EG25039A - Process for preparation of compounds used for inhibition of one or more tyrosine kinases. - Google Patents

Process for preparation of compounds used for inhibition of one or more tyrosine kinases.

Info

Publication number
EG25039A
EG25039A EGNA2007001382A EG25039A EG 25039 A EG25039 A EG 25039A EG NA2007001382 A EGNA2007001382 A EG NA2007001382A EG 25039 A EG25039 A EG 25039A
Authority
EG
Egypt
Prior art keywords
inhibition
preparation
compounds used
tyrosine kinases
kinases
Prior art date
Application number
Other languages
English (en)
Inventor
Mckenna Joseph
Wen-Chung Shieh
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of EG25039A publication Critical patent/EG25039A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Steroid Compounds (AREA)
EGNA2007001382 2005-06-09 2007-12-09 Process for preparation of compounds used for inhibition of one or more tyrosine kinases. EG25039A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68897705P 2005-06-09 2005-06-09
US70559005P 2005-08-04 2005-08-04
PCT/US2006/022155 WO2006135641A2 (fr) 2005-06-09 2006-06-07 Procede de synthese de composes organiques

Publications (1)

Publication Number Publication Date
EG25039A true EG25039A (en) 2011-07-06

Family

ID=37091153

Family Applications (1)

Application Number Title Priority Date Filing Date
EGNA2007001382 EG25039A (en) 2005-06-09 2007-12-09 Process for preparation of compounds used for inhibition of one or more tyrosine kinases.

Country Status (32)

Country Link
US (2) US8124763B2 (fr)
EP (1) EP1924574B1 (fr)
JP (1) JP5118024B2 (fr)
KR (3) KR101216249B1 (fr)
AR (1) AR053890A1 (fr)
AT (1) ATE487709T1 (fr)
AU (1) AU2006258051B2 (fr)
BR (1) BRPI0611663A2 (fr)
CA (1) CA2610105C (fr)
CY (1) CY1111428T1 (fr)
DE (1) DE602006018156D1 (fr)
DK (1) DK1924574T3 (fr)
EC (1) ECSP077982A (fr)
EG (1) EG25039A (fr)
GT (1) GT200600217A (fr)
HK (1) HK1117524A1 (fr)
IL (1) IL187421A (fr)
JO (1) JO2636B1 (fr)
MA (1) MA29599B1 (fr)
MX (1) MX2007015423A (fr)
MY (1) MY147436A (fr)
NO (1) NO340743B1 (fr)
NZ (1) NZ563740A (fr)
PE (1) PE20070015A1 (fr)
PL (1) PL1924574T3 (fr)
PT (1) PT1924574E (fr)
RU (1) RU2444520C2 (fr)
SA (1) SA06270147B1 (fr)
SI (1) SI1924574T1 (fr)
TN (1) TNSN07463A1 (fr)
TW (1) TWI430999B (fr)
WO (1) WO2006135641A2 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GT200600316A (es) * 2005-07-20 2007-04-02 Sales de 4-metilo-n-(3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo)-3-(4-piridina-3-ilo-pirimidina-2-iloamino)- benzamida.
WO2008151183A1 (fr) 2007-06-04 2008-12-11 Avila Therapeutics, Inc. Composés hétérocycliques et utilisations de ceux-ci
US20100016590A1 (en) * 2008-07-17 2010-01-21 Teva Pharmaceutical Industries Ltd. Nilotinib intermediates and preparation thereof
KR101251726B1 (ko) 2008-11-05 2013-04-05 테바 파마슈티컬 인더스트리즈 리미티드 닐로티닙 ＨＣｌ 결정형
WO2010060074A1 (fr) * 2008-11-24 2010-05-27 Teva Pharmaceutical Industries Ltd. Synthèse du nilotinib et ses intermédiaires
US20110053968A1 (en) 2009-06-09 2011-03-03 Auspex Pharmaceuticals, Inc. Aminopyrimidine inhibitors of tyrosine kinase
JO3634B1 (ar) 2009-11-17 2020-08-27 Novartis Ag طريقة لعلاج اضطرابات تكاثرية وحالات مرضية أخرى متوسطة بنشاط كيناز bcr-abl، c-kit، ddr1، ddr2، أو pdgf-r
JP5841234B2 (ja) 2011-03-31 2016-01-13 ザ プロクター アンド ギャンブルカンパニー フケ／脂漏性皮膚炎の治療に有効な皮膚活性剤を特定及び評価するためのシステム、モデル、及び方法
AR086913A1 (es) * 2011-06-14 2014-01-29 Novartis Ag 4-metil-3-[[4-(3-piridinil)-2-pirimidinil]-amino]-n-[5-(4-metil-1h-imidazol-1-il)-3-(trifluoro-metil)-fenil]-benzamida amorfa, forma de dosificacion que la contiene y metodo para prepararlas
WO2013120852A1 (fr) 2012-02-13 2013-08-22 Grindeks, A Joint Stock Company Intermédiaires pour un nouveau procédé de préparation d'imatinib et d'inhibiteurs de tyrosine kinase associés
US9920357B2 (en) 2012-06-06 2018-03-20 The Procter & Gamble Company Systems and methods for identifying cosmetic agents for hair/scalp care compositions
WO2015092624A1 (fr) 2013-12-16 2015-06-25 Ranbaxy Laboratories Limited Mono-oxalate de nilotinib et sa forme cristalline
CN103694176B (zh) 2014-01-07 2015-02-18 苏州立新制药有限公司 尼洛替尼中间体的制备方法
EP3095782A1 (fr) 2015-05-18 2016-11-23 Esteve Química, S.A. Nouveau procédé de préparation de 3- (4-methyl-1h-imidazol-1-yl) -5- (trifluorométhyl) benzénamine
EP3749697A4 (fr) 2018-02-05 2021-11-03 Bio-Rad Laboratories, Inc. Résine de chromatographie ayant un ligand mode mixte échange anionique/hydrophobe
CN116808044A (zh) 2018-06-15 2023-09-29 汉达癌症医药责任有限公司 激酶抑制剂的盐类及其组合物
JP2020007240A (ja) * 2018-07-04 2020-01-16 住友化学株式会社 ベンズアミド化合物の製造方法

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5136082A (en) * 1990-08-03 1992-08-04 Himont Incorporated Process for preparing organic esters and amides and catalyst system therefor
WO1994014415A1 (fr) 1992-12-24 1994-07-07 Hemagen/Pfc Emulsions d'hydrocarbure fluore
TW406020B (en) 1993-09-29 2000-09-21 Bristol Myers Squibb Co Stabilized pharmaceutical composition and its method for preparation and stabilizing solvent
US5597829A (en) 1994-05-09 1997-01-28 Bionumerik Pharmaceuticals, Inc. Lactone stable formulation of camptothecin and methods for uses thereof
US5726181A (en) 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
US6323366B1 (en) 1997-07-29 2001-11-27 Massachusetts Institute Of Technology Arylamine synthesis
AR013261A1 (es) 1997-08-01 2000-12-13 Smithkline Beecham Corp Formulaciones farmaceuticas para analogos de camptotecina en capsula de gelatina
US20030059465A1 (en) 1998-05-11 2003-03-27 Unger Evan C. Stabilized nanoparticle formulations of camptotheca derivatives
US6395916B1 (en) * 1998-07-10 2002-05-28 Massachusetts Institute Of Technology Ligands for metals and improved metal-catalyzed processes based thereon
EP1044977B1 (fr) 1999-03-09 2002-05-02 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Dérivés de camptothécine à activité anti-tumorale
IT1306129B1 (it) 1999-04-13 2001-05-30 Sigma Tau Ind Farmaceuti Esteri della l-carnitina o di alcanoil l-carnitine utilizzabili comelipidi cationici per l'immissione intracellulare di composti
DE19926056B4 (de) 1999-06-08 2004-03-25 Gkss-Forschungszentrum Geesthacht Gmbh Einrichtung zur Analyse atomarer und/oder molekularer Elemente mittels wellenlängendispersiver, röntgenspektrometrischer Einrichtungen
GB9918885D0 (en) 1999-08-10 1999-10-13 Pharmacia & Upjohn Spa Pharmaceutical formulations in hydroxypropymethycellulose capsules
GB9925127D0 (en) 1999-10-22 1999-12-22 Pharmacia & Upjohn Spa Oral formulations for anti-tumor compounds
US20040009229A1 (en) 2000-01-05 2004-01-15 Unger Evan Charles Stabilized nanoparticle formulations of camptotheca derivatives
US20020150615A1 (en) 2001-02-12 2002-10-17 Howard Sands Injectable pharmaceutical composition comprising microdroplets of a camptothecin
US6653319B1 (en) 2001-08-10 2003-11-25 University Of Kentucky Research Foundation Pharmaceutical formulation for poorly water soluble camptothecin analogues
US6629598B2 (en) 2001-08-10 2003-10-07 Vinod K. Narula Flexible ribbed splint system
ES2625340T3 (es) 2001-10-15 2017-07-19 Crititech, Inc. Composiciones y métodos para la administración de fármacos escasamente solubles en agua y métodos de tratamiento
US20060078618A1 (en) 2001-12-11 2006-04-13 Constantinides Panayiotis P Lipid particles and suspensions and uses thereof
JP2003267891A (ja) 2002-03-13 2003-09-25 Mitsubishi-Kagaku Foods Corp Ｗ／ｏ／ｗ型エマルション製剤
US7202367B2 (en) * 2002-05-31 2007-04-10 Rhodia Chimie Process for arylating or vinylating or alkynating a nucleophilic compound
CZ294371B6 (cs) 2002-06-10 2004-12-15 Pliva - Lachema, A. S. Stabilizovaná farmaceutická kompozice na bázi polyoxyethylovaného ricinového oleje a způsob její přípravy
EP1393719A1 (fr) 2002-08-23 2004-03-03 Munich Biotech AG Compositions à base de carboxylate de camptothécine
GB0215676D0 (en) * 2002-07-05 2002-08-14 Novartis Ag Organic compounds
JP4426749B2 (ja) 2002-07-11 2010-03-03 株式会社産学連携機構九州 Ｏ／ｗ型エマルション製剤
US20040171560A1 (en) 2002-12-23 2004-09-02 Dabur Research Foundation Stabilized pharmaceutical composition
JP2006199590A (ja) 2003-09-04 2006-08-03 Nano Career Kk 水溶性の塩基性薬物内包ナノ粒子含有組成物
JP2007509978A (ja) 2003-10-29 2007-04-19 ソーナス ファーマシューティカルズ， インコーポレイテッド トコフェロール修飾治療薬化合物
DK1694242T3 (da) 2003-12-17 2014-06-30 Bionumerik Pharmaceuticals Inc Fremgangsmåde til fremstilling af farmaceutiske 7-(2-trimethylsilylethyl)camptothecinpræparater
GT200500310A (es) 2004-11-19 2006-06-19 Compuestos organicos

Also Published As

Publication number Publication date
KR101514593B1 (ko) 2015-04-22
PL1924574T3 (pl) 2011-04-29
TWI430999B (zh) 2014-03-21
ECSP077982A (es) 2008-01-23
IL187421A (en) 2011-11-30
AR053890A1 (es) 2007-05-23
PE20070015A1 (es) 2007-02-06
NZ563740A (en) 2011-03-31
TW200726756A (en) 2007-07-16
KR20120066067A (ko) 2012-06-21
CY1111428T1 (el) 2015-08-05
DK1924574T3 (da) 2011-02-14
AU2006258051B2 (en) 2010-09-09
NO340743B1 (no) 2017-06-12
CA2610105A1 (fr) 2006-12-21
JO2636B1 (en) 2012-06-17
KR20080022093A (ko) 2008-03-10
WO2006135641A3 (fr) 2007-03-29
BRPI0611663A2 (pt) 2010-09-28
EP1924574A2 (fr) 2008-05-28
WO2006135641A2 (fr) 2006-12-21
US20080188656A1 (en) 2008-08-07
HK1117524A1 (en) 2009-01-16
JP5118024B2 (ja) 2013-01-16
DE602006018156D1 (de) 2010-12-23
NO20080157L (no) 2008-01-09
MY147436A (en) 2012-12-14
RU2007148231A (ru) 2009-07-20
KR101216249B1 (ko) 2012-12-28
US8124763B2 (en) 2012-02-28
RU2444520C2 (ru) 2012-03-10
MA29599B1 (fr) 2008-07-01
TNSN07463A1 (en) 2009-03-17
SA06270147B1 (ar) 2009-12-22
GT200600217A (es) 2007-03-28
MX2007015423A (es) 2008-02-21
ATE487709T1 (de) 2010-11-15
CA2610105C (fr) 2014-03-25
IL187421A0 (en) 2008-02-09
US20120116081A1 (en) 2012-05-10
KR20130118394A (ko) 2013-10-29
EP1924574B1 (fr) 2010-11-10
PT1924574E (pt) 2011-02-08
JP2008545786A (ja) 2008-12-18
SI1924574T1 (sl) 2011-02-28
AU2006258051A1 (en) 2006-12-21
US8946416B2 (en) 2015-02-03

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