CR9986A - Procedimiento graduable para la preparación de un 42-ester de rapamicina a partir de un boronato de 42-ester de rapamicina - Google Patents

Procedimiento graduable para la preparación de un 42-ester de rapamicina a partir de un boronato de 42-ester de rapamicina

Info

Publication number
CR9986A
CR9986A CR9986A CR9986A CR9986A CR 9986 A CR9986 A CR 9986A CR 9986 A CR9986 A CR 9986A CR 9986 A CR9986 A CR 9986A CR 9986 A CR9986 A CR 9986A
Authority
CR
Costa Rica
Prior art keywords
rapamycin
ester
boronate
preparation
procedure
Prior art date
Application number
CR9986A
Other languages
English (en)
Inventor
Chunhao Zhang
Clifford William Coughlin
Anthony Pilcher
Adam P Michaud
James S Farina
Ayman Sahli
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37813522&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR9986(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CR9986A publication Critical patent/CR9986A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se provee un procedimiento graduable para la preparación de un 42-éster de rapamicina mediante la reacción de un boronato de 42-éster de rapamicina con un diol y la purificación de 42-éster de rapamicina crudo por recristalización y tratamiento con un diol; se provee también un método para aislar y purificar un boronato de 42-éster de rapamicina de soluciones madre que comprenden acetona y contaminantes de rapamicina.
CR9986A 2005-12-07 2008-05-19 Procedimiento graduable para la preparación de un 42-ester de rapamicina a partir de un boronato de 42-ester de rapamicina CR9986A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74814305P 2005-12-07 2005-12-07

Publications (1)

Publication Number Publication Date
CR9986A true CR9986A (es) 2008-08-21

Family

ID=37813522

Family Applications (1)

Application Number Title Priority Date Filing Date
CR9986A CR9986A (es) 2005-12-07 2008-05-19 Procedimiento graduable para la preparación de un 42-ester de rapamicina a partir de un boronato de 42-ester de rapamicina

Country Status (18)

Country Link
US (1) US7622578B2 (es)
EP (1) EP1957501A2 (es)
JP (1) JP2009518412A (es)
KR (1) KR20080077619A (es)
CN (1) CN101321770A (es)
AR (1) AR058284A1 (es)
AU (1) AU2006322024A1 (es)
BR (1) BRPI0619578A2 (es)
CA (1) CA2630645A1 (es)
CR (1) CR9986A (es)
EC (1) ECSP088516A (es)
GT (1) GT200800087A (es)
IL (1) IL191550A0 (es)
NO (1) NO20082375L (es)
PE (1) PE20070748A1 (es)
RU (2) RU2008120670A (es)
TW (1) TW200804399A (es)
WO (1) WO2007067560A2 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1553940T3 (da) 2002-07-30 2008-06-02 Wyeth Corp Patenterale formuleringer indeholdende en rapamycin-hydroxyester
CN101340901A (zh) * 2005-12-20 2009-01-07 惠氏公司 通过控制药物物质杂质控制cci-779剂型稳定性
TW200824713A (en) * 2006-10-18 2008-06-16 Wyeth Corp Processes for the synthesis of individual isomers of mono-PEG CCI-779
CN102020661B (zh) * 2011-01-07 2013-02-13 天津市炜杰科技有限公司 一种驮瑞塞尔合成方法
US9051336B2 (en) 2011-04-01 2015-06-09 Sandoz Regioselective acylation of rapamycin at the C-42 position
US9446977B2 (en) 2012-12-10 2016-09-20 Corning Incorporated Method and system for making a glass article with uniform mold temperature

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5358909A (en) * 1991-02-27 1994-10-25 Nippon Steel Corporation Method of manufacturing field-emitter
US5358908A (en) * 1992-02-14 1994-10-25 Micron Technology, Inc. Method of creating sharp points and other features on the surface of a semiconductor substrate
US5385909A (en) 1993-11-22 1995-01-31 American Home Products Corporation Heterocyclic esters of rapamycin
US5385908A (en) 1993-11-22 1995-01-31 American Home Products Corporation Hindered esters of rapamycin
US5362718A (en) * 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
US6277983B1 (en) * 2000-09-27 2001-08-21 American Home Products Corporation Regioselective synthesis of rapamycin derivatives
JP2004509898A (ja) * 2000-09-19 2004-04-02 ワイス 水溶性ラパマイシンエステル
RU2339639C2 (ru) 2003-08-07 2008-11-27 Уайт Региоселективный синтез cci-779
JP2007504226A (ja) * 2003-09-03 2007-03-01 ワイス 非晶質状のラパマイシンの３−ヒドロキシ−２−（ヒドロキシメチル）−２−メチルプロピオン酸との４２−エステル、およびそれを含むその医薬組成物
AU2005238431A1 (en) * 2004-04-14 2005-11-10 Wyeth Regiospecific synthesis of rapamycin 42-ester derivatives
US7445916B2 (en) * 2004-04-14 2008-11-04 Wyeth Process for preparing rapamycin 42-esters and FK-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies
BRPI0509854A (pt) 2004-04-14 2007-10-23 Wyeth Corp composto, métodos para a preparação regio-especìfica de um 42-éster de rapamicina ou 42-éster de prolina-rapamicina e para a preparação de um 42-éster de prolina-rapamicina, composição, e, produto
SV2006002188A (es) * 2004-08-10 2006-03-15 Wyeth Corp Derivados de cci - 779 y metodos para su preparacion ref. am-101759salvo
DK1828202T3 (da) * 2004-12-20 2012-05-07 Wyeth Llc Rapamycinanaloge samt deres anvendelse ved behandling af neurologiske, proliferative og inflammatoriske lidelser
JP2008524232A (ja) * 2004-12-20 2008-07-10 ワイス ラパマイシン誘導体及び神経障害の治療におけるその使用
US7442707B2 (en) * 2005-02-09 2008-10-28 Wyeth CCI-779 polymorph and use thereof
BRPI0607390A2 (pt) * 2005-03-02 2017-08-22 Wyeth Corp Processo para recuperar cci-779 de licores mâe
JP2008533007A (ja) * 2005-03-07 2008-08-21 ワイス ４２−ｏ−（２−ヒドロキシ）エチル−ラパマイシンのオキセパン異性体

Also Published As

Publication number Publication date
TW200804399A (en) 2008-01-16
WO2007067560A3 (en) 2007-08-02
IL191550A0 (en) 2008-12-29
WO2007067560A2 (en) 2007-06-14
GT200800087A (es) 2008-10-06
KR20080077619A (ko) 2008-08-25
BRPI0619578A2 (pt) 2011-10-04
NO20082375L (no) 2008-09-04
RU2008120670A (ru) 2010-01-20
CA2630645A1 (en) 2007-06-14
US7622578B2 (en) 2009-11-24
PE20070748A1 (es) 2007-08-08
JP2009518412A (ja) 2009-05-07
AR058284A1 (es) 2008-01-30
EP1957501A2 (en) 2008-08-20
US20070129541A1 (en) 2007-06-07
AU2006322024A1 (en) 2007-06-14
CN101321770A (zh) 2008-12-10
RU2008142554A (ru) 2010-05-10
ECSP088516A (es) 2008-07-30

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FA Abandonment or withdrawal (granting procedure)