EA202190546A1 - Способы лечения инфекций с применением бактерий - Google Patents

Способы лечения инфекций с применением бактерий

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Publication number
EA202190546A1
EA202190546A1 EA202190546A EA202190546A EA202190546A1 EA 202190546 A1 EA202190546 A1 EA 202190546A1 EA 202190546 A EA202190546 A EA 202190546A EA 202190546 A EA202190546 A EA 202190546A EA 202190546 A1 EA202190546 A1 EA 202190546A1
Authority
EA
Eurasian Patent Office
Prior art keywords
infections
treatment
methods
bacteria
compositions
Prior art date
Application number
EA202190546A
Other languages
English (en)
Inventor
Майкл Дж. Ньюман
Original Assignee
Декой Биосистемс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Декой Биосистемс, Инк. filed Critical Декой Биосистемс, Инк.
Publication of EA202190546A1 publication Critical patent/EA202190546A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0258—Escherichia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0275—Salmonella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55588—Adjuvants of undefined constitution
    • A61K2039/55594—Adjuvants of undefined constitution from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Настоящее изобретение в целом относится к композициям, дозированным формам и способам профилактики и лечения инфекций. Композиции содержат интактные и по существу нежизнеспособные грамотрицательные бактериальные клетки, которые были обработаны для снижения активности липополисахарид (ЛПС)-ассоциированного эндотоксина, которые неожиданно обладают повышенной активностью в отношении запуска продукции цитокинов иммунными клетками.
EA202190546A 2018-09-27 2019-09-26 Способы лечения инфекций с применением бактерий EA202190546A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862737762P 2018-09-27 2018-09-27
PCT/US2019/053289 WO2020069211A1 (en) 2018-09-27 2019-09-26 Methods of treatment of infections using bacteria

Publications (1)

Publication Number Publication Date
EA202190546A1 true EA202190546A1 (ru) 2021-09-10

Family

ID=69947978

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202190546A EA202190546A1 (ru) 2018-09-27 2019-09-26 Способы лечения инфекций с применением бактерий

Country Status (14)

Country Link
US (2) US11147844B2 (ru)
EP (1) EP3856213B1 (ru)
JP (1) JP2022502439A (ru)
KR (1) KR20210068462A (ru)
CN (1) CN112770764A (ru)
AU (1) AU2019347502A1 (ru)
BR (1) BR112021005762A2 (ru)
CA (1) CA3114110A1 (ru)
DK (1) DK3856213T3 (ru)
EA (1) EA202190546A1 (ru)
FI (1) FI3856213T3 (ru)
IL (1) IL281775A (ru)
MX (1) MX2021003551A (ru)
WO (1) WO2020069211A1 (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113045498B (zh) * 2021-03-24 2023-01-24 江苏食品药品职业技术学院 一种1,5-二芳基吡唑衍生物、合成方法及用途
CN114717178A (zh) * 2022-03-03 2022-07-08 中国医学科学院医学生物学研究所 一种树鼩睾丸间质细胞的分离培养方法及其应用
US20240075123A1 (en) * 2022-11-17 2024-03-07 Indaptus Therapeutics, Inc. Treatment of cancers and infectious diseases with killed intact bacteria

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5997881A (en) 1995-11-22 1999-12-07 University Of Maryland, Baltimore Method of making non-pyrogenic lipopolysaccharide or A
FR2822071B1 (fr) * 2001-03-15 2005-07-01 Pf Medicament Utilisation d'une fraction membranaire de bacteries a gram negatif pour induire la maturation des cellules dendritiques
ITRM20030394A1 (it) * 2003-08-12 2005-02-13 Maria Gabriella Santoro Uso dell'indometacina e derivati come farmaci antivirali e relative composizioni farmaceutiche.
US9265804B2 (en) * 2013-01-02 2016-02-23 Decoy Biosystems, Inc. Compositions and methods for treatment of cancer using bacteria
CN107530397A (zh) 2014-12-18 2018-01-02 赫尔普百治疗有限公司 新型组合和用途
WO2018195097A1 (en) * 2017-04-17 2018-10-25 The Regents Of The University Of California Engineered commensal bacteria and methods of use
CN107184613A (zh) * 2017-05-23 2017-09-22 山东大学 一种促进乙型肝炎病毒清除的益生菌组合物及其应用

Also Published As

Publication number Publication date
US11147844B2 (en) 2021-10-19
IL281775A (en) 2021-05-31
EP3856213A4 (en) 2022-07-06
DK3856213T3 (da) 2024-05-27
KR20210068462A (ko) 2021-06-09
AU2019347502A1 (en) 2021-04-22
WO2020069211A1 (en) 2020-04-02
MX2021003551A (es) 2021-08-16
JP2022502439A (ja) 2022-01-11
EP3856213B1 (en) 2024-03-06
EP3856213A1 (en) 2021-08-04
CN112770764A (zh) 2021-05-07
FI3856213T3 (fi) 2024-05-30
US20200101119A1 (en) 2020-04-02
BR112021005762A2 (pt) 2021-06-29
CA3114110A1 (en) 2020-04-02
US20220031768A1 (en) 2022-02-03

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