EE03271B1 - Inimesele kohandatud antikehad või nende siduvad proteiinid, nende valmistamismeetodid ja neid sisaldav farmatseutiline kompositsioon - Google Patents
Inimesele kohandatud antikehad või nende siduvad proteiinid, nende valmistamismeetodid ja neid sisaldav farmatseutiline kompositsioonInfo
- Publication number
- EE03271B1 EE03271B1 EE9600108A EE9600108A EE03271B1 EE 03271 B1 EE03271 B1 EE 03271B1 EE 9600108 A EE9600108 A EE 9600108A EE 9600108 A EE9600108 A EE 9600108A EE 03271 B1 EE03271 B1 EE 03271B1
- Authority
- EE
- Estonia
- Prior art keywords
- preparation
- methods
- pharmaceutical composition
- composition containing
- binding proteins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939325182A GB9325182D0 (en) | 1993-12-08 | 1993-12-08 | Humanized antibodies or binding proteins thereof specific for t cell subpopulations exhibiting select beta chain variable regions |
PCT/IB1994/000387 WO1995016038A2 (en) | 1993-12-08 | 1994-11-21 | Humanized antibodies and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
EE03271B1 true EE03271B1 (et) | 2000-06-15 |
Family
ID=10746330
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EE9600108A EE03271B1 (et) | 1993-12-08 | 1994-11-21 | Inimesele kohandatud antikehad või nende siduvad proteiinid, nende valmistamismeetodid ja neid sisaldav farmatseutiline kompositsioon |
Country Status (24)
Country | Link |
---|---|
US (1) | US5861155A (ru) |
EP (1) | EP0737250A1 (ru) |
JP (1) | JPH09509307A (ru) |
KR (2) | KR100239607B1 (ru) |
CN (1) | CN1063792C (ru) |
AU (1) | AU699249B2 (ru) |
BR (1) | BR9408278A (ru) |
CA (1) | CA2178622A1 (ru) |
CZ (2) | CZ287347B6 (ru) |
EE (1) | EE03271B1 (ru) |
FI (1) | FI962377A (ru) |
GB (1) | GB9325182D0 (ru) |
HU (1) | HUT75553A (ru) |
IL (1) | IL111926A (ru) |
LV (1) | LV11631B (ru) |
NO (1) | NO962346L (ru) |
NZ (1) | NZ276170A (ru) |
PL (1) | PL180157B1 (ru) |
RU (1) | RU2139934C1 (ru) |
SG (1) | SG48420A1 (ru) |
SK (1) | SK73596A3 (ru) |
UA (1) | UA29494C2 (ru) |
WO (1) | WO1995016038A2 (ru) |
ZA (1) | ZA949341B (ru) |
Families Citing this family (86)
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US6348581B1 (en) * | 1996-10-31 | 2002-02-19 | The Dow Chemical Company | High affinity humanized anti-TAG-72 monoclonalantibodies |
CN1064052C (zh) * | 1997-09-29 | 2001-04-04 | 中国科学院微生物研究所 | 甲状旁腺素相关蛋白人源化抗体及其制备方法 |
AU2444899A (en) * | 1998-01-22 | 1999-08-09 | Astrazeneca Ab | Pharmaceutical formulation comprising an antibody and a citrate buffer |
GB9906233D0 (en) * | 1999-03-19 | 1999-05-12 | Univ Newcastle | Bone formation |
EP1326991A2 (en) * | 2000-10-20 | 2003-07-16 | Whitehead Institute For Biomedical Research | Expression vectors and uses thereof |
AU2003221118A1 (en) * | 2002-03-22 | 2003-10-08 | Bipha Corporation | Immunoglobulin/hydrophilic peptide complexes |
US7794716B2 (en) | 2002-07-25 | 2010-09-14 | Glenveigh Pharmaceuticals, Llc | Antibody composition and passive immunization against pregnancy-induced hypertension |
GB0302740D0 (en) * | 2003-02-06 | 2003-03-12 | Axis Shield Asa | Assay |
US7794713B2 (en) * | 2004-04-07 | 2010-09-14 | Lpath, Inc. | Compositions and methods for the treatment and prevention of hyperproliferative diseases |
PT1742966E (pt) * | 2004-04-22 | 2014-02-05 | Agensys Inc | Anticorpos e moléculas derivadas daí que se ligam às proteínas steap-1 |
EP1921137A4 (en) * | 2005-06-21 | 2011-01-26 | Med & Biological Lab Co Ltd | ANTIBODIES WITH INHIBITOR EFFECT ON THE FORMATION OF AMYLOID FIBRILLES |
KR100740201B1 (ko) * | 2005-10-21 | 2007-07-18 | 삼성전자주식회사 | 듀얼 전송 스트림 생성 장치 및 그 방법 |
US20090074720A1 (en) * | 2005-10-28 | 2009-03-19 | Sabbadini Roger A | Methods for decreasing immune response and treating immune conditions |
US20080213274A1 (en) * | 2005-10-28 | 2008-09-04 | Sabbadini Roger A | Compositions and methods for the treatment and prevention of fibrotic, inflammatory, and neovascularization conditions of the eye |
CA2650459A1 (en) * | 2006-04-28 | 2007-11-08 | Eth Zuerich | Antibodies for the detection of bacillus anthracis and vaccine against b. anthracis infections |
US7862812B2 (en) * | 2006-05-31 | 2011-01-04 | Lpath, Inc. | Methods for decreasing immune response and treating immune conditions |
AU2007269714A1 (en) | 2006-07-03 | 2008-01-10 | Charles David Adair | Composition for modulating the expression of cell adhesion molecules |
PL2087002T3 (pl) * | 2006-10-27 | 2015-02-27 | Lpath Inc | Kompozycje i sposoby do wiązania sfingozyno-1 fosforanu |
JP5732182B2 (ja) * | 2006-10-27 | 2015-06-10 | エルパス・インコーポレイテッドLpath, Inc. | 眼疾患と症状を処置するための組成物および方法 |
US8604172B2 (en) * | 2009-04-17 | 2013-12-10 | Lpath, Inc. | Humanized antibody compositions and methods for binding lysophosphatidic acid |
US9163091B2 (en) * | 2007-05-30 | 2015-10-20 | Lpath, Inc. | Compositions and methods for binding lysophosphatidic acid |
US8158124B2 (en) * | 2007-05-30 | 2012-04-17 | Lpath, Inc. | Compositions and methods for binding lysophosphatidic acid |
US20110064744A1 (en) * | 2007-05-30 | 2011-03-17 | Sabbadini Roger A | Prevention and treatment of pain using antibodies to lysophosphatidic acid |
JP2010535503A (ja) | 2007-08-10 | 2010-11-25 | エージェンシー フォー サイエンス,テクノロジー アンド リサーチ(エー*エスティーエーアール) | 癌の診断および治療のためのvhz |
US7867497B2 (en) * | 2007-09-24 | 2011-01-11 | Vanderbilt University | Monoclonal antibodies to respiratory syncytial virus and uses therefor |
US8361465B2 (en) * | 2007-10-26 | 2013-01-29 | Lpath, Inc. | Use of anti-sphingosine-1-phosphate antibodies in combination with chemotherapeutic agents |
JP5756014B2 (ja) * | 2008-08-08 | 2015-07-29 | エイジェンシー・フォー・サイエンス,テクノロジー・アンド・リサーチ(エイ・スター) | がんの診断および治療のためのvhz |
US8871202B2 (en) | 2008-10-24 | 2014-10-28 | Lpath, Inc. | Prevention and treatment of pain using antibodies to sphingosine-1-phosphate |
US20110229471A1 (en) | 2008-11-26 | 2011-09-22 | Cedars-Sinai Medical Center | Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease |
EP2370092A1 (en) | 2008-12-03 | 2011-10-05 | Research Development Foundation | Modulation of olfml-3 mediated angiogenesis |
JP2012511026A (ja) * | 2008-12-05 | 2012-05-17 | エルパス・インコーポレイテッド | 抗脂抗体結晶構造を用いた抗体設計 |
US8401799B2 (en) * | 2008-12-05 | 2013-03-19 | Lpath, Inc. | Antibody design using anti-lipid antibody crystal structures |
US20100292443A1 (en) * | 2009-02-26 | 2010-11-18 | Sabbadini Roger A | Humanized platelet activating factor antibody design using anti-lipid antibody templates |
US8859736B2 (en) | 2010-02-19 | 2014-10-14 | The Board Of Regents Of The University Of Oklahoma | Monoclonal antibodies that inhibit the wnt signaling pathway and methods of production and use thereof |
US20110212088A1 (en) * | 2010-02-26 | 2011-09-01 | Sabbadini Roger A | Anti-paf antibodies |
HUE037992T2 (hu) | 2010-12-21 | 2018-09-28 | Selexys Pharmaceuticals Corp | Anti-P-szelektin antitestek és eljárások azok alkalmazására és azonosítására |
PT2663579T (pt) | 2011-01-14 | 2017-07-28 | Univ California | Terapêutica de anticorpos contra a proteína r0r-1 e métodos para sua utilização |
US9555108B2 (en) | 2011-03-24 | 2017-01-31 | Texas Tech University System | TCR mimic antibodies as vascular targeting tools |
EP3623381A1 (en) | 2011-05-19 | 2020-03-18 | The Regents Of The University Of Michigan | Integrin alpha-2 binding agents and use thereof to inhibit cancer cell proliferation |
DK2739310T3 (en) | 2011-08-05 | 2018-07-16 | Res Found Dev | Improved methods and compositions for modulating OLFML3-mediated angiogenesis |
AU2013308409A1 (en) | 2012-08-31 | 2015-03-26 | University Of Birmingham | Target peptides for immunotherapy and diagnostics |
EP4088737A3 (en) | 2012-09-05 | 2023-02-08 | University Of Virginia Patent Foundation | Target peptides for colorectal cancer therapy and diagnostics |
CA2888345C (en) | 2012-10-24 | 2020-04-21 | Research Development Foundation | Jam-c antibodies and methods for treatment of cancer |
US20160000893A1 (en) | 2012-12-13 | 2016-01-07 | University Of Virginia Patent Foundation | Target peptides for ovarian cancer therapy and diagnostics |
AU2014241162A1 (en) | 2013-03-27 | 2015-10-22 | Cedars-Sinai Medical Center | Mitigation and reversal of fibrosis and inflammation by inhibition of TL1A function and related signaling pathways |
US10316083B2 (en) | 2013-07-19 | 2019-06-11 | Cedars-Sinai Medical Center | Signature of TL1A (TNFSF15) signaling pathway |
CN114621346A (zh) | 2013-08-21 | 2022-06-14 | 德克萨斯州大学系统董事会 | 用于靶向连接蛋白半通道的组合物和方法 |
MA45352A (fr) | 2015-08-07 | 2018-06-13 | Univ Birmingham | Identification de glycopeptides associés à mhc de catégorie i comme cibles d'immunothérapie de cancer |
US11253590B2 (en) | 2015-12-02 | 2022-02-22 | Stsciences, Inc. | Antibodies specific to glycosylated BTLA (B- and T- lymphocyte attenuator) |
WO2017096051A1 (en) | 2015-12-02 | 2017-06-08 | Stcube & Co., Inc. | Antibodies and molecules that immunospecifically bind to btn1a1 and the therapeutic uses thereof |
AU2017224122B2 (en) | 2016-02-26 | 2024-04-11 | The Board Of Regents Of The University Of Texas System | Connexin (Cx) 43 hemichannel-binding antibodies and uses thereof |
CN109462996A (zh) | 2016-03-17 | 2019-03-12 | 西达-赛奈医疗中心 | 通过rnaset2诊断炎性肠病的方法 |
KR102418372B1 (ko) | 2016-03-29 | 2022-07-08 | 주식회사 에스티큐브 | 글리코실화된 pd-l1에 특이적인 이중 기능 항체 및 이의 사용 방법 |
EP3436480A4 (en) | 2016-03-30 | 2019-11-27 | Musc Foundation for Research Development | METHOD FOR THE TREATMENT AND DIAGNOSIS OF CANCER BY TARGETING GLYCOPROTEIN A REPETITION PREDOMINANT (GARP) AND FOR EFFECTIVE IMMUNOTHERAPY ALONE OR IN COMBINATION |
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MY191324A (en) | 2016-10-26 | 2022-06-15 | Cedars Sinai Medical Center | Neutralizing anti-tl1a monoclonal antibodies |
SG11201909751TA (en) | 2017-05-12 | 2019-11-28 | Augusta University Research Institute Inc | Human alpha fetoprotein-specific t cell receptors and uses thereof |
KR20200015602A (ko) | 2017-05-31 | 2020-02-12 | 주식회사 에스티큐브앤컴퍼니 | Btn1a1에 면역특이적으로 결합하는 항체 및 분자 및 이의 치료적 용도 |
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WO2019055825A1 (en) | 2017-09-15 | 2019-03-21 | The Regents Of The University Of California | INHIBITION OF AMINOACYLASE 3 (AA3) IN THE TREATMENT OF CANCER |
WO2019195561A2 (en) | 2018-04-06 | 2019-10-10 | BioLegend, Inc. | Anti-tetraspanin 33 agents and compositions and methods for making and using the same |
MA52366A (fr) | 2018-04-25 | 2021-03-03 | Prometheus Biosciences Inc | Anticorps anti-tl1a optimisés |
DE202019005887U1 (de) | 2018-07-03 | 2023-06-14 | Marengo Therapeutics, Inc. | Anti-TCR-Antikörpermoleküle und Verwendungen davon |
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WO2020092969A1 (en) | 2018-11-02 | 2020-05-07 | Oklahoma Medical Research Foundation | Monoclonal antibodies to eltd1 and uses thereof |
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WO2020172571A1 (en) | 2019-02-21 | 2020-08-27 | Elstar Therapeutics, Inc. | Multifunctional molecules that bind to t cell related cancer cells and uses thereof |
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WO2021072277A1 (en) | 2019-10-09 | 2021-04-15 | Stcube & Co. | Antibodies specific to glycosylated lag3 and methods of use thereof |
AU2020371725A1 (en) | 2019-10-24 | 2022-05-26 | Cedars-Sinai Medical Center | Humanized antibodies to TNF-like ligand 1A (TL1A) and uses thereof |
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JP2023551535A (ja) | 2020-12-01 | 2023-12-08 | ザ・ジョンズ・ホプキンス・ユニバーシティー | T細胞がんを治療するための方法および材料 |
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ZA811368B (en) * | 1980-03-24 | 1982-04-28 | Genentech Inc | Bacterial polypedtide expression employing tryptophan promoter-operator |
GB8607679D0 (en) * | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
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JP3095168B2 (ja) * | 1988-02-05 | 2000-10-03 | エル. モリソン,シェリー | ドメイン‐変性不変部を有する抗体 |
AU618989B2 (en) * | 1988-02-12 | 1992-01-16 | British Technology Group Limited | Improvements in or relating to antibodies |
US5223426A (en) * | 1988-12-15 | 1993-06-29 | T Cell Sciences, Inc. | Monoclonal antibodies reactive with defined regions of the t-cell antigen receptor |
US5766947A (en) * | 1988-12-14 | 1998-06-16 | Astra Ab | Monoclonal antibodies reactive with an epitope of a Vβ3.1 variable region of a T cell receptor |
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-
1993
- 1993-12-08 GB GB939325182A patent/GB9325182D0/en active Pending
-
1994
- 1994-11-21 BR BR9408278A patent/BR9408278A/pt not_active Application Discontinuation
- 1994-11-21 EP EP95900892A patent/EP0737250A1/en not_active Withdrawn
- 1994-11-21 HU HU9601574A patent/HUT75553A/hu unknown
- 1994-11-21 JP JP7516077A patent/JPH09509307A/ja active Pending
- 1994-11-21 EE EE9600108A patent/EE03271B1/xx unknown
- 1994-11-21 US US08/652,558 patent/US5861155A/en not_active Expired - Fee Related
- 1994-11-21 CN CN94194971A patent/CN1063792C/zh not_active Expired - Fee Related
- 1994-11-21 CA CA002178622A patent/CA2178622A1/en not_active Abandoned
- 1994-11-21 SG SG1996009542A patent/SG48420A1/en unknown
- 1994-11-21 WO PCT/IB1994/000387 patent/WO1995016038A2/en not_active Application Discontinuation
- 1994-11-21 UA UA96072682A patent/UA29494C2/ru unknown
- 1994-11-21 SK SK735-96A patent/SK73596A3/sk unknown
- 1994-11-21 AU AU10333/95A patent/AU699249B2/en not_active Ceased
- 1994-11-21 CZ CZ19961628A patent/CZ287347B6/cs not_active IP Right Cessation
- 1994-11-21 KR KR1019960703068A patent/KR100239607B1/ko not_active IP Right Cessation
- 1994-11-21 RU RU96115107A patent/RU2139934C1/ru active
- 1994-11-24 ZA ZA949341A patent/ZA949341B/xx unknown
- 1994-12-07 IL IL11192694A patent/IL111926A/en not_active IP Right Cessation
-
1996
- 1996-06-05 NO NO962346A patent/NO962346L/no not_active Application Discontinuation
- 1996-06-07 FI FI962377A patent/FI962377A/fi unknown
- 1996-07-04 LV LVP-96-218A patent/LV11631B/en unknown
- 1996-08-07 PL PL94314908A patent/PL180157B1/pl unknown
- 1996-08-07 NZ NZ276170A patent/NZ276170A/en unknown
-
1998
- 1998-01-27 CZ CZ1998236A patent/CZ287298B6/cs not_active IP Right Cessation
-
1999
- 1999-03-02 KR KR1019997001727A patent/KR100258902B1/ko not_active IP Right Cessation
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