EP0000256B2 - Utilisation d'un sel de lanthane pour la préparation d'une composition aqueuse de nettoyage de dents - Google Patents

Utilisation d'un sel de lanthane pour la préparation d'une composition aqueuse de nettoyage de dents Download PDF

Info

Publication number
EP0000256B2
EP0000256B2 EP78300055A EP78300055A EP0000256B2 EP 0000256 B2 EP0000256 B2 EP 0000256B2 EP 78300055 A EP78300055 A EP 78300055A EP 78300055 A EP78300055 A EP 78300055A EP 0000256 B2 EP0000256 B2 EP 0000256B2
Authority
EP
European Patent Office
Prior art keywords
teeth
plaque
cation
aqueous
lanthanum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP78300055A
Other languages
German (de)
English (en)
Other versions
EP0000256A1 (fr
EP0000256B1 (fr
Inventor
Gunnar Rölla
Michael Roy Carlton Winters
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10241609&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP0000256(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of EP0000256A1 publication Critical patent/EP0000256A1/fr
Publication of EP0000256B1 publication Critical patent/EP0000256B1/fr
Application granted granted Critical
Publication of EP0000256B2 publication Critical patent/EP0000256B2/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients

Definitions

  • This invention relates to dental hygiene, and more particularly it relates to a method of cleaning teeth.
  • tooth enamel may be remineralised by sequential application to the teeth of a cationic and an anionic component which react below the tooth surface to form an insoluble salt.
  • the cationic component are ions derived from barium, lanthanum, manganese, lead, tin, zinc, indium, zirconium, iron, titanium, vanadium and cadmium (UK Patent Specification No. 1,452,125, equivalent to French Patent No. 2,202,697).
  • French Patent No. 997,488 states that caries can be prevented by using an oxidising solution containing a metallic catalyst derived from iron, copper, manganese, zinc, silver or one of the 14 rare earth elements. This patent contains no Examples.
  • deposits such as dental plaque may be removed from the surface of teeth, or may be prevented from adhering thereto, by application of the lanthanum cation.
  • the invention consists of the use of a salt of lanthanum for the manufacture of a non-oxiding aqueous composition for cleaning plaque and for stains from human teeth which consists essentially of the unbound cation of the element lanthanum in the form of a water soluble salt and in free of any ingredients which precipitates the cation as a water-insoluble salt.
  • the invention is particularly useful for cleaning teeth in human beings.
  • the efficient cleaning of teeth is, of course, of immense cosmetic value.
  • One of the substances routinely found on the surface of teeth is bacterial plaque and the method of this invention is particularly useful in removing plaque from teeth or in preventing its adhering thereto.
  • the method of the invention is also useful in removing various types of stain from teeth, for example the stain produced by smoking tobacco.
  • bacterial plaque is generally regarded as a dominant etiological factor in caries and periodontal disease and removal of plaque from teeth or prevention of its accumulation is known to have a beneficial effect in those conditions.
  • the cation is in the form of a water-soluble salt.
  • water soluble salts are the chloride, bromide, iodide, nitrate, acetate or sulphate.
  • the cation may also be used in the form of a salt with an antibacterial anion.
  • the preferred compound for use in the invention is lanthanum chloride, LaC1 3 .
  • the amount of cation used in the method of the invention may vary from 0.01 m.moles to 1 m.moles of cation and preferably form 0.1 m.moles to 0.5 m.moles of cation, and it may be applied from once a week to 1 to 10 times per day.
  • a preferred regime is three times per day, after meals, or failing this, twice per day, night and morning.
  • the invention achieves a satisfactory result simply by application of the cation to the teeth, for example in the form of a simple aqueous solution.
  • an improved degree of cleansing can be achieved if the invention is combined with one or more of the normal mechanical methods of cleaning teeth, for example if combined with the use of a toothbrush, toothpick, dental floss, dental probe or rotary dental brush.
  • a particularly preferred adjunct to the invention is the use of a toothbrush.
  • the cation for use in the invention may be presented in the form of a composition such as a simple aqueous solution or suspension or in the form of a more sophisticated composition such as a mouthwash, toothpaste, prophylaxis paste, toothpowder, pastille, chewing gum or oral spray, or it may be incorporated into a beverage, nutritional substance or confection. It may also be incorporated into the public water supply.
  • a composition such as a simple aqueous solution or suspension
  • a more sophisticated composition such as a mouthwash, toothpaste, prophylaxis paste, toothpowder, pastille, chewing gum or oral spray, or it may be incorporated into a beverage, nutritional substance or confection. It may also be incorporated into the public water supply.
  • compositions described above are those which are well known to those skilled in this art. They may incorporate any of the ingredients normally used in such compositions, with the addition of the cation in the form of a salt.
  • a mouthwash or oral spray the cation is incorporated at the desired user concentration.
  • a toothpaste, prophylactic paste, toothpowder, lozenge or chewing gum it may be necessary, depending on the nature of the ingredients in the composition, to increase the concentration of the cation to above the level of the desired user concentration, for example by up to five times the desired user concentration, in order to allow for incomplete availability of the cation in use as a result of specific binding of the cation to one or more of the ingredients.
  • these formulations it is preferable to use ingredients which avoid precipitation of the cation in the form of an insoluble salt.
  • a typical mouthwash has an aqueous base and generally incorporates a thickener and a flavour.
  • a gel has an aqueous base and generally incorporates a gelling agent, a surfactant, a flavour and a preservative.
  • a toothpaste has an aqueous base and generally contains an abrasive, a binder, a thickener, a surfactant, a humectant, a flavouring agent and a sweetening agent.
  • the control group had a mean Plaque Index of 1.0 whereas the treated group had a mean Plaque Index of zero.
  • the very small amount of deposit which was present in the treated group was very loosely attached to the tooth surface and could be blown off with an air jet.
  • the panel was provided with new toothbrushes and instructed to brush their teeth each morning and evening for 30 seconds over a period of four days, according to each individual's own habits, with a 10 ml. test solution, and then to rinse the teeth with the remainder of the test solution.
  • the whole experiment was carried out under double blind conditions, each person using one of the test solutions in turn. Each person's Plaque Index was brought to zero before using a new test solution.
  • the results obtained were as follows: ⁇
  • each group brushed their teeth with 20 mi. of either a 20 mM aqueous lanthanum acetate solution or water respectively with a new soft toothbrush dipped in the respective test solution. Rinsing for 1 minute was then carried out with the remainder of the test solution. No after-rinses with water were permitted.
  • a subject rinsed his mouth and teeth with 10 ml. of 20 mM aqueous LaCI 3 solution for 1 minute.
  • the solution tasted salty but was not unpleasant-there was no metallic taste.
  • After rinsing the subject spat out pieces of organic debris. His mouth and teeth felt much cleaner and in particular his teeth felt dry and dean.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Cosmetics (AREA)
  • Detergent Compositions (AREA)

Claims (2)

1. Utilisation d'un sel de lanthane pour la préparation d'une composition aqueuse non oxydante pour éliminer la plaque et/ou les taches de dents humaines, qui est essentiellement constituée du cation non lié de l'élément lanthane sous la forme d'un sel hydrosoluble et dépourvue de tous ingrédients qui précipitent le cation sous la forme d'un sel insoluble dans l'eau.
2. Utilisation de chlorure de lanthane pour l'utilisation suivant la revendication 1.
EP78300055A 1977-06-23 1978-06-20 Utilisation d'un sel de lanthane pour la préparation d'une composition aqueuse de nettoyage de dents Expired - Lifetime EP0000256B2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2630877 1977-06-23
GB2630877 1977-06-23

Publications (3)

Publication Number Publication Date
EP0000256A1 EP0000256A1 (fr) 1979-01-10
EP0000256B1 EP0000256B1 (fr) 1983-04-13
EP0000256B2 true EP0000256B2 (fr) 1991-09-25

Family

ID=10241609

Family Applications (1)

Application Number Title Priority Date Filing Date
EP78300055A Expired - Lifetime EP0000256B2 (fr) 1977-06-23 1978-06-20 Utilisation d'un sel de lanthane pour la préparation d'une composition aqueuse de nettoyage de dents

Country Status (19)

Country Link
US (1) US4218434A (fr)
EP (1) EP0000256B2 (fr)
JP (1) JPS5417137A (fr)
AT (1) AT376365B (fr)
AU (1) AU517737B2 (fr)
BE (1) BE868250A (fr)
CA (1) CA1226525A (fr)
CH (1) CH646603A5 (fr)
DE (2) DE2862228D1 (fr)
DK (1) DK155775C (fr)
ES (2) ES471084A1 (fr)
FI (1) FI69405C (fr)
FR (1) FR2395022A1 (fr)
IE (1) IE47251B1 (fr)
IL (1) IL54926A0 (fr)
IT (1) IT1098329B (fr)
NO (1) NO146839C (fr)
NZ (1) NZ187498A (fr)
ZA (1) ZA783241B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2493704A1 (fr) * 1980-11-07 1982-05-14 Lemouel Jean Composition pour la prophylaxie et les soins de la carie dentaire
US5340566A (en) * 1993-08-09 1994-08-23 Colgate-Palmolive Company Method for preventing the progression of gingivitis
US5875798A (en) * 1997-09-23 1999-03-02 Advanced Medical Instruments, Inc. Therapeutic toothpick for treating oral and systemic diseases
US20070196288A1 (en) * 2006-02-23 2007-08-23 Research Foundation Of The State University Of New York Method of treating periodontitis and of reducing dentinal sensitivity
US8951506B2 (en) * 2007-11-20 2015-02-10 Sasi Kumar Sunkara Formulation and method for treatment of teeth
US11110047B2 (en) * 2017-08-07 2021-09-07 Colgate-Palmolive Company Oral care compositions including cyclic anhydrides
US20230235248A1 (en) * 2022-01-24 2023-07-27 Inter-Med, Inc. Dental material compositions for cleansing and removal of anionic contaminants from substrates & their methods of use

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB654472A (en) * 1947-03-12 1951-06-20 Procter & Gamble Preparations for use in contact with the teeth
FR997488A (fr) * 1949-09-15 1952-01-07 Produit d'hygiène et de prophylaxie dentaire
US3004897A (en) * 1955-02-09 1961-10-17 Shore Joseph Dental preparation
US3151027A (en) * 1961-06-07 1964-09-29 Procter & Gamble Abrasive for dentifrice composition
JPS4816170B1 (fr) * 1969-07-02 1973-05-19
US3751568A (en) * 1971-06-18 1973-08-07 Eastman Dental Center Method of coating teeth with a durable glaze
AU6104973A (en) * 1972-10-13 1975-04-10 Procter & Gamble Remineralization of dental enamel
DE2452969A1 (de) * 1973-11-13 1975-05-15 Procter & Gamble Mittel zum remineralisieren von zahnschmelz
IE42129B1 (en) 1974-10-10 1980-06-04 Procter & Gamble Compositions for remineralizing tooth enamel
US4080440A (en) * 1974-12-13 1978-03-21 The Procter & Gamble Company Method for remineralizing tooth enamel
FR2297631A1 (fr) * 1975-01-17 1976-08-13 Carter Wallace Composition pour la prophylaxie dentaire
US4083955A (en) * 1975-04-02 1978-04-11 The Procter & Gamble Company Processes and compositions for remineralization of dental enamel

Also Published As

Publication number Publication date
IE781145L (en) 1978-12-23
DK274378A (da) 1978-12-24
JPS5417137A (en) 1979-02-08
AT376365B (de) 1984-11-12
DE2827666C3 (de) 1993-11-18
IE47251B1 (en) 1984-02-08
FI69405B (fi) 1985-10-31
FR2395022A1 (fr) 1979-01-19
FI69405C (fi) 1986-02-10
FR2395022B1 (fr) 1983-07-29
DE2827666C2 (fr) 1988-01-28
CH646603A5 (de) 1984-12-14
DE2862228D1 (en) 1983-05-19
ZA783241B (en) 1979-06-27
IL54926A0 (en) 1978-08-31
NO146839B (no) 1982-09-13
NO781972L (no) 1978-12-28
AU3691978A (en) 1979-12-13
AU517737B2 (en) 1981-08-20
DK155775C (da) 1989-10-02
ATA460178A (de) 1980-10-15
JPS6245841B2 (fr) 1987-09-29
ES8103645A1 (es) 1981-02-16
ES488073A0 (es) 1981-02-16
DE2827666A1 (de) 1979-01-11
FI782004A (fi) 1978-12-24
BE868250A (fr) 1978-12-19
US4218434A (en) 1980-08-19
NO146839C (no) 1982-12-22
EP0000256A1 (fr) 1979-01-10
CA1226525A (fr) 1987-09-08
ES471084A1 (es) 1980-05-16
DK155775B (da) 1989-05-16
EP0000256B1 (fr) 1983-04-13
IT7824646A0 (it) 1978-06-16
NZ187498A (en) 1984-05-31
IT1098329B (it) 1985-09-07

Similar Documents

Publication Publication Date Title
CA1322961C (fr) Composition orale
CA2111375C (fr) Compositions orales contenant des acides de houblon et mode d'utilisation
Svantun et al. A comparison of the plaque-inhibiting effect of stannous fluoride and chlorhexidine
US5064640A (en) Anticariogenic compositions
US4927625A (en) Toothpastes
EP0162574A2 (fr) Compositions d'hygiène orale
US4976954A (en) Anticariogenic compositions
GB2216005A (en) Dental compositions containing stannous ions
AU2011359108B2 (en) Dentifrice composition
US5028412A (en) Oral compositions comprising anti-calculus agents
EP0000256B2 (fr) Utilisation d'un sel de lanthane pour la préparation d'une composition aqueuse de nettoyage de dents
WO2011117216A2 (fr) Nouvelle utilisation
Etemadzadeh et al. Plaque growth‐inhibiting effects of an abrasive fluoride‐chlorhexidine toothpaste and a fluoride toothpaste containing oxidative enzymes
CN112334197B (zh) 包含羧酸或其碱金属盐和游离氟离子源的洁牙剂
EP0270977A1 (fr) Compositions anticarie
WO2018091300A1 (fr) Composition de soin buccal pour l'élimination du biofilm buccal
AU624070B2 (en) Oral compositions comprising anti-calculus agents
US6361762B1 (en) Prebrushing liquid oral composition

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Designated state(s): BE CH DE FR GB LU NL SE

17P Request for examination filed
RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: IMPERIAL CHEMICAL INDUSTRIES PLC

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Designated state(s): BE CH DE FR GB LU NL SE

ET Fr: translation filed
REF Corresponds to:

Ref document number: 2862228

Country of ref document: DE

Date of ref document: 19830519

PLBI Opposition filed

Free format text: ORIGINAL CODE: 0009260

26 Opposition filed

Opponent name: BLENDAX-WERKE R. SCHNEIDER GMBH & CO.

Effective date: 19830721

PUAH Patent maintained in amended form

Free format text: ORIGINAL CODE: 0009272

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: PATENT MAINTAINED AS AMENDED

27A Patent maintained in amended form

Effective date: 19910925

AK Designated contracting states

Kind code of ref document: B2

Designated state(s): BE CH DE FR GB LU NL SE

REG Reference to a national code

Ref country code: CH

Ref legal event code: AEN

NLR2 Nl: decision of opposition
NLR3 Nl: receipt of modified translations in the netherlands language after an opposition procedure
ET3 Fr: translation filed ** decision concerning opposition
REG Reference to a national code

Ref country code: GB

Ref legal event code: 732E

REG Reference to a national code

Ref country code: CH

Ref legal event code: PUE

Owner name: ZENECA LIMITED

NLS Nl: assignments of ep-patents

Owner name: ZENECA LIMITED TE LONDEN, GROOT-BRITTANNIE.

EPTA Lu: last paid annual fee
REG Reference to a national code

Ref country code: FR

Ref legal event code: TP

EAL Se: european patent in force in sweden

Ref document number: 78300055.7

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 19950609

Year of fee payment: 18

Ref country code: FR

Payment date: 19950609

Year of fee payment: 18

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CH

Payment date: 19950614

Year of fee payment: 18

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: SE

Payment date: 19950615

Year of fee payment: 18

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 19950617

Year of fee payment: 18

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NL

Payment date: 19950628

Year of fee payment: 18

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: LU

Payment date: 19950701

Year of fee payment: 18

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: BE

Payment date: 19950809

Year of fee payment: 18

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 19960620

Ref country code: GB

Effective date: 19960620

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Effective date: 19960621

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CH

Effective date: 19960630

Ref country code: BE

Effective date: 19960630

BERE Be: lapsed

Owner name: ZENECA LTD

Effective date: 19960630

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Effective date: 19970101

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 19960620

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Effective date: 19970228

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DE

Effective date: 19970301

EUG Se: european patent has lapsed

Ref document number: 78300055.7

NLV4 Nl: lapsed or anulled due to non-payment of the annual fee

Effective date: 19970101

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

APAH Appeal reference modified

Free format text: ORIGINAL CODE: EPIDOSCREFNO