ECSP066322A - Derivados de 4-indolilsulfonamidas, su preparación y su uso como moduladores de 5-ht-6 - Google Patents
Derivados de 4-indolilsulfonamidas, su preparación y su uso como moduladores de 5-ht-6Info
- Publication number
- ECSP066322A ECSP066322A EC2006006322A ECSP066322A ECSP066322A EC SP066322 A ECSP066322 A EC SP066322A EC 2006006322 A EC2006006322 A EC 2006006322A EC SP066322 A ECSP066322 A EC SP066322A EC SP066322 A ECSP066322 A EC SP066322A
- Authority
- EC
- Ecuador
- Prior art keywords
- preparation
- derivatives
- indolilsulfonamids
- modulators
- diastereomers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente invención se refiere a nuevos derivados de sulfonamidas, de fórmula general (1a, 1b, 1c) opcionalmente en forma de uno de sus estereoisómeros, preferiblemente enantiómeros o diasterómeros, su racemato o en forma de una mezcla de al menos dos de sus estereoisómeros, preferiblemente enantiómeros o diasterómeros, en cualquier razón de mezcla, o las sales de los mismos, preferiblemente las sales fisiológicamente aceptables correspondientes de los mismos o los solvatos correspondientes de los mismos; a los procedimientos para su preparación, a su aplicación como medicamentos en medicina humana y/o veterinaria y a las composiciones farmacéuticas que los contienen.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200301807A ES2222829B1 (es) | 2003-07-30 | 2003-07-30 | Derivados de 4-indolilsulfonamidas, su preparacion y su aplicacion como medicamentos. |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP066322A true ECSP066322A (es) | 2006-08-30 |
Family
ID=34130541
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2006006324A ECSP066324A (es) | 2003-07-30 | 2006-01-26 | Derivados de 6-indolilsulfonamidas, su preparación y su uso como moduladores de 5-ht-6. |
EC2006006322A ECSP066322A (es) | 2003-07-30 | 2006-01-26 | Derivados de 4-indolilsulfonamidas, su preparación y su uso como moduladores de 5-ht-6 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2006006324A ECSP066324A (es) | 2003-07-30 | 2006-01-26 | Derivados de 6-indolilsulfonamidas, su preparación y su uso como moduladores de 5-ht-6. |
Country Status (22)
Country | Link |
---|---|
US (1) | US8097643B2 (es) |
EP (1) | EP1648446B1 (es) |
JP (1) | JP2007500166A (es) |
KR (1) | KR20060123698A (es) |
CN (1) | CN100518736C (es) |
AT (1) | ATE432700T1 (es) |
AU (1) | AU2004262486A1 (es) |
BR (1) | BRPI0413068A (es) |
CA (1) | CA2534098A1 (es) |
DE (1) | DE602004021385D1 (es) |
EC (2) | ECSP066324A (es) |
ES (2) | ES2222829B1 (es) |
IL (1) | IL172892A0 (es) |
MX (1) | MXPA06001137A (es) |
NO (1) | NO20060155L (es) |
NZ (1) | NZ545300A (es) |
PE (1) | PE20050333A1 (es) |
PT (1) | PT1648446E (es) |
RU (1) | RU2006105778A (es) |
TW (1) | TW200505855A (es) |
WO (1) | WO2005013978A1 (es) |
ZA (1) | ZA200600421B (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009531443A (ja) * | 2006-03-29 | 2009-09-03 | フォールドアールエックス ファーマシューティカルズ インコーポレーティッド | α−シヌクレイン毒性の抑制 |
DE102007007751A1 (de) * | 2007-02-16 | 2008-08-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
DE102007012284A1 (de) | 2007-03-16 | 2008-09-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
EP2018861A1 (en) * | 2007-07-26 | 2009-01-28 | Laboratorios del Dr. Esteve S.A. | 5HT6-Ligands such as sulfonamide derivatives in drug-induced weight-gain |
DE102007035334A1 (de) * | 2007-07-27 | 2009-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
DE102007035333A1 (de) | 2007-07-27 | 2009-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
ATE495737T1 (de) | 2007-08-01 | 2011-02-15 | Esteve Labor Dr | Kombination von mindestens zwei 5-ht6-liganden |
DE102007042154A1 (de) | 2007-09-05 | 2009-03-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Arylsulfonylaminomethyphosphonsäure-Derivate, deren Herstellung und deren Verwendung als Arzneimittel |
EP2053052A1 (en) | 2007-10-23 | 2009-04-29 | Laboratorios del Dr. Esteve S.A. | Process for the preparation of 6-substituted imidazo[2,1-b]thiazole-5-sulfonyl halide |
EP2300489B1 (en) | 2008-06-06 | 2015-11-11 | Harbor Therapeutics, Inc. | Methods for preparing 17-alkynyl-7-hydroxy steroids and related compounds |
US20190336585A1 (en) * | 2018-05-03 | 2019-11-07 | John Lawrence Mee | Method for sustainable human cognitive enhancement |
US20190390193A1 (en) * | 2018-06-23 | 2019-12-26 | John Lawrence Mee | Reversible method for sustainable human cognitive enhancement |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3472870A (en) * | 1966-08-29 | 1969-10-14 | Mead Johnson & Co | Sulfonamidotryptamines |
GB9317764D0 (en) * | 1993-08-26 | 1993-10-13 | Pfizer Ltd | Therapeutic compound |
KR19980703048A (ko) | 1995-03-20 | 1998-09-05 | 피터쥐.스트링거 | 5-치환-3-(1,2,3,6-테트라히드로피리딘-4-일)- 및 3-(피페리딘-4-일)-1h-인돌: 신규한 5-ht1f 아고니스트 |
US5939451A (en) * | 1996-06-28 | 1999-08-17 | Hoffmann-La Roche Inc. | Use of sulfonamides |
US6043706A (en) | 1999-02-05 | 2000-03-28 | Ericsson Inc. | Methods and apparatus for controlling power amplifier quiescent current in a wireless communication device |
GB9902459D0 (en) * | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
US6521658B1 (en) * | 1999-05-28 | 2003-02-18 | Abbott Laboratories | Cell proliferation inhibitors |
GB9926302D0 (en) | 1999-11-05 | 2000-01-12 | Smithkline Beecham Plc | Novel compounds |
US7230011B2 (en) | 2001-01-30 | 2007-06-12 | Eli Lilly And Company | Benzenesulfonic acid indol-5-yl esters as antagonists of the 5ht6 receptor |
ES2187300B1 (es) * | 2001-11-14 | 2004-06-16 | Laboratorios Del Dr. Esteve, S.A. | Derivados de sulfonamidas, su preparacion y su aplicacion como medicamentos. |
CA2524682A1 (en) * | 2003-05-09 | 2004-11-18 | Laboratorios Del Dr. Esteve S.A. | Use of sulphonamide derivatives for the manufacture of a medicament for the prophylaxis and/or treatment of disorders of food ingestion |
-
2003
- 2003-07-30 ES ES200301807A patent/ES2222829B1/es not_active Expired - Fee Related
-
2004
- 2004-07-29 EP EP04763611A patent/EP1648446B1/en active Active
- 2004-07-29 CN CNB2004800221691A patent/CN100518736C/zh not_active Expired - Fee Related
- 2004-07-29 BR BRPI0413068-5A patent/BRPI0413068A/pt not_active Application Discontinuation
- 2004-07-29 DE DE602004021385T patent/DE602004021385D1/de active Active
- 2004-07-29 MX MXPA06001137A patent/MXPA06001137A/es unknown
- 2004-07-29 PT PT04763611T patent/PT1648446E/pt unknown
- 2004-07-29 JP JP2006521530A patent/JP2007500166A/ja active Pending
- 2004-07-29 ES ES04763611T patent/ES2327848T3/es active Active
- 2004-07-29 RU RU2006105778/04A patent/RU2006105778A/ru unknown
- 2004-07-29 AT AT04763611T patent/ATE432700T1/de not_active IP Right Cessation
- 2004-07-29 KR KR1020067001467A patent/KR20060123698A/ko not_active Application Discontinuation
- 2004-07-29 TW TW093122672A patent/TW200505855A/zh unknown
- 2004-07-29 WO PCT/EP2004/008512 patent/WO2005013978A1/en active Application Filing
- 2004-07-29 AU AU2004262486A patent/AU2004262486A1/en not_active Abandoned
- 2004-07-29 NZ NZ545300A patent/NZ545300A/en unknown
- 2004-07-29 ZA ZA200600421A patent/ZA200600421B/en unknown
- 2004-07-29 US US10/566,164 patent/US8097643B2/en not_active Expired - Fee Related
- 2004-07-29 CA CA002534098A patent/CA2534098A1/en not_active Abandoned
- 2004-08-02 PE PE2004000737A patent/PE20050333A1/es not_active Application Discontinuation
-
2005
- 2005-12-29 IL IL172892A patent/IL172892A0/en unknown
-
2006
- 2006-01-10 NO NO20060155A patent/NO20060155L/no not_active Application Discontinuation
- 2006-01-26 EC EC2006006324A patent/ECSP066324A/es unknown
- 2006-01-26 EC EC2006006322A patent/ECSP066322A/es unknown
Also Published As
Publication number | Publication date |
---|---|
CA2534098A1 (en) | 2005-02-17 |
RU2006105778A (ru) | 2007-09-20 |
NO20060155L (no) | 2006-01-10 |
DE602004021385D1 (de) | 2009-07-16 |
JP2007500166A (ja) | 2007-01-11 |
TW200505855A (en) | 2005-02-16 |
WO2005013978A1 (en) | 2005-02-17 |
ES2222829A1 (es) | 2005-02-01 |
AU2004262486A1 (en) | 2005-02-17 |
ES2327848T3 (es) | 2009-11-04 |
US8097643B2 (en) | 2012-01-17 |
PE20050333A1 (es) | 2005-06-12 |
ZA200600421B (en) | 2007-03-28 |
MXPA06001137A (es) | 2006-04-24 |
CN1829508A (zh) | 2006-09-06 |
EP1648446B1 (en) | 2009-06-03 |
NZ545300A (en) | 2008-05-30 |
PT1648446E (pt) | 2009-09-03 |
ECSP066324A (es) | 2006-08-30 |
US20070185158A1 (en) | 2007-08-09 |
ES2222829B1 (es) | 2006-03-01 |
ATE432700T1 (de) | 2009-06-15 |
IL172892A0 (en) | 2006-06-11 |
BRPI0413068A (pt) | 2006-10-17 |
CN100518736C (zh) | 2009-07-29 |
KR20060123698A (ko) | 2006-12-04 |
EP1648446A1 (en) | 2006-04-26 |
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