EE9400312A - Isosteerilised herpesevastased peptiididerivaadid - Google Patents
Isosteerilised herpesevastased peptiididerivaadidInfo
- Publication number
- EE9400312A EE9400312A EE9400312A EE9400312A EE9400312A EE 9400312 A EE9400312 A EE 9400312A EE 9400312 A EE9400312 A EE 9400312A EE 9400312 A EE9400312 A EE 9400312A EE 9400312 A EE9400312 A EE 9400312A
- Authority
- EE
- Estonia
- Prior art keywords
- alkyl
- amino acid
- peptide derivatives
- isosteric
- nhch
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84991892A | 1992-03-12 | 1992-03-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EE9400312A true EE9400312A (et) | 1996-04-15 |
Family
ID=25306833
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EE9400312A EE9400312A (et) | 1992-03-12 | 1994-11-23 | Isosteerilised herpesevastased peptiididerivaadid |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0560267B1 (sk) |
| JP (1) | JPH0625131A (sk) |
| KR (1) | KR950700322A (sk) |
| AT (1) | ATE169931T1 (sk) |
| BR (1) | BR9306074A (sk) |
| CA (1) | CA2131186C (sk) |
| CZ (1) | CZ220994A3 (sk) |
| DE (1) | DE69320390T2 (sk) |
| EE (1) | EE9400312A (sk) |
| FI (1) | FI944187A (sk) |
| HU (2) | HUT68675A (sk) |
| IL (1) | IL105001A0 (sk) |
| LT (1) | LT3270B (sk) |
| LV (1) | LV10461B (sk) |
| MX (1) | MX9301343A (sk) |
| NO (1) | NO943345L (sk) |
| NZ (1) | NZ251266A (sk) |
| PH (1) | PH30453A (sk) |
| RU (1) | RU94040865A (sk) |
| SG (1) | SG42995A1 (sk) |
| SK (1) | SK107794A3 (sk) |
| TW (1) | TW278080B (sk) |
| WO (1) | WO1993018056A1 (sk) |
| ZA (1) | ZA931745B (sk) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5846941A (en) * | 1992-03-12 | 1998-12-08 | Boehringer Ingelheim (Canada) Ltd. | Isosteric antiherpes peptide derivatives II |
| CA2095408A1 (en) * | 1993-05-03 | 1994-11-04 | James Gus Chafouleas | Method of combating acyclovir-resistant herpes simplex viral infections |
| CA2230750C (en) * | 1994-12-28 | 2002-05-21 | Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee | Antiherpes peptidomimetic compounds |
| CA2152541C (en) * | 1995-06-23 | 1998-12-15 | Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee | Herpes ribonucleotide reductase inhibitors |
| US5948935A (en) * | 1997-01-23 | 1999-09-07 | Boehringer Ingelheim (Canada) Ltd. | Process and intermediates for (s)-α-amino-1-carboxycyclopentaneacetic acid |
| EP1053243B1 (en) * | 1998-02-12 | 2011-03-30 | Emory University | Sphingolipid derivatives and their methods of use |
| JP5647972B2 (ja) * | 2008-04-08 | 2015-01-07 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | 環状ペプチドを含む組成物および使用方法 |
| WO2020053654A1 (en) | 2018-09-12 | 2020-03-19 | Novartis Ag | Antiviral pyridopyrazinedione compounds |
| AU2020353055B2 (en) | 2019-09-26 | 2024-03-07 | Gilead Sciences, Inc. | Antiviral pyrazolopyridinone compounds |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US481432A (en) | 1892-08-23 | soler | ||
| US4795740A (en) | 1986-05-20 | 1989-01-03 | Cohen Eric A | Antiviral peptides and means for treating herpes infections |
| US4845195A (en) | 1987-05-22 | 1989-07-04 | Merck & Co., Inc. | Inhibitor of ribonucleotide reductase |
| US4837304A (en) | 1987-05-22 | 1989-06-06 | Merck & Co., Inc. | Inhibitor of ribonucleotide reductase |
| ATE123294T1 (de) * | 1989-07-07 | 1995-06-15 | Bio Mega Boehringer Ingelheim | Antiherpes-tetrapeptid-derivate mit einer substituierten seitenkette aus asparaginsäure. |
| EP0411334B1 (en) | 1989-07-07 | 1995-02-22 | Bio-Mega/Boehringer Ingelheim Research Inc. | Antiherpes pentapeptide derivatives having a substituted aspartic acid side chain |
| CA1340682C (en) * | 1989-07-07 | 1999-07-27 | Pierre Lavallee | Antiviral peptides having a 2-oxoalkyl amino acid side chain |
| CA1340684C (en) | 1989-07-07 | 1999-07-27 | Pierre Louis Beaulieu | Antiherpes pentapeptides |
| US5110799A (en) | 1989-07-28 | 1992-05-05 | Merck & Co., Inc. | Antiherpetic agents |
| CA2018801C (en) | 1990-06-12 | 2000-08-22 | Pierre Louis Beaulieu | Antiherpes peptide derivatives having a 1,4-dioxo c n-terminus |
| CA2033447C (en) * | 1990-12-31 | 1999-08-31 | Robert Deziel | Synergistic combination for treating herpes infections |
-
1993
- 1993-03-09 AT AT93103711T patent/ATE169931T1/de not_active IP Right Cessation
- 1993-03-09 DE DE69320390T patent/DE69320390T2/de not_active Expired - Fee Related
- 1993-03-09 SG SG1996001914A patent/SG42995A1/en unknown
- 1993-03-09 EP EP93103711A patent/EP0560267B1/en not_active Expired - Lifetime
- 1993-03-10 IL IL105001A patent/IL105001A0/xx unknown
- 1993-03-11 ZA ZA931745A patent/ZA931745B/xx unknown
- 1993-03-11 JP JP5051004A patent/JPH0625131A/ja active Pending
- 1993-03-11 PH PH45860A patent/PH30453A/en unknown
- 1993-03-11 MX MX9301343A patent/MX9301343A/es not_active IP Right Cessation
- 1993-03-12 HU HU9402593A patent/HUT68675A/hu unknown
- 1993-03-12 LV LVP-93-186A patent/LV10461B/en unknown
- 1993-03-12 WO PCT/CA1993/000095 patent/WO1993018056A1/en not_active Application Discontinuation
- 1993-03-12 NZ NZ251266A patent/NZ251266A/en unknown
- 1993-03-12 LT LTIP408A patent/LT3270B/lt not_active IP Right Cessation
- 1993-03-12 BR BR9306074A patent/BR9306074A/pt not_active Application Discontinuation
- 1993-03-12 CZ CZ942209A patent/CZ220994A3/cs unknown
- 1993-03-12 CA CA002131186A patent/CA2131186C/en not_active Expired - Fee Related
- 1993-03-12 SK SK1077-94A patent/SK107794A3/sk unknown
- 1993-03-12 RU RU94040865/04A patent/RU94040865A/ru unknown
- 1993-03-23 TW TW082102135A patent/TW278080B/zh active
-
1994
- 1994-09-09 NO NO943345A patent/NO943345L/no unknown
- 1994-09-10 KR KR1019940703166A patent/KR950700322A/ko not_active Application Discontinuation
- 1994-09-12 FI FI944187A patent/FI944187A/fi not_active Application Discontinuation
- 1994-11-23 EE EE9400312A patent/EE9400312A/xx unknown
-
1995
- 1995-06-23 HU HU95P/P00431P patent/HU211926A9/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0560267B1 (en) | 1998-08-19 |
| NO943345D0 (no) | 1994-09-09 |
| NZ251266A (en) | 1996-08-27 |
| BR9306074A (pt) | 1997-11-18 |
| LV10461A (lv) | 1995-02-20 |
| JPH0625131A (ja) | 1994-02-01 |
| KR950700322A (ko) | 1995-01-16 |
| CA2131186C (en) | 2000-12-12 |
| IL105001A0 (en) | 1993-07-08 |
| AU3880793A (en) | 1993-10-05 |
| HU9402593D0 (en) | 1994-11-28 |
| ZA931745B (en) | 1993-09-24 |
| DE69320390D1 (de) | 1998-09-24 |
| MX9301343A (es) | 1994-01-31 |
| FI944187A0 (fi) | 1994-09-12 |
| PH30453A (en) | 1997-05-28 |
| TW278080B (sk) | 1996-06-11 |
| RU94040865A (ru) | 1996-08-10 |
| FI944187A (fi) | 1994-09-12 |
| WO1993018056A1 (en) | 1993-09-16 |
| SK107794A3 (en) | 1995-03-08 |
| HU211926A9 (en) | 1996-01-29 |
| EP0560267A1 (en) | 1993-09-15 |
| ATE169931T1 (de) | 1998-09-15 |
| CZ220994A3 (en) | 1995-09-13 |
| SG42995A1 (en) | 1997-10-17 |
| LT3270B (en) | 1995-05-25 |
| AU671825B2 (en) | 1996-09-12 |
| NO943345L (no) | 1994-09-09 |
| DE69320390T2 (de) | 1999-02-11 |
| LTIP408A (en) | 1994-09-25 |
| CA2131186A1 (en) | 1993-09-16 |
| HUT68675A (en) | 1995-07-28 |
| LV10461B (en) | 1996-02-20 |
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