EE03854B1 - Levosimendaani suu kaudu manustatavad segud - Google Patents

Levosimendaani suu kaudu manustatavad segud

Info

Publication number
EE03854B1
EE03854B1 EEP200000187A EEP200000187A EE03854B1 EE 03854 B1 EE03854 B1 EE 03854B1 EE P200000187 A EEP200000187 A EE P200000187A EE P200000187 A EEP200000187 A EE P200000187A EE 03854 B1 EE03854 B1 EE 03854B1
Authority
EE
Estonia
Prior art keywords
levosimendan
oral formulations
formulations
oral
Prior art date
Application number
EEP200000187A
Other languages
English (en)
Estonian (et)
Inventor
Harjula Maarit
Larma Ilkka
Antila Saila
Lehtonen Lasse
Original Assignee
Orion Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Corporation filed Critical Orion Corporation
Publication of EE200000187A publication Critical patent/EE200000187A/xx
Publication of EE03854B1 publication Critical patent/EE03854B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
EEP200000187A 1997-09-26 1998-09-24 Levosimendaani suu kaudu manustatavad segud EE03854B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI973804A FI973804A (fi) 1997-09-26 1997-09-26 Levosimendaanin oraalisia koostumuksia
PCT/FI1998/000753 WO1999016443A1 (en) 1997-09-26 1998-09-24 Oral compositions of levosimendan

Publications (2)

Publication Number Publication Date
EE200000187A EE200000187A (et) 2001-04-16
EE03854B1 true EE03854B1 (et) 2002-10-15

Family

ID=8549609

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000187A EE03854B1 (et) 1997-09-26 1998-09-24 Levosimendaani suu kaudu manustatavad segud

Country Status (36)

Country Link
US (1) US6355269B1 (de)
EP (1) EP1014987B1 (de)
JP (1) JP4493840B2 (de)
KR (1) KR100762022B1 (de)
CN (1) CN1149994C (de)
AR (1) AR013519A1 (de)
AT (1) ATE260659T1 (de)
AU (1) AU732489B2 (de)
BG (1) BG64746B1 (de)
BR (1) BR9813213A (de)
CA (1) CA2304702C (de)
CZ (1) CZ294984B6 (de)
DE (1) DE69822172T2 (de)
DK (1) DK1014987T3 (de)
EA (1) EA001647B1 (de)
EE (1) EE03854B1 (de)
ES (1) ES2217580T3 (de)
FI (1) FI973804A (de)
GE (1) GEP20032943B (de)
HK (1) HK1032001A1 (de)
HR (1) HRP20000171B1 (de)
HU (1) HUP0003757A3 (de)
ID (1) ID24486A (de)
IL (1) IL134802A (de)
MX (1) MXPA00002956A (de)
MY (1) MY118156A (de)
NO (1) NO320047B1 (de)
NZ (1) NZ503207A (de)
PL (1) PL190862B1 (de)
PT (1) PT1014987E (de)
RS (1) RS49708B (de)
SI (1) SI1014987T1 (de)
SK (1) SK283187B6 (de)
TR (1) TR200000635T2 (de)
WO (1) WO1999016443A1 (de)
YU (1) YU17700A (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9606474D0 (en) * 1996-03-27 1996-06-05 Orion Yhytmo Oy Method for obtaining pure enantiomers of a pyridazinone derivative
FI980901A (fi) * 1998-04-23 1999-10-24 Orion Yhtymae Oyj Levosimendaania säädellysti vapauttavia oraalisia koostumuksia
FI980902A (fi) 1998-04-23 1999-10-24 Orion Yhtymae Oyj Levosimendaanin stabiileja koostumuksia
FI20000577A0 (fi) * 2000-03-13 2000-03-13 Orion Yhtymae Oy Pyridatsinyylifenyylihydratsoneja
WO2002055059A2 (en) * 2000-12-22 2002-07-18 Baxter Int Method for preparing submicron particle suspensions
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
FI20010233A0 (fi) * 2001-02-08 2001-02-08 Orion Corp Menetelmä sydämen vajaatoiminnan hoitoon
FI20011465A0 (fi) * 2001-07-04 2001-07-04 Orion Corp Pyridatsinonijohdannaisen uusi käyttö
CA2461349C (en) 2001-09-26 2011-11-29 Baxter International Inc. Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
CN100428937C (zh) * 2003-10-30 2008-10-29 北京海合天科技开发有限公司 左西孟旦冷冻干燥组合物
JP5747030B2 (ja) * 2009-07-14 2015-07-08 シプラ・リミテッド レボシメンダンの製造方法及びその方法で用いる中間体
CN104418810A (zh) * 2013-09-04 2015-03-18 北京博时安泰科技发展有限公司 一种左西孟旦的合成新路线
CN103554032A (zh) * 2013-11-12 2014-02-05 江苏正大清江制药有限公司 高光学纯度(-)-6-(4-氨基苯基)-4,5-二氢-5-甲基-3(2h)-哒嗪酮的制备方法
ITMI20132185A1 (it) * 2013-12-23 2015-06-24 Edmond Pharma Srl Polimorfi di levosimendan
CN104987310A (zh) * 2015-06-03 2015-10-21 青岛农业大学 左西孟旦的合成工艺
CN111474289A (zh) * 2019-10-31 2020-07-31 武汉嘉诺康医药技术有限公司 一种利用反相色谱分离分析左西孟旦中右西孟旦的方法
JP2023507626A (ja) * 2019-12-16 2023-02-24 テナックス・セラピューティクス，インコーポレイテッド 駆出率が保たれた心不全を伴う肺高血圧症（ＰＨ－ＨＦ－ｐＥＦ）を治療するためのレボシメンダン
CN111548310B (zh) * 2020-05-12 2021-07-02 成都欣捷高新技术开发股份有限公司 一种左西孟旦钠晶型及其制备方法
CN111718299B (zh) * 2020-07-23 2023-03-10 成都欣捷高新技术开发股份有限公司 一种左西孟旦钠晶型b及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8903130D0 (en) 1989-02-11 1989-03-30 Orion Yhtymae Oy Substituted pyridazinones
GB2251615B (en) 1991-01-03 1995-02-08 Orion Yhtymae Oy (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile
GB2266841A (en) * 1992-05-06 1993-11-17 Orion Yhtymae Oy Compounds for use as anti-ischemic medicaments
GB9606474D0 (en) * 1996-03-27 1996-06-05 Orion Yhytmo Oy Method for obtaining pure enantiomers of a pyridazinone derivative
GB9614098D0 (en) 1996-07-05 1996-09-04 Orion Yhtymae Oy Transdermal delivery of levosimendan

Also Published As

Publication number Publication date
SI1014987T1 (en) 2004-08-31
MY118156A (en) 2004-09-30
HUP0003757A2 (hu) 2001-05-28
ATE260659T1 (de) 2004-03-15
BR9813213A (pt) 2000-08-29
AU9350698A (en) 1999-04-23
BG104250A (en) 2000-12-29
PT1014987E (pt) 2004-06-30
HUP0003757A3 (en) 2001-07-30
HK1032001A1 (en) 2001-07-06
RS49708B (sr) 2007-12-31
PL190862B1 (pl) 2006-02-28
CA2304702C (en) 2007-09-04
DE69822172T2 (de) 2005-02-24
ES2217580T3 (es) 2004-11-01
GEP20032943B (en) 2003-04-25
CN1149994C (zh) 2004-05-19
NO20001585L (no) 2000-03-27
EA001647B1 (ru) 2001-06-25
HRP20000171A2 (en) 2000-12-31
ID24486A (id) 2000-07-20
AU732489B2 (en) 2001-04-26
NZ503207A (en) 2001-04-27
IL134802A0 (en) 2001-04-30
JP2001517702A (ja) 2001-10-09
JP4493840B2 (ja) 2010-06-30
CZ294984B6 (cs) 2005-04-13
EA200000360A1 (ru) 2000-10-30
TR200000635T2 (tr) 2000-09-21
AR013519A1 (es) 2000-12-27
KR100762022B1 (ko) 2007-09-28
FI973804A (fi) 1999-03-27
MXPA00002956A (es) 2003-05-19
NO20001585D0 (no) 2000-03-27
CA2304702A1 (en) 1999-04-08
WO1999016443A1 (en) 1999-04-08
CN1271282A (zh) 2000-10-25
DK1014987T3 (da) 2004-05-24
FI973804A0 (fi) 1997-09-26
DE69822172D1 (de) 2004-04-08
IL134802A (en) 2004-01-04
US6355269B1 (en) 2002-03-12
CZ2000919A3 (cs) 2000-09-13
SK283187B6 (sk) 2003-03-04
EE200000187A (et) 2001-04-16
EP1014987B1 (de) 2004-03-03
KR20010030679A (ko) 2001-04-16
NO320047B1 (no) 2005-10-17
YU17700A (sh) 2002-10-18
PL339461A1 (en) 2000-12-18
HRP20000171B1 (en) 2009-06-30
SK3842000A3 (en) 2000-09-12
BG64746B1 (bg) 2006-02-28
EP1014987A1 (de) 2000-07-05

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Legal Events

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KB4A Valid patent at the end of a year

Effective date: 20021231

KB4A Valid patent at the end of a year

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Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

Effective date: 20061231

GB1A Change in the ownership or in the address of the owner
KB4A Valid patent at the end of a year

Effective date: 20071231

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Effective date: 20091231

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Effective date: 20101231

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Effective date: 20110924