ECSP088516A - Procedimiento graduable para la preparacion de un 42-ester de rapamicina a partir de un boronato de 42-ester de rapamicina - Google Patents

Procedimiento graduable para la preparacion de un 42-ester de rapamicina a partir de un boronato de 42-ester de rapamicina

Info

Publication number
ECSP088516A
ECSP088516A EC2008008516A ECSP088516A ECSP088516A EC SP088516 A ECSP088516 A EC SP088516A EC 2008008516 A EC2008008516 A EC 2008008516A EC SP088516 A ECSP088516 A EC SP088516A EC SP088516 A ECSP088516 A EC SP088516A
Authority
EC
Ecuador
Prior art keywords
rapamycin
ester
boronate
preparation
procedure
Prior art date
Application number
EC2008008516A
Other languages
English (en)
Inventor
Anthony Scott Pilcher
Adam P Michaud
Chunhao Zhang
Clifford William Coughlin
James S Farina
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37813522&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP088516(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of ECSP088516A publication Critical patent/ECSP088516A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se provee un procedimiento graduable para la preparación de un 42-éster de rapamicina mediante la reacción de un boronato de 42-éster de rapamicina con un diol y la purificación de 42-éster de rapamicina crudo por recristalización y tratamiento con un diol; se provee también un método para aislar y purificar un boronato de 42-éster de rapamicina de soluciones madre que comprenden acetona y contaminantes de rapamicina.
EC2008008516A 2005-12-07 2008-06-09 Procedimiento graduable para la preparacion de un 42-ester de rapamicina a partir de un boronato de 42-ester de rapamicina ECSP088516A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74814305P 2005-12-07 2005-12-07

Publications (1)

Publication Number Publication Date
ECSP088516A true ECSP088516A (es) 2008-07-30

Family

ID=37813522

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008516A ECSP088516A (es) 2005-12-07 2008-06-09 Procedimiento graduable para la preparacion de un 42-ester de rapamicina a partir de un boronato de 42-ester de rapamicina

Country Status (18)

Country Link
US (1) US7622578B2 (es)
EP (1) EP1957501A2 (es)
JP (1) JP2009518412A (es)
KR (1) KR20080077619A (es)
CN (1) CN101321770A (es)
AR (1) AR058284A1 (es)
AU (1) AU2006322024A1 (es)
BR (1) BRPI0619578A2 (es)
CA (1) CA2630645A1 (es)
CR (1) CR9986A (es)
EC (1) ECSP088516A (es)
GT (1) GT200800087A (es)
IL (1) IL191550A0 (es)
NO (1) NO20082375L (es)
PE (1) PE20070748A1 (es)
RU (2) RU2008120670A (es)
TW (1) TW200804399A (es)
WO (1) WO2007067560A2 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0313024A (pt) 2002-07-30 2005-07-12 Wyeth Corp Formulações parenterais contendo um hidroxiéster de rapamicina
TW200731967A (en) * 2005-12-20 2007-09-01 Wyeth Corp Control of CCI-779 dosage form stability through control of drug substance impurities
TW200824713A (en) * 2006-10-18 2008-06-16 Wyeth Corp Processes for the synthesis of individual isomers of mono-PEG CCI-779
CN102020661B (zh) * 2011-01-07 2013-02-13 天津市炜杰科技有限公司 一种驮瑞塞尔合成方法
RU2603261C2 (ru) * 2011-04-01 2016-11-27 Сандоз Аг Региоселективное ацилирование рапамицина в положении с-42
US9446977B2 (en) 2012-12-10 2016-09-20 Corning Incorporated Method and system for making a glass article with uniform mold temperature

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5358909A (en) * 1991-02-27 1994-10-25 Nippon Steel Corporation Method of manufacturing field-emitter
US5358908A (en) * 1992-02-14 1994-10-25 Micron Technology, Inc. Method of creating sharp points and other features on the surface of a semiconductor substrate
US5385909A (en) 1993-11-22 1995-01-31 American Home Products Corporation Heterocyclic esters of rapamycin
US5385908A (en) 1993-11-22 1995-01-31 American Home Products Corporation Hindered esters of rapamycin
US5362718A (en) * 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
US6277983B1 (en) * 2000-09-27 2001-08-21 American Home Products Corporation Regioselective synthesis of rapamycin derivatives
JP2004509898A (ja) * 2000-09-19 2004-04-02 ワイス 水溶性ラパマイシンエステル
DK1658295T3 (da) 2003-08-07 2007-09-24 Wyeth Corp Regioselektiv syntese af CCI-779
CN1874771A (zh) * 2003-09-03 2006-12-06 惠氏公司 3－羟基－2－(羟甲基)－2－甲基丙酸的非晶态雷帕霉素42－酯及其包含相同化合物的药用组合物
JP2007532650A (ja) 2004-04-14 2007-11-15 ワイス プロリンｃｃｉ−７７９（２，２−ビス（ヒドロキシメチル）プロピオン酸とのプロリン−ラパマイシン４２−エステル）ならびに細菌リパーゼを使用するプロリンｃｃｉ−７７９およびｃｃｉ−７７９の二段階酵素的合成
AU2005238432A1 (en) * 2004-04-14 2005-11-10 Wyeth Process for preparing rapamycin 42-esters and FK-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies
CA2562952A1 (en) * 2004-04-14 2005-11-10 Wyeth Regiospecific synthesis of rapamycin 42-ester derivatives
PA8641501A1 (es) * 2004-08-10 2006-09-08 Wyeth Corp Derivados de cci-779 y metodo para su preparacion
ES2380779T3 (es) * 2004-12-20 2012-05-18 Wyeth Llc Análogos de rapamicina y usos de los mismos en el tratamiento de trastornos neurológicos, proliferativos e inflamatorios
CN101084226A (zh) * 2004-12-20 2007-12-05 惠氏公司 雷帕霉素衍生物及其治疗神经紊乱的用途
AU2006213061A1 (en) * 2005-02-09 2006-08-17 Wyeth CCI-779 polymorph and use thereof
EP1853611A1 (en) * 2005-03-02 2007-11-14 Wyeth Recovery of cci-779 from mother liquors
JP2008533007A (ja) * 2005-03-07 2008-08-21 ワイス ４２−ｏ−（２−ヒドロキシ）エチル−ラパマイシンのオキセパン異性体

Also Published As

Publication number Publication date
NO20082375L (no) 2008-09-04
AU2006322024A1 (en) 2007-06-14
WO2007067560A3 (en) 2007-08-02
GT200800087A (es) 2008-10-06
CA2630645A1 (en) 2007-06-14
AR058284A1 (es) 2008-01-30
EP1957501A2 (en) 2008-08-20
PE20070748A1 (es) 2007-08-08
IL191550A0 (en) 2008-12-29
BRPI0619578A2 (pt) 2011-10-04
RU2008120670A (ru) 2010-01-20
JP2009518412A (ja) 2009-05-07
KR20080077619A (ko) 2008-08-25
WO2007067560A2 (en) 2007-06-14
CR9986A (es) 2008-08-21
RU2008142554A (ru) 2010-05-10
US7622578B2 (en) 2009-11-24
US20070129541A1 (en) 2007-06-07
TW200804399A (en) 2008-01-16
CN101321770A (zh) 2008-12-10

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