Preparations for use in contact with the teeth
FR997488A (fr) * 1949-09-15 1952-01-07 Produit d'hygiène et de prophylaxie dentaire
US3004897A (en) * 1955-02-09 1961-10-17 Shore Joseph Dental preparation
US3151027A (en) * 1961-06-07 1964-09-29 Procter & Gamble Abrasive for dentifrice composition
FR2059469B1 (fr) * 1969-07-02 1974-06-14 Richter Gedeon Vegyeszet
US3751568A (en) * 1971-06-18 1973-08-07 Eastman Dental Center Method of coating teeth with a durable glaze
AU6104973A (en) 1972-10-13 1975-04-10 Procter & Gamble Remineralization of dental enamel
DE2452969A1 (de) * 1973-11-13 1975-05-15 Procter & Gamble Mittel zum remineralisieren von zahnschmelz
IE42129B1 (en) 1974-10-10 1980-06-04 Procter & Gamble Compositions for remineralizing tooth enamel
US4080440A (en) * 1974-12-13 1978-03-21 The Procter & Gamble Company Method for remineralizing tooth enamel
SE7600504L (sv) * 1975-01-17 1976-07-18 Carter Wallace Tandstensmotverkande medel
US4083955A (en) * 1975-04-02 1978-04-11 The Procter & Gamble Company Processes and compositions for remineralization of dental enamel

Also Published As

Publication number Publication date
JPS6245841B2 (fr) 1987-09-29
ES8103645A1 (es) 1981-02-16
IL54926A0 (en) 1978-08-31
IT1098329B (it) 1985-09-07
FI69405B (fi) 1985-10-31
AU517737B2 (en) 1981-08-20
NZ187498A (en) 1984-05-31
ES471084A1 (es) 1980-05-16
DE2827666C3 (de) 1993-11-18
DK274378A (da) 1978-12-24
JPS5417137A (en) 1979-02-08
ES488073A0 (es) 1981-02-16
EP0000256A1 (fr) 1979-01-10
EP0000256B2 (fr) 1991-09-25
AT376365B (de) 1984-11-12
FR2395022B1 (fr) 1983-07-29
IE781145L (en) 1978-12-23
ZA783241B (en) 1979-06-27
FI69405C (fi) 1986-02-10
DE2827666A1 (de) 1979-01-11
NO781972L (no) 1978-12-28
DK155775B (da) 1989-05-16
NO146839B (no) 1982-09-13
DE2862228D1 (en) 1983-05-19
FR2395022A1 (fr) 1979-01-19
DE2827666C2 (fr) 1988-01-28
US4218434A (en) 1980-08-19
BE868250A (fr) 1978-12-19
IT7824646A0 (it) 1978-06-16
AU3691978A (en) 1979-12-13
FI782004A (fi) 1978-12-24
CA1226525A (fr) 1987-09-08
CH646603A5 (de) 1984-12-14
ATA460178A (de) 1980-10-15
DK155775C (da) 1989-10-02
NO146839C (no) 1982-12-22
IE47251B1 (en) 1984-02-08

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