ECSP088516A - Procedimiento graduable para la preparacion de un 42-ester de rapamicina a partir de un boronato de 42-ester de rapamicina - Google Patents

Procedimiento graduable para la preparacion de un 42-ester de rapamicina a partir de un boronato de 42-ester de rapamicina

Info

Publication number
ECSP088516A
ECSP088516A EC2008008516A ECSP088516A ECSP088516A EC SP088516 A ECSP088516 A EC SP088516A EC 2008008516 A EC2008008516 A EC 2008008516A EC SP088516 A ECSP088516 A EC SP088516A EC SP088516 A ECSP088516 A EC SP088516A
Authority
EC
Ecuador
Prior art keywords
rapamycin
ester
boronate
preparation
procedure
Prior art date
Application number
EC2008008516A
Other languages
English (en)
Inventor
Anthony Scott Pilcher
Adam P Michaud
Chunhao Zhang
Clifford William Coughlin
James S Farina
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37813522&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP088516(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of ECSP088516A publication Critical patent/ECSP088516A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se provee un procedimiento graduable para la preparación de un 42-éster de rapamicina mediante la reacción de un boronato de 42-éster de rapamicina con un diol y la purificación de 42-éster de rapamicina crudo por recristalización y tratamiento con un diol; se provee también un método para aislar y purificar un boronato de 42-éster de rapamicina de soluciones madre que comprenden acetona y contaminantes de rapamicina.
EC2008008516A 2005-12-07 2008-06-09 Procedimiento graduable para la preparacion de un 42-ester de rapamicina a partir de un boronato de 42-ester de rapamicina ECSP088516A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74814305P 2005-12-07 2005-12-07

Publications (1)

Publication Number Publication Date
ECSP088516A true ECSP088516A (es) 2008-07-30

Family

ID=37813522

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008516A ECSP088516A (es) 2005-12-07 2008-06-09 Procedimiento graduable para la preparacion de un 42-ester de rapamicina a partir de un boronato de 42-ester de rapamicina

Country Status (18)

Country Link
US (1) US7622578B2 (es)
EP (1) EP1957501A2 (es)
JP (1) JP2009518412A (es)
KR (1) KR20080077619A (es)
CN (1) CN101321770A (es)
AR (1) AR058284A1 (es)
AU (1) AU2006322024A1 (es)
BR (1) BRPI0619578A2 (es)
CA (1) CA2630645A1 (es)
CR (1) CR9986A (es)
EC (1) ECSP088516A (es)
GT (1) GT200800087A (es)
IL (1) IL191550A0 (es)
NO (1) NO20082375L (es)
PE (1) PE20070748A1 (es)
RU (2) RU2008120670A (es)
TW (1) TW200804399A (es)
WO (1) WO2007067560A2 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE385795T1 (de) 2002-07-30 2008-03-15 Wyeth Corp Parenterale formulierungen mit einem rapamycin hydroxyester
PE20071067A1 (es) * 2005-12-20 2007-11-26 Wyeth Corp Composiciones de rapamicina y cci-779 y metodo para su preparacion
TW200824713A (en) * 2006-10-18 2008-06-16 Wyeth Corp Processes for the synthesis of individual isomers of mono-PEG CCI-779
CN102020661B (zh) * 2011-01-07 2013-02-13 天津市炜杰科技有限公司 一种驮瑞塞尔合成方法
WO2012131019A1 (en) * 2011-04-01 2012-10-04 Sandoz Ag Regioselective acylation of rapamycin at the c-42 position
US9446977B2 (en) 2012-12-10 2016-09-20 Corning Incorporated Method and system for making a glass article with uniform mold temperature

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5358909A (en) * 1991-02-27 1994-10-25 Nippon Steel Corporation Method of manufacturing field-emitter
US5358908A (en) * 1992-02-14 1994-10-25 Micron Technology, Inc. Method of creating sharp points and other features on the surface of a semiconductor substrate
US5385908A (en) 1993-11-22 1995-01-31 American Home Products Corporation Hindered esters of rapamycin
US5385909A (en) 1993-11-22 1995-01-31 American Home Products Corporation Heterocyclic esters of rapamycin
US5362718A (en) 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
US6277983B1 (en) * 2000-09-27 2001-08-21 American Home Products Corporation Regioselective synthesis of rapamycin derivatives
DK1319008T3 (da) 2000-09-19 2009-02-09 Wyeth Corp Vandoplöselige rapamycinestere
CN1829722B (zh) 2003-08-07 2010-10-27 惠氏公司 区域选择性合成cci-779
JP2007504226A (ja) 2003-09-03 2007-03-01 ワイス 非晶質状のラパマイシンの３−ヒドロキシ−２−（ヒドロキシメチル）−２−メチルプロピオン酸との４２−エステル、およびそれを含むその医薬組成物
DE602005010228D1 (de) 2004-04-14 2008-11-20 Wyeth Corp Verfahren zur herstellung von rapamycin-42-estern und fk-506-32-estern mit dicarbonsäure, vorstufen für rapamycinkonjugate und antikörper
SG152234A1 (en) 2004-04-14 2009-05-29 Wyeth Corp Regiospecific synthesis of rapamycin 42-ester derivatives
BRPI0509854A (pt) * 2004-04-14 2007-10-23 Wyeth Corp composto, métodos para a preparação regio-especìfica de um 42-éster de rapamicina ou 42-éster de prolina-rapamicina e para a preparação de um 42-éster de prolina-rapamicina, composição, e, produto
JP2008517874A (ja) 2004-08-10 2008-05-29 ワイス Ｃｃｉ−７７９誘導体及びそれらの作製法
RU2007119585A (ru) 2004-12-20 2009-01-27 Вайет (Us) Производные рапамицина и их применение при лечении неврологических заболеваний
US7276498B2 (en) 2004-12-20 2007-10-02 Wyeth Rapamycin analogues and uses thereof in the treatment of neurological disorders
CA2595766A1 (en) 2005-02-09 2006-08-17 Wyeth Cci-779 polymorph and use thereof
KR20070107072A (ko) 2005-03-02 2007-11-06 와이어쓰 모액으로부터의 ｃｃｉ-７７９의 회수
BRPI0608885A2 (pt) 2005-03-07 2017-02-21 Wyeth Corp composto de isômero c de sdz-rad, composição farmacêutica, e, embalagem farmacêutica

Also Published As

Publication number Publication date
AR058284A1 (es) 2008-01-30
CR9986A (es) 2008-08-21
CN101321770A (zh) 2008-12-10
KR20080077619A (ko) 2008-08-25
RU2008142554A (ru) 2010-05-10
CA2630645A1 (en) 2007-06-14
TW200804399A (en) 2008-01-16
GT200800087A (es) 2008-10-06
JP2009518412A (ja) 2009-05-07
US20070129541A1 (en) 2007-06-07
EP1957501A2 (en) 2008-08-20
WO2007067560A2 (en) 2007-06-14
AU2006322024A1 (en) 2007-06-14
PE20070748A1 (es) 2007-08-08
BRPI0619578A2 (pt) 2011-10-04
US7622578B2 (en) 2009-11-24
NO20082375L (no) 2008-09-04
WO2007067560A3 (en) 2007-08-02
IL191550A0 (en) 2008-12-29
RU2008120670A (ru) 2010-01-20

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