ECSP055818A - Métodos y composiciones para inducir apoptosis en células de cáncer. - Google Patents

Métodos y composiciones para inducir apoptosis en células de cáncer.

Info

Publication number
ECSP055818A
ECSP055818A EC2005005818A ECSP055818A ECSP055818A EC SP055818 A ECSP055818 A EC SP055818A EC 2005005818 A EC2005005818 A EC 2005005818A EC SP055818 A ECSP055818 A EC SP055818A EC SP055818 A ECSP055818 A EC SP055818A
Authority
EC
Ecuador
Prior art keywords
cancer cells
compositions
methods
induce apoptosis
apoptosis
Prior art date
Application number
EC2005005818A
Other languages
English (en)
Inventor
Marc Nasoff
Quinn L Deveraux
Deborah A Knee
Pedro Aza-Blanc
Garret M Hampton
Klaus Wagner
Original Assignee
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Irm Llc filed Critical Irm Llc
Publication of ECSP055818A publication Critical patent/ECSP055818A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/207—Modifications characterised by siRNA, miRNA

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Anticuerpos agonistas anti-DR4 o anti-DR5, combinados con agentes inductores de la apoptosis, inducen sigérgicamente apoptosis en células de cáncer.
EC2005005818A 2002-11-27 2005-05-26 Métodos y composiciones para inducir apoptosis en células de cáncer. ECSP055818A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US42984202P 2002-11-27 2002-11-27
US44896003P 2003-02-21 2003-02-21
US49471403P 2003-08-12 2003-08-12
US50490103P 2003-09-22 2003-09-22

Publications (1)

Publication Number Publication Date
ECSP055818A true ECSP055818A (es) 2006-01-27

Family

ID=32475709

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2005005818A ECSP055818A (es) 2002-11-27 2005-05-26 Métodos y composiciones para inducir apoptosis en células de cáncer.

Country Status (17)

Country Link
US (2) US7229617B2 (es)
EP (1) EP1576179B1 (es)
JP (1) JP2006514096A (es)
KR (3) KR20070122578A (es)
AT (1) ATE481092T1 (es)
AU (1) AU2003297579A1 (es)
BR (1) BR0316737A (es)
CA (1) CA2507077A1 (es)
CO (1) CO5640147A2 (es)
DE (1) DE60334247D1 (es)
EC (1) ECSP055818A (es)
MX (1) MXPA05005726A (es)
NO (1) NO20052922L (es)
PL (1) PL210174B1 (es)
PT (1) PT1576179E (es)
RU (1) RU2379056C2 (es)
WO (1) WO2004050895A2 (es)

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US7348003B2 (en) 2001-05-25 2008-03-25 Human Genome Sciences, Inc. Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors
US20050129616A1 (en) * 2001-05-25 2005-06-16 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to TRAIL receptors
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AU2002361784A1 (en) * 2001-12-20 2003-07-09 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to trail receptors
BR0316737A (pt) * 2002-11-27 2005-12-13 Irm Llc Métodos e composições para induzir apoptose em células cancerosas
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Also Published As

Publication number Publication date
KR20070122578A (ko) 2007-12-31
MXPA05005726A (es) 2005-08-16
ATE481092T1 (de) 2010-10-15
NO20052922L (no) 2005-08-17
KR20050094811A (ko) 2005-09-28
KR20090046973A (ko) 2009-05-11
BR0316737A (pt) 2005-12-13
AU2003297579A1 (en) 2004-06-23
US20070128204A1 (en) 2007-06-07
CO5640147A2 (es) 2006-05-31
WO2004050895A2 (en) 2004-06-17
RU2005120167A (ru) 2006-03-10
PL210174B1 (pl) 2011-12-30
RU2379056C2 (ru) 2010-01-20
US20050079172A1 (en) 2005-04-14
CA2507077A1 (en) 2004-06-17
JP2006514096A (ja) 2006-04-27
WO2004050895A3 (en) 2005-12-08
DE60334247D1 (de) 2010-10-28
EP1576179A2 (en) 2005-09-21
NO20052922D0 (no) 2005-06-15
PL377726A1 (pl) 2006-02-06
US7229617B2 (en) 2007-06-12
PT1576179E (pt) 2010-12-21
EP1576179B1 (en) 2010-09-15
US8173128B2 (en) 2012-05-08
EP1576179A4 (en) 2007-06-06
KR100915257B1 (ko) 2009-09-03

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