EP0000256B1 - Die Verwendung eines Lanthansalzes zur Herstellung einer wässerigen Zusammensetzung zur Reinigung von Zähnen - Google Patents
Die Verwendung eines Lanthansalzes zur Herstellung einer wässerigen Zusammensetzung zur Reinigung von Zähnen Download PDFInfo
- Publication number
- EP0000256B1 EP0000256B1 EP78300055A EP78300055A EP0000256B1 EP 0000256 B1 EP0000256 B1 EP 0000256B1 EP 78300055 A EP78300055 A EP 78300055A EP 78300055 A EP78300055 A EP 78300055A EP 0000256 B1 EP0000256 B1 EP 0000256B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- cation
- teeth
- plaque
- lanthanum
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
Definitions
- This invention relates to dental hygiene, and more particularly it relates to a method of cleaning teeth.
- tooth enamel may be remineralised by sequential application to the teeth of a cationic and an anionic component which react below the tooth surface to form an insoluble salt.
- the cationic component are ions derived from barium, lanthanum, manganese, lead, tin, zinc, indium, zirconium, iron, titanium, vanadium and cadmium (UK Patent Specification No. 1,452,125, equivalent to French Patent No. 2,202,697).
- French Patent No. 997,488 states that caries can be prevented by using an oxidising solution containing a metallic catalyst derived from iron, copper, manganese, zinc, silver or one of the 14 rare earth elements. This patent contains no Examples.
- deposits such as dental plaque may be removed from the surface of teeth, or may be prevented from adhering thereto, by application of the lanthanum cation.
- a method of cleaning plaque and/or stains from human teeth by applying thereto, as the sole oral hygiene agent, a non-oxidising aqueous composition which consists essentially of the unbound cation of the element lanthanum in the form of a water-soluble salt, said composition being free from any ingredients which precipitate the cation as a water-insoluble salt.
- the method of the invention is particularly useful for cleaning teeth in human beings.
- the efficient cleaning of teeth is, of course, of immense cosmetic value.
- One of the substances routinely found on the surface of teeth is bacterial plaque and the method of this invention is particularly useful in removing plaque from teeth or in preventing its adhering thereto.
- the method of the invention is also useful in removing various types of stain from teeth, for example the stain produced by smoking tobacco.
- bacterial plaque is generally regarded as a dominant etiological factor in caries and periodontal disease and removal of plaque from teeth or prevention of its accumulation is known to have a beneficial effect in those conditions.
- the cation is in the form of a water-soluble salt.
- water soluble salts are the chloride, bromide, iodide, nitrate, acetate or sulphate.
- the cation may also be used in the form of a salt with an antibacterial anion.
- the preferred compound for use in the method of the invention is lanthanum chloride, LaCl 3 .
- the amount of cation used in the method of the invention may vary from 0.01 m.moles to 1 m.moles of cation and preferably from 0.1 m.moles to 0.5 m.moles of cation, and it may be applied from once a week to 1 to 10 times per day.
- a preferred regime is three times per day, after meals, or failing this, twice per day, night and morning.
- the method of the invention achieves a satisfactory result simply by application of the cation to the teeth, for example in the form of a simple aqueous solution.
- an improved degree of cleansing can be achieved if the method of the invention is combined with one or more of the normal mechanical methods of cleaning teeth, for example if combined with the use of a toothbrush, toothpick, dental floss, dental probe or rotary dental brush.
- a particularly preferred adjunct to the method of the invention is the use of a toothbrush.
- the cation for use in the method of the invention may be presented in the form of a composition such as a simple aqueous solution or suspension or in the form of a more sophisticated composition such as a mouthwash, toothpaste, prophylaxis paste, toothpowder, pastille, chewing gum or oral spray, or it may be incorporated into a beverage, nutritional substance or confection. It may also be incorporated into the public water supply.
- a composition such as a simple aqueous solution or suspension
- a more sophisticated composition such as a mouthwash, toothpaste, prophylaxis paste, toothpowder, pastille, chewing gum or oral spray, or it may be incorporated into a beverage, nutritional substance or confection. It may also be incorporated into the public water supply.
- compositions described above are those which are well known to those skilled in this art. They may incorporate any of the ingredients normally used in such compositions, with the addition of the cation in the form of a salt.
- a mouthwash or oral spray the cation is incorporated at the desired user concentration.
- a toothpaste, prophylactic paste, toothpowder, lozenge or chewing gum it may be necessary, depending on the nature of the ingredients in the composition, to increase the concentration of the cation to above the level of the desired user concentration, for example by up to five times the desired user concentration, in order to allow for incomplete availability of the cation in use as a result of specific binding of the cation to one or more of the ingredients.
- these formulations it is preferable to use ingredients which avoid precipitation of the cation in the form of an insoluble salt.
- a typical mouthwash has an aqueous base and generally incorporates a thickener and a flavour.
- a gel has an aqueous base and generally incorporates a gelling agent, a surfactant, a flavour and a preservative.
- a toothpaste has an aqueous base and generally contains an abrasive, a binder, a thickener, a surfactant, a humectant, a flavouring agent and a sweetening agent.
- a non-oxidising aqueous composition which consists essentially of the unbound cation of the element lanthanum in the form of a water soluble salt, said composition being free from any ingredients which precipitate the cation as a water insoluble salt, and being a mouthwash, oral spray, toothpaste or dental gel.
- a preferred water soluble salt is lanthanum chloride.
- the control group had a mean Plaque Index of 1.0 whereas the treated group had a mean Plaque Index of zero.
- the very small amount of deposit which was present in the treated group was very loosely attached to the tooth surface and could be blown off with an air jet.
- the panel was provided with new toothbrushes and instructed to brush their teeth each morning and evening for 30 seconds over a period of four days, according to each individual's own habits, with a 10 ml. test solution, and then to rinse the teeth with the remainder of the test solution.
- the whole experiment was carried out under double blind conditions, each person using one of the test solutions in turn. Each person's Plaque Index was brought to zero before using a new test solution.
- the results obtained were as follows:-
- each group brushed their teeth with 20 ml. of either a 20 mM aqueous lanthanum acetate solution or water respectively with a new soft toothbrush dipped in the respective test solution. Rinsing for 1 minute was then carried out with the remainder of the test solution. No after-rinses with water were permitted.
- a subject rinsed his mouth and teeth with 10 ml. of 20 mM aqueous LaCl 3 solution for 1 minute.
- the solution tasted salty but was not unpleasant-there was no metallic taste.
- After rinsing the subject spat out pieces of organic debris. His mouth and teeth felt much cleaner and in particular his teeth felt dry and clean.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Detergent Compositions (AREA)
Claims (4)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2630877 | 1977-06-23 | ||
GB2630877 | 1977-06-23 |
Publications (3)
Publication Number | Publication Date |
---|---|
EP0000256A1 EP0000256A1 (de) | 1979-01-10 |
EP0000256B1 true EP0000256B1 (de) | 1983-04-13 |
EP0000256B2 EP0000256B2 (de) | 1991-09-25 |
Family
ID=10241609
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP78300055A Expired - Lifetime EP0000256B2 (de) | 1977-06-23 | 1978-06-20 | Die Verwendung eines Lanthansalzes zur Herstellung einer wässerigen Zusammensetzung zur Reinigung von Zähnen |
Country Status (19)
Country | Link |
---|---|
US (1) | US4218434A (de) |
EP (1) | EP0000256B2 (de) |
JP (1) | JPS5417137A (de) |
AT (1) | AT376365B (de) |
AU (1) | AU517737B2 (de) |
BE (1) | BE868250A (de) |
CA (1) | CA1226525A (de) |
CH (1) | CH646603A5 (de) |
DE (2) | DE2862228D1 (de) |
DK (1) | DK155775C (de) |
ES (2) | ES471084A1 (de) |
FI (1) | FI69405C (de) |
FR (1) | FR2395022A1 (de) |
IE (1) | IE47251B1 (de) |
IL (1) | IL54926A0 (de) |
IT (1) | IT1098329B (de) |
NO (1) | NO146839C (de) |
NZ (1) | NZ187498A (de) |
ZA (1) | ZA783241B (de) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2493704A1 (fr) * | 1980-11-07 | 1982-05-14 | Lemouel Jean | Composition pour la prophylaxie et les soins de la carie dentaire |
US5340566A (en) * | 1993-08-09 | 1994-08-23 | Colgate-Palmolive Company | Method for preventing the progression of gingivitis |
US5875798A (en) * | 1997-09-23 | 1999-03-02 | Advanced Medical Instruments, Inc. | Therapeutic toothpick for treating oral and systemic diseases |
WO2007100541A2 (en) * | 2006-02-23 | 2007-09-07 | Research Foundation Of The State University Of New York | Method of treating periodontitis and of reducing dentinal sensitivity |
EP2219693B1 (de) * | 2007-11-20 | 2019-04-03 | Sunkara, Nagendra Babu | Formulierung und verfahren zur behandlung von zähnen |
US11110047B2 (en) * | 2017-08-07 | 2021-09-07 | Colgate-Palmolive Company | Oral care compositions including cyclic anhydrides |
US20230235248A1 (en) * | 2022-01-24 | 2023-07-27 | Inter-Med, Inc. | Dental material compositions for cleansing and removal of anionic contaminants from substrates & their methods of use |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB654472A (en) * | 1947-03-12 | 1951-06-20 | Procter & Gamble | Preparations for use in contact with the teeth |
FR997488A (fr) * | 1949-09-15 | 1952-01-07 | Produit d'hygiène et de prophylaxie dentaire | |
US3004897A (en) * | 1955-02-09 | 1961-10-17 | Shore Joseph | Dental preparation |
US3151027A (en) * | 1961-06-07 | 1964-09-29 | Procter & Gamble | Abrasive for dentifrice composition |
FR2059469B1 (de) * | 1969-07-02 | 1974-06-14 | Richter Gedeon Vegyeszet | |
US3751568A (en) * | 1971-06-18 | 1973-08-07 | Eastman Dental Center | Method of coating teeth with a durable glaze |
AU6104973A (en) | 1972-10-13 | 1975-04-10 | Procter & Gamble | Remineralization of dental enamel |
DE2452969A1 (de) * | 1973-11-13 | 1975-05-15 | Procter & Gamble | Mittel zum remineralisieren von zahnschmelz |
IE42129B1 (en) | 1974-10-10 | 1980-06-04 | Procter & Gamble | Compositions for remineralizing tooth enamel |
US4080440A (en) * | 1974-12-13 | 1978-03-21 | The Procter & Gamble Company | Method for remineralizing tooth enamel |
SE7600504L (sv) * | 1975-01-17 | 1976-07-18 | Carter Wallace | Tandstensmotverkande medel |
US4083955A (en) * | 1975-04-02 | 1978-04-11 | The Procter & Gamble Company | Processes and compositions for remineralization of dental enamel |
-
1978
- 1978-06-06 ZA ZA00783241A patent/ZA783241B/xx unknown
- 1978-06-06 IE IE1145/78A patent/IE47251B1/en not_active IP Right Cessation
- 1978-06-06 NO NO781972A patent/NO146839C/no unknown
- 1978-06-06 CA CA000304853A patent/CA1226525A/en not_active Expired
- 1978-06-08 AU AU36919/78A patent/AU517737B2/en not_active Expired
- 1978-06-08 NZ NZ187498A patent/NZ187498A/en unknown
- 1978-06-15 IL IL7854926A patent/IL54926A0/xx not_active IP Right Cessation
- 1978-06-16 IT IT24646/78A patent/IT1098329B/it active
- 1978-06-19 DK DK274378A patent/DK155775C/da active
- 1978-06-19 US US05/916,937 patent/US4218434A/en not_active Expired - Lifetime
- 1978-06-19 BE BE188677A patent/BE868250A/xx not_active IP Right Cessation
- 1978-06-20 DE DE7878300055T patent/DE2862228D1/de not_active Expired
- 1978-06-20 EP EP78300055A patent/EP0000256B2/de not_active Expired - Lifetime
- 1978-06-21 JP JP7528378A patent/JPS5417137A/ja active Granted
- 1978-06-22 FI FI782004A patent/FI69405C/fi not_active IP Right Cessation
- 1978-06-22 FR FR7818704A patent/FR2395022A1/fr active Granted
- 1978-06-23 ES ES471084A patent/ES471084A1/es not_active Expired
- 1978-06-23 DE DE2827666A patent/DE2827666C3/de not_active Expired - Fee Related
- 1978-06-23 CH CH690178A patent/CH646603A5/de not_active IP Right Cessation
- 1978-06-23 AT AT0460178A patent/AT376365B/de not_active IP Right Cessation
-
1980
- 1980-01-31 ES ES488073A patent/ES488073A0/es active Granted
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