LT3270B - Isosteric antiherpes peptide derivatives - Google Patents
Isosteric antiherpes peptide derivatives Download PDFInfo
- Publication number
- LT3270B LT3270B LTIP408A LTIP408A LT3270B LT 3270 B LT3270 B LT 3270B LT IP408 A LTIP408 A LT IP408A LT IP408 A LTIP408 A LT IP408A LT 3270 B LT3270 B LT 3270B
- Authority
- LT
- Lithuania
- Prior art keywords
- cme
- tbg
- asp
- cypn
- chnhc
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84991892A | 1992-03-12 | 1992-03-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LTIP408A LTIP408A (en) | 1994-09-25 |
| LT3270B true LT3270B (en) | 1995-05-25 |
Family
ID=25306833
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTIP408A LT3270B (en) | 1992-03-12 | 1993-03-12 | Isosteric antiherpes peptide derivatives |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0560267B1 (sk) |
| JP (1) | JPH0625131A (sk) |
| KR (1) | KR950700322A (sk) |
| AT (1) | ATE169931T1 (sk) |
| BR (1) | BR9306074A (sk) |
| CA (1) | CA2131186C (sk) |
| CZ (1) | CZ220994A3 (sk) |
| DE (1) | DE69320390T2 (sk) |
| EE (1) | EE9400312A (sk) |
| FI (1) | FI944187A (sk) |
| HU (2) | HUT68675A (sk) |
| IL (1) | IL105001A0 (sk) |
| LT (1) | LT3270B (sk) |
| LV (1) | LV10461B (sk) |
| MX (1) | MX9301343A (sk) |
| NO (1) | NO943345D0 (sk) |
| NZ (1) | NZ251266A (sk) |
| PH (1) | PH30453A (sk) |
| RU (1) | RU94040865A (sk) |
| SG (1) | SG42995A1 (sk) |
| SK (1) | SK107794A3 (sk) |
| TW (1) | TW278080B (sk) |
| WO (1) | WO1993018056A1 (sk) |
| ZA (1) | ZA931745B (sk) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5846941A (en) * | 1992-03-12 | 1998-12-08 | Boehringer Ingelheim (Canada) Ltd. | Isosteric antiherpes peptide derivatives II |
| CA2095408A1 (en) * | 1993-05-03 | 1994-11-04 | James Gus Chafouleas | Method of combating acyclovir-resistant herpes simplex viral infections |
| CA2230750C (en) * | 1994-12-28 | 2002-05-21 | Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee | Antiherpes peptidomimetic compounds |
| CA2152541C (en) * | 1995-06-23 | 1998-12-15 | Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee | Herpes ribonucleotide reductase inhibitors |
| US5948935A (en) * | 1997-01-23 | 1999-09-07 | Boehringer Ingelheim (Canada) Ltd. | Process and intermediates for (s)-α-amino-1-carboxycyclopentaneacetic acid |
| US6610835B1 (en) * | 1998-02-12 | 2003-08-26 | Emory University | Sphingolipid derivatives and their methods of use |
| EP2259768B1 (en) * | 2008-04-08 | 2019-05-22 | Merck Patent GmbH | Compositions containing cyclic peptides and methods of use |
| KR102672512B1 (ko) | 2018-09-12 | 2024-06-10 | 노파르티스 아게 | 항바이러스 피리도피라진디온 화합물 |
| AU2020353055B2 (en) | 2019-09-26 | 2024-03-07 | Gilead Sciences, Inc. | Antiviral pyrazolopyridinone compounds |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US481432A (en) | 1892-08-23 | soler | ||
| US4795740A (en) | 1986-05-20 | 1989-01-03 | Cohen Eric A | Antiviral peptides and means for treating herpes infections |
| US4837304A (en) | 1987-05-22 | 1989-06-06 | Merck & Co., Inc. | Inhibitor of ribonucleotide reductase |
| US4845195A (en) | 1987-05-22 | 1989-07-04 | Merck & Co., Inc. | Inhibitor of ribonucleotide reductase |
| EP0408973A1 (en) | 1989-07-07 | 1991-01-23 | Bio-Mega/Boehringer Ingelheim Research Inc. | Antiherpes pentapeptides |
| EP0411332A1 (en) | 1989-07-07 | 1991-02-06 | Bio-Mega/Boehringer Ingelheim Research Inc. | Antiviral peptides having a 2-oxoalkyl amino acid side chain |
| EP0411334A1 (en) | 1989-07-07 | 1991-02-06 | Bio-Mega/Boehringer Ingelheim Research Inc. | Antiherpes pentapeptide derivatives having a substituted aspartic acid side chain |
| EP0411333A1 (en) | 1989-07-07 | 1991-02-06 | Bio-Mega/Boehringer Ingelheim Research Inc. | Antiherpes tetrapeptide derivatives having a substituted aspartic acid side chain |
| EP0412595A1 (en) | 1989-07-28 | 1991-02-13 | Merck & Co. Inc. | Antiherpetic agents |
| EP0461546A2 (en) | 1990-06-12 | 1991-12-18 | Bio-Mega/Boehringer Ingelheim Research Inc. | Antiherpes peptide derivatives having a 1,4-dioxo-C4 N-terminus |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2033447C (en) * | 1990-12-31 | 1999-08-31 | Robert Deziel | Synergistic combination for treating herpes infections |
-
1993
- 1993-03-09 EP EP93103711A patent/EP0560267B1/en not_active Expired - Lifetime
- 1993-03-09 DE DE69320390T patent/DE69320390T2/de not_active Expired - Fee Related
- 1993-03-09 AT AT93103711T patent/ATE169931T1/de not_active IP Right Cessation
- 1993-03-09 SG SG1996001914A patent/SG42995A1/en unknown
- 1993-03-10 IL IL105001A patent/IL105001A0/xx unknown
- 1993-03-11 MX MX9301343A patent/MX9301343A/es not_active IP Right Cessation
- 1993-03-11 ZA ZA931745A patent/ZA931745B/xx unknown
- 1993-03-11 JP JP5051004A patent/JPH0625131A/ja active Pending
- 1993-03-11 PH PH45860A patent/PH30453A/en unknown
- 1993-03-12 RU RU94040865/04A patent/RU94040865A/ru unknown
- 1993-03-12 LV LVP-93-186A patent/LV10461B/en unknown
- 1993-03-12 NZ NZ251266A patent/NZ251266A/en unknown
- 1993-03-12 BR BR9306074A patent/BR9306074A/pt not_active Application Discontinuation
- 1993-03-12 HU HU9402593A patent/HUT68675A/hu unknown
- 1993-03-12 LT LTIP408A patent/LT3270B/lt not_active IP Right Cessation
- 1993-03-12 WO PCT/CA1993/000095 patent/WO1993018056A1/en not_active Application Discontinuation
- 1993-03-12 CZ CZ942209A patent/CZ220994A3/cs unknown
- 1993-03-12 SK SK1077-94A patent/SK107794A3/sk unknown
- 1993-03-12 CA CA002131186A patent/CA2131186C/en not_active Expired - Fee Related
- 1993-03-23 TW TW082102135A patent/TW278080B/zh active
-
1994
- 1994-09-09 NO NO943345A patent/NO943345D0/no unknown
- 1994-09-10 KR KR1019940703166A patent/KR950700322A/ko not_active Application Discontinuation
- 1994-09-12 FI FI944187A patent/FI944187A/fi not_active Application Discontinuation
- 1994-11-23 EE EE9400312A patent/EE9400312A/xx unknown
-
1995
- 1995-06-23 HU HU95P/P00431P patent/HU211926A9/hu unknown
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US481432A (en) | 1892-08-23 | soler | ||
| US4795740A (en) | 1986-05-20 | 1989-01-03 | Cohen Eric A | Antiviral peptides and means for treating herpes infections |
| US4837304A (en) | 1987-05-22 | 1989-06-06 | Merck & Co., Inc. | Inhibitor of ribonucleotide reductase |
| US4845195A (en) | 1987-05-22 | 1989-07-04 | Merck & Co., Inc. | Inhibitor of ribonucleotide reductase |
| EP0408973A1 (en) | 1989-07-07 | 1991-01-23 | Bio-Mega/Boehringer Ingelheim Research Inc. | Antiherpes pentapeptides |
| EP0411332A1 (en) | 1989-07-07 | 1991-02-06 | Bio-Mega/Boehringer Ingelheim Research Inc. | Antiviral peptides having a 2-oxoalkyl amino acid side chain |
| EP0411334A1 (en) | 1989-07-07 | 1991-02-06 | Bio-Mega/Boehringer Ingelheim Research Inc. | Antiherpes pentapeptide derivatives having a substituted aspartic acid side chain |
| EP0411333A1 (en) | 1989-07-07 | 1991-02-06 | Bio-Mega/Boehringer Ingelheim Research Inc. | Antiherpes tetrapeptide derivatives having a substituted aspartic acid side chain |
| EP0412595A1 (en) | 1989-07-28 | 1991-02-13 | Merck & Co. Inc. | Antiherpetic agents |
| EP0461546A2 (en) | 1990-06-12 | 1991-12-18 | Bio-Mega/Boehringer Ingelheim Research Inc. | Antiherpes peptide derivatives having a 1,4-dioxo-C4 N-terminus |
Non-Patent Citations (3)
| Title |
|---|
| B.M. DUTIA ET AL: "Specific inhibition of herpesvirus ribonucleotide reductase by synthetic peptides", NATURE, 1986 |
| E.A. COHEN ET AL: "Specific inhibition of herpesvirus ribonucleotide reductase by a nonapeptide derived from the carboxy terminus of subunit 2.", NATURE, 1986 |
| M.C.NAHATA: "Antiviral Drugs: Pharmacokinetics, Adverse Effects and Therapeutic Use", J. PHARM. TECHNOL., 1987 |
Also Published As
| Publication number | Publication date |
|---|---|
| NZ251266A (en) | 1996-08-27 |
| FI944187A0 (fi) | 1994-09-12 |
| IL105001A0 (en) | 1993-07-08 |
| JPH0625131A (ja) | 1994-02-01 |
| EP0560267B1 (en) | 1998-08-19 |
| AU3880793A (en) | 1993-10-05 |
| EP0560267A1 (en) | 1993-09-15 |
| CZ220994A3 (en) | 1995-09-13 |
| SG42995A1 (en) | 1997-10-17 |
| LV10461A (lv) | 1995-02-20 |
| HU211926A9 (en) | 1996-01-29 |
| CA2131186A1 (en) | 1993-09-16 |
| DE69320390D1 (de) | 1998-09-24 |
| FI944187A (fi) | 1994-09-12 |
| DE69320390T2 (de) | 1999-02-11 |
| LV10461B (en) | 1996-02-20 |
| CA2131186C (en) | 2000-12-12 |
| PH30453A (en) | 1997-05-28 |
| HU9402593D0 (en) | 1994-11-28 |
| ZA931745B (en) | 1993-09-24 |
| KR950700322A (ko) | 1995-01-16 |
| AU671825B2 (en) | 1996-09-12 |
| HUT68675A (en) | 1995-07-28 |
| TW278080B (sk) | 1996-06-11 |
| WO1993018056A1 (en) | 1993-09-16 |
| MX9301343A (es) | 1994-01-31 |
| SK107794A3 (en) | 1995-03-08 |
| NO943345L (no) | 1994-09-09 |
| RU94040865A (ru) | 1996-08-10 |
| ATE169931T1 (de) | 1998-09-15 |
| LTIP408A (en) | 1994-09-25 |
| BR9306074A (pt) | 1997-11-18 |
| NO943345D0 (no) | 1994-09-09 |
| EE9400312A (et) | 1996-04-15 |
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| LT3270B (en) | Isosteric antiherpes peptide derivatives | |
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| US5574015A (en) | Isosteric antiherpes peptide derivatives | |
| AU683465B2 (en) | Method of combating acyclovir-resistant herpes simplex viral infections | |
| EP0560274B1 (en) | Antiherpes peptide derivatives having a ureido N-terminus | |
| US5830864A (en) | Antiherpes peptide derivatives having a ureido n-terminus | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PD9A | Change of patent owner |
Free format text: BOEHRINGER INGELHEIM (CANADA) LTD.,2100, RUE CUNARD, LAVAL (QUEBEC), H7S 2G5,CA,19971215 |
|
| MM9A | Lapsed patents |
Effective date: 19980312 |