EA202190709A1 - Универсальные донорские клетки - Google Patents

Универсальные донорские клетки

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Publication number
EA202190709A1
EA202190709A1 EA202190709A EA202190709A EA202190709A1 EA 202190709 A1 EA202190709 A1 EA 202190709A1 EA 202190709 A EA202190709 A EA 202190709A EA 202190709 A EA202190709 A EA 202190709A EA 202190709 A1 EA202190709 A1 EA 202190709A1
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Eurasian Patent Office
Prior art keywords
mhc
universal donor
donor cells
encodes
genetic modification
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EA202190709A
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English (en)
Inventor
Алиреза РЕЗАНИА
Тони У. Хо
Ребека Рамос-Зейес
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Криспр Терапьютикс Аг
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Application filed by Криспр Терапьютикс Аг filed Critical Криспр Терапьютикс Аг
Publication of EA202190709A1 publication Critical patent/EA202190709A1/ru

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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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Abstract

В данном документе представлены генетически модифицированные клетки, которые совместимы со многими субъектами, например универсальные донорские клетки, и способы получения указанных генетически модифицированных клеток. Универсальные донорские клетки содержат по меньшей мере одну генетическую модификацию в пределах по меньшей мере одного гена, который кодирует один или несколько человеческих лейкоцитарных антигенов MHC-I или MHC-II или компонент или регулятор транскрипции комплекса MHC-I или MHC-II, или рядом с ним, по меньшей мере одну генетическую модификацию, которая обеспечивает повышение экспрессии по меньшей мере одного полинуклеотида, который кодирует толерогенный фактор, и необязательно по меньшей мере одну генетическую модификацию, которая обеспечивает повышение или снижение экспрессии по меньшей мере одного гена, который кодирует фактор выживания.
EA202190709A 2018-09-07 2019-09-07 Универсальные донорские клетки EA202190709A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862728529P 2018-09-07 2018-09-07
PCT/IB2019/057555 WO2020049535A1 (en) 2018-09-07 2019-09-07 Universal donor cells

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EA202190709A1 true EA202190709A1 (ru) 2021-07-23

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EA202190709A EA202190709A1 (ru) 2018-09-07 2019-09-07 Универсальные донорские клетки

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US (9) US10724052B2 (ru)
EP (1) EP3847189B1 (ru)
JP (1) JP2021534806A (ru)
KR (1) KR20210075086A (ru)
CN (1) CN113423727A (ru)
AU (1) AU2019334208A1 (ru)
BR (1) BR112021004254A2 (ru)
CA (1) CA3111696A1 (ru)
CO (1) CO2021004223A2 (ru)
EA (1) EA202190709A1 (ru)
IL (1) IL281280A (ru)
MX (1) MX2021002645A (ru)
PH (1) PH12021550476A1 (ru)
SG (1) SG11202102266TA (ru)
WO (1) WO2020049535A1 (ru)

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