EE03686B1 - Dopamiini D4 retseptorite bensoksasinoonantagonistid - Google Patents
Dopamiini D4 retseptorite bensoksasinoonantagonistidInfo
- Publication number
- EE03686B1 EE03686B1 EE9800417A EE9800417A EE03686B1 EE 03686 B1 EE03686 B1 EE 03686B1 EE 9800417 A EE9800417 A EE 9800417A EE 9800417 A EE9800417 A EE 9800417A EE 03686 B1 EE03686 B1 EE 03686B1
- Authority
- EE
- Estonia
- Prior art keywords
- benzoxazinone
- dopamine
- antagonists
- receptors
- benzoxazinone antagonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1838396P | 1996-05-29 | 1996-05-29 | |
US4020897P | 1997-03-06 | 1997-03-06 | |
PCT/US1997/008524 WO1997045419A1 (en) | 1996-05-29 | 1997-05-20 | Benzoxazinone dopamine d4 receptor antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
EE9800417A EE9800417A (et) | 1999-06-15 |
EE03686B1 true EE03686B1 (et) | 2002-04-15 |
Family
ID=26691052
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EE9800417A EE03686B1 (et) | 1996-05-29 | 1997-05-20 | Dopamiini D4 retseptorite bensoksasinoonantagonistid |
Country Status (37)
Country | Link |
---|---|
EP (1) | EP0906294B1 (hu) |
JP (1) | JP2000511534A (hu) |
KR (1) | KR20000016151A (hu) |
CN (1) | CN1074764C (hu) |
AR (1) | AR008372A1 (hu) |
AT (1) | ATE231846T1 (hu) |
AU (1) | AU731104B2 (hu) |
BG (1) | BG64049B1 (hu) |
BR (1) | BR9709630A (hu) |
CA (1) | CA2253406A1 (hu) |
CO (1) | CO4940505A1 (hu) |
CZ (1) | CZ384698A3 (hu) |
DE (1) | DE69718786T2 (hu) |
DK (1) | DK0906294T3 (hu) |
EA (1) | EA001486B1 (hu) |
EE (1) | EE03686B1 (hu) |
ES (1) | ES2191180T3 (hu) |
GE (1) | GEP20012389B (hu) |
HK (1) | HK1019737A1 (hu) |
HN (1) | HN1997000075A (hu) |
HR (1) | HRP970301B1 (hu) |
HU (1) | HUP9903758A3 (hu) |
ID (1) | ID17266A (hu) |
IL (1) | IL126895A (hu) |
NO (1) | NO312296B1 (hu) |
NZ (1) | NZ332737A (hu) |
PA (1) | PA8431101A1 (hu) |
PE (1) | PE69398A1 (hu) |
PL (1) | PL330195A1 (hu) |
PT (1) | PT906294E (hu) |
RO (1) | RO120845B1 (hu) |
SI (1) | SI0906294T1 (hu) |
SK (1) | SK282703B6 (hu) |
SV (1) | SV1997000047A (hu) |
TW (1) | TW542833B (hu) |
UY (1) | UY24569A1 (hu) |
WO (1) | WO1997045419A1 (hu) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6177422B1 (en) | 1996-05-29 | 2001-01-23 | Warner-Lambert Company | Benzoxazinone dopamine D4 receptor antagonists |
GB9801392D0 (en) * | 1998-01-22 | 1998-03-18 | Smithkline Beecham Plc | Novel compounds |
AU4832699A (en) * | 1998-06-30 | 2000-01-17 | Neurogen Corporation | 1-(benzothiazol-2-yl)-4-(1-phenylmethyl)piperazines: dopamine receptor subtype specific ligands |
US6291463B1 (en) | 1998-06-30 | 2001-09-18 | Neurogen Corporation | 1-(Benzothiazol-2-yl)-4-(1-phenylmethyl) piperazines: dopamine receptor subtype specific ligands |
CA2336089A1 (en) * | 1998-06-30 | 2000-01-06 | Neurogen Corporation | 6-(4-arylalkylpiperazin-1-yl)benzodioxane and 6-(4-arylalkylpiperazin-1-yl)chromane derivatives: dopamine receptor subtype specific ligands |
US6177566B1 (en) | 1998-06-30 | 2001-01-23 | Neurogen Corporation | 6-(4-arylalkylpiperazin-1-yl) benzodioxane and 6-(4-arylalkylpiperazin-1-yl) chromane derivatives: dopamine receptor subtype specific ligands |
DE19844291A1 (de) * | 1998-09-18 | 2000-03-23 | Schering Ag | Benzoxazin- und Benzothiazin-Derivate und deren Verwendung in Arzneimitteln |
GB9912411D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
EP1330460B1 (en) | 2000-10-26 | 2007-03-21 | Smithkline Beecham Plc | Benzoxazinone derivatives, their preparation and use |
GB0203804D0 (en) | 2002-02-18 | 2002-04-03 | Glaxo Group Ltd | Compounds |
GB0209244D0 (en) * | 2002-04-23 | 2002-06-05 | Glaxo Group Ltd | Compounds |
GB0227240D0 (en) * | 2002-11-21 | 2002-12-31 | Glaxo Group Ltd | Compounds |
ES2232292B1 (es) * | 2003-07-30 | 2006-11-01 | Laboratorios Del Dr. Esteve, S.A. | Compuestos sulfonamidicos derivados de benzoxazinona, su preparacion y uso como medicamentos. |
CN100455573C (zh) * | 2005-11-11 | 2009-01-28 | 华东理工大学 | 一种制备1,4-苯并噁唑嗪-3-酮化合物的微波合成方法 |
KR200482995Y1 (ko) | 2015-08-19 | 2017-03-23 | 이현진 | 물 공급부를 구비하는 얼음 트레이 |
CA3215823A1 (en) * | 2021-04-23 | 2022-10-27 | Peng Gao | Heterocyclic derivative inhibitor and preparation method therefor and application thereof |
WO2023178035A1 (en) | 2022-03-14 | 2023-09-21 | Slap Pharmaceuticals Llc | Multicyclic compounds |
WO2023207283A1 (en) * | 2022-04-28 | 2023-11-02 | Ningbo Newbay Technology Development Co., Ltd | Compounds as parp1 inhibitiors |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4613598A (en) * | 1984-03-13 | 1986-09-23 | Mitsubishi Chemical Industries Limited | Piperazine derivatives and their acid addition salts |
EP0233728A1 (en) * | 1986-02-11 | 1987-08-26 | Takeda Chemical Industries, Ltd. | 1,4-Benzoxazine derivatives their production and use |
JPH07509705A (ja) * | 1992-08-06 | 1995-10-26 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | ドーパミンd3レセプター拮抗薬用5−(2−オキシフェニル)−ピロール誘導体 |
-
1997
- 1997-05-20 PT PT97925651T patent/PT906294E/pt unknown
- 1997-05-20 EP EP97925651A patent/EP0906294B1/en not_active Expired - Lifetime
- 1997-05-20 GE GEAP19974623A patent/GEP20012389B/en unknown
- 1997-05-20 NZ NZ332737A patent/NZ332737A/en unknown
- 1997-05-20 JP JP09542647A patent/JP2000511534A/ja not_active Ceased
- 1997-05-20 SI SI9730482T patent/SI0906294T1/xx unknown
- 1997-05-20 PL PL97330195A patent/PL330195A1/xx unknown
- 1997-05-20 HU HU9903758A patent/HUP9903758A3/hu unknown
- 1997-05-20 DK DK97925651T patent/DK0906294T3/da active
- 1997-05-20 RO RO98-01622A patent/RO120845B1/ro unknown
- 1997-05-20 SK SK1627-98A patent/SK282703B6/sk unknown
- 1997-05-20 AU AU30727/97A patent/AU731104B2/en not_active Ceased
- 1997-05-20 DE DE69718786T patent/DE69718786T2/de not_active Expired - Fee Related
- 1997-05-20 ES ES97925651T patent/ES2191180T3/es not_active Expired - Lifetime
- 1997-05-20 EA EA199800987A patent/EA001486B1/ru not_active IP Right Cessation
- 1997-05-20 EE EE9800417A patent/EE03686B1/xx not_active IP Right Cessation
- 1997-05-20 WO PCT/US1997/008524 patent/WO1997045419A1/en not_active Application Discontinuation
- 1997-05-20 KR KR1019980709719A patent/KR20000016151A/ko not_active Application Discontinuation
- 1997-05-20 CZ CZ983846A patent/CZ384698A3/cs unknown
- 1997-05-20 BR BR9709630A patent/BR9709630A/pt not_active Application Discontinuation
- 1997-05-20 CN CN97195015A patent/CN1074764C/zh not_active Expired - Fee Related
- 1997-05-20 CA CA002253406A patent/CA2253406A1/en not_active Abandoned
- 1997-05-20 IL IL12689597A patent/IL126895A/en not_active IP Right Cessation
- 1997-05-20 AT AT97925651T patent/ATE231846T1/de not_active IP Right Cessation
- 1997-05-22 HN HN1997000075A patent/HN1997000075A/es unknown
- 1997-05-27 AR ARP970102249A patent/AR008372A1/es unknown
- 1997-05-28 ID IDP971778A patent/ID17266A/id unknown
- 1997-05-28 UY UY24569A patent/UY24569A1/es not_active Application Discontinuation
- 1997-05-28 CO CO97029474A patent/CO4940505A1/es unknown
- 1997-05-28 TW TW086107221A patent/TW542833B/zh active
- 1997-05-28 SV SV1997000047A patent/SV1997000047A/es not_active Application Discontinuation
- 1997-05-28 PE PE1997000432A patent/PE69398A1/es not_active Application Discontinuation
- 1997-05-28 PA PA19978431101A patent/PA8431101A1/es unknown
- 1997-05-29 HR HR970301A patent/HRP970301B1/xx not_active IP Right Cessation
-
1998
- 1998-11-26 BG BG102959A patent/BG64049B1/bg unknown
- 1998-11-27 NO NO19985531A patent/NO312296B1/no not_active IP Right Cessation
-
1999
- 1999-10-28 HK HK99104867A patent/HK1019737A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EE03686B1 (et) | Dopamiini D4 retseptorite bensoksasinoonantagonistid | |
NO960081D0 (no) | Östrogen-agonist/antagonister | |
DE69734833D1 (de) | Vitronektin rezeptor antagonisten | |
ID24836A (id) | Agonis prostaglandin | |
ATE233260T1 (de) | Muscarin-antagonisten | |
NO986110D0 (no) | IL-8 reseptor-antagonister | |
NO986109D0 (no) | IL-8 reseptor-antagonister | |
PT1131291E (pt) | Antagonistas iii do receptor 4-aroil-piperidin-ccr-3 | |
PT1036072E (pt) | Antagonistas de receptores de trombina | |
ID24162A (id) | Antagonis-antagonis reseptor vitronektin | |
NO994106D0 (no) | Oksazolidiner som 5-HT2A-antagonister | |
DE69703242D1 (de) | Indolin-derivate verwendbar als 5-ht-2c rezeptor-antagonisten | |
DE69735811D1 (de) | Piperazinoderivate als neurokinin-antagonisten | |
DE69717449D1 (de) | Indolin-derivate verwendbar als 5-ht-2c rezeptor-antagonisten | |
PT1207159E (pt) | Derivados aroma-heterociclicos como antagonistas de receptores da dopamina d4 | |
SE9703745D0 (sv) | New receptors | |
ZA974684B (en) | Benzoxazinone dopamine D4 receptor antagonists. | |
SE9803428D0 (sv) | Blocking of alfa2beta1-receptors |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
KB4A | Valid patent at the end of a year |
Effective date: 20021231 |
|
KB4A | Valid patent at the end of a year |
Effective date: 20031231 |
|
KB4A | Valid patent at the end of a year |
Effective date: 20041231 |
|
KB4A | Valid patent at the end of a year |
Effective date: 20051231 |
|
MM4A | Lapsed by not paying the annual fees |
Effective date: 20060520 |